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RCGPLNTRVFEEEIMSHAQPNVVDGAHFDFVVVGGGTAGNVVAGRLAENPNASVLVVEAGVGNPWELDGV NTPGTAMELRHSPYDWDYLAKFVDRGVWQRIDKQETRGKILGGSSAANYFSWIPGCKPTYDRWAEYGGPE WTWQPLLPYLRKSATYHDDHGSFSPDMKRIGAGGPLPISHNNIPELQPFRDVVAQAWKSRGLPVTENIYD GEMNGLTHAVSTIYRGVRSGSYLFVKDRPNITILPEVRSKRLIIDYADRTCKGVTVIDASGTERSFYANR EVILSQGVFESPKLLMLSGIGPGRELAKHGIPVVVDSRHVGQHLFDHPGVPFVLRIKEGYAIDDYLRPGP KHDSAVADYQKDHQGPLGSGLLEMIGFPRVDEYLDRDPIYREAKAANGGLDPFSPEGQPHFELDFVPAFG SAFQWQYPTPPEGDHITVMVDLVRPAYDGGEVTLNSTDPFMQPNINLNYLSNELDIIALREGIRLAYDIL TKGDGFKDLVISQYPWDMPLHSDELMRTSIQDRVQTSYHPCGTNRLSKNIDQGVVDPKLKVHGVNKLRVV DASVFPIIPDCRIQNTVYMVGEKGADAIKADHTDLYK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4925 | - | - | 100% (598) | glucose-methanol-choline |
| M. avium 104 | MAV_4980 | - | 1e-33 | 29.37% (504) | choline dehydrogenase |
| M. avium 104 | MAV_4474 | - | 2e-25 | 26.47% (578) | FAD dependent oxidoreductase, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 9e-53 | 32.65% (582) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1255 | - | 4e-47 | 30.28% (568) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 9e-53 | 32.65% (582) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 5e-54 | 32.12% (579) | GMC-type oxidoreductase |
| M. marinum M | MMAR_4141 | - | 5e-52 | 31.65% (575) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_0526 | - | 2e-44 | 27.65% (575) | oxidoreductase, GMC family protein |
| M. thermoresistible (build 8) | TH_4204 | - | 1e-49 | 27.77% (569) | PUTATIVE glucose-methanol-choline oxidoreductase |
| M. ulcerans Agy99 | MUL_4004 | - | 2e-50 | 31.77% (576) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5894 | - | 1e-41 | 28.09% (566) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0526|M.smegmatis_MC2_155 -------------------------MTSYDYIIAGAGSAGCVLANRLSED
TH_4204|M.thermoresistible__bu -------------------------MSSYDYIIAGSGSAGCVLANRLSAD
Mflv_1255|M.gilvum_PYR-GCK -----------------------MAVTGYDYIVVGAGSAGCVLANRLSAD
Mvan_5894|M.vanbaalenii_PYR-1 -------------------------MTDFDYIIVGAGSAGCVLAHRLSED
Mb1310|M.bovis_AF2122/97 ------------------------MDTQSDYVVVGTGSAGAVVASRLSTD
Rv1279|M.tuberculosis_H37Rv ------------------------MDTQSDYVVVGTGSAGAVVASRLSTD
MMAR_4141|M.marinum_M ------------------------MDIECDYVVVGTGSAGAAVVNRLSAD
MUL_4004|M.ulcerans_Agy99 ------------------------MDIECDYVVVGTGSAGAAVVNRLSAD
