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MAANELRTGSEPPLPGSHRADEAVAGHWLLARLGKRVLRPGGVELTRTLLSHAQLTGADVVELAPGLGRT ATEIVARAPRSYVGAEADPDAANVVRGVLGDLGAHNAAVRVADAADTGLPDASGDVVIGEAMLTMQGDAA KRAIVAEAARVLRPGGRYAIHELALTPDTVSAEVSTDIRRALARAIKVNARPLTVAEWSALLAEHGLVVD HVATAPMALLQPRRLVSDEGLFGALRFARNVLVHRDARKRVLTMRRTFRKHRRQLAAVAIVAHKPTASQT G
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3501 | - | - | 100% (281) | SAM-dependent methyltransferase |
| M. avium 104 | MAV_4539 | - | 8e-06 | 33.33% (135) | methyltransferase small domain-containing protein |
| M. avium 104 | MAV_3877 | - | 2e-05 | 28.12% (192) | hypothetical protein MAV_3877 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2655 | - | 1e-108 | 74.35% (269) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4299 | - | 4e-85 | 60.53% (266) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv2622 | - | 1e-108 | 74.35% (269) | methyltransferase (methylase) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2961 | - | 1e-08 | 32.12% (137) | putative menaquinone biosynthesis methyltransferase |
| M. marinum M | MMAR_2078 | - | 1e-111 | 76.58% (269) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_5310 | - | 1e-83 | 61.11% (270) | SAM-dependent methyltransferase |
| M. thermoresistible (build 8) | TH_1606 | - | 8e-82 | 59.77% (266) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_3266 | - | 1e-111 | 76.58% (269) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2049 | - | 7e-87 | 61.28% (266) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2655|M.bovis_AF2122/97 MANKRGNAGQ--PLPLSDRDDDHMQGHWLLARLGKRVLRPGGVELTRTLL
Rv2622|M.tuberculosis_H37Rv MANKRGNAGQ--PLPLSDRDDDHMQGHWLLARLGKRVLRPGGVELTRTLL
MMAR_2078|M.marinum_M MAGTQGESGQ--PLPLSNRSDDHLQGHWLLARLGKRVLRPGGVELTRTLL
MUL_3266|M.ulcerans_Agy99 MAGTQGESGQ--PLPLSNRSDDHLQGHWLLARLGKRVLRPGGVELTRTLL
MAV_3501|M.avium_104 MAANELRTGSEPPLPGSHRADEAVAGHWLLARLGKRVLRPGGVELTRTLL
Mflv_4299|M.gilvum_PYR-GCK -MADS-------PLPLAERSDADLPGHWLLARLGKRVLRPGGLELTTRLL
Mvan_2049|M.vanbaalenii_PYR-1 -MADS-------PLPLAERSDADLPGHWLLARLGKRVLRPGGLELTTRLL
TH_1606|M.thermoresistible__bu MTAKS-------PLPLANRSDADLPGHWLLARLGKRVLRPGGLELTRRLL
MSMEG_5310|M.smegmatis_MC2_155 MTSKS-------DLPLAQRPDADLPGHWLLARLGKRVLRPGGVELTTRLL
MAB_2961|M.abscessus_ATCC_1997 MPTTWMDTVVRQVRRVGDFPFPRQAALVLDNPIHRKFVNPAGVAEQLALH
.. . * : ::.:.*.*: *
Mb2655|M.bovis_AF2122/97 ARAEVTDADVLELAPGLGRTAAEILARNPRSYVG-AESDPNAANLVRHVL
Rv2622|M.tuberculosis_H37Rv ARAEVTDADVLELAPGLGRTAAEILARNPRSYVG-AESDPNAANLVRHVL
MMAR_2078|M.marinum_M ARADVNHADVLELAPGLGRTASEILARHPRSYVG-AEADPDAANLVRTIV
MUL_3266|M.ulcerans_Agy99 ARADVNHADVLELAPGLGRTASEILARHPRSYVG-AEADPDAANLVRTIV
MAV_3501|M.avium_104 SHAQLTGADVVELAPGLGRTATEIVARAPRSYVG-AEADPDAANVVRGVL
Mflv_4299|M.gilvum_PYR-GCK TAARIQGADVVELGPGLGRTATDIVAERPRSYVG-VDDTAAATEQVRSIV
Mvan_2049|M.vanbaalenii_PYR-1 AAARIGGSDVVELGPGLGRTASDIIAAQPRSYVG-VDDTAAATENVKAIV
TH_1606|M.thermoresistible__bu TAARVTGADVVELGPGLGRTATDIVAAGPRSYVG-VDDTAAATEAVRRIV
MSMEG_5310|M.smegmatis_MC2_155 SAAGITGSDVVELGPGLGRTAVDIAAAEPRSYVG-VDDNSTTSALLQSAV
MAB_2961|M.abscessus_ATCC_1997 G-----GEHVLEIGPGPGIFSVHIASRLPSGRLELFDVQPEMLEMVKSKL
.*:*:.** * : .* : * . : : . :: :
Mb2655|M.bovis_AF2122/97 AGRGD----VRVTDAADTGLSDASADVVIGEAMLTMQGNAAKHTIVAEAA
Rv2622|M.tuberculosis_H37Rv AGRGD----VRVTDAADTGLSDASADVVIGEAMLTMQGNAAKHTIVAEAA
MMAR_2078|M.marinum_M AGHGD----VRVADAADTGLPDSSADVVIGEAMLTMQGDAAKHAIVAEAA
MUL_3266|M.ulcerans_Agy99 AGRGD----VRVADAADTGLPDSSADVVIGEAMLTMQGDAAKHAIVAEAA
MAV_3501|M.avium_104 GDLGAHNAAVRVADAADTGLPDASGDVVIGEAMLTMQGDAAKRAIVAEAA
Mflv_4299|M.gilvum_PYR-GCK APVGG---KVVVADAASTGLPDGSADVVVGEAMLTMQGEKAKRAIIGEAF
Mvan_2049|M.vanbaalenii_PYR-1 APVNG---AVVVADASTTGLPDGSADVVVGEAMLTMQGEKAKRAIIAEAF
TH_1606|M.thermoresistible__bu EPVDG---KVVVANAADTGLPSGSADVVIGEAMLTMQGDRDKRAIVNEAF
MSMEG_5310|M.smegmatis_MC2_155 ATSGG---RLVAADAAETGLDTGSADVVVGEAMLTMQGEKAKKAIVDEAF
MAB_2961|M.abscessus_ATCC_1997 DRAGYRNAGFHSGDAGN-GLPFSDNTFDVAFLASVIGEVPDKAACVRSLA
. . :*. ** .. . :. .: * : : .
