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MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAELATTAEAYGSVLSGLAALHWRGPAAESMAVTAA PYIGWLYTTAEKTQQTAIQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATEAQY AEMWAQDAAAMYGYATASAAAALLTPFSPPRQTTNPAGLTAQAAAVSQATDPLSLLIETVTQALQALTIP SFIPEDFTFLDAIFAGYATVGVTQDVESFVAGTIGAESNLGLLNVGDENPAEVTPGDFGIGELVSATSPG GGVSASGAGGAASVGNTVLASVGRANSIGQLSVPPSWAAPSTRPVSALSPAGLTTLPGTDVAEHGMPGVP GVPVAAGRASGVLPRYGVRLTVMAHPPAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3160 | PPE51 | - | 100% (380) | PPE family protein |
| M. bovis AF2122 / 97 | Mb3159 | PPE50 | e-134 | 64.36% (390) | PPE family protein |
| M. bovis AF2122 / 97 | Mb3562 | PPE61 | 8e-99 | 47.55% (408) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 4e-32 | 30.05% (376) | PPE protein |
| M. tuberculosis H37Rv | Rv3136 | PPE51 | 0.0 | 100.00% (380) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-44 | 33.09% (417) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 2e-31 | 44.51% (164) | PPE family protein |
| M. marinum M | MMAR_1513 | - | 1e-152 | 70.95% (389) | PPE family protein, PPE51 |
| M. avium 104 | MAV_4015 | - | 2e-98 | 52.86% (384) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 9e-33 | 36.80% (231) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 9e-31 | 38.81% (201) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2428 | - | 1e-151 | 70.69% (389) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-31 | 40.00% (185) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3160|M.bovis_AF2122/97 -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE
Rv3136|M.tuberculosis_H37Rv -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE
MMAR_1513|M.marinum_M -------------MDFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAE
MUL_2428|M.ulcerans_Agy99 -------------MDFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAE
MAV_4015|M.avium_104 -------------MDFGFLPPEVNSARMYAGPGSGSLLAAAGSWDSLAAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: .**.:*: : ***...:*:*. * *. .
Mb3160|M.bovis_AF2122/97 LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA
Rv3136|M.tuberculosis_H37Rv LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA
MMAR_1513|M.marinum_M LGTTAETCGSILTGLTDLSWRGPASESMAASAAPYVGWLYRTAEQTQQAA
MUL_2428|M.ulcerans_Agy99 LGTTAETCGSILTGLTDLSWRGPASESMAASAAPCVGWLYRTAEQTQQAA
MAV_4015|M.avium_104 LSITAAVYESVLAGLTGLYWHGPASRAMAAGAAPYVGWLHTTAERAQQTA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
:* : : :.* :: . :* ** : *
Mb3160|M.bovis_AF2122/97 IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE
Rv3136|M.tuberculosis_H37Rv IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE
MMAR_1513|M.marinum_M IQARTAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANE
MUL_2428|M.ulcerans_Agy99 IQARTAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANE
MAV_4015|M.avium_104 TQARAAAAAYELAHAMTVPPAAVAANRTQLAALVATNFFGQNTAAIAATE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: .** *: * : . : *: *: :*::* *: .* .*
Mb3160|M.bovis_AF2122/97 AQYAEMWAQDAAAMYGYATASAAAALLTPFSPPRQTTNPAGLTAQAAAVS
Rv3136|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYGYATASAAAALLTPFSPPRQTTNPAGLTAQAAAVS
MMAR_1513|M.marinum_M AQYAEMWAQDAAAMYGYATTSAAAGMLTPFSSPNQATSPAGLAAQSTAVT
MUL_2428|M.ulcerans_Agy99 AQYAEMWAQDAAAMYGYATTSAAAGMLTPFSSPNQATSPAGLAAQSTAVT
MAV_4015|M.avium_104 AQYAEYWAQDAAAMYAYSASSAAAAQFSPFASPRRTTDPGGVTAQQAAVA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
*:*.. * * *::* * : * : ..
Mb3160|M.bovis_AF2122/97 QA------TDPLSLLIETVTQALQALT------------------IPSFI
Rv3136|M.tuberculosis_H37Rv QA------TDPLSLLIETVTQALQALT------------------IPSFI
MMAR_1513|M.marinum_M QANATAAATDPITQLVSSLTQSLGAIQA-----------------IPSIL
MUL_2428|M.ulcerans_Agy99 QANATAAATDPITQLVSSLTQSLGAIQA-----------------IPSIL
MAV_4015|M.avium_104 AAETGSTGTDSGTQVIPPTAG-------------------------ASEI
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAGEMV
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEG----------------MEATVV
:
Mb3160|M.bovis_AF2122/97 PEDFTFLDAIFAGYATVGVTQDVESFVAGTIGAESNLGLLNVGDENPAEV
Rv3136|M.tuberculosis_H37Rv PEDFTFLDAIFAGYATVGVTQDVESFVAGTIGAESNLGLLNVGDENPAEV
MMAR_1513|M.marinum_M PDDFTILDGVFSAYATVGVTQDIESFCAGVIGAENNLGLIGS-SENPAEV
MUL_2428|M.ulcerans_Agy99 PDDFTILDGVFSAYATVGVTQDIESFCAGVIGAENNLGLIGS-SENPAEV
MAV_4015|M.avium_104 PLDFRILDTILGAQTTFRSIFTTEGIPAGIIQADKNLGILPNLATIPAAL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MAB_0809c|M.abscessus_ATCC_199 EHFELLLNNLLTDPAALLTNLPMVLADVAFHAAQLASTIGQFAPALIQPA
MLBr_01182|M.leprae_Br4923 PQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNH
: .