MAB_0250|M.abscessus_ATCC_1997 ----------------------MVEDLAADFVIVGAGSAGAPLATRLSER
MAV_4925|M.avium_104 MRCGPLNTRVFEEEIMSHAQPNVVDGAHFDFVVVGGGTAGNVVAGRLAEN
*:::.* *:** :. **:
MSMEG_0526|M.smegmatis_MC2_155 PRIKVLLLEAGGSD--RNPLFSIPKGSGKLFDSEKHMWHYSTEPFG--PN
TH_4204|M.thermoresistible__bu PKVSVLLIEAGGFD--RNPLFSIPKGSGKLFDSERHMWHYETTPFG--PG
Mflv_1255|M.gilvum_PYR-GCK PAIRVLLLEAGRGD--RNLWLHIPKGAGKLFDSERHMWHYETTPFG--PD
Mvan_5894|M.vanbaalenii_PYR-1 PRVNVLLIEAGGRD--RSPMIRIPKGVGKILGDPKLTWHFPVRPIG--PS
Mb1310|M.bovis_AF2122/97 PATTVVALEAGPRD--KNRFIGVPAAFSKLFRSEIDWDYLTEPQPE--LD
Rv1279|M.tuberculosis_H37Rv PATTVVALEAGPRD--KNRFIGVPAAFSKLFRSEIDWDYLTEPQPE--LD
MMAR_4141|M.marinum_M SGTSVVALEAGPSD--KNRFIGIPAAFPKLFRSEVDWDYTTEPEPQ--LG
MUL_4004|M.ulcerans_Agy99 SGTSVVALEAGPSD--KNRFIGIPAAFPKLFRSEVDWDYTTEPEPQ--LG
MAB_0250|M.abscessus_ATCC_1997 TNDQVLVLEAGPKD--KDMGIHIPAAFSKLFRSDVDWDYLTEPQPQ--LN
MAV_4925|M.avium_104 PNASVLVVEAGVGNPWELDGVNTPGTAMELRHSPYDWDYLAKFVDRGVWQ
. *: :*** : . . * :: . :
MSMEG_0526|M.smegmatis_MC2_155 PHAEQWMRGKVLGGSSSINGMIYNRGTRADYDGLERLGNKGWGWDDILPI
TH_4204|M.thermoresistible__bu RHTEQWMRGKVLGGSSSVNGMIYNRGNRADYDGLEQLGNKGWGWDDILPI
Mflv_1255|M.gilvum_PYR-GCK AHVEQWMRGKVIGGSSAVNGMIYNRGHRADYDALEQMGNKGWGWDEILPI
Mvan_5894|M.vanbaalenii_PYR-1 QIVEQWVRGKTLGGSSSVNGMVYNRGSAPDYDALAALGNPAWGWDHILPA
Mb1310|M.bovis_AF2122/97 GREIYWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAGPRWSYADVLGY
Rv1279|M.tuberculosis_H37Rv GREIYWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAGPRWSYADVLGY
MMAR_4141|M.marinum_M GREIYWPRGKVLGGSSSMNAMMWVRGFAADYDEWARLAGSHWSYGELLGY
MUL_4004|M.ulcerans_Agy99 GREIYWPRDKVLGGSSSMNAMMWVRGFAADYDEWARLAGSHWSYGELLGY
MAB_0250|M.abscessus_ATCC_1997 NRQIYWPRGKTLGGSSSMNAMMWVRGFAADYDDWAQVAGEQWSFANIAPY
MAV_4925|M.avium_104 RIDKQETRGKILGGSSAANYFSWIPGCKPTYDRWAEYGGPEWTWQPLLPY
*.* :****: * : : * . ** .. * : :
MSMEG_0526|M.smegmatis_MC2_155 FKRFEDNEFG----PSATR--GVGGPLHISIP--RDPDPLCEEMLAAAEA
TH_4204|M.thermoresistible__bu FKQFEDNEFG----PSPTR--GAGGPLHISVP--RDADPLCDEMIDAGTV
Mflv_1255|M.gilvum_PYR-GCK FKGFEDHEFG----PSATR--GTGGPLHISVP--RDPDPLCEDMIEAATG
Mvan_5894|M.vanbaalenii_PYR-1 FRAIENHELG----PDPTR--GTGGPLEISVD--AHLPRICHDVIAAGEK
Mb1310|M.bovis_AF2122/97 FRRIENVTAAWHFVSGDDS--GVTGPLHISRQ--RSPRSVTAAWLAAARE
Rv1279|M.tuberculosis_H37Rv FRRIENVTAAWHFVSGDDS--GVTGPLHISRQ--RSPRSVTAAWLAAARE
MMAR_4141|M.marinum_M FRQIEDVTAAWHFVNGDDS--GVTGPLQISRQ--RSPSPLTAAWLAATRD
MUL_4004|M.ulcerans_Agy99 FRQIEDVTAAWHFVNGDDS--GVTGPLQISRQ--RSPSPLTAAWLAATRD
