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VGAAPLSIDVADTRSMLEAAAAIHGDTEAYVEPGARITFADWVGRARSVATQFADLGVGKGDVVALWLPS GIDYATCYAAAAMIGAITTGLNPRLGRREVESILQQADPALIVADDRLGLLPDLGRRILSRTALATDVSG SRVPTVDLTRRDLVAVIFTSGTTGTPKGAVFDADRLAAGAAAAGVMSAPYDRRLTSTPFAHAGYMFKLWD QLVWGSTLVVPPTPWSAQGMFDILRAERITVAGAVPTQWAKLLEVDGVSPSALPDLRIGIAATAPASPEL VRRVADRVGVPLVVRYAMTECPTICGTDPNDSPEVQFRTVGRPATGMDVRIAPDGVVEVHGPCVMRGYWR NPEVTAEVLRDGWLRTGDVGTLDGDGNLTLVGRSGDMYIRGGYNIHPGEVERTLAGHPGVKQAAVIGRSA PVIGEIGVACVVPADRTAPPTLADLRAHVTSELADYKAPDELLIVDELPLTAMLKPDRIALRELITMRHD EIQRRQPTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1912 | - | - | 100% (499) | acyl-CoA synthase |
| M. avium 104 | MAV_2622 | - | 0.0 | 84.17% (499) | acyl-CoA synthase |
| M. avium 104 | MAV_0971 | - | 6e-59 | 35.56% (478) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 2e-50 | 31.23% (506) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_2525 | - | 7e-61 | 35.59% (472) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 2e-50 | 31.23% (506) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_02257 | menE | 2e-38 | 33.60% (378) | O-succinylbenzoic acid--CoA ligase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 2e-44 | 29.33% (508) | AMP-binding domain protein |
| M. marinum M | MMAR_4688 | fadD3_2 | 2e-55 | 32.58% (485) | fatty-acid-CoA ligase FadD3_2 |
| M. smegmatis MC2 155 | MSMEG_4772 | - | 1e-55 | 32.17% (488) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4544 | - | 8e-60 | 34.36% (486) | PUTATIVE acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 4e-43 | 31.64% (493) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4133 | - | 5e-57 | 34.15% (492) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2525|M.gilvum_PYR-GCK ------------------------------MVASAADRFGDAEAVVD---
Mvan_4133|M.vanbaalenii_PYR-1 ------------------MTFQSRWQTIPEMVASAADRFGDAEAVVD---
MSMEG_4772|M.smegmatis_MC2_155 ------------------MTHPS-WQTIPEMVLSAADRFGDAEAVVDHGD
TH_4544|M.thermoresistible__bu ------------------VSPRDTWRTIPEMVLSAADRFGDAEAVVD---
MMAR_4688|M.marinum_M ---------------------MNEWQTIPEMVLSAGERFGDAEAIVD---
MUL_4126|M.ulcerans_Agy99 --------------------MTSDPRTVPTALDRLVRRLPNHDALVT---
Mb2533c|M.bovis_AF2122/97 MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMV-
Rv2505c|M.tuberculosis_H37Rv MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMV-
MAB_4377c|M.abscessus_ATCC_199 ----------MKAYDAGATLSPIIEETIGENFERIARAHPDVGALVDVS-
MAV_1912|M.avium_104 ---------------MGAAPLSIDVADTRSMLEAAAAIHGDTEAYVEPG-
MLBr_02257|M.leprae_Br4923 --------------------------------------------------
Mflv_2525|M.gilvum_PYR-GCK ------GSLRLSFDDVVERIRCAAGAFADLGIGKGDRAAIWAPNSVEWIV
Mvan_4133|M.vanbaalenii_PYR-1 ------GPLRLSFTELVERISCAAGAFAELGIEKGDRAAIWAPNSAEWII
MSMEG_4772|M.smegmatis_MC2_155 NPAGAAGPLRLTFVELADRVRRAAGAFLAHGIGRGDRVAIWAPNSAEWMI
TH_4544|M.thermoresistible__bu ------GPLRLTFTEVVHRIRCAAGAFRDLGIGKGDRAAIWAPNSAEWII
MMAR_4688|M.marinum_M ------GSLRITFTELTNRVHRAAGAFAAMGIDKGDRVAVWAPNSAEWII
MUL_4126|M.ulcerans_Agy99 ------DERSFTVSELNDEVYRAAAALIELGVKPAARVGIWSPNTWHWVV
Mb2533c|M.bovis_AF2122/97 ------ARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVL
Rv2505c|M.tuberculosis_H37Rv ------ARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVL
MAB_4377c|M.abscessus_ATCC_199 ------GDRRWTYRELDAEINRVARGLMSLGVAAGDRVGIWAPNCAEWVL
MAV_1912|M.avium_104 --------ARITFADWVGRARSVATQFADLGVGKGDVVALWLPSGIDYAT
MLBr_02257|M.leprae_Br4923 ---------------------------------------MLLPT------
: *.
