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ESKRRTQEERSAATRDALIAAARKLWGLRGYTEVGTPEIAAAAGVTRGAMYHQFADKAALFRAVVEAVEQ DVMARMAVVVAESGASTPTDAIRAAVDAWLEVSADPEVRQLILLDAPSVLGWAEFRDVAQRYSLGMTEQL LTEAIRAGELAEQPVRPLAHVLIGALDEAAMVIATADDPDRARRETRQVLQRLVDGMFDAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5253 | - | - | 100% (202) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_1931 | - | 4e-35 | 44.39% (196) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_1977 | - | 2e-09 | 38.10% (105) | TetR-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0080 | - | 2e-93 | 86.00% (200) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_2327 | - | 2e-09 | 34.95% (103) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0078 | - | 2e-93 | 86.50% (200) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_02677 | - | 1e-63 | 73.71% (175) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4352c | - | 1e-22 | 32.99% (197) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0224 | - | 5e-92 | 85.50% (200) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_1565 | - | 8e-10 | 28.25% (177) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_3094 | - | 2e-35 | 41.27% (189) | PUTATIVE putative transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_4890 | - | 2e-91 | 85.00% (200) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4321 | - | 4e-11 | 35.85% (106) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0224|M.marinum_M MEIKRRTQEER-------SAATREALITAARKLWGSRGYAEVGTPEIAAE
MUL_4890|M.ulcerans_Agy99 MESKRRTQEER-------SAATREALITAARKLWGSRGYAEVGTPEIAAE
Mb0080|M.bovis_AF2122/97 MEIKRRTQEER-------SAATREALITGARKLWGLRGYAEVGTPEIATE
Rv0078|M.tuberculosis_H37Rv MEIKRRTQEER-------SAATREALITGARKLWGLRGYAEVGTPEIATE
MAV_5253|M.avium_104 MESKRRTQEER-------SAATRDALIAAARKLWGLRGYTEVGTPEIAAA
MLBr_02677|M.leprae_Br4923 MESQRRTQEER-------STATRDALTLARHRLWRLRGYAEVGTPEIAKE
TH_3094|M.thermoresistible__bu MSKRGGRVEDRR----ARGDQTRRDLIDAGRALFVDPGYFHTSVGDLVER
Mflv_2327|M.gilvum_PYR-GCK -MAERWTKERR-------TEHTRQILLDAAEEVFARKGLTGAALEEIADA
Mvan_4321|M.vanbaalenii_PYR-1 -MAERWTKERR-------TEHTRQILLDAAEEVFARKGLTGAALEEIAEA
MAB_4352c|M.abscessus_ATCC_199 MVPLRQAQALA----------TRQRLVDVATELFALHGFTSVTTTSLSEA
MSMEG_1565|M.smegmatis_MC2_155 MRQTRAARSGPGRPAGTDSVDTRQRVIDAACRCFAQFGYGPATNNQIAEM
** : : * . .:
MMAR_0224|M.marinum_M AGV-TRGAMYHQFADKAALFGEVVEAVEQDVMTRMATSVAASGAATPADA
MUL_4890|M.ulcerans_Agy99 AGV-TRGAMYHQFADKAALFGEVVEAVEQDVMTRMATSVTTSGAATPADA
Mb0080|M.bovis_AF2122/97 AGV-TRGAMYHQFADKAALFRDVVEVVEQDVMARMATLVAASGAATPADA
Rv0078|M.tuberculosis_H37Rv AGV-TRGAMYHQFADKAALFRDVVEVVEQDVMARMATLVAASGAATPADA
MAV_5253|M.avium_104 AGV-TRGAMYHQFADKAALFRAVVEAVEQDVMARMAVVVAESGASTPTDA
MLBr_02677|M.leprae_Br4923 ADT-TRGAVYHQFTDKAALFRDVVETVEQDAMAQIASVVASSGAKTPVDA
TH_3094|M.thermoresistible__bu SGVGTRGAFYHHFPDKAALFRAVFEDVEQDLTLRSIASPPEG--SDSWER
Mflv_2327|M.gilvum_PYR-GCK AGF-TRGAIYSQFGAKEKLFLAVVDRQRERFLDGFADVMDSFHRLSDVD-
Mvan_4321|M.vanbaalenii_PYR-1 AGF-TRGAIYSQFGAKEKLFLAVVDRQRQRFLDGFADVMMSFHRLSDVD-
MAB_4352c|M.abscessus_ATCC_199 SGM-TRGALYHHFANMTEVMEAVFERAEGFLVAEVNHS--LTSIESPAER
