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QNERVQGFGFHTLALLTAVGFAGPLLASAKRFRIPVVIGELIAGLAIGRTGFGVVDVADPTFQLLANIGF ALVMFVVGTHVPLRARLMRSALPAALARAALAGGIAAVLGVALAVQFDTGHAALYAVLMASSSAALALPV IDSLRLRGPRVLSVTTQIAIADAACIVLLPLVIDIRRAPTAALGALAVAGCAAALFVLLRAADRKGWRRR LHAYSEQHRFALELRTSLLVLFALAALAVATQVSIMLAGFAVGLVVGAVGEPHRLARQLFGITEGFFSPL FFVWLGASLQVRELGAHPQLILLGAGLGCGAVLAHCAGRLLGQPLTLAVLSAAQLGVPVAAATIGTQQHL LAPGEASALMFGALLTIAAASIAAGLAARRQGAPEPGEPAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4118 | - | - | 100% (392) | transporter, monovalent cation:proton antiporter-2 (CPA2) family protein |
| M. avium 104 | MAV_4198 | - | 2e-13 | 24.55% (391) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3264c | - | 6e-11 | 25.75% (369) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1126 | - | 3e-05 | 29.17% (192) | copper resistance D domain-containing protein |
| M. tuberculosis H37Rv | Rv3236c | - | 7e-11 | 25.75% (369) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_00782 | - | 9e-15 | 27.11% (284) | putative transmembrane transport protein |
| M. abscessus ATCC 19977 | MAB_0385 | - | 1e-135 | 65.01% (383) | hypothetical protein MAB_0385 |
| M. marinum M | MMAR_1309 | - | 7e-15 | 29.69% (293) | membrane transporter |
| M. smegmatis MC2 155 | MSMEG_6769 | - | 3e-14 | 25.67% (413) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
| M. thermoresistible (build 8) | TH_4424 | - | 2e-05 | 29.05% (210) | PUTATIVE putative putative ABC transporter membrane-spanning |
| M. ulcerans Agy99 | MUL_2572 | - | 9e-16 | 28.03% (396) | membrane transporter |
| M. vanbaalenii PYR-1 | Mvan_1424 | - | 3e-14 | 25.30% (415) | sodium/hydrogen exchanger |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4118|M.avium_104 ----MQNERVQGFGFHTLALLTAVGFAGPLLASAKRFRIPVVIGELIAGL
MAB_0385|M.abscessus_ATCC_1997 ---------MSGFGFPTLAIVVIVGMIGPLLALNTRLRIPVVIGELLAGI
Mb3264c|M.bovis_AF2122/97 ------MEVSRALLFELGVLLAVLAVLG---AVARRFALSPIPVYLLAGL
Rv3236c|M.tuberculosis_H37Rv ------MEVSRALLFELGVLLAVLAVLG---AVARRFALSPIPVYLLAGL
MMAR_1309|M.marinum_M ------MEVSRALLFEVGALLTTLALLG---AIARRFALSPIPVYLLAGL
MUL_2572|M.ulcerans_Agy99 ------MEVSRALLFEVGALLTTLALLG---AIARRFALSPIPVYLLAGL
MLBr_00782|M.leprae_Br4923 ------MEISGALLSQVGALLTTLAVLG---AGARRYSLSPIPVYLMAGL
Mvan_1424|M.vanbaalenii_PYR-1 ---------MDGHLFPTIAIILALATAAG--VVATRLRQPLIVAFIMVGV
MSMEG_6769|M.smegmatis_MC2_155 ----MPADTAIHFFLQLAVILMACRLAG---LVARRIGQAQVVGEMIAGV
Mflv_1126|M.gilvum_PYR-GCK ------------MLVTVAACVMAWGLAYP-------------------AS
TH_4424|M.thermoresistible__bu MSATVTARHARAARPATGSTLTGLGRLIALALRRDRIRLPVWVVVLTVSI
: .
MAV_4118|M.avium_104 AIGRTGFGVVDV-----------ADPTFQLLANIGFALVMFVVGTH---V
MAB_0385|M.abscessus_ATCC_1997 VIGRTGFGWIDA-----------FDPTFKMFADVGFALVMFVAGTH---V
Mb3264c|M.bovis_AF2122/97 SLGNGGILGVAA-----------AGEFIATGAPIGVVLLLLALGLE---F
Rv3236c|M.tuberculosis_H37Rv SLGNGGILGVAA-----------AGEFIATGAPIGVVLLLLALGLE---F
MMAR_1309|M.marinum_M SLGKGGVLPVAA-----------ADDFVATGAPIGIVLLLLTLGLE---F
MUL_2572|M.ulcerans_Agy99 SLGKGGVLPVAA-----------ADDFVATGAPIGIVLLLLTLGLE---F
MLBr_00782|M.leprae_Br4923 SLGKGGIMPVSA-----------ADEFITTGAPIGIVLLLLTLGLE---F
Mvan_1424|M.vanbaalenii_PYR-1 AVGPVGAGWVS------------ADSTMELLARLGLAVLLFLVGLR---L
MSMEG_6769|M.smegmatis_MC2_155 ILGPSLLGRIAPDLQGLLFPPGITNVVLYTTAQIGLVLYMFIIGLN---F
Mflv_1126|M.gilvum_PYR-GCK PLGPAVVRAVAD---------------AAAVATLGLVVVPLLDGPR---Y
TH_4424|M.thermoresistible__bu GYMPAALEMAYPDEVDR------LARVNLMKNPAGIMFAGPMFGKNETAL
*. . * .
