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NDAVSHSDVLIVGAGSAGSVVAERLSADPGCTVTVVEAGPSLDDPALLARTANGLQLPIGVGSPLVRRYQ TQLTERPARRHPLVRGATIGGSGAINGGYFCRGLRRDFDRLGLPGWAWSDVLDSFRAIETDLDFDGPAHG RSGPILVRRTREMTGTTERFIDAAWRAGFGWIDDLNDAAAQPVSGIGAVPLNIVDGVRKGSGAGYLIPAL SRPNLRVQAHTRVARLRFAGTVARGADVVGPHGRATLTADRIVLCAGAIETAHLLMLSGIGEPGMLRAAG VPVRVALPVGTSFSDHAEWVLPTDWPVAPGRPVLEVVLSTADDLEIRPYTGGFVAMTGDGTAGHADWPHL GVALMQPRARGCLTLMSADPAVPPRIEHRYDSEPGDVAALARGAELARELAGGTTDAAAAIWSTSQHLCG TAPMGVDGDPRAVVDPRCRVRGIDNLWVIDGSVLPAITSRGPHATIVMIGHRAAEFVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4474 | - | - | 100% (479) | FAD dependent oxidoreductase, putative |
| M. avium 104 | MAV_4980 | - | 8e-48 | 34.33% (434) | choline dehydrogenase |
| M. avium 104 | MAV_4925 | - | 2e-25 | 26.47% (578) | glucose-methanol-choline |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0716 | - | 0.0 | 73.32% (476) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_5056 | - | 1e-158 | 61.36% (471) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv0697 | - | 0.0 | 73.32% (476) | dehydrogenase |
| M. leprae Br4923 | MLBr_00389 | choD | 8e-05 | 31.82% (88) | putative cholesterol oxidase |
| M. abscessus ATCC 19977 | MAB_3830c | - | 1e-117 | 53.18% (472) | dehydrogenase (glucose-methanol-choline oxidoreductase) |
| M. marinum M | MMAR_1025 | - | 0.0 | 70.92% (478) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1428 | - | 1e-152 | 59.45% (471) | glucose-methanol-choline oxidoreductase |
| M. thermoresistible (build 8) | TH_4588 | - | 2e-91 | 62.19% (283) | PUTATIVE glucose-methanol-choline oxidoreductase |
| M. ulcerans Agy99 | MUL_0777 | - | 0.0 | 70.08% (478) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1300 | - | 1e-157 | 60.25% (473) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0716|M.bovis_AF2122/97 ----MTAAVRHSDVLVVGAGSAGSVVAERLSMDSSCVVTVLEAGPGLADP
Rv0697|M.tuberculosis_H37Rv ----MTAAVRHSDVLVVGAGSAGSVVAERLSMDSSCVVTVLEAGPGLADP
MAV_4474|M.avium_104 ----MNDAVSHSDVLIVGAGSAGSVVAERLSADPGCTVTVVEAGPSLDDP
MMAR_1025|M.marinum_M ----MTAALRHSDVLIVGAGSAGSVLAARLSADPSCAVTLVEAGPGLADP
MUL_0777|M.ulcerans_Agy99 ----MTAALRHSDVLVVGAGSAGSVLAARLSTDPSCAVTLVEAGPGLADP
Mflv_5056|M.gilvum_PYR-GCK -----------MSVLIVGAGSAGSVLAERLSADPGCEVTVVEAGPGLSDS
Mvan_1300|M.vanbaalenii_PYR-1 ---------MRSDVLIVGAGSAGSVLAERLSADDGCQVTVVEAGPGPFDP
MSMEG_1428|M.smegmatis_MC2_155 -------------MLIVGAGSAGSVLAERLSADPSCQVTVVEAGPAPSDP
MAB_3830c|M.abscessus_ATCC_199 ----------------MGAGSAGSILAGRLSEDPSFRVVLVEAGP--VSS
TH_4588|M.thermoresistible__bu VTGRPGAERCHSDVLIVGAGSAGSVLAERLSADSGCRVTVVEAGPGPSDP
MLBr_00389|M.leprae_Br4923 -------MKPDYDVLIIGSGFGGSVSALRLT-EKGYRVGVLEAGRRFADE
:*:* .**: * **: : . * ::*** .
