For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TSPHFAWLPPEINSALMFAGPGSGPLIAAATAWGELAEKLLASIASLGSVTSELTSGAWLGPSAAAMMAV ATQYLAWLSTAAAQAEQAAAQAMAIATAFEAALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVEA AYEQMWALDVAAMAGYHFDASAAVAQLAPWQQVLRNLGIDIGKNGQINLGFGNTGSGNIGNNNIGNNNIG SGNTGTGNIGSGNTGSGNLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSGTGN VGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAGMQNAALGSAAGSEAALVSSAGYA TGGMSTAALSSGILASALGSTGGLQHGLANVLNSGLTNTPVAAPASAPVGGLDSGNPNPGSGSAAAGSGA NPGLRSPGTSYPSFVNSGSNDSGLRNTAVREPSTPGSGIPKSNFYPSPDRESAYASPRIGQPVGSE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0442c | PPE10 | - | 100% (487) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3533c | PPE62 | e-117 | 45.75% (529) | PPE family protein |
| M. tuberculosis H37Rv | Rv0755c | PPE12 | e-110 | 41.56% (551) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0450c | PPE10 | 0.0 | 99.79% (479) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-24 | 37.35% (166) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-28 | 43.12% (160) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 5e-28 | 38.73% (173) | PPE-family protein |
| M. marinum M | MMAR_0761 | - | 0.0 | 64.66% (498) | PPE family protein, PPE10 |
| M. avium 104 | MAV_4704 | - | 1e-71 | 72.07% (179) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-26 | 39.16% (166) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-25 | 43.04% (158) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1395 | - | 1e-180 | 64.20% (500) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-27 | 39.16% (166) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
Rv0442c|M.tuberculosis_H37Rv ----------MTSPHFAWLPPEINSALMFAGPGSGPLIAAATAWGELAEK
Mb0450c|M.bovis_AF2122/97 ------------------MPPEINSALMFAGPGSGPLIAAATAWGELAEE
MMAR_0761|M.marinum_M ----------MTNPHFAWLPPEINSALMFAGPGAGPLLAAAAAWGGLAEE
MUL_1395|M.ulcerans_Agy99 ----------MTNPHFAWLPPEINSALMFAGPGAGPLLAAAAAWGGLAEE
MAV_4704|M.avium_104 ----------MTNPHFAWLPPEVNSALIYSGPGPGPLLAAAAAWDGLAEE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
.** :*: : ***...: :*. * :. :
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
Rv0442c|M.tuberculosis_H37Rv LLASIASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAA
Mb0450c|M.bovis_AF2122/97 LLASIASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAA
MMAR_0761|M.marinum_M LASAVSSFSSVTSELTSGSWLGPSAAAMMAVATQYMAWLGAAAAQAEQAA
MUL_1395|M.ulcerans_Agy99 LASAVSSFSSVTSELTSGSWLGPSAAAMMAVATQYMAWLGAAAAQAEQAA
MAV_4704|M.avium_104 LASSAQSFSSVTSDLASGSWQGASSAAMMTVANQYVSWLSAAAAQAEEVS
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
: : : :: * .: * ** :* . .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
Rv0442c|M.tuberculosis_H37Rv AQAMAIATAFEAALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVE
Mb0450c|M.bovis_AF2122/97 AQAMAIATAFEAALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVE
MMAR_0761|M.marinum_M AQAAVTAGAFESALAATVQPAVVTANRGLMQVLAATNWLGFNTPAIMDIE
MUL_1395|M.ulcerans_Agy99 AQAAVTAGAFESALAATVQPAVVTANRGLMQVLAATNWLGFNTPAIIDIE
MAV_4704|M.avium_104 HQASAIATAFEVALAATVQPAVVAANRALVQALAATNWLGQNTPAIADIE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
* . * *. *:: : *: * :* :* *: .: *
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARSDQS
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
Rv0442c|M.tuberculosis_H37Rv AAYEQMWALDVAAMAGYHFDASAAVAQLAPWQQVLRNLGIDIGKNGQINL
Mb0450c|M.bovis_AF2122/97 AAYEQMWALDVAAMAGYHFDASAAVAQLAPWQQVLRNLGIDIGKNGQINL
MMAR_0761|M.marinum_M AAYEQMWALDVAAMAAYHAEASAAASALAPWKQVLRNLGIDIGKNGQINL
MUL_1395|M.ulcerans_Agy99 AAYEQMWALDVAAMAAYHAEASAAASALAPWKQVLRNLGIDIGKNGQINL
MAV_4704|M.avium_104 AAYEQMWASDVAAMFGYHADASAAVAKLPPWNEVLQ------------NL
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVN---------EV
* * .** .::* *. .
