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MTSPGADRYLSAAFRNKSLPERLRDLEAMVEAITDCAIIQLDANGDVARWCPGAEAMTGYSAAEALGRPA ALLYTSEDRAAGLAERELAAARESGRCEFEGWRARKNGQRFRAGVALSVFTDDAGSAIGFTTVMRDVTAE HQRAETMFHALLESAPDAMVIVGPDGRIVLANAQADQMFGYPREELIGREVEILIPPRHRGSHERYRTGF FAAPAARRMGAGLELWGMRCDGTVFPVDVSLSPLQTEQGVMVSAAIRDITEQLAVQAELTETRAQAEVLA ERDRIAGDLQDHAIQRVFAVGLALQGTIPRARSADVQQRLNAAVDDLHAVVQDFRTAIFDLRHTKTDVPG LRQRFDEVIGRLAEGLAATVQYKGPLSVVEGELADQAEAVVAEAIGNAVRHTAATKLTIAVEVADEVSIE VIDNGKGLPDDVSEAGLKTLRRRAERVGGTLTVGAAAGGGTRLRWVAPLP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2508 | - | - | 100% (470) | PAS domain-containing protein |
| M. avium 104 | MAV_4108 | - | 3e-49 | 45.91% (220) | GAF family protein |
| M. avium 104 | MAV_5281 | - | 3e-07 | 26.27% (217) | histidine kinase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 2e-56 | 49.40% (249) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_3844 | - | 4e-52 | 48.50% (233) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 2e-56 | 49.40% (249) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | MLBr_01419 | - | 1e-06 | 28.05% (164) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_3890c | - | 2e-45 | 49.28% (207) | histidine kinase response regulator |
| M. marinum M | MMAR_1517 | devS | 2e-57 | 50.20% (249) | two-component sensor histidine kinase DevS |
| M. smegmatis MC2 155 | MSMEG_5241 | - | 3e-62 | 44.51% (337) | GAF family protein |
| M. thermoresistible (build 8) | TH_0388 | - | 4e-53 | 52.86% (210) | TWO COMPONENT SENSOR HISTIDINE KINASE DEVS |
| M. ulcerans Agy99 | MUL_2422 | devS | 9e-58 | 50.00% (258) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_1395 | - | 3e-58 | 51.39% (251) | GAF sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3844|M.gilvum_PYR-GCK ----MHDGAVADADDHRARDGARPVRTTLSQLRLRELLTEVQDRVEQIIR
Mvan_1395|M.vanbaalenii_PYR-1 ---------------------MRPLRDTLSQLRLRELLNEVQDRVEQIVE
MSMEG_5241|M.smegmatis_MC2_155 ------MGGVNGHHPRRDDDQRTPLRDTLSQLRLRELLSEVQDRVEQIVE
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
MMAR_1517|M.marinum_M MTDEPHPQDAGPALGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MAB_3890c|M.abscessus_ATCC_199 -------------MVEDVGAQPNRVTAELAHLQLRELLAEVQGRIEQIVD
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAV_2508|M.avium_104 ---------------MTSPGADRYLSAAFRNKSLPERLRDLEAMVEAITD
MLBr_01419|M.leprae_Br4923 --------------MLETVRSVMVHSGECSAESTADKEHRHHDLVAQRYQ
Mflv_3844|M.gilvum_PYR-GCK G-RDRLDGLVEAMLAVTSGLELDETLRTIVHTAIELVDAQYGALGVRGHD
Mvan_1395|M.vanbaalenii_PYR-1 G-RDRLDGLLDAMLVVTSGLELDETLRTIVRTAIDLVDAQYGALGVRGHD
MSMEG_5241|M.smegmatis_MC2_155 G-RDRLDGLVEAMLVVTSGLELDVTLRTIVHTAIELVDARYGALGVRGED
Mb3156c|M.bovis_AF2122/97 G-RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQ
Rv3132c|M.tuberculosis_H37Rv G-RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQ
MMAR_1517|M.marinum_M G-RDRLDGLVEAMLVVTSGLELNATLRTIVHSATNLVDARYCALEVHDRD
MUL_2422|M.ulcerans_Agy99 G-RDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRD
MAB_3890c|M.abscessus_ATCC_199 GTRGRMDALLDAVMAVSSGLELDATLREIVCAASELVSARYGALGVVGSD
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAV_2508|M.avium_104 C----------------AIIQLDANGDVARWCPGAEAMTGYSAAEALG--
MLBr_01419|M.leprae_Br4923 R-------------LVDHSPNMTCVHESGRVTYLNPVGVKWMAAQSPEQI
Mflv_3844|M.gilvum_PYR-GCK QELVEFIYEGIDEPMRERIGHLPEGRGVLGVLINDPKPIRLEDISRHADS
Mvan_1395|M.vanbaalenii_PYR-1 HELVEFIYQGIDEQSKELIGHLPEGRGVLGVLIDDPKPIRLDRISQHPAS
MSMEG_5241|M.smegmatis_MC2_155 HHLIEFIYEGITPEVREEIGPLPEGRGVLGVLIDDPKPIRLDDIRLHPAS
Mb3156c|M.bovis_AF2122/97 HRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPAS
Rv3132c|M.tuberculosis_H37Rv HRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPAS
MMAR_1517|M.marinum_M KRVLQFVYEGIDEDTVARIGHLPEGLGVIGLLIDEPKPLRLEDISQHPAS
MUL_2422|M.ulcerans_Agy99 KRVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHPAS
MAB_3890c|M.abscessus_ATCC_199 EKLAEFVYEGIDEATRDLIGPLPTGHGVLGVVIDEAKPLRLRDIAAHPAS
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAV_2508|M.avium_104 -RPAALLYTSEDRAAGLAERELAAARESGRCEFEG---------------
MLBr_01419|M.leprae_Br4923 IGHPLIEFVHPDSMPAMMSRIAPLREVGDASQPSEAVLLRLDGTTLEVEA
Mflv_3844|M.gilvum_PYR-GCK VGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKSDGQPFSEDDEVLVQAL
Mvan_1395|M.vanbaalenii_PYR-1 VGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSEDDEVLVQAL
MSMEG_5241|M.smegmatis_MC2_155 VGFPPNHPPMRTFLGVPVRTRDKVFGNLYLTEKTNGQPFSEDDEVLVQAL
Mb3156c|M.bovis_AF2122/97 IGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQAL
Rv3132c|M.tuberculosis_H37Rv IGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQAL
MMAR_1517|M.marinum_M IGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQAL
MUL_2422|M.ulcerans_Agy99 IGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQAL
MAB_3890c|M.abscessus_ATCC_199 VGFPANHPPMRTFLGVPVQVRGEVFGRLYLTEKLDGQEFTEDDEVVVRAL
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAV_2508|M.avium_104 -----------------------------WRARKNGQRFRAG--VALSVF
MLBr_01419|M.leprae_Br4923 VSVLTVWEGKPAYQVIFRDLTTQKAAEETLRFQAALVNHVSDAIIATTST
Mflv_3844|M.gilvum_PYR-GCK AAAAGIAIDNARLYAQSQARQSWIEATRDIGTELLSGIDPAG----VFRR
Mvan_1395|M.vanbaalenii_PYR-1 AAAAGIAIENARLYQQSKTRRSWIEATRDIGTEMLSGADPSK----VFRL
MSMEG_5241|M.smegmatis_MC2_155 AAAAGIAVDNARLYEESQARQAWIAATRDIGTQLLSGTDPAT----VFRL
Mb3156c|M.bovis_AF2122/97 AAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPAT----VFRL
Rv3132c|M.tuberculosis_H37Rv AAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPAT----VFRL
MMAR_1517|M.marinum_M AAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPAS----VFRL
MUL_2422|M.ulcerans_Agy99 AAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPAS----VFRL