Mb0716|M.bovis_AF2122/97 GLLAQTANGLQLPIGAGSPLVERYRTRLTDRPVRHLPIVRGATVGGSGAI
Rv0697|M.tuberculosis_H37Rv GLLAQTANGLQLPIGAGSPLVERYRTRLTDRPVRHLPIVRGATVGGSGAI
MAV_4474|M.avium_104 ALLARTANGLQLPIGVGSPLVRRYQTQLTERPARRHPLVRGATIGGSGAI
MMAR_1025|M.marinum_M RLLAQTANGLQLPISADSPLVQRYQSQLTDHPVRRIPILRGATLGGSGAV
MUL_0777|M.ulcerans_Agy99 RLLAQTANGLQLPISADSPLVQCYQSQLTDHPVRRTPILRGATLGGSGAV
Mflv_5056|M.gilvum_PYR-GCK RVRDQISDGLRLPIGAASSVVRRYDTALTEEPRRHARIMRGVVVGGSGAV
Mvan_1300|M.vanbaalenii_PYR-1 RVGTQITDGLRLPIGVASSVVRRYPTALTDEPRRHAQIMRGAVVGGSGAV
MSMEG_1428|M.smegmatis_MC2_155 RVAAQITDGVRLPIGAASSVVRHYGSTLTEDPPRRTEIIRGSVVGGSGAV
MAB_3830c|M.abscessus_ATCC_199 ADEAGVRNGYRLPIGPGSQIATYYWATLTSTG-DQAELVRGSVVGGSGAI
TH_4588|M.thermoresistible__bu RVAHQITDGLRLPIGDASSVVRRYPTTLTDHPRRPAQLMRGAVVGGSGAV
MLBr_00389|M.leprae_Br4923 DFAKTSWDLRKFLWAPKLGCYG----IQRIHLLRNVMILAGAGVGG-GSL
: :: . :: * :** *::
Mb0716|M.bovis_AF2122/97 NGGYFCRGLPSDFDR---ASIPGWAWSDVLEHFRAIETDLDFET-PVHGR
Rv0697|M.tuberculosis_H37Rv NGGYFCRGLPSDFDR---ASIPGWAWSDVLEHFRAIETDLDFET-PVHGR
MAV_4474|M.avium_104 NGGYFCRGLRRDFDR---LGLPGWAWSDVLDSFRAIETDLDFDG-PAHGR
MMAR_1025|M.marinum_M NGGYFCRGLARDFDG---AAIPGWSWSQVLPHFRAIETDLDFDT-PVHGR
MUL_0777|M.ulcerans_Agy99 NGGYFCRGLARDFDG---AAIPGWSWSQVLPHFRAIETDLDFDT-PVHGR
Mflv_5056|M.gilvum_PYR-GCK NGGYFCRALPADVDG---WGMDGWSWDDVLPHFRAIETDLDFAT-PVHGD
Mvan_1300|M.vanbaalenii_PYR-1 NGGYFCRALPSDFDG---WGIAGWSWDEVLPHYTAIETDLDFTG-PLHGS
MSMEG_1428|M.smegmatis_MC2_155 NGGYFCRGLPTDFTA---WAVPGWSWDDVLPHFRAIETDLDFAT-ALHGS
MAB_3830c|M.abscessus_ATCC_199 NGGYFVRGRPADFDG---WAVSGWSWAEVRDHFRAIETDHDFRDDPLHGS
TH_4588|M.thermoresistible__bu NGGYFCRGLPADFDR---WGLGDWTWDRVLPHFRAIETDLDFDG-PLHGA
MLBr_00389|M.leprae_Br4923 NYANTLYVPPEPFFANQQWAHITDWHSELAPHYDQAQRMLGVVCNPTFTD
* . . . : : : .. . .