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_0669|M.abscessus_ATCC_1997 DVPGSPDQIMKMLQG---------------------------FQQWFEKM
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
Rv0442c|M.tuberculosis_H37Rv GFGNTGSGNIGNNNIGNNNIGSGNTGTGNIG------------SGNTGSG
Mb0450c|M.bovis_AF2122/97 GFGNTGSGNIGNNNIGNNNIGSGNTGTGNIG------------SGNTGSG
MMAR_0761|M.marinum_M GFGNSGTGNVGNNNVGNNNWGSGNTGSSNVGTGNTGSSNI--GSGNTGNS
MUL_1395|M.ulcerans_Agy99 GFGNSGTGNVGNNNVGNDNWGSGNTGSSNVGTGNTGSSNIGIGSGNTGNS
MAV_4704|M.avium_104 GFSNASTAVTR---------------------------------------
MLBr_01182|M.leprae_Br4923 GLAQEVVEEVVEEVVEEVVEAEQAISQAALD-------------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGP------FLLAVVYQA----VSWVGASI
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGP------FLAAVAYQA----VSWVGASI
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWP------FLFGVAYQVFFNLVGWPTWGM
MAB_0669|M.abscessus_ATCC_1997 G--------FNPATSAVLAVIML------FLYDLLWYP---------YYA
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
Rv0442c|M.tuberculosis_H37Rv NLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSG
Mb0450c|M.bovis_AF2122/97 NLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSG
MMAR_0761|M.marinum_M NVGLGNLGSGNVGFGNTGNGDFGFGLTGDHQFGFGGFNSGSGNVGIGNSG
MUL_1395|M.ulcerans_Agy99 NVGLGNLGSGNVGFGNTGNGDFGFGLTGDHQFGFGGFNSGSGNVGIGNSG
MAV_4704|M.avium_104 -------------------------------------PAGSGAVARG---
MLBr_01182|M.leprae_Br4923 -------QAVNEGMEATVVPQVDQQVN---------VDVATPQTAVPDSS
Mflv_0325|M.gilvum_PYR-GCK LYPSLFLLPLLATT-------LAIVAGVGQHLLSLLNTPPAEEAAEEPAP
Mvan_0415|M.vanbaalenii_PYR-1 LYPSLLLLPLVATT-------LAIVLGVGAYLLENLPAPAEDAPAEEPAA
MSMEG_0619|M.smegmatis_MC2_155 IFASPFLIPALAALG-----ITGLVLLIDHVLNNPVDVPAEDEAPQEVAA
MAB_0669|M.abscessus_ATCC_1997 SYLLPFLIPALSGLS-----GLAALMHLRPAAPGPVPA-AALSPGDRPIR
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
Rv0442c|M.tuberculosis_H37Rv TGNVGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAG
Mb0450c|M.bovis_AF2122/97 TGNVGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAG
MMAR_0761|M.marinum_M TGNVGFFNSGNGNMGIGNSGSLNSGLGNSGSMSTGFGTAS------MSSG
MUL_1395|M.ulcerans_Agy99 TGNVGFFNSGNGNMGIGNSGSLNSGLGNSGSMSTGFGTAS------MSSG
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 SAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVN----------
Mflv_0325|M.gilvum_PYR-GCK AQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT
Mvan_0415|M.vanbaalenii_PYR-1 SSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS
MSMEG_0619|M.smegmatis_MC2_155 AP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT
MAB_0669|M.abscessus_ATCC_1997 RPTQHVEPNLAALPLPTSSVVPSGGSSVPVSTPTAPAHTVSSVPAPSAA-
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTG-SAAPTTGTAPGGAGSPPPAGHSVP
Rv0442c|M.tuberculosis_H37Rv MQNAALGSAAGSEAALVSSAGYATGGMSTAALSSGILASALGSTGGLQHG
Mb0450c|M.bovis_AF2122/97 MQNAALGSAAGSEAALVSSAGYATGGMSTAALSSGILASALGSTGGLQHG
MMAR_0761|M.marinum_M MWQSMHGSDMASSTSLASSATYATG--GTATLSSGILSSALAHTGGLNPA
MUL_1395|M.ulcerans_Agy99 MWQSMHGSDMASSTSLASSATYATG--GTATLSSGILSSALAHTGGLNPA
MAV_4704|M.avium_104 ---------------------YTSR-------------------------
MLBr_01182|M.leprae_Br4923 GMGSAMKSLAPTTTKAAESAFKAMG---SAVQSTGRGLLGSSSGGHVTAQ
.
