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M. thermoresistible (build 8) TH_4424 (-)

annotation: putative putative ABC transporter membrane-spanning protein
coordinates: 1168922 - 1170541
length: 540

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4424--100% (540)putative putative ABC transporter membrane-spanning protein
M. thermoresistible (build 8)TH_3461-2e-0628.09% (388) PUTATIVE putative Arsenical pump membrane protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1249c-6e-6834.11% (557) tetronasin-transport integral membrane protein ABC transporter
M. gilvum PYR-GCKMflv_2196-0.061.58% (531) putative ABC transporter membrane-spanning protein
M. tuberculosis H37RvRv1217c-2e-6834.29% (557) tetronasin-transport integral membrane protein ABC transporter
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_1358c-1e-15853.77% (530) ABC transporter permease
M. marinum MMMAR_4221-2e-7233.64% (544) tetronasin-transport integral membrane protein ABC transporter
M. avium 104MAV_1361-9e-6632.85% (554) ABC transporter membrane-spanning protein
M. smegmatis MC2 155MSMEG_5076-0.061.85% (519) ABC transporter membrane-spanning protein
M. ulcerans Agy99MUL_4207-1e-0525.69% (432) hypothetical protein MUL_4207
M. vanbaalenii PYR-1Mvan_4500-0.061.63% (529) putative ABC transporter membrane-spanning protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb1249c|M.bovis_AF2122/97           -MSSTVIDRARPAGHRAPHRGSGFTGTLGLLRLYLRRDRVSLPLWVLLLS
Rv1217c|M.tuberculosis_H37Rv        -MSSTVIDRARPAGHRAPHRGSGFTGTLGLLRLYLRRDRVSLPLWVLLLS
MMAR_4221|M.marinum_M               -MSTTVLDRPSRPAHRGPQRASGLAGTLRLLRLYLRRDRVGLPLWVMLLS
MAV_1361|M.avium_104                -MSATTLTRPSASASPAPLGGAHFSGTLQMLRLYLRRDRISLPLWVLLLS
Mflv_2196|M.gilvum_PYR-GCK          -MTTAGHLTHTRHAAPSAPSKSMWTHTGLLIRLALRRDRIRLSIWIAMLS
Mvan_4500|M.vanbaalenii_PYR-1       MSTTAGLPTRGRHAAPAARSP--WTGTGDLIGLALRRDRVRLSVWIAALT
MSMEG_5076|M.smegmatis_MC2_155      ----------------------MITGAGALVRLALRRDRVRLAVWIAVLT
TH_4424|M.thermoresistible__bu      -MSATVTARHARAARPATGST--LTGLGRLIALALRRDRIRLPVWVVVLT
MAB_1358c|M.abscessus_ATCC_199      -MSTDFATLPIHRPGTDGTPRHPLTGIGTLIMLALRRDRFRICMWVGWLT
MUL_4207|M.ulcerans_Agy99           ---------------------------------------------MARVG
                                                                                 :  : 

Mb1249c|M.bovis_AF2122/97           VPLATVYIASVETVYPDRSARAAAAAAIMASPAQRALYGPVYNDSLGAVG
Rv1217c|M.tuberculosis_H37Rv        VPLATVYIASVETVYPDRSARAAAAAAIMASPAQRALYGPVYNDSLGAVG
MMAR_4221|M.marinum_M               VPLATVYVGSIQAVYPDQAARAVAAAAIMASPAQRALYGPVYNDSLGAVG
MAV_1361|M.avium_104                VPLSTVYVGSIEKVYPTAAARAGFAASIMASPAQRALYGKVYSDSLGAVG
Mflv_2196|M.gilvum_PYR-GCK          LLMIYTPN-ALELAYPEEAQRL-ARVNLLKTPAGMMMGGPVFGVDETDLG
Mvan_4500|M.vanbaalenii_PYR-1       AMTAYAPG-AIKLAYPEEAQRQ-ARVDLLKTPAGMMLGGPMFGGNETDLG
MSMEG_5076|M.smegmatis_MC2_155      STMVYAPN-TIRMTYPDEAQRQ-SRVELLKTPAGMMLGGPMFGVNETDLG
TH_4424|M.thermoresistible__bu      VSIGYMPA-ALEMAYPDEVDRL-ARVNLMKNPAGIMFAGPMFGKNETALG
MAB_1358c|M.abscessus_ATCC_199      LLMTYTPL-AFESMYPTTADRM-ARVTMMKTPAGIIMSGPSFGINETDVG
MUL_4207|M.ulcerans_Agy99           TATAVTALCGYTVIYLAARDLA---------PSGFSVFGVFWG-------
                                                  *                *:   . *  :.       

