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MPTTWMDTVVRQVRRVGDFPFPRQAALVLDNPIHRKFVNPAGVAEQLALHGGEHVLEIGPGPGIFSVHIA SRLPSGRLELFDVQPEMLEMVKSKLDRAGYRNAGFHSGDAGNGLPFSDNTFDVAFLASVIGEVPDKAACV RSLAQVLKPGGRLVFHEIFLDPDRLGISELRSLVEPAGFTFAAATGSRWRDIVEFART
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2961 | - | - | 100% (198) | putative menaquinone biosynthesis methyltransferase |
| M. abscessus ATCC 19977 | MAB_3381c | - | 6e-09 | 32.04% (103) | hypothetical protein MAB_3381c |
| M. abscessus ATCC 19977 | MAB_4018 | - | 1e-07 | 27.43% (113) | similarity with UbiE/COQ5 methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3064c | - | 7e-09 | 31.07% (103) | hypothetical protein Mb3064c |
| M. gilvum PYR-GCK | Mflv_4269 | - | 6e-10 | 33.01% (103) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3038c | - | 7e-09 | 31.07% (103) | hypothetical protein Rv3038c |
| M. leprae Br4923 | MLBr_01723 | - | 5e-10 | 34.00% (100) | hypothetical protein MLBr_01723 |
| M. marinum M | MMAR_4799 | - | 1e-09 | 29.84% (124) | hypothetical protein MMAR_4799 |
| M. avium 104 | MAV_0854 | - | 1e-11 | 31.00% (100) | methyltransferase-UbiE family protein |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 2e-09 | 38.18% (110) | methyltransferase |
| M. thermoresistible (build 8) | TH_2189 | - | 5e-10 | 31.40% (121) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1900 | - | 1e-09 | 33.01% (103) | hypothetical protein MUL_1900 |
| M. vanbaalenii PYR-1 | Mvan_3244 | - | 1e-10 | 33.94% (109) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3064c|M.bovis_AF2122/97 --------------------------------------------------
Rv3038c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK --------------------------------------------------
TH_2189|M.thermoresistible__bu VIRRLMATALTALTTAVLAGCGDAGSWVEAKPAEGWSAQYGDAANSSYTS
MMAR_4799|M.marinum_M --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MAB_2961|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3064c|M.bovis_AF2122/97 --------------------------------------------------
Rv3038c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK --------------------------------------------------
TH_2189|M.thermoresistible__bu AAGAEALTLEWSRSVKGELAAQVAVGASGYLAVNAQTPAGCSLMVWEYAN
MMAR_4799|M.marinum_M --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MAB_2961|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3064c|M.bovis_AF2122/97 --------------------------------------------------
Rv3038c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK --------------------------------------------------
TH_2189|M.thermoresistible__bu SARQRWCTRLVQGGGRTSPLLDGFDNVYIGQPGAILSFPPTQWIRWRKPV
MMAR_4799|M.marinum_M --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MAB_2961|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3064c|M.bovis_AF2122/97 --------------------------------------------------
Rv3038c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK --------------------------------------------------
TH_2189|M.thermoresistible__bu IGMPTTPRILAPGELLVVTHLGQVLLFDAHRGTVTGTPLDLVAGVDPTDS
MMAR_4799|M.marinum_M --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MAB_2961|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3064c|M.bovis_AF2122/97 ------------------------------------------MTRSSNIP