MAB_3890c|M.abscessus_ATCC_199 AGAAGIAIENARLYQHARRREQWQRATADITAELLGGVDPGK----ALHL
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAV_2508|M.avium_104 TDDAGSAIG-------------FTTVMRDVTAEHQRAETMFH----ALLE
MLBr_01419|M.leprae_Br4923 GMVTSWNPAAEAIYRRSASDVLGMPIGEAVGAPLDPGAIITEGGVLSTTQ
Mflv_3844|M.gilvum_PYR-GCK VADRAQKLSGAAATLVAVPDDPDLPVGEVAELTVAASAGETIA-AAHDPI
Mvan_1395|M.vanbaalenii_PYR-1 VADQSRLLSGAQSTLVAVRSDLDELDGRVDELVVVATAGDGPG-VSLSAI
MSMEG_5241|M.smegmatis_MC2_155 VAAEALTLTGADGTLVAVPADPDASA--AEELVIVEVAGAVPAEVEASAI
Mb3156c|M.bovis_AF2122/97 VAAEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTI
Rv3132c|M.tuberculosis_H37Rv VAAEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTI
MMAR_1517|M.marinum_M VAEEALKLTSADAALVAVPVDEDVPASEVAQLLVIETVGNAVAAAEGCTI
MUL_2422|M.ulcerans_Agy99 VAEEALKLTSADAALVAIPVDEDVPASEVAQLLVIETVGNAVAAAEGCTI
MAB_3890c|M.abscessus_ATCC_199 VASSAALLAEADFAFIALPAGD---EEDTAELVVAVCEGKGAEVLNDKLI
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAV_2508|M.avium_104 SAPDAMVIVGPDGRIVLANAQADQMFGYPREELIGR---EVEILIPPRHR
MLBr_01419|M.leprae_Br4923 YASDGMALAVRVSAAVMENGFVLVCSDYTALLRVERRFQTVVALLEEGVI
Mflv_3844|M.gilvum_PYR-GCK PVAGTAIGDAFVHRTPGMTDRADIG-I---GATVGPALLLPLRAPDAVPG
Mvan_1395|M.vanbaalenii_PYR-1 PTHGSAIGEVFSTKTPVRFDTLELEPR---HLAPGPALVLPLRATDTVAG
MSMEG_5241|M.smegmatis_MC2_155 PVQDNAIGQAFRDRAPRRLDVLDGP------GLGGPALVLPLRATDTVAG
Mb3156c|M.bovis_AF2122/97 PVAGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLRARGTVAG
Rv3132c|M.tuberculosis_H37Rv PVAGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLRARGTVAG
MMAR_1517|M.marinum_M AVAGTALAEVLLDSAPRQVDKIAVEGVD-ELGDTGPALVLPLRATDAVAG
MUL_2422|M.ulcerans_Agy99 AVAGTALAEVLLDSAPRQVDKIAVEDVD-ELGDMGPALVLPLRATDAVAG
MAB_3890c|M.abscessus_ATCC_199 PIDGSTSGSTFIDHEPRNVGRLAVNLAEGTDLAFGPALVLPLGGGESTAG
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAV_2508|M.avium_104 GSHERYRTGFFAAPAARRMG--------------AGLELWGMRCDGTVFP
MLBr_01419|M.leprae_Br4923 VLDGDGYVESVNPAALRILGVSDRSALD------DPVRRAATLPMYDAQG
Mflv_3844|M.gilvum_PYR-GCK VLIVLRSVGAQPFRSDELDMLAAFA--DQAAQAWQLASTQHRLRELGILT
Mvan_1395|M.vanbaalenii_PYR-1 VLVALRPEGAPPFNAEELDMMAAFV--DQAALAWQLATTQRQLRELDVLT
MSMEG_5241|M.smegmatis_MC2_155 VLVAVQGSGARPFTAEQLEMMTGFA--DQAAVAWQLASSQRRMSELDILA
Mb3156c|M.bovis_AF2122/97 VVVVLSQGGPGAFTDEQLEMMAAFA--DQAALAWQLATSQRRMRELDVLT
Rv3132c|M.tuberculosis_H37Rv VVVVLSQGGPGAFTDEQLEMMAAFA--DQAALAWQLATSQRRMRELDVLT
MMAR_1517|M.marinum_M VVVLLHPSSPESVTEEQLEMMAAFA--DQAALALQLATSQRRMRELDVMT
MUL_2422|M.ulcerans_Agy99 VVVLLHPSSPESVTEEQLEMMAAFA--DQAALALQLATSQRRMRELDVVT
MAB_3890c|M.abscessus_ATCC_199 VLILLRTVGAIAFDEEQLDMAASFA--GQAALALEQAEVRLAKHELDVLA
TH_0388|M.thermoresistible__bu VLVVCRAEEGRPFTDEQLEILVTFA--DQAALAWQLAATQRRMRELDVLS
MAV_2508|M.avium_104 VDVSLSP----LQTEQGVMVSAAIR--DITEQLAVQAELTETRAQAEVLA
MLBr_01419|M.leprae_Br4923 RLLDHGRGAVREFLRTGTPKTGFIVGIDRPSDGTRVWLSVNSRSLNPVDP
: : . . : .