Mb1249c|M.bovis_AF2122/97           IWKAG----MFHTLIAVAVILTVIRHTRADEESGRAELIDSTVVGRYTNL
Rv1217c|M.tuberculosis_H37Rv        IWKAG----MFHTLIAVAVILTVIRHTRADEESGRAELIDSTVVGRYANL
MMAR_4221|M.marinum_M               VWKAG----MFHTLIAVAVILTMIRHTRADEETGRAELVESTAVGRYANL
MAV_1361|M.avium_104                IWKAG----MFHVLIAIAVILTVIRHTRADEENGRTELVDSTAIGRYAGL
Mflv_2196|M.gilvum_PYR-GCK          VMMANELMLTLIVATSILAILTVIRHTRAEEESGTAELVLASVVGRYART
Mvan_4500|M.vanbaalenii_PYR-1       AMMANELMLTMIIATSILAILTVIRHTRAEEESGAAELVLASVVGRYART
MSMEG_5076|M.smegmatis_MC2_155      AMMANELMLTLMVAASILSILTVIRHTRAEEESGAAELVLSSVVGRHART
TH_4424|M.thermoresistible__bu      AMVANEAMLTFIVAASILAILTVVRRTRAEEESGTAELVLAAPVGRHART
MAB_1358c|M.abscessus_ATCC_199      VMVANELMTVMIAAAAIMSILTVIRHTRAEEESGAAELVMSAVIGHQART
MUL_4207|M.ulcerans_Agy99           ----------AFGLVSGTANGLLQEATREVRSAQYLDVVPEGGRTHPLRI
                                                   :      : . **  ..    :::      :    

Mb1249c|M.bovis_AF2122/97           TGALLLSFGASIATGAIGALGLLATDVAPAGSVAFGVALAASGMVFTAVA
Rv1217c|M.tuberculosis_H37Rv        TGALLLSFGASIATGAIGALGLLATDVAPAGSVAFGVALAASGMVFTAVA
MMAR_4221|M.marinum_M               TAALLLSFGASVATGAIGAAGLLTTDVPAAGSLAFGAALAASGLVFTSVA
MAV_1361|M.avium_104                TAALTLSFAASIATGAIGAAGLLGTDVPAGGSLAFGAALAWSGLVFTAVA
Mflv_2196|M.gilvum_PYR-GCK          TAALSVAAGVNVVLTVTMTAAMVASGFGVSDSLGMCAGVTAVAMVFAAVA
Mvan_4500|M.vanbaalenii_PYR-1       TAALILVAAVNVVLAVTTTAAMAAGGFGVVDSAAMCVGVTAVAMVFGAVA
MSMEG_5076|M.smegmatis_MC2_155      TAALVLVAGVNVVLAVAMTLAMTVSGFAPADSAAMCFGVSGVAMVFGALA
TH_4424|M.thermoresistible__bu      VAAILLLAGVNAVLAVTLTAATAATGLPVVDSAAMSLGITGVAMVFGATA
MAB_1358c|M.abscessus_ATCC_199      YAALIVVALMNAVLAVAMTAALSAADFDFINSLGISLGIIGASMVFAGLG
MUL_4207|M.ulcerans_Agy99           AGMVGLASAVVIAGSSPLWSGRVFVEDRWLSVGLLSVGLAGFCLHATLLG
                                     . : :      .       .         .   :  .:    :     .