Mb3160|M.bovis_AF2122/97 TPGDFGIGELVSATSPGGGVSASGAGGAASVGNTVLASVGRANSIGQLSV
Rv3136|M.tuberculosis_H37Rv TPGDFGIGELVSATSPGGGVSASGAGGAASVGNTVLASVGRANSIGQLSV
MMAR_1513|M.marinum_M TPSDFGLGSLISSTAPAS--AASGGG----LGSAVAASVGRSGSIGQLSV
MUL_2428|M.ulcerans_Agy99 TPSDFGLGSLISSTAPAS--AASGGG----LGSAVAASVGRSGSIGQLSV
MAV_4015|M.avium_104 P------------RTPALSASPTGLG-------RIDAVLARAARIGPMSV
MSMEG_0619|M.smegmatis_MC2_155 LIPALAAL----GITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQP
TH_3569|M.thermoresistible__bu LIPLAITL----GVAGLVMIADQAQP-----PAEEAAPEEDVAAP-----
Mflv_0325|M.gilvum_PYR-GCK LATTLAIV----AGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQS
Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIV----LGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPS
MAB_0809c|M.abscessus_ATCC_199 LALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMAASAGTALAPS
MLBr_01182|M.leprae_Br4923 AGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGS
.
Mb3160|M.bovis_AF2122/97 PPSWAAPSTRPVSALSPAGLTTLPG-TDVAEHGMPGVPG-VPVAAGRA-S
Rv3136|M.tuberculosis_H37Rv PPSWAAPSTRPVSALSPAGLTTLPG-TDVAEHGMPGVPG-VPVAAGRA-S
MMAR_1513|M.marinum_M PPSWSAPSARMVSALSPSGLTTIPGTEEAAAAGSPGFPGMVAPPATRA-S
MUL_2428|M.ulcerans_Agy99 PPSWSAPSARMVSALSPSGLTTIPGTEEAAAAGSPGFPGMVAPPATRA-S
MAV_4015|M.avium_104 PAGWTAATGNPVAAAPVTGWSEPSAADARPGVTAPGLPGIPGATLRRA-A
MSMEG_0619|M.smegmatis_MC2_155 LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRD-P
TH_3569|M.thermoresistible__bu --------------VRAEPQNPLPLTXXX---------------------
Mflv_0325|M.gilvum_PYR-GCK FPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRD-P
Mvan_0415|M.vanbaalenii_PYR-1 PAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRD-P
MAB_0809c|M.abscessus_ATCC_199 PPASAAAPAAPASAPAPTASGTAPAPPSPPPVGDPGFSFPYAVGGGPR-L
MLBr_01182|M.leprae_Br4923 SSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATES
Mb3160|M.bovis_AF2122/97 GVLPRYGVRLTVMAHPPAAG------------------------------
Rv3136|M.tuberculosis_H37Rv GVLPRYGVRLTVMAHPPAAG------------------------------
MMAR_1513|M.marinum_M GVLPRYGVRLTVMAHPPAAG------------------------------
MUL_2428|M.ulcerans_Agy99 GVLPRYGVRLTVMAHPPAAG------------------------------
MAV_4015|M.avium_104 LVVPRYGVRITVMARPPAAG------------------------------
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRG
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRA
MAB_0809c|M.abscessus_ATCC_199 GTGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGRG
MLBr_01182|M.leprae_Br4923 ESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG----
Mb3160|M.bovis_AF2122/97 --------------------------------------------------
Rv3136|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1513|M.marinum_M --------------------------------------------------
MUL_2428|M.ulcerans_Agy99 --------------------------------------------------
MAV_4015|M.avium_104 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 YADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGL
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK YADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGL
Mvan_0415|M.vanbaalenii_PYR-1 YADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGL
MAB_0809c|M.abscessus_ATCC_199 -----IEYMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGATASGL
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb3160|M.bovis_AF2122/97 -----------------------------------------------
Rv3136|M.tuberculosis_H37Rv -----------------------------------------------
MMAR_1513|M.marinum_M -----------------------------------------------
MUL_2428|M.ulcerans_Agy99 -----------------------------------------------
MAV_4015|M.avium_104 -----------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 TTLT-GDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu -----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TTLA-GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TTLP-GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_0809c|M.abscessus_ATCC_199 AMLSRDDDLFEGVRAPMVPNTWDPEHGRQD-----------------
MLBr_01182|M.leprae_Br4923 -----------------------------------------------