Mflv_0325|M.gilvum_PYR-GCK FVPYVVAGRDP-YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKR
Mvan_0415|M.vanbaalenii_PYR-1 FVPYAVAGRDP-GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKR
MSMEG_0619|M.smegmatis_MC2_155 FVPYAVANRDP-GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKR
MAB_0669|M.abscessus_ATCC_1997 -ISYAIPGLVPPGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARRRL
TH_3113|M.thermoresistible__bu PAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAA
Rv0442c|M.tuberculosis_H37Rv LANVLNSGLTNTPVAAPASAPVGGLDSGNPNPGSGSAAAGSGANPGLRSP
Mb0450c|M.bovis_AF2122/97 LANVLNSGLTNTPVAAPASAPVGGLDSGNPNPGSGSAAAGSGANPGLRSP
MMAR_0761|M.marinum_M LAGGLTPTAATPAAAAPAAAAPVAAAAADAGPVSAGANSGSTAGAGLRSP
MUL_1395|M.ulcerans_Agy99 LAGGLTPTAATPAAAAPAAAAPVAAAAADAGPVSAGANSGSTAGAGLRSP
MAV_4704|M.avium_104 IAGFLAPRAPQ---------------------------------------
MLBr_01182|M.leprae_Br4923 LGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGG
Mflv_0325|M.gilvum_PYR-GCK RRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAG
Mvan_0415|M.vanbaalenii_PYR-1 RRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAG
MSMEG_0619|M.smegmatis_MC2_155 RRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTG
MAB_0669|M.abscessus_ATCC_1997 RGKNKAEAGGR--RHEYLEETAGMGAT-ATADVPAYAATGRGTGPLGFAG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHGHRHEHQQPASMS-AATAPSAAGIRVLGGAG
Rv0442c|M.tuberculosis_H37Rv GTSYPSFVNSGSNDSGLRNTAVRE-PSTPGSGIPKSNFYPSPDRESAYAS
Mb0450c|M.bovis_AF2122/97 GTSYPSFVNSGSNDSGLRNTAVRE-PSTPGSGIPKSNFYPSPDRESAYAS
MMAR_0761|M.marinum_M AAGYSGLYNSANSDAGARSVATREAPANAGAGIPRSSFYP--NRETADSE
MUL_1395|M.ulcerans_Agy99 AVGYSGLYNSANSDAGARSVATREAPANAGAGIPRSSFYP--NRETADSE
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 LPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-------------
Mflv_0325|M.gilvum_PYR-GCK TVSRGD-EQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGH
Mvan_0415|M.vanbaalenii_PYR-1 TVSRDA-AQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERH
MSMEG_0619|M.smegmatis_MC2_155 TVTRHD-VTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SP
MAB_0669|M.abscessus_ATCC_1997 TAPAAASTHVAATVRLSSD--EARQVIPMLPSTWDAD-------------
TH_3113|M.thermoresistible__bu RISRTR-GSVPHAEITPGDPTEPSSPTDRAHRPAEPN-------------
Rv0442c|M.tuberculosis_H37Rv PRIGQPVGSE----------------------------------------
Mb0450c|M.bovis_AF2122/97 PRIGQPVGSE----------------------------------------
MMAR_0761|M.marinum_M ADIQLPLRTE----------------------------------------
MUL_1395|M.ulcerans_Agy99 ADIQLPLRTE----------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 NHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DDPEGGPRR
MAB_0669|M.abscessus_ATCC_1997 ----GGDQN
TH_3113|M.thermoresistible__bu ---------
Rv0442c|M.tuberculosis_H37Rv ---------
Mb0450c|M.bovis_AF2122/97 ---------
MMAR_0761|M.marinum_M ---------
MUL_1395|M.ulcerans_Agy99 ---------
MAV_4704|M.avium_104 ---------
MLBr_01182|M.leprae_Br4923 ---------