Mb1249c|M.bovis_AF2122/97           AVAAQLSPSARFTRAVAFAVLGTAFALRAIGDAGSGT---LSWCSPLGWS
Rv1217c|M.tuberculosis_H37Rv        AVAAQLSPSARFTRAVAFAVLGTAFALRAIGDAGSGT---LSWCSPLGWS
MMAR_4221|M.marinum_M               AVCAQLSPSARSCRSAAFAVLGTAFTLRAIGDAGSGA---LSWFSPLGWS
MAV_1361|M.avium_104                AVTAQLSPSARFARGAAFAVLGTSFTVRAVGDAGPGG---LSWLSPLGWS
Mflv_2196|M.gilvum_PYR-GCK          AVTAQMWRAARAATGTAMAALALAALIRGIGDVIDNSGSALSWFSPIAWA
Mvan_4500|M.vanbaalenii_PYR-1       AVTAQMWRAARAATGAAMATLALAALVRGIGDVIDNSGSVLSWFSPIAWA
MSMEG_5076|M.smegmatis_MC2_155      ALTAQMWRQARAATGAAMAALGVAALIRGVGDVIDNSGSILSWFSPIAWA
TH_4424|M.thermoresistible__bu      AVTAQLWRTSRAATGAALGALAAAVVVRGVGDVINHSGSVVSWLSPVAWA
MAB_1358c|M.abscessus_ATCC_199      AVTAQLWRTARAASGAAMAALAAAVVVRGLGDIIDNKGSALSWFSPLAWA
MUL_4207|M.ulcerans_Agy99           MLAGTNRWSHYGSLMVTDAIIRVAVSAATF---------------AIGWG
                                     : .           .: . :  :     .               .:.*.

Mb1249c|M.bovis_AF2122/97           LQVRPYAGERWWVLLLSLATAAVLTVLAYRLRAGRDVGAGLIAERPGAGT
Rv1217c|M.tuberculosis_H37Rv        LQVRPYAGERWWVLLLSLATAAVLTVLAYRLRAGRDVGAGLIAERPGAGT
MMAR_4221|M.marinum_M               LLVRPYAGERWWVLLLPLATTAALTVLAYRLRAGRDVGAGLIAERAGAGA
MAV_1361|M.avium_104                LLVKPYAGDRWWVLVLHLVTTAGLTVLAYRLLAGRDVGAGLIAERPGPAT
Mflv_2196|M.gilvum_PYR-GCK          QQMRSFVDLRWWPLALLIGLTLALVTLAAALERRREYDDATLSSR-GEHP
Mvan_4500|M.vanbaalenii_PYR-1       QQMRPFVELRWWPLALLSALSLTLVAIAAALEVQREYDDATIVSS-GESP
MSMEG_5076|M.smegmatis_MC2_155      QQMRPFVALRCWPFALLVLLAVALIALAAVAEARRQYDDGTIPAT-GDRP
TH_4424|M.thermoresistible__bu      QQMRAFVEVRWWPLALLVLLTVVLLGAAAVLERSREYDAGTLPAG-GDRP
MAB_1358c|M.abscessus_ATCC_199      QQMRPFVDLRWWPFLLLLGTTLALMLTAHLLEGHRQYDAGVLPSR-GENP
MUL_4207|M.ulcerans_Agy99           LVGFLWATVAGSVSWLILLLASPVARATARLLTPGNTATFLRGAAHSITA
                                         :.        *    :  :   :       :          .  .

Mb1249c|M.bovis_AF2122/97           AGPMLSEPFGLAWRLNRGS-LLLWTVGLCLYGLVMGSVVHGIGDQLGDNT
Rv1217c|M.tuberculosis_H37Rv        AGPMLSEPFGLAWRLNRGS-LLLWTVGLCLYGLVMGSVVHGIGDQLGDNT
MMAR_4221|M.marinum_M               AAPMLSNTFGLAWRLDRGA-LLLWTIGLCLYGLVMGSVVHGIGDQLGDNT
MAV_1361|M.avium_104                AAPRLGNAFGLAWRLDRAA-LLLWTAGLALYGLLIGSVVHGIGDELGDSG
Mflv_2196|M.gilvum_PYR-GCK          GARPVRGVLALHLVLQRGQ-TIGWSAGLFIAGLAFGSMTKSLLDAAEGNE
Mvan_4500|M.vanbaalenii_PYR-1       NARPIRGVLALHLRLQRGQ-TLGWSVGLFAAGLAFGSMTKSLLEAAHDNE
MSMEG_5076|M.smegmatis_MC2_155      DAAPITGVLGLHLRLHRGQ-TIAWGAGLFVAGLAFGSMTKSLMDAAQTNE
TH_4424|M.thermoresistible__bu      GAPPIRGVFGLQLVLQRGQ-LIGWSVGLFLGGLTFGSLTQAMLDIAEENE
MAB_1358c|M.abscessus_ATCC_199      NAPEIKTVVGLNGQLQRGL-ITGWGFGVFLGGMAFGSMAKSLRDSIDTNP
MUL_4207|M.ulcerans_Agy99           AGASAILVMGFPVLLKLTSNELGPQGGVIILAVTLTRAPLLVPLTAMQGN
                                     .      ..:   *.          *:   .: :      :      . 