Mb0716|M.bovis_AF2122/97 SGPIPVRRTHEMTGITESFMAAAEDAGFAWIADLN---DVGPEMPSGVGA
Rv0697|M.tuberculosis_H37Rv SGPIPVRRTHEMTGITESFMAAAEDAGFAWIADLN---DVGPEMPSGVGA
MAV_4474|M.avium_104 SGPILVRRTREMTGTTERFIDAAWRAGFGWIDDLN---DAAAQPVSGIGA
MMAR_1025|M.marinum_M TGPIPVRRTRDQTGVTQRFVTAAQRAGFGWIADLN---DVGPDIAAGVGA
MUL_0777|M.ulcerans_Agy99 TGPIPVRRIRDQTGVTQRFVTAAQRAGFGWIADLN---DVGPDIAAGVGA
Mflv_5056|M.gilvum_PYR-GCK TGPITVRRVAEFDGATASFVDAARTAGFGWVEDLNG-ATAEHAVPAGIGA
Mvan_1300|M.vanbaalenii_PYR-1 AGPISVRRVSEFDGCTASFVESAREAGFGWIEDLNG-STPERPLPAGVGA
MSMEG_1428|M.smegmatis_MC2_155 EGPIKVRRVHEFDGCTAAFVDAVSAAGYGWIDDLNG-SDADAALPPGVGA
MAB_3830c|M.abscessus_ATCC_199 QGPIPVGRRHEQSSAGTELMDLAVNRGYPVVADLN------GSAGAGVGL
TH_4588|M.thermoresistible__bu DGPIPVRRSTEFDGCTAKFIEAVEDAGYPWIPDLNG-ATPDQPLPPGVGQ
MLBr_00389|M.leprae_Br4923 ADRILKEVVDEMG-FGDTFVPTPVGVFFGPDGTQTPGRTVADPYFGGVGP
. * : :: : . *:*
Mb0716|M.bovis_AF2122/97 VPLN------IVNGVRTSSAVGYLMPALGRPN---LTLLARTRAVRLRFS
Rv0697|M.tuberculosis_H37Rv VPLN------IVNGVRTSSAVGYLMPALGRPN---LTLLARTRAVRLRFS
MAV_4474|M.avium_104 VPLN------IVDGVRKGSGAGYLIPALSRPN---LRVQAHTRVARLRFA
MMAR_1025|M.marinum_M VPLN------IVDGVRTGSGAAYLLPALGRPN---LTLLEETRAQQVRFS
MUL_0777|M.ulcerans_Agy99 VPLN------IVDGVRTGSGAAYLLPALGRPN---LTLLEETRAQQVRFS
Mflv_5056|M.gilvum_PYR-GCK VPLN------IDRGTRVGPGGAFLQPALGRAN---LTVLTDTRVLRLTFA
Mvan_1300|M.vanbaalenii_PYR-1 VPLN------INGGTRVGPGGAFLQPALQRAN---LTLVTDTRVGGLRFS
MSMEG_1428|M.smegmatis_MC2_155 VPLN------IDGGTRLGPGGAYLQPALDRPN---LHLRADTRVRRVLVE
MAB_3830c|M.abscessus_ATCC_199 VPLN------IDSGIRVGPARAYLESAVWRPN---LAVYSGTRVLRVLCS
TH_4588|M.thermoresistible__bu VPLN------INGGTRVGPGAAYLQPALARPN---LTVLTETRVRRVRIA
MLBr_00389|M.leprae_Br4923 VRTGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFELR
* . * * .. : : .: : * . .
Mb0716|M.bovis_AF2122/97 ATTAVGVDAIGPG-----GPVSLSADRIVLCAGAIQSAHLLMLSGVGEEE
Rv0697|M.tuberculosis_H37Rv ATTAVGVDAIGPG-----GPVSLSADRIVLCAGAIQSAHLLMLSGVGEEE
MAV_4474|M.avium_104 GTVARGADVVGPH-----GRATLTADRIVLCAGAIETAHLLMLSGIGEPG
MMAR_1025|M.marinum_M AATAVGVDAVGPR-----GPMTLWADRIVLCAGAIGSAHLLMLSGIGDHA
MUL_0777|M.ulcerans_Agy99 AATAVGVDAVGPR-----GPMTLWADRIVLCAGAIGSAHLLMLSGIGDHA
Mflv_5056|M.gilvum_PYR-GCK AGRVTGVLCVGPD-----GPVTVGADRIVLCAGAIATAQLLMVSGVGPPP
