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LVTVAACVMAWGLAYPASPLGPAVVRAVADAAAVATLGLVVVPLLDGPRYRAELSRRAWLPLVVASATWV VAEVVRLTITAAGAAGTGATSLGLRTAVEFATRTAPGRAGLLTILAAALVCALAVLRIGSVPTAVASAGA AAVGIVGHPLTGHLADSPFGGVAIAVHALAAAVWCGALAAVVLTVDHRGQWARILPRFSRLSFGCVAALL AGGVVGGVAMLASAADLYATGYGRVLTAKIALTVVLVVLAWRNRRIWVPAARTHRSSAVLSRSRAHVEVA LMAAALAAAATLSVTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1126 | - | - | 100% (297) | copper resistance D domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2566 | - | 1e-16 | 29.10% (299) | copper resistance D domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2826 | - | 3e-15 | 26.71% (292) | copper resistance D domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1557 | - | 2e-13 | 25.32% (312) | copper resistance D precursor |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1692 | - | 5e-20 | 31.70% (306) | ABC-type transporter, permease components |
| M. smegmatis MC2 155 | MSMEG_6437 | - | 2e-86 | 54.43% (305) | copper resistance protein D |
| M. thermoresistible (build 8) | TH_1178 | - | 2e-39 | 61.90% (126) | copper resistance protein D |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_5680 | - | 1e-114 | 69.93% (296) | copper resistance D domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1126|M.gilvum_PYR-GCK ----------------------------------------MLVTVAACVM
Mvan_5680|M.vanbaalenii_PYR-1 ------------------------------MTHRRAVAGGALVTVASCVA
MSMEG_6437|M.smegmatis_MC2_155 ------------------------------------MAGGVLVIAASAVT
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 MTTAPTAR--------KTDSPIWTIVVGLAVLAGLVAATIGALSLAEALL
MAV_1692|M.avium_104 MTVAPPAGTASTEAVPQHRTQVWPVLAGVAVLAGCTAAGIGTLSLASALT
Mflv_1126|M.gilvum_PYR-GCK AWGLAYP--ASPLGPAVVRAVADAAAVATLGLVVVPLLDGPRYRAELSR-
Mvan_5680|M.vanbaalenii_PYR-1 AWALAYP--AGSLTSAVPRAVADGAAVVTLGLAVVPALDGPRYRDELVR-
MSMEG_6437|M.smegmatis_MC2_155 AWALAFP--HTPIIGAAVRALADAAAVATLGLATVPMLDQARHRADVAR-
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 ATGLPNPGPVTSYGLPFVRAAAEIAAVVAVGAFLLAAFFVPPQTSGVLDV
MAV_1692|M.avium_104 ATGLPDPGPVTTLGLPFLRAAGEIAAVLAVGSFLFAAFLVPPQPSGVLDA
Mflv_1126|M.gilvum_PYR-GCK ---RAWLPLVVASATWVVAEVVRLTITAAGAAGTGATSLGLRTAVEFATR
Mvan_5680|M.vanbaalenii_PYR-1 ---RATAPLVSASAVWVVAELVRLALAGAEAAGTTVTGLGLREAWEFAAY
MSMEG_6437|M.smegmatis_MC2_155 ---VAATPLAVTAAVWALAELVRLVTDAALAAGLSVRHIGVRTVADFGWY
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 DGYRALRLGTAAATVLAVLSAVMVPLSVSDVSGQPLSDFGPGELWTLASE
MAV_1692|M.avium_104 DGYRALRLGTVASGVWAVCAALLVPLTLSDVSGHPVADLRPAQMWSLAGL
Mflv_1126|M.gilvum_PYR-GCK TAPGRAGLLTILAAALVCALAVLRIGSV--------PTAVASAGAAAVGI
Mvan_5680|M.vanbaalenii_PYR-1 TAPGRAGLLTVLAAAAVCAVTSVAPRSG--------PACIAGAGLACIGV
MSMEG_6437|M.smegmatis_MC2_155 TTVGRSGLVSIVAAVAVCGVASATQRPARFSVVSGPSAMLATVGISAAGM
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 IETVNAWRWMAFIAAGVAITSRVVLRWS------WTPLLVLGSVATLMPL
MAV_1692|M.avium_104 ITTASAWRWTAILAAAITLASLPVLRWS------WAPVLVAASLTTLIPL
Mflv_1126|M.gilvum_PYR-GCK VGHPLTGHLADSPFGGVAIAVHALAAAVWCGALAAVVLTVDHRG----QW
Mvan_5680|M.vanbaalenii_PYR-1 IGHPLTGHLSGSVLGGVSIAVHALAAALWCGTLAGLVLTVDHRG----QW
MSMEG_6437|M.smegmatis_MC2_155 AARTLAGHLSESPLGGLAVAVHALAAALWCGLLAALVVTVTHRG----QW
TH_1178|M.thermoresistible__bu -----VDRLXXX-------------AALWCGVLAALVLTVAHRG----RW
MAB_1557|M.abscessus_ATCC_1997 ALVGHSATGGAHDLGTNSLIIHLVSAALWAGGLVSLLIHALRGG---GHL
MAV_1692|M.avium_104 GLTGHSSAGGSHDLATNGLLIHLVAAALWSGGLLALLAYALRGGQGGGHL
**:*.* * .:: . : * :
Mflv_1126|M.gilvum_PYR-GCK ARILPRFSRLSFGCVAALLAGGVVGGVAMLASAADLYATGYGRVLTAKIA