MAB_0250|M.abscessus_ATCC_1997 FKRIEAVEG----ATESDE--GTDGALKISKQ--RSPRSSTAAWLEAVKE
MAV_4925|M.avium_104 LRKSATYHDDHGSFSPDMKRIGAGGPLPISHNNIPELQPFRDVVAQAWKS
:: *. *.* ** *
MSMEG_0526|M.smegmatis_MC2_155 SGLTRVQDINEHDTERIGYATSTIRNGRRVSAATAFLKPALGRPNLTVRT
TH_4204|M.thermoresistible__bu AGLHRVEDINESDDERIGYATATIKNGRRVSAARAFLKPALRRANLSVRT
Mflv_1255|M.gilvum_PYR-GCK AGMWRVRDINESDGERIGYATSTIRGGRRVSAATAFLKPVLHRPNLTVRT
Mvan_5894|M.vanbaalenii_PYR-1 LGWSATDDVNGSDAARIGPAPRTIRNGQRVSSARAFLHPVAHRPNLTIAT
Mb1310|M.bovis_AF2122/97 CGFAAAR-PNSPRPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLT
Rv1279|M.tuberculosis_H37Rv CGFAAAR-PNSPRPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLT
MMAR_4141|M.marinum_M CGFPPVQ-PNSAEPEGFCETIVTQRRGSRWSTVDAYLRPAMGRRNLSILT
MUL_4004|M.ulcerans_Agy99 CGFAPVQ-PNSAEPEGFCETIVTQRRGSRWSTVDAYLRPAMGRRNLSILT
MAB_0250|M.abscessus_ATCC_1997 AGFDVER-ANTPEPKGFSETMVCQHGGRRWSTADGYLKPGLRRRNLNVVT
MAV_4925|M.avium_104 RGLPVTENIYDGEMNGLTHAVSTIYRGVRSGSYLFVKD----RPNITILP
* : : * * .: * *: : .
MSMEG_0526|M.smegmatis_MC2_155 SATVGRILFEGTR--AVGVDVTGT-SGTTQVRASREVIVSLGSLNSPVLL
TH_4204|M.thermoresistible__bu RAVAQRILLAGGR--AVGLEIASR-GRTGKVYATREVIIAMGSLNTPKLL
Mflv_1255|M.gilvum_PYR-GCK GATVRRVLFDGER--ADGVEIATG-AGTEQVRAAREVVLSLGSLNSPKLL
Mvan_5894|M.vanbaalenii_PYR-1 DTTVNRILFKADK--AIGVQATTSKGGAAVCTAGREVLLSLGSISTPRLL
Mb1310|M.bovis_AF2122/97 GATATRVVIDGDR--AVGVEYQSD-GQTRIVYARREVVLCAGAVNSPQLL
Rv1279|M.tuberculosis_H37Rv GATATRVVIDGDR--AVGVEYQSD-GQTRIVYARREVVLCAGAVNSPQLL
MMAR_4141|M.marinum_M GATATRIVIHGTR--ATGIEYQRE-GQHCTVHARREVVLCGGAVNSPQLL
MUL_4004|M.ulcerans_Agy99 GATATRIVIHGTR--ATGVEYQRE-GQHCTVHARREVVLCGGAVNSPQLL
MAB_0250|M.abscessus_ATCC_1997 DAQARRVLFDGIR--AVGVEYVRD-GITHTVHARREVILSGGAINSPQLL
MAV_4925|M.avium_104 EVRSKRLIIDYADRTCKGVTVIDASGTERSFYANREVILSQGVFESPKLL
. *::: . *: . * ***::. * ..:* **
MSMEG_0526|M.smegmatis_MC2_155 QLSGIGPREVLRSAGVQVFIEHDRVGRGLREHRCATLRFDLIEDLGYNKQ
TH_4204|M.thermoresistible__bu QLSGIGPREVLDAAGVPVYLDRANVGRRMREHRCATLRFDLREDLGYNRL
Mflv_1255|M.gilvum_PYR-GCK QLSGIGPSDVLGAAGVPVLVERDNVGRRMREHRCATLRYRLKEDLGYNKL
Mvan_5894|M.vanbaalenii_PYR-1 QLSGIGDRSLLRGLGIDTLADSPNVGRRMREHRCFALQFRLDRPVGYNRQ
Mb1310|M.bovis_AF2122/97 MLSGIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDS-----
Rv1279|M.tuberculosis_H37Rv MLSGIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDS-----
MMAR_4141|M.marinum_M MLSGIGDRSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDS-----