Mflv_2525|M.gilvum_PYR-GCK AAFGLLTAGGVLVPVNTRFKADEAADIISRSGAKAVLVHQGFLGVD----
Mvan_4133|M.vanbaalenii_PYR-1 AAFGLLTAGGVLVPVNTRFKTDEAADIIARSGAKAVLVQQGFLGVD----
MSMEG_4772|M.smegmatis_MC2_155 AAFGALTAGGVVVPVNTRFKAEEAADVIRRSGAKVVLRQQGFLGQD----
TH_4544|M.thermoresistible__bu AAFGLLTAGGVLVPVNTRFRPDEAADIIGRSNARAVLVQKDFLSQD----
MMAR_4688|M.marinum_M AAFGLLTAGAVLVPVNTRFKTDEAADIIRRSGARAVLFEKGFLGMD----
MUL_4126|M.ulcerans_Agy99 ACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAMGHFLGSDRVAG
Mb2533c|M.bovis_AF2122/97 VQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDAD----
Rv2505c|M.tuberculosis_H37Rv VQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDAD----
MAB_4377c|M.abscessus_ATCC_199 VQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKSSD----
MAV_1912|M.avium_104 CYAAAAMIGAITTGLNPRLGRREVESILQQADPALIVADDRLGLLP----
MLBr_02257|M.leprae_Br4923 -----------------------LERILDGRAPAMVVVPAQHEPIA----
: :.
Mflv_2525|M.gilvum_PYR-GCK ---YRAP-----QGVPVIDLK---SDFLASGT-----------PFSR-PV
Mvan_4133|M.vanbaalenii_PYR-1 ---YTAP-----GGVPVIDLR---SDFLSSGT-----------PFSR-PV
MSMEG_4772|M.smegmatis_MC2_155 ---FEVP-----AGVPAIEIK---SDFLASGE-----------PAVVGGL
TH_4544|M.thermoresistible__bu ---YTLSDTDLAGGPPVIDIK---SDFLSGGA-----------PFERDDI
MMAR_4688|M.marinum_M ---FTVP-----DGIPAIDLR---SGFLECGK-----------PFER-AV
MUL_4126|M.ulcerans_Agy99 LDRKALPALRHIVRIPIEEPDGTWDEFIETGTD------TGAVTARAAAV
Mb2533c|M.bovis_AF2122/97 --YAAMLAEVGPRCPDLADVILLESDRWDALAG--AEPDLPALQQTAARL
Rv2505c|M.tuberculosis_H37Rv --YAAMLAEVGPRCPDLADVILLESDRWDALAG--AEPDLPALQQTAARL
MAB_4377c|M.abscessus_ATCC_199 --YVAMASQVMPDAPGLRDVVFIGTSDWTELVAGAERVTETALRARMSQL
MAV_1912|M.avium_104 ---------------DLGRRILSRTALATDVSG---------SRVPTVDL
MLBr_02257|M.leprae_Br4923 ---------------ALRALRVG-------------------------EE
Mflv_2525|M.gilvum_PYR-GCK QGTDVSDIIFTSGTTGRPKGVMMNHQQNLRLYEEWCDLADLREGDRYLMV
Mvan_4133|M.vanbaalenii_PYR-1 QGTDVSDIIFTSGTTGRPKGVMMNHRQNLRLYQEWCDLADLRQGDRYLMV
MSMEG_4772|M.smegmatis_MC2_155 RGTDIADIVYTSGTTGRPKGVMMNHLQTLRLYAEWCDLADLREGDRYLIV
TH_4544|M.thermoresistible__bu AGTDISDIIFTSGTTGRPKGAMMNHLQSLRMYEEWATLADLREGDRYLMI
MMAR_4688|M.marinum_M SGSDIADIVYTSGTTGRPKGVMMDHAQTLRHYAHWCDRADLRTGDRYLIV
MUL_4126|M.ulcerans_Agy99 SPDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITADDRHLCI
Mb2533c|M.bovis_AF2122/97 DGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIP
Rv2505c|M.tuberculosis_H37Rv DGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIP
MAB_4377c|M.abscessus_ATCC_199 SNTDPINIQYTSGTTGYPKGATLSHRNVLNNGFFVAESIQLQAGDRLCIP
MAV_1912|M.avium_104 TRRDLVAVIFTSGTTGTPKGAVFDADRLAAGAAAAGVMSAPY--DRRLTS
MLBr_02257|M.leprae_Br4923 IDDDVALVATTSGTTGVPKGALLTAAALTASASATHDRLGGP--GSWLLA
* : *****. .**. .
Mflv_2525|M.gilvum_PYR-GCK NPYFHTFGYKAGLIASFIRG-ATMFPVPVFDVDRVVELIAAERITMLP--
Mvan_4133|M.vanbaalenii_PYR-1 NPYFHTFGYKAGLIASFIRG-ATMLPVSVFDVDRVVELIAAERITMLP--
MSMEG_4772|M.smegmatis_MC2_155 NPFFHTFGYKAGCIASLIRG-ATVLPVAVFDVDAIVELIATERVTMLP--
TH_4544|M.thermoresistible__bu NPYFHTFGLKAGLIASFLRG-ATMVPVAVFDAEQVVDLVERERITMLP--
MMAR_4688|M.marinum_M NPFFHIFGYKAGCIASLIRG-ATIIPVRVFVLENVLELIEHERITMLP--
MUL_4126|M.ulcerans_Agy99 NPFFHNFGYKAGILACLQTG-ATLFPHLTFDPLRTLQAIERHRITVLP--
Mb2533c|M.bovis_AF2122/97 VPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLY--
Rv2505c|M.tuberculosis_H37Rv VPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLY--
MAB_4377c|M.abscessus_ATCC_199 VPFYHCFGMVMGNLGCTTHGATIVMPAPGFDPGRTLEAIERERCVGVY--
MAV_1912|M.avium_104 TPFAHAG-YMFKLWDQLVWGSTLVVPPTPWSAQGMFDILRAERITVAG--
MLBr_02257|M.leprae_Br4923 LPPYHIG-GLQVLVRSVLAGSVPIELDISAGFDLAKLPDAVGRLGTGRRY
* * * . : *
Mflv_2525|M.gilvum_PYR-GCK --GPPTLYHSLLA--VKDKSRLATLRAGVTGAADIPVELIRRVHEELPFQ
Mvan_4133|M.vanbaalenii_PYR-1 --GPPTLYHSLLN--VTDKSKLATLRAGVTGAADIPVELVRRVHEELPFQ
MSMEG_4772|M.smegmatis_MC2_155 --GPPTLYHSLLG--VPDKAKLATLRAGVTGAADIPVELIRRIHEELPFE
TH_4544|M.thermoresistible__bu --GPPTLYHSLLA--VRDKDKLATLRAAVTGAADIPVELIRRIRDELPFR
MMAR_4688|M.marinum_M --GPPTLYHSLLS--ARGQRDLSSLRAGVTGAADIPVELIRRVRTELPFQ
MUL_4126|M.ulcerans_Agy99 --GPPTIYQTLLDHPARDDYDLSSLRFAVTGAATVPVVLVERMQSELDID
Mb2533c|M.bovis_AF2122/97 --GVPTMFIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMP
Rv2505c|M.tuberculosis_H37Rv --GVPTMFIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMP
MAB_4377c|M.abscessus_ATCC_199 --GVPTMFIAMLADPGFAHRDLSTLRTGIMAGSVCPVEVMKRCIDEMHMA
MAV_1912|M.avium_104 --AVPTQWAKLLEVDGVSPSALPDLRIGIAATAPASPELVRRVADRVGVP
MLBr_02257|M.leprae_Br4923 TSLVATQLAKALTDS-TATAVLAELDAVLVGGGPA-PRPILDAATSAGIM
.* * * * : . . : .