Mb1249c|M.bovis_AF2122/97           AVRDIVTRMGGTGALEQAFLALAFTMIGMVAAAFAVSLTLRLHQEETGLR
Rv1217c|M.tuberculosis_H37Rv        AVRDIVTRMGGTGALEQAFLALAFTMIGMVAAAFAVSLTLRLHQEETGLR
MMAR_4221|M.marinum_M               AVREIVTRMGGTAALEEAFVTLAFTLVGMVAAAFAISLTLRLHQEETGQR
MAV_1361|M.avium_104                QARDIVARMGGTSALEDAFIAVAFAMMGMVAAAFAVSLTLRLHQEESSQR
Mflv_2196|M.gilvum_PYR-GCK          LIAQMISAQG-----TDGVYMTMSQFLAAAASAYVVACVLRLHADERSGL
Mvan_4500|M.vanbaalenii_PYR-1       LLARIVSTQG-----LDGVYTTMTQFLAAAAGAYVVSAVLRVFADEQSGL
MSMEG_5076|M.smegmatis_MC2_155      LIAQVLAAQG-----PDGAYTTMTQFLAAAAAAYTVSGVLRLYDDEQNGR
TH_4424|M.thermoresistible__bu      LVAAMLAAHG-----NAGIFTTMTQFLAAATTAFIAITVLRLRSDEQSGL
MAB_1358c|M.abscessus_ATCC_199      LLARAFTAHG-----LDSIFATFNQVLAIAVTAYAVSAILRLAKDEQSGI
MUL_4207|M.ulcerans_Agy99           LIAHFVDESA-------------QRLRALISPAALIGGIGVIGVLAAGAV
                                         .   .               . .    *        :     .  

Mb1249c|M.bovis_AF2122/97           AETLLAGAVSRTHWLASHLAMALAGSAVATLISGVAAGLAYGMTVGDVGG
Rv1217c|M.tuberculosis_H37Rv        AETLLAGAVSRTHWLASHLAMALAGSAVATLISGVAAGLAYGMTVGDVGG
MMAR_4221|M.marinum_M               AEPLLAGSVSRTRWLSSHLVMALAGSAVATVLSGLVAGIAYGIAAGDVGA
MAV_1361|M.avium_104                AETVLASAVSRTRWLASHLVIALAGSGVAMLASGTVAGLVYGIAAGDVGG
Mflv_2196|M.gilvum_PYR-GCK          GESVLAGAVSRWRWLSTSVVAAVLGATVLMFFAGLGNGVGAGITLGEP-G
Mvan_4500|M.vanbaalenii_PYR-1       GEAVLAGAVSRPRWLSTAVLSAVLGASVLMFFAGLGNGLGAGVTLGEP-A
MSMEG_5076|M.smegmatis_MC2_155      AEAVLAGPVSRWRWLLGATVAAVLGSAVVLLCAGVGNGLGAGLTLGDL-P
TH_4424|M.thermoresistible__bu      AEPVLAGSVSRWQWLLSTVAATLLGAATLLFFAGLGNGLGAGIALGDP-G
MAB_1358c|M.abscessus_ATCC_199      TEAVLARAVSRWTWLLSAVAMTALGSALLMTIAGLGAGLGAASTLHDP-D
MUL_4207|M.ulcerans_Agy99           GPWLLRSAFGQQYQASGSLLAWLTAAAVAIAMLTLTG-------------
                                       :*  ...:             .:                        