MUL_4004|M.ulcerans_Agy99 MLSGIGDRSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDS-----
MAB_0250|M.abscessus_ATCC_1997 MLSGIGEATRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSDS-----
MAV_4925|M.avium_104 MLSGIGPGRELAKHGIPVVVDSRHVGQHLFDHPGVPFVLRIKEGYAIDDY
***** * .: . . .** : :* . :
MSMEG_0526|M.smegmatis_MC2_155 LASSVAQALTGLRYLATRRGPLGAPSFDIVGFVKTRADVDR---------
TH_4204|M.thermoresistible__bu LATGTGQALTGAKYLATRKGPLAAPSFDVVGFVKTQPGLDR---------
Mflv_1255|M.gilvum_PYR-GCK LATNVGQALTGMKYLATRKGPLAAPSFDVVGFVKDRPDSER---------
Mvan_5894|M.vanbaalenii_PYR-1 LSTPLRQAFTAARYLATRRGPLAGAAFDVIGFFKTSPELER---------
Mb1310|M.bovis_AF2122/97 -LFAAEKPGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKL---------
Rv1279|M.tuberculosis_H37Rv -LFAAEKPGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKL---------
MMAR_4141|M.marinum_M -LAAAEKPMQLINYLLRRRGMLTSNVGEAYGFVRSRPGLDL---------
MUL_4004|M.ulcerans_Agy99 -LAAAEKPMQLINYLLRRRGMLTSNVGEAYGFVRSRPGLDL---------
MAB_0250|M.abscessus_ATCC_1997 -LFGAEKPLQLANYFLRHRGMLTSNVGEAYGFLRSHPNLTL---------
MAV_4925|M.avium_104 LRPGPKHDSAVADYQKDHQGPLGSGLLEMIGFPRVDEYLDRDPIYREAKA
: * ::* * . : ** :
MSMEG_0526|M.smegmatis_MC2_155 -------------PDGQIMMGPYTLPPYN-VGEPVTIQRQAGLSCLGMVL
TH_4204|M.thermoresistible__bu -------------PDGQIMLGPWTIPPYNQSGEPVVIPRQAGVSALGMAL
Mflv_1255|M.gilvum_PYR-GCK -------------PLGQVMMGPWTLPPYN-TGEPVVIEREPGISCLGMVL
Mvan_5894|M.vanbaalenii_PYR-1 -------------PDAQILMAPFSLAPYE-QGKEATVERDPGIQAIGYLL
Mb1310|M.bovis_AF2122/97 -------------PDLELIFAPAPFYDEA----LVP-PAGHGVVFGPILV
Rv1279|M.tuberculosis_H37Rv -------------PDLELIFAPAPFYDEA----LVP-PAGHGVVFGPILV
MMAR_4141|M.marinum_M -------------PDLELIFAPAPFYDEG----LPAHPPGHGVVFGPILV
MUL_4004|M.ulcerans_Agy99 -------------PDLELIFAPAPFYDEG----LPAHPPGHGVVFGPILV
MAB_0250|M.abscessus_ATCC_1997 -------------PDLELIFAPAPFFDEG----IGV-ATEHAIVMGPILL
MAV_4925|M.avium_104 ANGGLDPFSPEGQPHFELDFVPAFGSAFQ-WQYPTPPEGDHITVMVDLVR
* :: : *
MSMEG_0526|M.smegmatis_MC2_155 RPTSEGALEITSSGPRPSVRIEPNYLGS--EHDRTATADLLRRMRAVFAE
TH_4204|M.thermoresistible__bu RPTSEGTVEITAVDPAAPLRIDPNYLGS--DADRETTANLLRRMRSVFEQ
Mflv_1255|M.gilvum_PYR-GCK RPTSQGYVEITSADPGAALRITPNYLTT--EHDRTATAALVRRMRSIFEQ
Mvan_5894|M.vanbaalenii_PYR-1 RPDSEGSVAITSSDPEAPLDIDPGFLIT--THDREKGAALFRTMRRLFSQ
Mb1310|M.bovis_AF2122/97 APQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQA
Rv1279|M.tuberculosis_H37Rv APQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQA
MMAR_4141|M.marinum_M APQSRGQITLRSADPHAKPIIEARYLSDPGGVDRAAMMEGLRICARIAQA
MUL_4004|M.ulcerans_Agy99 APQSRGQITLRSADPHAKPIIEARYLSDPGGVDRAAMMEGLRICARIAQA
MAB_0250|M.abscessus_ATCC_1997 KPESSGEITLTSPDPLAKPRIDPRYLSDPAGRDRAAMMFGLRTTARIAET
MAV_4925|M.avium_104 PAYDGGEVTLNSTDPFMQPNINLNYLSN--ELDIIALREGIRLAYDILTK
. . * : : : .* * :* * .* :
MSMEG_0526|M.smegmatis_MC2_155 SPIAERISHETFPGPGVATDDELVDSALDGG-YCGYHAVGTCAMGP-GDD
TH_4204|M.thermoresistible__bu SPIAERISHETFPGPHIRSDDELVDAALDGG-YCGYHAIGTCAMGP-SDD
Mflv_1255|M.gilvum_PYR-GCK SPIAERISHETYPGPRVDSDEELVDAALEGG-YCGYHAVGTCAMGP-DDD
Mvan_5894|M.vanbaalenii_PYR-1 SPVADHLVAETRPGADVSSDQAIIDAALTQG-YCGYHAIGTCAMGP-EDD
Mb1310|M.bovis_AF2122/97 RPLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGS-DEA
Rv1279|M.tuberculosis_H37Rv RPLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGS-DEA
MMAR_4141|M.marinum_M PALRGLLGPVARPHNSSELDEATLELALTTCSHTLYHPLGTCRMGS-DEA
MUL_4004|M.ulcerans_Agy99 PALRGLLGPVARPHNSSELDEATLELALTTCSHTLYHPLGTCRMGS-DEA
MAB_0250|M.abscessus_ATCC_1997 PSMRAVLGKILRPRNPSDDLEETLVAALENNSHTLYHPVGTCRMGA-DDA
MAV_4925|M.avium_104 GDGFKDLVISQYPWDMPLHSDELMRTSIQDRVQTSYHPCGTNRLSKNIDQ
: * : : :: **. ** :. :
MSMEG_0526|M.smegmatis_MC2_155 AVVDDRLRVRGVDGLRVVDCSVLPTMVAGNLNGPIMAVAWRAADFILDR-
TH_4204|M.thermoresistible__bu DVVDPQLRVRGVDGLRVVDCSVLPVMVAGNLNGPIMAVAWRAADLIRQDL
Mflv_1255|M.gilvum_PYR-GCK DVVDSHLRVRGVDGLRVVDCSVMPTIVAGNLNGPIMAMAWRAADFILHGR
Mvan_5894|M.vanbaalenii_PYR-1 DVVDSALRVRGVRNLRIMDCSVMPTMVSGNLNGPVMAMAWRASDLILSGG
Mb1310|M.bovis_AF2122/97 SVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS--
Rv1279|M.tuberculosis_H37Rv SVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS--
MMAR_4141|M.marinum_M SVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGAKAADLIRN--
MUL_4004|M.ulcerans_Agy99 SVVDRQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGAKAADLIRN--
MAB_0250|M.abscessus_ATCC_1997 SVVTPDLTVRGVQGLRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQ
MAV_4925|M.avium_104 GVVDPKLKVHGVNKLRVVDASVFPIIPDCRIQNTVYMVGEKGADAIKADH
** * *:** **: *.**:* . : . :. :.:* *
MSMEG_0526|M.smegmatis_MC2_155 -----
TH_4204|M.thermoresistible__bu -----
Mflv_1255|M.gilvum_PYR-GCK -----
Mvan_5894|M.vanbaalenii_PYR-1 -----
Mb1310|M.bovis_AF2122/97 -----
Rv1279|M.tuberculosis_H37Rv -----
MMAR_4141|M.marinum_M -----
MUL_4004|M.ulcerans_Agy99 -----
MAB_0250|M.abscessus_ATCC_1997 P----
MAV_4925|M.avium_104 TDLYK