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MANKRGNAGQPLPLSDRDDDHMQGHWLLARLGKRVLRPGGVELTRTLLARAEVTDADVLELAPGLGRTAA EILARNPRSYVGAESDPNAANLVRHVLAGRGDVRVTDAADTGLSDASADVVIGEAMLTMQGNAAKHTIVA EAARVLRPGGRYAIHELALVPDDVAEQVRTDLRQSLARALKVNARPLTVAEWSHLLAGHGLVVEHVVTAS MALLQPRRVIADEGLLGALRFAGNLLIHRAARRRVLLMRHTFRRHRERLTAVAIVAHKPHVDS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2622 | - | - | 100% (273) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. tuberculosis H37Rv | Rv1523 | - | 5e-06 | 33.62% (116) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2655 | - | 1e-152 | 100.00% (273) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4299 | - | 2e-83 | 60.46% (263) | methyltransferase type 11 |
| M. leprae Br4923 | MLBr_00130 | - | 6e-05 | 26.50% (200) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_4103c | - | 8e-06 | 27.27% (165) | methyltransferase |
| M. marinum M | MMAR_2078 | - | 1e-122 | 80.67% (269) | methyltransferase |
| M. avium 104 | MAV_3501 | - | 1e-108 | 74.35% (269) | SAM-dependent methyltransferase |
| M. smegmatis MC2 155 | MSMEG_5310 | - | 1e-83 | 62.16% (259) | SAM-dependent methyltransferase |
| M. thermoresistible (build 8) | TH_1606 | - | 4e-81 | 60.08% (263) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_3266 | - | 1e-123 | 81.04% (269) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2049 | - | 2e-84 | 60.84% (263) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2622|M.tuberculosis_H37Rv ----------------MANKRGNAGQ--PLPLSDRDDDHMQGHWLLARLG
Mb2655|M.bovis_AF2122/97 ----------------MANKRGNAGQ--PLPLSDRDDDHMQGHWLLARLG
MMAR_2078|M.marinum_M ----------------MAGTQGESGQ--PLPLSNRSDDHLQGHWLLARLG
MUL_3266|M.ulcerans_Agy99 ----------------MAGTQGESGQ--PLPLSNRSDDHLQGHWLLARLG
MAV_3501|M.avium_104 ----------------MAANELRTGSEPPLPGSHRADEAVAGHWLLARLG
Mflv_4299|M.gilvum_PYR-GCK -----------------MADS-------PLPLAERSDADLPGHWLLARLG
Mvan_2049|M.vanbaalenii_PYR-1 -----------------MADS-------PLPLAERSDADLPGHWLLARLG
TH_1606|M.thermoresistible__bu ----------------MTAKS-------PLPLANRSDADLPGHWLLARLG
MSMEG_5310|M.smegmatis_MC2_155 ----------------MTSKS-------DLPLAQRPDADLPGHWLLARLG
MLBr_00130|M.leprae_Br4923 MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDEIMFINWAYEEDP
MAB_4103c|M.abscessus_ATCC_199 --MQRSRDWVMFKLNAVFTQRVQKFIYRHATRKLETEDVVFLNYGYEEEP
. : : :: .