Mflv_3844|M.gilvum_PYR-GCK DRDRIARDLHDHVIQRLFAVGLSLQGSIARARSEEVQQRLSANVDDLQSV
Mvan_1395|M.vanbaalenii_PYR-1 DRDRIARDLHDHVIQRLFAVGLALQGTIPRARAPEVRERLTDCVDDLQQV
MSMEG_5241|M.smegmatis_MC2_155 DRDRIARDLHDHVIQRLFAVGLSLQGTIPRARSAEVQQRIADCVDDLQAV
Mb3156c|M.bovis_AF2122/97 DRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDV
Rv3132c|M.tuberculosis_H37Rv DRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDV
MMAR_1517|M.marinum_M ERDRIARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGV
MUL_2422|M.ulcerans_Agy99 ERDRIARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGV
MAB_3890c|M.abscessus_ATCC_199 DRDRIARDLHDHVIQRLFAVGLAMQSTHRRSVDPTVAARLADHIDQLHEV
TH_0388|M.thermoresistible__bu DRDRIARDLHDHVIQRLFAVGLTLQGTIPRARSTEVQQRLSECIDDLQAV
MAV_2508|M.avium_104 ERDRIAGDLQDHAIQRVFAVGLALQGTIPRARSADVQQRLNAAVDDLHAV
MLBr_01419|M.leprae_Br4923 EDATLLISFTDVTAERQASQYLAHQAAHDTLTGLPNRTSILARIDEQRYC
: : .: * . :* : *: *.: : :*: :
Mflv_3844|M.gilvum_PYR-GCK IQEIRTAIFDLHGGSSAVTRLRQRLDAAVAAFPES-GVRTSMQCAGPLSV
Mvan_1395|M.vanbaalenii_PYR-1 IQEIRTAIFDLHGGHGGSNRLRQRLDEAIAQFTAS-DVHTTVQFSGPLSV
MSMEG_5241|M.smegmatis_MC2_155 ISEIRTAIFDLHHTAPGGTRLRQRLDEAIAQFSGA-GLHTTSQFVGPLSV
Mb3156c|M.bovis_AF2122/97 IQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADS-GLRTSVQFVGPLSV
Rv3132c|M.tuberculosis_H37Rv IQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADS-GLRTSVQFVGPLSV
MMAR_1517|M.marinum_M IQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSS-GLRTTVQFIGPLSV
MUL_2422|M.ulcerans_Agy99 IQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSS-GLRTTVQFIGPLSV
MAB_3890c|M.abscessus_ATCC_199 IQEIRTAIFDLHTNDES---LRATLRSTINELTAETGLRVSVRMSGPLDV
TH_0388|M.thermoresistible__bu IGEIRTTIFDLHGGPATGSQIRQRIGEAANQFSDA-GVRTRVQFAGPLSV
MAV_2508|M.avium_104 VQDFRTAIFDLRHTKTDVPGLRQRFDEVIGRLAEG--LAATVQYKGPLSV
MLBr_01419|M.leprae_Br4923 GAPDQLLTAVLFIDLDNFKGINDSLGHDVGDVVLQTAAQRLRAGLRSRDV
: * :. : . . .*
Mflv_3844|M.gilvum_PYR-GCK VDAGLADHAEAVVREAVSNAVRHAEASTVAVTVTVEDDLAITVTDDGRGI
Mvan_1395|M.vanbaalenii_PYR-1 VDPALSDHAEAVVREAVSNAIRHSGATTLDVSVTAADELIIEVADDGCGM
MSMEG_5241|M.smegmatis_MC2_155 VDAELADHAEAVLREAVSNVVRHSGANELTVRVKVEDDLSIEVTDDGEGI
Mb3156c|M.bovis_AF2122/97 VDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGL
Rv3132c|M.tuberculosis_H37Rv VDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGL
MMAR_1517|M.marinum_M VDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGM
MUL_2422|M.ulcerans_Agy99 VDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGM
MAB_3890c|M.abscessus_ATCC_199 VPASTSGDAEAVVREAVSNVVRHARARELSVTVSVDDELVIEVVDDGIGI
TH_0388|M.thermoresistible__bu ISAVLADHAEAVVREAVSNAVRHGGATDLSVDVSVDDDLTIEVTDNGRGF
MAV_2508|M.avium_104 VEGELADQAEAVVAEAIGNAVRHTAATKLTIAVEVADEVSIEVIDNGKGL
MLBr_01419|M.leprae_Br4923 VGRFGGDEFVALILGKITHTELSKVVDRMHAALSEPTYVADAVLHLRASI
: ... *:: : :. . : : : * . .:
Mflv_3844|M.gilvum_PYR-GCK A-ADVTGSGLANLARRAQDVGGSFSVRRGAQV-GTTLTWRAPLP--
Mvan_1395|M.vanbaalenii_PYR-1 P-ADVTESGLTNLRQRAGDVGGTFTVESGDAG-GTRLRWCAPLR--
MSMEG_5241|M.smegmatis_MC2_155 S-GPVTESGLSNLRQRADQCGGELRIIDRPGG-GTILRWTAPLPD-
Mb3156c|M.bovis_AF2122/97 P-DEFTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
Rv3132c|M.tuberculosis_H37Rv P-DEFTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
MMAR_1517|M.marinum_M P-KTYTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
MUL_2422|M.ulcerans_Agy99 P-KTYTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
MAB_3890c|M.abscessus_ATCC_199 P-DVVARSGLSGLANRAAQSGGTFSVSAMDTG-GTRLVWSAPLP--
TH_0388|M.thermoresistible__bu PEGEVTESGLANLRHRARHAGGTLEVHNRPDG-GARLHWSVPLT--
MAV_2508|M.avium_104 P-DDVSEAGLKTLRRRAERVGGTLTVGAAAGG-GTRLRWVAPLP--
MLBr_01419|M.leprae_Br4923 GVVAIKGDDPRNIGQILRDADTAMYRAKLSGEGTSYYTDTFNQQPS
. : . . : :