MAV_4118|M.avium_104 PLR--ARLMRSALPAALARAALAGGIAAVLGVALAV---------QFDTG
MAB_0385|M.abscessus_ATCC_1997 PVR--DKTMRASLPQAALRAIVVGAVAAVLGVLLAN---------VFHTG
Mb3264c|M.bovis_AF2122/97 SATEFASSLRHHLPSAGVDIVLNATPGAVAGWLLG----------LDGVA
Rv3236c|M.tuberculosis_H37Rv SATEFASSLRHHLPSAGVDIVLNATPGAVAGWLLG----------LDGVA
MMAR_1309|M.marinum_M SATEFASSLRHHMPSAMVDIVLNATPGAVAGWLLG----------LDGVA
MUL_2572|M.ulcerans_Agy99 SATEFASSLRHHMPSAMVDIVLNATPGAVAGWLLG----------LDGVA
MLBr_00782|M.leprae_Br4923 SATEFASSLRRHLPSAGVDIILNATPGAVAGWLLG----------LDGVA
Mvan_1424|M.vanbaalenii_PYR-1 DLHMIRNTGPVAVITGLGQVLVTFALGLLIALALG----------MDNVT
MSMEG_6769|M.smegmatis_MC2_155 DVNHVKQRAGTAAAVSATGTLAPLALGGVAAIPLLAHGGFFGDGVNVGMA
Mflv_1126|M.gilvum_PYR-GCK RAELSRRAWLPLVVASATWVVAEVVRLTITAAGAAG--------------
TH_4424|M.thermoresistible__bu GAMVANEAMLTFIVAASILAILTVVRRTRAEEESGTAELVLAAPVGRHAR
.
MAV_4118|M.avium_104 HAALYAVLMASSSAALALPVIDSLRLRGPRVLSVTTQIAIADAACIVLLP
MAB_0385|M.abscessus_ATCC_1997 HAPLYAVLIASSSAALVLPVIDSLGLGGPKVLITTAQVAIADTASIILLP
Mb3264c|M.bovis_AF2122/97 ILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMAAYLP
Rv3236c|M.tuberculosis_H37Rv ILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMAAYLP
MMAR_1309|M.marinum_M ILALAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVLEDFAMAGYLP
MUL_2572|M.ulcerans_Agy99 ILALAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVLEDFAMAGYLP
MLBr_00782|M.leprae_Br4923 VLALAGVTYISSSGVIARLLADLRRLGNRETPAVLSVLVLEDFAMAAYLP
Mvan_1424|M.vanbaalenii_PYR-1 ALYVAVALTFSSTIIIVKLLSDKRELEQLHGRIALGILIVQDIVVVVVMI
MSMEG_6769|M.smegmatis_MC2_155 MMFLGASVAITAFPMLARIIFEKRLSGTSLGTLALACGATSDAISWCILA
Mflv_1126|M.gilvum_PYR-GCK ------------TGATSLGLRTAVEFATRTAPGRAGLLTILAAALVCALA
TH_4424|M.thermoresistible__bu TVAAILLLAGVNAVLAVTLTAATAATGLPVVDSAAMSLGITGVAMVFGAT
MAV_4118|M.avium_104 LVIDIRRAPTAALGALAVAGCAAALFVLLRAADRKG-------------W
MAB_0385|M.abscessus_ATCC_1997 LVIDLKHAPRAAVGAVAVAACAGIVFVILHALDQAG-------------K
Mb3264c|M.bovis_AF2122/97 LFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGH------------H
Rv3236c|M.tuberculosis_H37Rv LFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGH------------H
MMAR_1309|M.marinum_M LFTVLALHGDWLHALGGTLAAIAALLGAFAASFYWGH------------H
MUL_2572|M.ulcerans_Agy99 LFTVLALHGDWLHALGGTLAAIAALLGAFAASFYWGH------------H
MLBr_00782|M.leprae_Br4923 LFAVLAAGGSWLDAVVGMIVAVCALFAAFAASYHWGH------------H
Mvan_1424|M.vanbaalenii_PYR-1 ALTASGRGGEGSVGAGIAAVALKGIGLLATLWVLMRF------------V
MSMEG_6769|M.smegmatis_MC2_155 VVLAVYRNSPVMAVVAIVGGLVYTLVLLTLGRRAFAK------------L
Mflv_1126|M.gilvum_PYR-GCK VLRIGSVPTAVASAGAAAVGIVGHPLTGHLADSPFG--------------