Rv2622|M.tuberculosis_H37Rv KRVLRPGG--------VELTRTLLARAEVTDADVLELAPGLGRTAAEIL-
Mb2655|M.bovis_AF2122/97 KRVLRPGG--------VELTRTLLARAEVTDADVLELAPGLGRTAAEIL-
MMAR_2078|M.marinum_M KRVLRPGG--------VELTRTLLARADVNHADVLELAPGLGRTASEIL-
MUL_3266|M.ulcerans_Agy99 KRVLRPGG--------VELTRTLLARADVNHADVLELAPGLGRTASEIL-
MAV_3501|M.avium_104 KRVLRPGG--------VELTRTLLSHAQLTGADVVELAPGLGRTATEIV-
Mflv_4299|M.gilvum_PYR-GCK KRVLRPGG--------LELTTRLLTAARIQGADVVELGPGLGRTATDIV-
Mvan_2049|M.vanbaalenii_PYR-1 KRVLRPGG--------LELTTRLLAAARIGGSDVVELGPGLGRTASDII-
TH_1606|M.thermoresistible__bu KRVLRPGG--------LELTRRLLTAARVTGADVVELGPGLGRTATDIV-
MSMEG_5310|M.smegmatis_MC2_155 KRVLRPGG--------VELTTRLLSAAGITGSDVVELGPGLGRTAVDIA-
MLBr_00130|M.leprae_Br4923 PMALPLEASDEPNRAHINLYHRTATQVNLSGKRILEVSCGHGGGASYLTR
MAB_4103c|M.abscessus_ATCC_199 AMGVPLSASDEPDRYSIQLYHSTATQADLGGQRVLEVGCGHGGGASYLVR
: . ::* : . : ::*:. * * * :
Rv2622|M.tuberculosis_H37Rv ARNPRSYVGAESDPNAANLVRHVLAGRGD----VRVTDAADTGLSDASAD
Mb2655|M.bovis_AF2122/97 ARNPRSYVGAESDPNAANLVRHVLAGRGD----VRVTDAADTGLSDASAD
MMAR_2078|M.marinum_M ARHPRSYVGAEADPDAANLVRTIVAGHGD----VRVADAADTGLPDSSAD
MUL_3266|M.ulcerans_Agy99 ARHPRSYVGAEADPDAANLVRTIVAGRGD----VRVADAADTGLPDSSAD
MAV_3501|M.avium_104 ARAPRSYVGAEADPDAANVVRGVLGDLGAHNAAVRVADAADTGLPDASGD
Mflv_4299|M.gilvum_PYR-GCK AERPRSYVGVDDTAAATEQVRSIVAPVGG---KVVVADAASTGLPDGSAD
Mvan_2049|M.vanbaalenii_PYR-1 AAQPRSYVGVDDTAAATENVKAIVAPVNG---AVVVADASTTGLPDGSAD
TH_1606|M.thermoresistible__bu AAGPRSYVGVDDTAAATEAVRRIVEPVDG---KVVVANAADTGLPSGSAD
MSMEG_5310|M.smegmatis_MC2_155 AAEPRSYVGVDDNSTTSALLQSAVATSGG---RLVAADAAETGLDTGSAD
MLBr_00130|M.leprae_Br4923 ALHPASYTGLDLNPAGIKLCQKRHQLPGL---EFVRGDAENLPFDNESFD
MAB_4103c|M.abscessus_ATCC_199 ALQPASYTGLDLNPDGISFCRRRHDLPGL---EFVQGDAEDLPFPDESFD
* * **.* : . : . . :* : * *
Rv2622|M.tuberculosis_H37Rv VVIGEAMLTMQGNAAKHTIVAEAARVLRPGGRYAIHELALVPDDVAEQVR
Mb2655|M.bovis_AF2122/97 VVIGEAMLTMQGNAAKHTIVAEAARVLRPGGRYAIHELALVPDDVAEQVR
MMAR_2078|M.marinum_M VVIGEAMLTMQGDAAKHAIVAEAARVLRPHGRYAIHELALTPDDVPEEIS
MUL_3266|M.ulcerans_Agy99 VVIGEAMLTMQGDAAKHAIVAEAARVLRPHGRYAIHELALTPDDVPEEIS
MAV_3501|M.avium_104 VVIGEAMLTMQGDAAKRAIVAEAARVLRPGGRYAIHELALTPDTVSAEVS
Mflv_4299|M.gilvum_PYR-GCK VVVGEAMLTMQGEKAKRAIIGEAFRVLRPGGRYAIHELGLSPDDLSQGIK
Mvan_2049|M.vanbaalenii_PYR-1 VVVGEAMLTMQGEKAKRAIIAEAFRVLRPGGRYAIHELGLTPDDLSQDIK
TH_1606|M.thermoresistible__bu VVIGEAMLTMQGDRDKRAIVNEAFRVLRPGGRYAIHELGLQPDSLPQDTK
MSMEG_5310|M.smegmatis_MC2_155 VVVGEAMLTMQGEKAKKAIVDEAFRVLRPGGRYAIHELGLMPDDLSDGIK
MLBr_00130|M.leprae_Br4923 VVINIEASHCYPHFP--RFLAEVVRVLRPGGHLAYADLRPSNK----VGE
MAB_4103c|M.abscessus_ATCC_199 AVINVESSHLYPHFP--VFLTEVARVLRPGGNFLYTDARSVQD----VAG
.*:. . :: *. ***** *. : .