Mvan_1300|M.vanbaalenii_PYR-1 AGRVVGVDCLGPG-----GPTTLVADRVVLCAGAIASAQLLMVSGVGPQQ
MSMEG_1428|M.smegmatis_MC2_155 HDAAVGVECVDG--------EILYADRIVLSAGAIGSAHLLLLSGIGPAG
MAB_3830c|M.abscessus_ATCC_199 GGKATGVQVAVGN-----SVRTLTADRIILSAGAIESAKLLLLSGLGPAD
TH_4588|M.thermoresistible__bu DGRADGVECLGPD-----GATVLTADRIVLSAGAIGSAHLLMLSGIGPQR
MLBr_00389|M.leprae_Br4923 SEGLWEVHTVRTGSWLRRGRRTFTAAHLLLAAGTWGTQRLLFR--MRDQG
. . * :::*.**: : :**: :
Mb0716|M.bovis_AF2122/97 VLRSAGVKVLMALP-VGMGCSDHPEWVMPTNWAVAVDRPVLEVLLSTHD-
Rv0697|M.tuberculosis_H37Rv VLRSAGVKVLMALP-VGMGCSDHPEWVMPTNWAVAVDRPVLEVLLSTHD-
MAV_4474|M.avium_104 MLRAAGVPVRVALP-VGTSFSDHAEWVLPTDWPVAPGRPVLEVVLSTAD-
MMAR_1025|M.marinum_M MLRSAGVPVVQALP-VGMNCSDHPEWALPTTWTVAAGRPVLEAVLNTAD-
MUL_0777|M.ulcerans_Agy99 MLRAAGVPVVQALP-VGMNCSDHPEWALPTTWTVVAGRPVLEAVLNTAD-
Mflv_5056|M.gilvum_PYR-GCK VLRAAGVPVEIDLP-VGVDTIDHPEWVLPVSWAPTHGVPPLEAVLTTDD-
Mvan_1300|M.vanbaalenii_PYR-1 VLRAAGVAVQIDLP-VGVDTVDHPEWVLPVTWPPTHGVPPLEAVLTTGD-
MSMEG_1428|M.smegmatis_MC2_155 DLAAHGIAVAANLP-VGTATVDHPEWVLPVAWTPTHDLPPLEAVLTTAD-
MAB_3830c|M.abscessus_ATCC_199 ELRAVGVQPVVDLPGVGTRVMDHAEWVLDTGEQGQQGHPVLDTVLHTDHP
TH_4588|M.thermoresistible__bu LLGALGIPVVAAXXXXGVGEPDPAHLAGQVDGGQGVDRDARRVTLHREHR
MLBr_00389|M.leprae_Br4923 KLPRLSQRLGVLTRTNSESIVGAGTLNVMPDRDLTHGVAITSSIHPTSDT
* . . . . .
Mb0716|M.bovis_AF2122/97 -GIEIRPYTGGFVAM-------TGDGTAGHRDWPHIGVALMQPRARG--R
Rv0697|M.tuberculosis_H37Rv -GIEIRPYTGGFVAM-------TGDGTAGHRDWPHIGVALMQPRARG--R
MAV_4474|M.avium_104 -DLEIRPYTGGFVAM-------TGDGTAGHADWPHLGVALMQPRARG--C
MMAR_1025|M.marinum_M -GIEIRPYTTGFAAM-------AGAAAKGHRDWPHLGVALMRPRSRA--R
MUL_0777|M.ulcerans_Agy99 -GIEIRPYTTGFEAM-------AGAAAKGHRDWPHLGVALMRPRSRA--R
Mflv_5056|M.gilvum_PYR-GCK -GVEIRPYTVGFEAM-------MTGRRDDPTDQPHLGVTLMRPLSRG--R
Mvan_1300|M.vanbaalenii_PYR-1 -GLEIRPYTAGFGAM-------MTGRRDDPTDQPHLGVTLMQPLSRG--R
MSMEG_1428|M.smegmatis_MC2_155 -GIEIRPYTAGFSAL-------VHGPEHDPAELPHLGVALMRPHSRG--R
MAB_3830c|M.abscessus_ATCC_199 MCLEIRPYTTGFAAM-------AGVVADG-ADARQIGVALMTPQCRG--R
TH_4588|M.thermoresistible__bu -GPRIG---GGQHVE-------HRRGRRVEHERLLAGEPPLVARAAGGGR
MLBr_00389|M.leprae_Br4923 -HIEPIRYGKGSNAMGLLQTLMTDGPGPEGTDVPRWRQLLHQASEDPRRM
. * . : .