TH_4424|M.thermoresistible__bu AAVTAQLWRTSRAATGAALGALAAAVVVRGVGDVINHSGSVVSWLSPVAW
MAV_4118|M.avium_104 RRRLHAYSEQHRFALELRTSLLVLFALAALAVATQVSIMLAGFAVGLVVG
MAB_0385|M.abscessus_ATCC_1997 LDRFHDYSKQRRVAMELRISLAIVFGLAALAVETHVSIMLAGFALGLVVA
Mb3264c|M.bovis_AF2122/97 VGRLVTHPDSEQLLLRV---LGITLIVAAVAESLHASAAVGAFLVGLTLT
Rv3236c|M.tuberculosis_H37Rv VGRLVTHPDSEQLLLRV---LGITLIVAAVAESLHASAAVGAFLVGLTLT
MMAR_1309|M.marinum_M FGRLFAHPDSEQLLLRV---LGITLMVAALAETLHASAAVGAFLVGLTLT
MUL_2572|M.ulcerans_Agy99 FGRLFAHPDSEQLLLRV---LGITLMVAALAETLHASAAVGAFLVGLTLT
MLBr_00782|M.leprae_Br4923 VGRLVAHPDSEQLLLRV---LGVTLIVAAVAESLHASAAVGAFLVGLTLT
Mvan_1424|M.vanbaalenii_PYR-1 LPWLMPQIARSQELLVLFG-VAYAVSVASFSEWLGFSSEVGAFLAGVSLA
MSMEG_6769|M.smegmatis_MC2_155 GDAAEARQAITAPMLST--VLIVLMACAWLTDTIGIYAIFGAFILGAAMP
Mflv_1126|M.gilvum_PYR-GCK ---------------------GVAIAVHALAAAVWCGALAAVVLTVDHRG
TH_4424|M.thermoresistible__bu AQQMRAFVEVRWWPLALLVLLTVVLLGAAAVLERSREYDAGTLPAGGDRP
. . .
MAV_4118|M.avium_104 AVGEPHRLARQLFGITEG-FFSPLFFVWLGASLQV--RELG-AHPQLILL
MAB_0385|M.abscessus_ATCC_1997 GIGEPRRLAKQLFGFTEG-FFSPLFFVWLGASLHV--RELG-ENPKLILL
Mb3264c|M.bovis_AF2122/97 --GETADRARMVLTPLRD-LFATIFFLGIGLSVDP--GKLVSMLPVALAL
Rv3236c|M.tuberculosis_H37Rv --GETADRARMVLTPLRD-LFATIFFLGIGLSVDP--GKLVSMLPVALAL
MMAR_1309|M.marinum_M --GETAERARRVLGPLRD-LFAAIFFLGIGLSVAP--KELIPALPVAMVL
MUL_2572|M.ulcerans_Agy99 --GETAERARRVLGPLRD-LFAAIFFLGIGLSVAP--KELIPALPVAILL
MLBr_00782|M.leprae_Br4923 --GDTAERARKVLGPLRD-LFAAIFFLAIGISVDP--HKLLPMFPTALIL
Mvan_1424|M.vanbaalenii_PYR-1 G-TQFRDALGARLVSLRD-FLLFFFFLNLGAGLDF--SEAAGQITAAIIL
MSMEG_6769|M.smegmatis_MC2_155 SGFFAERLTGRLEPLTTT-FLLPLFFVYSGLNTEIGLVNTPFLWAVTAGL
Mflv_1126|M.gilvum_PYR-GCK ------QWARILPRFSRL-SFGCVAALLAGGVVGG----------VAMLA
TH_4424|M.thermoresistible__bu GAPPIRGVFGLQLVLQRGQLIGWSVGLFLGGLTFGSLTQAMLDIAEENEL
: : *
MAV_4118|M.avium_104 GAGLGCGAVLAHCAGRLLGQPLTLAVLSAAQLGVPVAAATIGTQQHLLAP
MAB_0385|M.abscessus_ATCC_1997 GVGLGVAAVLAHLVVRIFGQPLPLGALAAAQLGVPIAAAAIGEQQQSLIH
Mb3264c|M.bovis_AF2122/97 AAVTAATKVATGMFAARREGVARRGQLRAG--TALVARGEFSLIIIGLAG
Rv3236c|M.tuberculosis_H37Rv AAVTAATKVATGMFAARREGVARRGQLRAG--TALVARGEFSLIIIGLAG
MMAR_1309|M.marinum_M AVVTAATKVLTGMFAARRDGVARRGQLRAG--TALIARGEFSLIIIGLVG
MUL_2572|M.ulcerans_Agy99 AVVTAATKVLTGMFAARRDGVARRGQLRAG--TALIARGEFSLIIIGLVG
MLBr_00782|M.leprae_Br4923 ATVTAVTKVATGILAARYDGVARRGQLRAG--TALVARGEFSLIIIGLVG
Mvan_1424|M.vanbaalenii_PYR-1 SVFVLVAKPAIVIAIMSVMRYPVRVGFLVGLPLAQISEFSLILAALGLSL
MSMEG_6769|M.smegmatis_MC2_155 LVVAVVGKGVACAVAARLSRVPVRDSLALGSLMNARGLIELILLNIGLEA
Mflv_1126|M.gilvum_PYR-GCK SAADLYATGYGRVLTAKIALTVVLVVLAWRNRRIWVPAARTHRSSAVLSR