Rv2622|M.tuberculosis_H37Rv TDLRQSLARALKVNARPLTVAEWSHLLAGHGLVVEHVVTASMALLQPRRV
Mb2655|M.bovis_AF2122/97 TDLRQSLARALKVNARPLTVAEWSHLLAGHGLVVEHVVTASMALLQPRRV
MMAR_2078|M.marinum_M TEVRQALARSIKVNARPLTVAEWSQLLAGHGLVVSHVATAPMALLQPRRI
MUL_3266|M.ulcerans_Agy99 TEVRQALARSIKVNARPLTVAEWSQLLAGHGLVVSHVATAPMALLQPRRI
MAV_3501|M.avium_104 TDIRRALARAIKVNARPLTVAEWSALLAEHGLVVDHVATAPMALLQPRRL
Mflv_4299|M.gilvum_PYR-GCK DDIRRDMSRAIKVNARPLTSAEWTALLTDAGFKIESVDHAPMALLNPARV
Mvan_2049|M.vanbaalenii_PYR-1 DDIRREMSRAIKVNARPLTIAEWTALLTEAGFQVETVDQAPMALLSPARV
TH_1606|M.thermoresistible__bu DQIRKDMARAIKVNARPLTASEWVNLLTDAGFEVVSVDHAKMALLNPGRV
MSMEG_5310|M.smegmatis_MC2_155 DDIRKEMARAIKVNARPLTVAEWTDLLTSAGFEVRSVDLAPMALLQPKRV
MLBr_00130|M.leprae_Br4923 WEVDFANSRLQQLSQREINAEVLRGIASNS---------------QKSRD
MAB_4103c|M.abscessus_ATCC_199 WKVALANAPLRMVSERGINAEVRRGMEKNL---------------ARWRY
.: : :. * :. : *
Rv2622|M.tuberculosis_H37Rv IADEGLLGALRFAGNLLIHRAARRRVLLMRHTFRRHRERLTAVAIVAHKP
Mb2655|M.bovis_AF2122/97 IADEGLLGALRFAGNLLIHRAARRRVLLMRHTFRRHRERLTAVAIVAHKP
MMAR_2078|M.marinum_M IADEGLLGALRFAKNLLTQPAARKRVLMMRSTFRKHRDRMAAVAIVAYKP
MUL_3266|M.ulcerans_Agy99 IADEGLLGALRFAKNLLTQPAARKRVLMMRSTFRKHRDRMAAVAIVAYKP
MAV_3501|M.avium_104 VSDEGLFGALRFARNVLVHRDARKRVLTMRRTFRKHRRQLAAVAIVAHKP
Mflv_4299|M.gilvum_PYR-GCK LADEGPLGALRIVGNLIRRPAARKRVIGMRKTFQRYRRSLTAVAVVGVVP
Mvan_2049|M.vanbaalenii_PYR-1 LADEGLFGALRIVGNMIRRPAARRRVLGMRATFARYRRSLTAVAVVGVVP
TH_1606|M.thermoresistible__bu LADEGLFGALRIVGNLIRRPAARKRVIGMRKTFQRYRHSLTAIAVVGVVP
MSMEG_5310|M.smegmatis_MC2_155 VADEGFLGALRIVFNALTHPAARKRVLGMRRTFNRYRDELTAVAIVAVVP
MLBr_00130|M.leprae_Br4923 LVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYSFAKD------
MAB_4103c|M.abscessus_ATCC_199 VIDRATPAPLRGIVRRFAPAQ-RAYDDLRAGGSVEYRMYRFVKA------
: *. . ** . : :* .
Rv2622|M.tuberculosis_H37Rv HVDS--
Mb2655|M.bovis_AF2122/97 HVDS--
MMAR_2078|M.marinum_M SASGS-
MUL_3266|M.ulcerans_Agy99 SASGS-
MAV_3501|M.avium_104 TASQTG
Mflv_4299|M.gilvum_PYR-GCK GQ----
Mvan_2049|M.vanbaalenii_PYR-1 GQ----
TH_1606|M.thermoresistible__bu EK----
MSMEG_5310|M.smegmatis_MC2_155 TESK--
MLBr_00130|M.leprae_Br4923 ------
MAB_4103c|M.abscessus_ATCC_199 ------