Mflv_2525|M.gilvum_PYR-GCK TLATGYGLTEA-GTATLSRPGDSFDDIATTAGVACDGVELRIAED-----
Mvan_4133|M.vanbaalenii_PYR-1 TLATGYGLTEA-GTVTLSRPGDSFTDIATTAGVACDGVEMRIADD-----
MSMEG_4772|M.smegmatis_MC2_155 TVATGYGLTEA-GTATLSRPGDSFTDIATTVGTACDGVEVNLADD-----
TH_4544|M.thermoresistible__bu SLMTGYGLTEA-GNVTLSRPGDTPEQVATTAGLPCEDVEVRIAAD-----
MMAR_4688|M.marinum_M TIMTGYGLTEA-GTVTLSKPEDSFEDIATTAGLACDGIELATADD-----
MUL_4126|M.ulcerans_Agy99 IVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFADFELRIGPDT----
Mb2533c|M.bovis_AF2122/97 GVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVVDPATGET
Rv2505c|M.tuberculosis_H37Rv GVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVVDPATGET
MAB_4377c|M.abscessus_ATCC_199 GVAIAYGMTETSPVSCQTLFDDDLDRRTATVGRAHPHIEIKIVDPNSGET
MAV_1912|M.avium_104 LVVR-YAMTEC-PTICGTDPNDSPEVQFRTVGRPATGMDVRIAPD-----
MLBr_02257|M.leprae_Br4923 VVGT-YGMSET-AGGCVYD------------GVPLDGVCIRVLVN-----
: *.::* * . :
Mflv_2525|M.gilvum_PYR-GCK ------GEVLIRGYTVMQGYLDDPDATAEAIDPDGWLHTGDLGTLDEAGR
Mvan_4133|M.vanbaalenii_PYR-1 ------GEVLVRGYTVMQGYLDDPVATAETIDPDGWLHTGDLGTVDDAGR
MSMEG_4772|M.smegmatis_MC2_155 ------GEVLVRGYSVMQGYLDDPAATAEAIDADGWLHTGDLGEFTESGR
TH_4544|M.thermoresistible__bu ------GEVLVRGYGVMQGYLDDPAGTAQAIDPDGWLHTGDLGSFDDTGR
MMAR_4688|M.marinum_M ------GEILVRGYNVMKGYLDDPVATAEAIDGEGWLHTGDLGTIDETGR
MUL_4126|M.ulcerans_Agy99 ------GEVLLRGPNVMLGYLDDPRATAAAIDADGWLHTGDIGVLDEAGN
Mb2533c|M.bovis_AF2122/97 VPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGY
Rv2505c|M.tuberculosis_H37Rv VPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGY
MAB_4377c|M.abscessus_ATCC_199 VQRGQSGELCTRGYSVMLGYWNDEAHTREVLDTDGWMHTGDLAVMRDDGY
MAV_1912|M.avium_104 ------GVVEVHGPCVMRGYWRNPEVTAEVLRD-GWLRTGDVGTLDGDGN
MLBr_02257|M.leprae_Br4923 ------GHVAIGGATLAKGYR-NPIVPDPFAES-GWFHTDDLGTVDGSGV
* . * : ** : . **::*.*:. . *
Mflv_2525|M.gilvum_PYR-GCK LRIVGRKKDMFIVGGFNAYPAEIEGFLLEHPGVAQAAVVGVPDERMGQVG
Mvan_4133|M.vanbaalenii_PYR-1 LRIVGRKKDMFIVGGFNAYPAEIEGFLLEHRAVAQAAVIGVPDERLGQVG
MSMEG_4772|M.smegmatis_MC2_155 LRIIGRKKDMFIVGGFNAYPAEIEGFLLEHPDVAQVAVIGVDDDRMGQVG
TH_4544|M.thermoresistible__bu LRIVGRKKDMFIVGGFNAYPAEIEGFLMEHPAVAQAAVIGVPDERLGQVG