Mb1249c|M.bovis_AF2122/97           KLPTVVGTAAVQLPAVWLLSAVTVGLFGLAPRFTPVAWGVLVGFIALYLL
Rv1217c|M.tuberculosis_H37Rv        KLPTVVGTAAVQLPAVWLLSAVTVGLFGLAPRFTPVAWGVLVGFIALYLL
MMAR_4221|M.marinum_M               KLATVVGAAAVQLPAVWLLAAVAVGLFGLAPRFTPVVWGVLIGFVALYLL
MAV_1361|M.avium_104                KLAMVVASAAVQLPAVWLLSAVTVCVFGVAPRFAPVAWGVLIGFVALYLI
Mflv_2196|M.gilvum_PYR-GCK          TVGRLTVAGLAFVPALAVMAGVAA--VGVALRQPWIGWLAVASVVLSLYL
Mvan_4500|M.vanbaalenii_PYR-1       TVLRLTVAGLAFVPALAVLAGVAA--LAVALRQSWIGWLAVTFVVASLYL
MSMEG_5076|M.smegmatis_MC2_155      TVGRLALAALAYLPALAVMAAVAT--LAVALRTPWIAWLAVAFVIVALYL
TH_4424|M.thermoresistible__bu      TVGELVLSALAHLPAMAVMTGIAA--LAFALRMNWIAWLTVTFVIVSLYM
MAB_1358c|M.abscessus_ATCC_199      LVWRLILAGLAQIPALLVVCGIAA--VAVALRQSWIGWVVVAFSVGMLYA
MUL_4207|M.ulcerans_Agy99           --AAAVAAALHRAYSLGWVSATAASGLLLLLPLPLEAR-----TVVALLC
                                           :.     ::  : . :.  . .               :     

Mb1249c|M.bovis_AF2122/97           GSLAGFPQMLLNLEPFAHIPRVGGGDFTAVPLLWLLAIDAALITLGAMAF
Rv1217c|M.tuberculosis_H37Rv        GSLAGFPQMLLNLEPFAHIPRVGGGDFTAVPLLWLLAIDAALITLGAMAF
MMAR_4221|M.marinum_M               GSLAGFPQWLLDLEPFAHVPRIG-RDFTAVPLLWLLAIDITLILLGALAL
MAV_1361|M.avium_104                GSLAGFSQWLLDLEPFAHIPRVG-ADFTAVPLLWLLAIDIGLTILGAMAF
Mflv_2196|M.gilvum_PYR-GCK          GALLRLPRWLIDLSPVSRTTVPT--DVPVVALVVMCVAAATLTVLAGFLY
Mvan_4500|M.vanbaalenii_PYR-1       GALLRLPGWLLDLSPVAQTSYPA--DVPALGWFVMCCAAAALTVFAAVRY
MSMEG_5076|M.smegmatis_MC2_155      GALLRLPRWLLDLSPVGRTTAPM--DYPVTALFVMAVVAVLLACAAGGLY
TH_4424|M.thermoresistible__bu      GALLRVPQWLLDLSPVTRIKVPM--ETSVTTMVVMVLIGAALTATAGWRY
MAB_1358c|M.abscessus_ATCC_199      G-ILQLPTWMVKLSPVMRVSAPV--EYPWLTMSLLIVLGAGLAAAAGALY
MUL_4207|M.ulcerans_Agy99           GPLVGIGVHLLALARAGYASR-----------------------------
                                    * :  .   :: *                                     

Mb1249c|M.bovis_AF2122/97           RRRDVRC
Rv1217c|M.tuberculosis_H37Rv        RRRDVRC
MMAR_4221|M.marinum_M               RRRDLRC
MAV_1361|M.avium_104                RRRDLRC
Mflv_2196|M.gilvum_PYR-GCK          RRRDAA-
Mvan_4500|M.vanbaalenii_PYR-1       RHRDAV-
MSMEG_5076|M.smegmatis_MC2_155      RRRDAV-
TH_4424|M.thermoresistible__bu      RGRDAL-
MAB_1358c|M.abscessus_ATCC_199      RRRDAI-
MUL_4207|M.ulcerans_Agy99           -------