Mb2655|M.bovis_AF2122/97 RVLRPGGRYAIHELALVPDDVAEQVRTDLRQSLARALKVNARPLTVAEWS
Rv2622|M.tuberculosis_H37Rv RVLRPGGRYAIHELALVPDDVAEQVRTDLRQSLARALKVNARPLTVAEWS
MMAR_2078|M.marinum_M RVLRPHGRYAIHELALTPDDVPEEISTEVRQALARSIKVNARPLTVAEWS
MUL_3266|M.ulcerans_Agy99 RVLRPHGRYAIHELALTPDDVPEEISTEVRQALARSIKVNARPLTVAEWS
MAV_3501|M.avium_104 RVLRPGGRYAIHELALTPDTVSAEVSTDIRRALARAIKVNARPLTVAEWS
Mflv_4299|M.gilvum_PYR-GCK RVLRPGGRYAIHELGLSPDDLSQGIKDDIRRDMSRAIKVNARPLTSAEWT
Mvan_2049|M.vanbaalenii_PYR-1 RVLRPGGRYAIHELGLTPDDLSQDIKDDIRREMSRAIKVNARPLTIAEWT
TH_1606|M.thermoresistible__bu RVLRPGGRYAIHELGLQPDSLPQDTKDQIRKDMARAIKVNARPLTASEWV
MSMEG_5310|M.smegmatis_MC2_155 RVLRPGGRYAIHELGLMPDDLSDGIKDDIRKEMARAIKVNARPLTVAEWT
MAB_2961|M.abscessus_ATCC_1997 QVLKPGGRLVFHEIFLDPD-----------------------RLGISELR
:**:* ** .:**: * ** * :*
Mb2655|M.bovis_AF2122/97 HLLAGHGLVVEHVVTASMALLQPRRVIADEGLLGALRFAGNLLIHRAARR
Rv2622|M.tuberculosis_H37Rv HLLAGHGLVVEHVVTASMALLQPRRVIADEGLLGALRFAGNLLIHRAARR
MMAR_2078|M.marinum_M QLLAGHGLVVSHVATAPMALLQPRRIIADEGLLGALRFAKNLLTQPAARK
MUL_3266|M.ulcerans_Agy99 QLLAGHGLVVSHVATAPMALLQPRRIIADEGLLGALRFAKNLLTQPAARK
MAV_3501|M.avium_104 ALLAEHGLVVDHVATAPMALLQPRRLVSDEGLFGALRFARNVLVHRDARK
Mflv_4299|M.gilvum_PYR-GCK ALLTDAGFKIESVDHAPMALLNPARVLADEGPLGALRIVGNLIRRPAARK
Mvan_2049|M.vanbaalenii_PYR-1 ALLTEAGFQVETVDQAPMALLSPARVLADEGLFGALRIVGNMIRRPAARR
TH_1606|M.thermoresistible__bu NLLTDAGFEVVSVDHAKMALLNPGRVLADEGLFGALRIVGNLIRRPAARK
MSMEG_5310|M.smegmatis_MC2_155 DLLTSAGFEVRSVDLAPMALLQPKRVVADEGFLGALRIVFNALTHPAARK
MAB_2961|M.abscessus_ATCC_1997 SLVEPAGFTFAAATGS-------------------------------RWR
*: *: . . : :
Mb2655|M.bovis_AF2122/97 RVLLMRHTFRRHRERLTAVAIVAHKPHVDS--
Rv2622|M.tuberculosis_H37Rv RVLLMRHTFRRHRERLTAVAIVAHKPHVDS--
MMAR_2078|M.marinum_M RVLMMRSTFRKHRDRMAAVAIVAYKPSASGS-
MUL_3266|M.ulcerans_Agy99 RVLMMRSTFRKHRDRMAAVAIVAYKPSASGS-
MAV_3501|M.avium_104 RVLTMRRTFRKHRRQLAAVAIVAHKPTASQTG
Mflv_4299|M.gilvum_PYR-GCK RVIGMRKTFQRYRRSLTAVAVVGVVPGQ----
Mvan_2049|M.vanbaalenii_PYR-1 RVLGMRATFARYRRSLTAVAVVGVVPGQ----
TH_1606|M.thermoresistible__bu RVIGMRKTFQRYRHSLTAIAVVGVVPEK----
MSMEG_5310|M.smegmatis_MC2_155 RVLGMRRTFNRYRDELTAVAIVAVVPTESK--
MAB_2961|M.abscessus_ATCC_1997 DIVEFART------------------------
:: : *