Mvan_5680|M.vanbaalenii_PYR-1 ARVLPRFSQLSLGCVAALLAGGIAAGVTVLESPAALYATGYGRVLSLKIA
MSMEG_6437|M.smegmatis_MC2_155 ARVLPRFSQLSLGCVAVLLVAGVVGALVRLQSPADLVVTGYGRLLSAKML
TH_1178|M.thermoresistible__bu ARVLPRFSQVSLWCVIVLLVCGVAGAAVTLASPAALFDTGYGRVLSGKIA
MAB_1557|M.abscessus_ATCC_1997 DVAARRFSMLALWCYVAIGLSGIINALIRVQ-LSDLFTTRYGWLLMGKAT
MAV_1692|M.avium_104 GLATRRFSAIALWCWVAMALSGLVNAAVRVQ-PSDLLATGYGRLVLAKAA
*** ::: * .: *: . : : * * ** :: *
Mflv_1126|M.gilvum_PYR-GCK LTVVLVVLAWRNRRIWVPAARTHRSSAVLSR---SRAHVEVALMAAALAA
Mvan_5680|M.vanbaalenii_PYR-1 LTLVLIALAWRNRELWLPAARTHRSTAAVSR---TRAYTELTLMAATVAA
MSMEG_6437|M.smegmatis_MC2_155 VTAGLLVLAWRNRSGWLPAARAHRSSAGLSQ---RRSLVELGAMGVVVTF
TH_1178|M.thermoresistible__bu VTVALIGLAWRNRTGWVPAARAHRTTAEVST---ARSLTELALMTVALTF
MAB_1557|M.abscessus_ATCC_1997 ALLLLGVLGYLQRRSAITALDED---PENRQPLIRLAGVEAIIFAVTFGI
MAV_1692|M.avium_104 ALCLLGGVGWRQRRVNVAALQAVSTLARARRALLRLTLIEAALFGLTFGI
* :.: :* :.* . : * : ..
Mflv_1126|M.gilvum_PYR-GCK AATLSVTG------------------------------------------
Mvan_5680|M.vanbaalenii_PYR-1 AAVLSVTG------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 AAALAVTG------------------------------------------
TH_1178|M.thermoresistible__bu AAVLTVTG------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 AVGLGRTPPPPPVNLNPSPVEVAIGYNLDGPPTPGRLMFDWRFDLIFGTA
MAV_1692|M.avium_104 AVGLGRTAPPPPPARLPSIAEAEIGYDFDGPPTLTRILFDWRFDLIFGTA
*. * *
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5680|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 --------------------------------------------------
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 AIVFAIAYVVGVRRLKQRGDEWPIGRTISWLFGCGFLLIATSSGVGRYMP
MAV_1692|M.avium_104 AIVLAGLYVAGVVRLRRRGDRWQPGCTSSWLLGCLVLLFVTSSGVGRYMP
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5680|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 --------------------------------------------------
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 AMFSMHMVAHMMLSMLVPVLLVLGGPVTLLLRVLPAAGKSDPPGLREWVQ
MAV_1692|M.avium_104 AMFSMHMVVHMCLSMLVPILLALGAPVTLALRALPAAGRGDPPGPREWLL
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5680|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 --------------------------------------------------
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 LALHSKFSRFLTHPLVATSLFIGGFYGLYLSGLYDAAVDVHAAHLAMNLH
MAV_1692|M.avium_104 AALHSRFSRLLTNPVVATVLFVAGFYGLYLSNLFDTTASSHAGHLLMNLH
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5680|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 --------------------------------------------------
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 FLLSGYLFYWVVIGIDPSPRRLPPVAKLGIVLVSLPLHAFFGVILMGTKS
MAV_1692|M.avium_104 FLLSGYLFYWVVIGVDPTPRPIPPLAKLAVVFASLPLHAFFGVVLMGTRK
Mflv_1126|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5680|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 --------------------------------------------------
TH_1178|M.thermoresistible__bu --------------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 ILGEKFYSNLALPWRIDLAADQHMGGAITWATGELPLMVVMIALVVQWSR
MAV_1692|M.avium_104 VLGADYYRSLGFSWHTDLLGDQRLGGGIAWSAGEFPLVIVMLALLVQWAR
Mflv_1126|M.gilvum_PYR-GCK ----------------------------------------------
Mvan_5680|M.vanbaalenii_PYR-1 ----------------------------------------------
MSMEG_6437|M.smegmatis_MC2_155 ----------------------------------------------
TH_1178|M.thermoresistible__bu ----------------------------------------------
MAB_1557|M.abscessus_ATCC_1997 SDERLARRQDRAADRDDDADLAAYNAMLAKMAQHNEKTRG------
MAV_1692|M.avium_104 SDRRTAKRLDRAADRDDDAELAAYNAMLAQLAGRDKPGEGSATGQA