MSMEG_1565|M.smegmatis_MC2_155 AGV-TAGSVYYHFGTKNKLFEAVCDDVYGKILTRVMLAVSGS--HSVVGL
:. * *:.* :* :: * :
MMAR_0224|M.marinum_M IRAAVDAWLEVSG-DPEVRQLILLDAPAVLGWAGFRDVAQ---RYSLGMT
MUL_4890|M.ulcerans_Agy99 IRAAVDAWLEVSG-DPEVRQLILLDAPAVLGWAGFCDVAQ---RYSLGMT
Mb0080|M.bovis_AF2122/97 IRAAVDAWLEVSG-DPEVRQLVLLDAPVVLGWAGFRDVAQ---RYSLGMT
Rv0078|M.tuberculosis_H37Rv IRAAVDAWLEVSG-DPEVRQLILLDAPVVLGWAGFRDVAQ---RYSLGMT
MAV_5253|M.avium_104 IRAAVDAWLEVSA-DPEVRQLILLDAPSVLGWAEFRDVAQ---RYSLGMT
MLBr_02677|M.leprae_Br4923 IRAKVDAWLEGLA-DPQVRQLILLYAPSVLGWAAFRDVAQ---HYSLGMT
TH_3094|M.thermoresistible__bu LTRGLHGFLDAAA-EPEVQRIILIDGPVVLGWQTLRSIEE---RSSLAMI
Mflv_2327|M.gilvum_PYR-GCK IDELAQRWRQLSS-GADRAALGYELTLYLLRNPDARASVAAQRRETIRAL
Mvan_4321|M.vanbaalenii_PYR-1 IDELAERWRQLSS-GPDRAALGHELTLYLLRNPEARESVAGQRRETVRAL
MAB_4352c|M.abscessus_ATCC_199 FLAIGSAVLDVLAREPIVQRIVFVEAPMALGWSRWRALDG---GRSLGLI
MSMEG_1565|M.smegmatis_MC2_155 LRAVLTESMRINHESPELAGFVATAPIDARRHRELAESFATQGARMADAL
: . :
MMAR_0224|M.marinum_M EQ-LITEAIRAGQLDRHPVRPLAHVLIGALDEAAMFIATAD-----DPKR
MUL_4890|M.ulcerans_Agy99 EQ-LITEAIRAGQLDRHPVRPLAHVLIGALDEAAMFIATAD-----DPKR
Mb0080|M.bovis_AF2122/97 EQ-LITEAIRAGQLARQPVRPLAQVLIGALDEAAMFIATAD-----DPKR
Rv0078|M.tuberculosis_H37Rv EQ-LITEAIRAGQLARQPVRPLAQVLIGALDEAAMFIATAD-----DPKR
MAV_5253|M.avium_104 EQ-LLTEAIRAGELAEQPVRPLAHVLIGALDEAAMVIATAD-----DPDR
MLBr_02677|M.leprae_Br4923 EQQLLSEASRARQLA----QPLDHVLIGKLYESAMAIRRHHRLPEASPAR
TH_3094|M.thermoresistible__bu QQ-ILRRAIADGSIEEQPVTALTHMLVSAVEEASLLIAHST-----DPER
Mflv_2327|M.gilvum_PYR-GCK GEFISKNVARIGGTLTIEAETLARIVLAANDGVTLDSHIDGED-------
Mvan_4321|M.vanbaalenii_PYR-1 GEFISKNVARIGGTLTIEAETLARVVLAANDGITLNSHLDGED-------
MAB_4352c|M.abscessus_ATCC_199 QDILEELYRRGELVEAVDPQMAAQLILGAINESGMYAAAAPSERS-----
MSMEG_1565|M.smegmatis_MC2_155 TDAVRSGQDAGDIAADLDPVRVARLISAVVDGFAHAAVSAD---------
: : ::: .
MMAR_0224|M.marinum_M -------------AR------------RESRQVLRRLIDGMLND------
MUL_4890|M.ulcerans_Agy99 -------------AR------------RESRQVLRRLIDGMLND------
Mb0080|M.bovis_AF2122/97 -------------AR------------RETRQVLRRLIDGMLNG------
Rv0078|M.tuberculosis_H37Rv -------------AR------------RETRQVLRRLIDGMLNG------
MAV_5253|M.avium_104 -------------AR------------RETRQVLQRLVDGMFDAR-----
MLBr_02677|M.leprae_Br4923 NQTGAAPTHREHVARPSCEALTRHIRHRSTRTRSHRGKRGELLPRAATSS
TH_3094|M.thermoresistible__bu --------AR-----------------SDAEAVLDTLLNALTRRRSRSR-
Mflv_2327|M.gilvum_PYR-GCK ----------------------------LYRPYLQLVMSSVQTPH-----
Mvan_4321|M.vanbaalenii_PYR-1 ----------------------------LYRPYLQLVISSVQTPP-----
MAB_4352c|M.abscessus_ATCC_199 ---------------------------SRAAEQLTLLCRGLLSPRSG---
MSMEG_1565|M.smegmatis_MC2_155 ---------------------------PDEMDNMNELFQSLLLDTT----
.
MMAR_0224|M.marinum_M --
MUL_4890|M.ulcerans_Agy99 --
Mb0080|M.bovis_AF2122/97 --
Rv0078|M.tuberculosis_H37Rv --
MAV_5253|M.avium_104 --
MLBr_02677|M.leprae_Br4923 LL
TH_3094|M.thermoresistible__bu --
Mflv_2327|M.gilvum_PYR-GCK --
Mvan_4321|M.vanbaalenii_PYR-1 --
MAB_4352c|M.abscessus_ATCC_199 --
MSMEG_1565|M.smegmatis_MC2_155 --