Mb0716|M.bovis_AF2122/97 ITLV-----SSDPQIPVRIEHRYDSEPA---------------------D
Rv0697|M.tuberculosis_H37Rv ITLV-----SSDPQIPVRIEHRYDSEPA---------------------D
MAV_4474|M.avium_104 LTLM-----SADPAVPPRIEHRYDSEPG---------------------D
MMAR_1025|M.marinum_M VTLA-----SPDPSVPPRIGHHYDSEPA---------------------D
MUL_0777|M.ulcerans_Agy99 VTLA-----SPDPSVPPRIGHHYDSEPA---------------------D
Mflv_5056|M.gilvum_PYR-GCK VTIC-----SADPDADPVIEHRYDSAPA---------------------D
Mvan_1300|M.vanbaalenii_PYR-1 VTIT-----SADPDADPVIEHRYDSEPA---------------------D
MSMEG_1428|M.smegmatis_MC2_155 VRLA-----SADPAVPPIIEHRYDTVAG---------------------D
MAB_3830c|M.abscessus_ATCC_199 LELR-----STDPAAPVYIDLRYDSETA---------------------D
TH_4588|M.thermoresistible__bu RHVG-----DQRRGRALGIGHGGDELPGG--------------------D
MLBr_00389|M.leprae_Br4923 LRLINPRRWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGNGEPN
: . : : . :
Mb0716|M.bovis_AF2122/97 VAALRQGSALAHELCGAATRIGPAVWATSQ------HLCGSAPMGTDDDP
Rv0697|M.tuberculosis_H37Rv VAALRQGSALAHELCGAATRIGPAVWATSQ------HLCGSAPMGTDDDP
MAV_4474|M.avium_104 VAALARGAELARELAGGTTDAAAAIWSTSQ------HLCGTAPMGVDGDP
MMAR_1025|M.marinum_M VAALQRGTELARELAGSAVAGEPG-WSTSQ------HLCGSAPMGVDADP
MUL_0777|M.ulcerans_Agy99 VAALQRGTELARELAGSAVAGEPG-WSTSQ------HLCGSAPMGVDADP
Mflv_5056|M.gilvum_PYR-GCK VALLREGAQLASELAGATVQS-EPSWATSQ------HLCGTAKMGA----
Mvan_1300|M.vanbaalenii_PYR-1 VELLRAGTRLAHELAGATVQS-EASWATSQ------HLCGTARMGA----
MSMEG_1428|M.smegmatis_MC2_155 VDALRAGAELARELVSHAVKVGEASWSTSQ------HLAGTAPLSADG--
MAB_3830c|M.abscessus_ATCC_199 MDRLRDGVHLVSELYG--RRFGGPRWSTSQ------HLCGTAPLGNDRDK
TH_4588|M.thermoresistible__bu PRQHRRPFVTGAELVEQVRHHDRAGQIRPA------QQRAAHLLGDDAQL
MLBr_00389|M.leprae_Br4923 PSWIPIGNEVTRRLAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDN-AE
.* : . :.
Mb0716|M.bovis_AF2122/97 RAVVDPRCRVRG-IENLWVIDGSVLP---SITSRGPHATIVMLGHRAAEF
Rv0697|M.tuberculosis_H37Rv RAVVDPRCRVRG-IENLWVIDGSVLP---SITSRGPHATIVMLGHRAAEF
MAV_4474|M.avium_104 RAVVDPRCRVRG-IDNLWVIDGSVLP---AITSRGPHATIVMIGHRAAEF
MMAR_1025|M.marinum_M TAVVDPECRVRG-IENLWVVDGSILP---LIPSRGPHATIVMLGHRAAEF
MUL_0777|M.ulcerans_Agy99 TAVVDPECRVRG-IENLWVVDGSILP---LIPSRGPHATIVMLGHRAAEF
Mflv_5056|M.gilvum_PYR-GCK --VVDERCRVYG-VDNLWVVDGSILP---DIPSRGPHATIVMAGHRAAEF
Mvan_1300|M.vanbaalenii_PYR-1 --VVDARCRVYG-VSNLWVVDGSILP---AIPSRGPHATIVMAGHRAAEF
MSMEG_1428|M.smegmatis_MC2_155 QGVLDPTCRVLG-VERLWVVDGSIMP---AITSRGPHATIAMIGHRAAEF
MAB_3830c|M.abscessus_ATCC_199 HAVVDKYCRVRG-IDGLFVIDGSILP---TIPSRGPAATIAMIGHRAAQF
TH_4588|M.thermoresistible__bu DRSRARSAEVLGNHQAEQTHPGQLLPQRRIVAGVGRHQRPHLLLRRALLH
MLBr_00389|M.leprae_Br4923 HGVIDPYHRVYG-YPTLYVVDGAAIS---ANLGVNPSLSIAAQAERAASL
.* * . * :. . . .**
Mb0716|M.bovis_AF2122/97 VQ---------------------------------------
Rv0697|M.tuberculosis_H37Rv VQ---------------------------------------
MAV_4474|M.avium_104 VR---------------------------------------
MMAR_1025|M.marinum_M IG---------------------------------------
MUL_0777|M.ulcerans_Agy99 IG---------------------------------------
Mflv_5056|M.gilvum_PYR-GCK VSSS----AGA------------------------------
Mvan_1300|M.vanbaalenii_PYR-1 VSATSTERAGA------------------------------
MSMEG_1428|M.smegmatis_MC2_155 IAT--------------------------------------
MAB_3830c|M.abscessus_ATCC_199 VAWS-------------------------------------
TH_4588|M.thermoresistible__bu EVGDSFA----------------------------------
MLBr_00389|M.leprae_Br4923 WPNKGQHDQRPRQGESYRRLAPIAPDHPVVPAEAPGALRWL