TH_4424|M.thermoresistible__bu VAAMLAAHGNAGIFTTMTQFLAAATTAFIAITVLRLRSDEQSGLAEPVLA
. :
MAV_4118|M.avium_104 GEASALMFGALLTIAAASIAA---------GLAARRQGAPEPG--EPAR-
MAB_0385|M.abscessus_ATCC_1997 GEASALILGALVTIAAATVGG---------SLYAKTSQGNQPGVAKPERP
Mb3264c|M.bovis_AF2122/97 ASIPGVAALATAYVFVMAIVG---------PILARYTGGGLPAAAVASN-
Rv3236c|M.tuberculosis_H37Rv ASIPGVAALATAYVFVMAIVG---------PILARYTGGGLPAAAVASN-
MMAR_1309|M.marinum_M ASIPAVAALATAYVFIMAVAG---------PVLARYTGG--PVATTA---
MUL_2572|M.ulcerans_Agy99 ASIPAVAALATAYVFIMAVAG---------PVLARYTGG--PVATTA---
MLBr_00782|M.leprae_Br4923 TSTPAVAALATAYVFIMAIAG---------PVLARYTPGSLPTSSGSAN-
Mvan_1424|M.vanbaalenii_PYR-1 GHISNATVSLITVVGLITIAASTYMTMYSDGIFARSQRWLSHLERKHQRD
MSMEG_6769|M.smegmatis_MC2_155 GVITPTLFTILVLVAIVTTLMAS-------PIFEFVYGRHRTDETGDTTQ
Mflv_1126|M.gilvum_PYR-GCK SRAHVEVALMAAALAAAATLS--------------VTG------------
TH_4424|M.thermoresistible__bu GSVSRWQWLLSTVAATLLGAATLLFFAGLGNGLGAGIALGDPGTVGELVL
MAV_4118|M.avium_104 --------------------------------------------------
MAB_0385|M.abscessus_ATCC_1997 VDDSEGSGAGGGAEGAGGGVAG----------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 HEVAGLSDGDFDIILFGLGRFGSHLADRLSGAGHRVLGVDFDPHGVRAHR
MSMEG_6769|M.smegmatis_MC2_155 ERVPQPSA------------------------------------------
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
TH_4424|M.thermoresistible__bu SALAHLPAMAVMTGIAALAFALRMNWIAWLTVTFVIVSLYMGALLRVPQW
MAV_4118|M.avium_104 --------------------------------------------------
MAB_0385|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 RDGVTTTFGSAEDLDLLEALPLDRAKYVISAIPVLQTNLALLHGLRQHQF
MSMEG_6769|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
TH_4424|M.thermoresistible__bu LLDLSPVTRIKVPMETSVTTMVVMVLIGAALTATAGWRYRGRDAL-----
MAV_4118|M.avium_104 --------------------------------------------------
MAB_0385|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 SGAVALTAHTRHDAERLRATGVEIVIEPFSSAAHTTSNTLHDLLTTEFED
MSMEG_6769|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
TH_4424|M.thermoresistible__bu --------------------------------------------------
MAV_4118|M.avium_104 -------------------
MAB_0385|M.abscessus_ATCC_1997 -------------------
Mb3264c|M.bovis_AF2122/97 -------------------
Rv3236c|M.tuberculosis_H37Rv -------------------
MMAR_1309|M.marinum_M -------------------
MUL_2572|M.ulcerans_Agy99 -------------------
MLBr_00782|M.leprae_Br4923 -------------------
Mvan_1424|M.vanbaalenii_PYR-1 TDDEGYSDDEGGAQPRPSR
MSMEG_6769|M.smegmatis_MC2_155 -------------------
Mflv_1126|M.gilvum_PYR-GCK -------------------
TH_4424|M.thermoresistible__bu -------------------