For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TNPHFAWLPPEINSALMFAGPGAGPLLAAAAAWGGLAEELASAVSSFSSVTSELTSGSWLGPSAAAMMAV ATQYMAWLGAAAAQAEQAAAQAAVTAGAFESALAATVQPAVVTANRGLMQVLAATNWLGFNTPAIIDIEA AYEQMWALDVAAMAAYHAEASAAASALAPWKQVLRNLGIDIGKNGQINLGFGNSGTGNVGNNNVGNDNWG SGNTGSSNVGTGNTGSSNIGIGSGNTGNSNVGLGNLGSGNVGFGNTGNGDFGFGLTGDHQFGFGGFNSGS GNVGIGNSGTGNVGFFNSGNGNMGIGNSGSLNSGLGNSGSMSTGFGTASMSSGMWQSMHGSDMASSTSLA SSATYATGGTATLSSGILSSALAHTGGLNPALAGGLTPTAATPAAAAPAAAAPVAAAAADAGPVSAGANS GSTAGAGLRSPAVGYSGLYNSANSDAGARSVATREAPANAGAGIPRSSFYPNRETADSEADIQLPLRTE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1395 | - | - | 100% (490) | PPE family protein |
| M. ulcerans Agy99 | MUL_0782 | - | 6e-97 | 46.10% (423) | PPE family protein |
| M. ulcerans Agy99 | MUL_0965 | - | 1e-95 | 42.54% (489) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0450c | PPE10 | 1e-175 | 63.82% (492) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-27 | 38.92% (167) | PPE protein |
| M. tuberculosis H37Rv | Rv0442c | PPE10 | 1e-180 | 64.00% (500) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-28 | 43.21% (162) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 2e-30 | 42.20% (173) | PPE-family protein |
| M. marinum M | MMAR_0761 | - | 0.0 | 98.98% (490) | PPE family protein, PPE10 |
| M. avium 104 | MAV_4704 | - | 2e-73 | 74.86% (179) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 8e-29 | 40.12% (167) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-30 | 42.86% (175) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-30 | 40.72% (167) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
MUL_1395|M.ulcerans_Agy99 ----------MTNPHFAWLPPEINSALMFAGPGAGPLLAAAAAWGGLAEE
MMAR_0761|M.marinum_M ----------MTNPHFAWLPPEINSALMFAGPGAGPLLAAAAAWGGLAEE
Mb0450c|M.bovis_AF2122/97 ------------------MPPEINSALMFAGPGSGPLIAAATAWGELAEE
Rv0442c|M.tuberculosis_H37Rv ----------MTSPHFAWLPPEINSALMFAGPGSGPLIAAATAWGELAEK
MAV_4704|M.avium_104 ----------MTNPHFAWLPPEVNSALIYSGPGPGPLLAAAAAWDGLAEE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
.** :*: : ***...:::*. * :. :
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
MUL_1395|M.ulcerans_Agy99 LASAVSSFSSVTSELTSGSWLGPSAAAMMAVATQYMAWLGAAAAQAEQAA
MMAR_0761|M.marinum_M LASAVSSFSSVTSELTSGSWLGPSAAAMMAVATQYMAWLGAAAAQAEQAA
Mb0450c|M.bovis_AF2122/97 LLASIASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAA
Rv0442c|M.tuberculosis_H37Rv LLASIASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAA
MAV_4704|M.avium_104 LASSAQSFSSVTSDLASGSWQGASSAAMMTVANQYVSWLSAAAAQAEEVS
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
: : . : : :: * *: * ** :* . :
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
MUL_1395|M.ulcerans_Agy99 AQAAVTAGAFESALAATVQPAVVTANRGLMQVLAATNWLGFNTPAIIDIE
MMAR_0761|M.marinum_M AQAAVTAGAFESALAATVQPAVVTANRGLMQVLAATNWLGFNTPAIMDIE
Mb0450c|M.bovis_AF2122/97 AQAMAIATAFEAALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVE
Rv0442c|M.tuberculosis_H37Rv AQAMAIATAFEAALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVE
MAV_4704|M.avium_104 HQASAIATAFEVALAATVQPAVVAANRALVQALAATNWLGQNTPAIADIE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: . * *: *:: : *: * :* :* *: .: *
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARSDQS
MUL_1395|M.ulcerans_Agy99 AAYEQMWALDVAAMAAYHAEASAAASALAPWKQVLRNLGIDIGKNGQINL
MMAR_0761|M.marinum_M AAYEQMWALDVAAMAAYHAEASAAASALAPWKQVLRNLGIDIGKNGQINL
Mb0450c|M.bovis_AF2122/97 AAYEQMWALDVAAMAGYHFDASAAVAQLAPWQQVLRNLGIDIGKNGQINL
Rv0442c|M.tuberculosis_H37Rv AAYEQMWALDVAAMAGYHFDASAAVAQLAPWQQVLRNLGIDIGKNGQINL
MAV_4704|M.avium_104 AAYEQMWASDVAAMFGYHADASAAVAKLPPWNEVLQ------------NL
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVN---------EV
* * .** .::* *:
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MAB_0669|M.abscessus_ATCC_1997 DVPGSPDQ---------------IMKMLQGFQQWFEKMG--FNPATSAVL
MUL_1395|M.ulcerans_Agy99 GFGNSGTGNVGNNNVGNDNWGSGNTGSSNVGTGNTGSSNIGIGSGNTGNS
MMAR_0761|M.marinum_M GFGNSGTGNVGNNNVGNNNWGSGNTGSSNVGTGNTGSSNI--GSGNTGNS
Mb0450c|M.bovis_AF2122/97 GFGNTGSGNIGNNNIGNNNIGSGNTGTGNIG------------SGNTGSG
Rv0442c|M.tuberculosis_H37Rv GFGNTGSGNIGNNNIGNNNIGSGNTGTGNIG------------SGNTGSG
MAV_4704|M.avium_104 GFSNASTAVTR---------------------------------------
MLBr_01182|M.leprae_Br4923 GLAQEVVEEVVEEVVEEVVEAEQAISQAALD-------------------
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MAB_0669|M.abscessus_ATCC_1997 AVIMLFLYDLLWYPY-----YASYLLPFLIPALSGLSG-LAALMHLRPAA
MUL_1395|M.ulcerans_Agy99 NVGLGNLGSGNVGFGNTGNGDFGFGLTGDHQFGFGGFNSGSGNVGIGNSG
MMAR_0761|M.marinum_M NVGLGNLGSGNVGFGNTGNGDFGFGLTGDHQFGFGGFNSGSGNVGIGNSG
Mb0450c|M.bovis_AF2122/97 NLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSG
Rv0442c|M.tuberculosis_H37Rv NLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSG
MAV_4704|M.avium_104 -------------------------------------PAGSGAVARG---
MLBr_01182|M.leprae_Br4923 -------QAVNEGMEATVVPQVDQQVN---------VDVATPQTAVPDSS
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVG
TH_3569|M.thermoresistible__bu LIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---------
Mflv_0325|M.gilvum_PYR-GCK LATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPAT
Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIA
MAB_0669|M.abscessus_ATCC_1997 PGPVPAAALSPGDRPIRRPTQHVEPNLAALPLPTSSVVPSGG--------
MUL_1395|M.ulcerans_Agy99 TGNVGFFNSGNGNMGIGNSGSLNSGLGNSGSMSTGFGTAS------MSSG
MMAR_0761|M.marinum_M TGNVGFFNSGNGNMGIGNSGSLNSGLGNSGSMSTGFGTAS------MSSG
Mb0450c|M.bovis_AF2122/97 TGNVGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAG
Rv0442c|M.tuberculosis_H37Rv TGNVGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAG
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 SAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVN----------
MSMEG_0619|M.smegmatis_MC2_155 ISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGFT
TH_3569|M.thermoresistible__bu ----------VRAEPQNPLPLTXXX-------------------------
Mflv_0325|M.gilvum_PYR-GCK MSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFS
Mvan_0415|M.vanbaalenii_PYR-1 VSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGFS
MAB_0669|M.abscessus_ATCC_1997 -------SSVPVSTPTAPAHTVSSVPAPSAAISYAIPGLVP---PGVSFG
MUL_1395|M.ulcerans_Agy99 MWQSMHGSDMASSTSLASSATYATG--GTATLSSGILSSALAHTGGLNPA
MMAR_0761|M.marinum_M MWQSMHGSDMASSTSLASSATYATG--GTATLSSGILSSALAHTGGLNPA
Mb0450c|M.bovis_AF2122/97 MQNAALGSAAGSEAALVSSAGYATGGMSTAALSSGILASALGSTGGLQHG
Rv0442c|M.tuberculosis_H37Rv MQNAALGSAAGSEAALVSSAGYATGGMSTAALSSGILASALGSTGGLQHG
MAV_4704|M.avium_104 ---------------------YTSR-------------------------
MLBr_01182|M.leprae_Br4923 GMGSAMKSLAPTTTKAAESAFKAMG---SAVQSTGRGLLGSSSGGHVTAQ
MSMEG_0619|M.smegmatis_MC2_155 PTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAY
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK PTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAY
Mvan_0415|M.vanbaalenii_PYR-1 PTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAY
MAB_0669|M.abscessus_ATCC_1997 PKSTEKSSESAVDTVAAVAAARGAVAAQARRRLRGKNKAEAGGR--RHEY
MUL_1395|M.ulcerans_Agy99 LAGGLTPTAATPAAAAPAAAAPVAAAAADAGPVS------------AGAN
MMAR_0761|M.marinum_M LAGGLTPTAATPAAAAPAAAAPVAAAAADAGPVS------------AGAN
Mb0450c|M.bovis_AF2122/97 LANVLNSGLTNTPVAAPASAPVGGLDSGNPNPGS------------GSAA
Rv0442c|M.tuberculosis_H37Rv LANVLNSGLTNTPVAAPASAPVGGLDSGNPNPGS------------GSAA
MAV_4704|M.avium_104 IAGFLAPRAPQ---------------------------------------
MLBr_01182|M.leprae_Br4923 LGRAASIGSLRVPQTWTTASQPVTAATRALSPAR------------VAVA
MSMEG_0619|M.smegmatis_MC2_155 MDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLTTLTG
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK ADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGLTTLAG
Mvan_0415|M.vanbaalenii_PYR-1 ADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGLTTLPG
MAB_0669|M.abscessus_ATCC_1997 LEETAGMGAT-ATADVPAYAATGRGTGPLGFAGTAPAAASTHVAATVRLS
MUL_1395|M.ulcerans_Agy99 SGSTAGAGLRSPAVGYSGLYNSANSDAGARSVATREAPANAGAGIPRSSF
MMAR_0761|M.marinum_M SGSTAGAGLRSPAAGYSGLYNSANSDAGARSVATREAPANAGAGIPRSSF
Mb0450c|M.bovis_AF2122/97 AGSGANPGLRSPGTSYPSFVNSGSNDSGLRNTAVRE-PSTPGSGIPKSNF
Rv0442c|M.tuberculosis_H37Rv AGSGANPGLRSPGTSYPSFVNSGSNDSGLRNTAVRE-PSTPGSGIPKSNF
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 TESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-
MSMEG_0619|M.smegmatis_MC2_155 DTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu -----------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 DPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_0669|M.abscessus_ATCC_1997 -SDEARQVIPMLPSTWDADGGDQN-----------------
MUL_1395|M.ulcerans_Agy99 YP--NRETADSEADIQLPLRTE-------------------
MMAR_0761|M.marinum_M YP--NRETADSEADIQLPLRTE-------------------
Mb0450c|M.bovis_AF2122/97 YPSPDRESAYASPRIGQPVGSE-------------------
Rv0442c|M.tuberculosis_H37Rv YPSPDRESAYASPRIGQPVGSE-------------------
MAV_4704|M.avium_104 -----------------------------------------
MLBr_01182|M.leprae_Br4923 -----------------------------------------