MMAR_4688|M.marinum_M LRVVGRKKDMFIVGGFNAYPAEIEGFLMEHEAVAQVAVIGVPDERLGQVG
MUL_4126|M.ulcerans_Agy99 LRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVAVIGIPDHRLGEVG
Mb2533c|M.bovis_AF2122/97 VRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGEEL
Rv2505c|M.tuberculosis_H37Rv VRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGEEL
MAB_4377c|M.abscessus_ATCC_199 CTIIGRLKDMVIRGGENIYPREIEEFLLTHPDIEDVHVVGVPDEKYGEEL
MAV_1912|M.avium_104 LTLVGRSGDMYIRGGYNIHPGEVERTLAGHPGVKQAAVIGRSAPVIGEIG
MLBr_02257|M.leprae_Br4923 LTVLGRADDAISTGGLTVLPGPVEAALCTHPAVSDCAVFGLTDDRLGQRV
: .* * ** . * :* * : : *.* *:
Mflv_2525|M.gilvum_PYR-GCK KAFVVAAAPAD-GSAGSLDAHALIAWCRERMAGFKVPRYVEFLDELPLNA
Mvan_4133|M.vanbaalenii_PYR-1 KAFVVAKTPAD-GSGAALTAEGLIAWCRDRMAGFKVPRYVEFLDELPLNA
MSMEG_4772|M.smegmatis_MC2_155 KAFVVLREPLD-GTRQCVTAEDLIAWSRERMAGYKVPRYVEFLEELPLNA
TH_4544|M.thermoresistible__bu KAFIVLDASARRADGPTVSAEDIIEWSRQRMAGYKVPRHVEFRDALPLNA
MMAR_4688|M.marinum_M KAFVVRQSGKS-----ALSAEDLLGWCRERMAGFKVPRSVRFVDALPLNA
MUL_4126|M.ulcerans_Agy99 RAFIVARPGFN------LDEKSVIDYTREHLANFKAPRSVRFVDTLPRNA
Mb2533c|M.bovis_AF2122/97 MAVVKLRNDAP-----ELTIERLREYCMGRIARFKIPRYLWIVDEFPMTV
Rv2505c|M.tuberculosis_H37Rv MAVVKLRNDAP-----ELTIERLREYCMGRIARFKIPRYLWIVDEFPMTV
MAB_4377c|M.abscessus_ATCC_199 CAWVRMRPDRV-----VIDAVAIRAFASGRLAHYKIPRYVHVVESFPMTV
MAV_1912|M.avium_104 VACVVPADRTA-----PPTLADLRAHVTSELADYKAPDELLIVDELPLTA
MLBr_02257|M.leprae_Br4923 VAAVVLTDGYA-----TPTLSMLRAHVTRRLDAMAAPRELHIVDTLPRRG
* : : .: * : . : :*
Mflv_2525|M.gilvum_PYR-GCK TGKVMKDRLNTVGR--------------
Mvan_4133|M.vanbaalenii_PYR-1 TGKVMKDRLQNRQS--------------
MSMEG_4772|M.smegmatis_MC2_155 TGKVMKDHLKAREALSKR----------
TH_4544|M.thermoresistible__bu TGKVVKEQLR------------------
MMAR_4688|M.marinum_M TGKVVKDLLR------------------
MUL_4126|M.ulcerans_Agy99 GGKVVKPQLRELA---------------
Mb2533c|M.bovis_AF2122/97 TGKVRKVEMRQQALEYLRGQQ-------
Rv2505c|M.tuberculosis_H37Rv TGKVRKVEMRQQALEYLRGQQ-------
MAB_4377c|M.abscessus_ATCC_199 TGKVRKIEMRQQTIQIFGLPEPGRTDEQ
MAV_1912|M.avium_104 MLKPDRIALRELITMRHDEIQRRQPTR-
MLBr_02257|M.leprae_Br4923 IGKVDRTALVRRFAKSG-----------
* : :