Rv3038c|M.tuberculosis_H37Rv ------------------------------------------MTRSSNIP
MUL_1900|M.ulcerans_Agy99 ------------------------------------------MTRSSEIP
MLBr_01723|M.leprae_Br4923 ------------------------------------------MTRSTEIS
Mflv_4269|M.gilvum_PYR-GCK ------------------------------------------MTETKEPG
TH_2189|M.thermoresistible__bu ERGLADCAGARXXXCWPPPRPPSTVTPRARDAARHPTARLPAMTETTEPG
MMAR_4799|M.marinum_M --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MAB_2961|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 ---------------------------------------------MDTAL
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3064c|M.bovis_AF2122/97 AD-------ATPNPHATAEQVAAARHDSKLAQVLYHDWEAENYDEKWSIS
Rv3038c|M.tuberculosis_H37Rv AD-------ATPNPHATAEQVAAARHDSKLAQVLYHDWEAENYDEKWSIS
MUL_1900|M.ulcerans_Agy99 AD-------AAPNPHATAEEVEAARHDSKLAQVLYHDWEAENYDEKWSIS
MLBr_01723|M.leprae_Br4923 AN-------AVPNPHATAEQVAAARKDSKLAQVLYHDWEAENYDEKWSIS
Mflv_4269|M.gilvum_PYR-GCK AYPDVA--VPAPTPHATKEQVEAALHDTKLAQVLYHDWEAETYDDKWSIS
TH_2189|M.thermoresistible__bu IGSEGAGDLPAPNPHATAEQVEAAMRDSKLAQILYHDWEAESYDDKWSIS
MMAR_4799|M.marinum_M ----------------MNDERRAVYTHGHHESVLR--------------G
MAV_0854|M.avium_104 ----------------MNDQHRATYTHGHHESVLR--------------S
MAB_2961|M.abscessus_ATCC_1997 -----------MPTTWMDTVVRQVRRVGDFPFPRQAALVLDN-------P
MSMEG_0098|M.smegmatis_MC2_155 RRAMDLLIDPPAEPDFSKGYLDLLGRGDSTAPKNTGLIQKAWASPLGSKL
Mvan_3244|M.vanbaalenii_PYR-1 ----------------MNRAETALINSPPRR------------------W
Mb3064c|M.bovis_AF2122/97 YDQRCVDYARGRFDAIVPDEVIAQLPYDRALELGCGTGFFLLNLIQAG-V
Rv3038c|M.tuberculosis_H37Rv YDQRCVDYARGRFDAIVPDEVIAQLPYDRALELGCGTGFFLLNLIQAG-V
MUL_1900|M.ulcerans_Agy99 YDQRCVEYARGRFDAIVPAQVHADLPYERALELGCGTGFFLLNLIQAG-V
MLBr_01723|M.leprae_Br4923 YDQRCVDYVRHCFDAIVPDELFTELPYDCALELGCGTGFFLLNLIQSG-V
Mflv_4269|M.gilvum_PYR-GCK YDQRCVDYARGRFDAAVPEEVQRELPYDRALELGCGTGFFLLNLIQAG-V
TH_2189|M.thermoresistible__bu YDQRCVDYARGRFDAIVPDHVQRELPYDNALELGCGTGFFLLNLIQSG-V
MMAR_4799|M.marinum_M HRQRTVANSAGYLSPHLRAGLS-------VLDIGCGPGTITVDLAARV-A
MAV_0854|M.avium_104 HRRRTAEDSAGYLLAHLTPGLS-------VLDVGCGPGTITADLAARV-A
MAB_2961|M.abscessus_ATCC_1997 IHRKFVNPAGVAEQLALHGGEH-------VLEIGPGPGIFSVHIASRL-P
MSMEG_0098|M.smegmatis_MC2_155 YDRAQLLNRRLVASTRPPVEWLRIPPGGTVLDIGCGPGNITAQLARAAGL
Mvan_3244|M.vanbaalenii_PYR-1 LQRLYEVPVLLRFGGRLPPGSG-------ALEIGCGSG-YGSQLVLQRFG
: .*::* *.* .:
Mb3064c|M.bovis_AF2122/97 ARRGSVTDLSPGMVKVATRNGQAL--GLD-IDGRVADA-EGIPYDDDAFD
Rv3038c|M.tuberculosis_H37Rv ARRGSVTDLSPGMVKVATRNGQAL--GLD-IDGRVADA-EGIPYDDDAFD
MUL_1900|M.ulcerans_Agy99 ARRGSVTDLSPGMVKVATRNGQSL--GLD-IDGRVADA-EGIPYDDDTFD
MLBr_01723|M.leprae_Br4923 ARRGSVTDLSPGMVKIATRNGQSL--GLD-INGRVADA-EGIPYDDNTFD
Mflv_4269|M.gilvum_PYR-GCK ARRGSVTDLSPGMVKVATRNGQSL--GLD-IDGRVADA-EGIPYEDNTFD
TH_2189|M.thermoresistible__bu ARRGSVTDLSPGMVRVATRNGRSL--GLD-VDGRVADA-EGIPYDDNTFD
MMAR_4799|M.marinum_M PATVTAVEPTDAALNLARAEVQRC--DVSNVAFVTSDV-HALDFPDDVFD
MAV_0854|M.avium_104 PGQVTAVDQAADVLEVARAEAEQR--NLSNVSFGTADV-HRLDFADDTFD
MAB_2961|M.abscessus_ATCC_1997 SGRLELFDVQPEMLEMVKSKLDRA--GYRNAGFHSGDAGNGLPFSDNTFD
MSMEG_0098|M.smegmatis_MC2_155 DGLALGVDISEPMLARAVAAEAGR--QVG---FVRADA-QQLPFRDEVFD
Mvan_3244|M.vanbaalenii_PYR-1 AARIDAVDLDPAMIERARTRLAPYGDRVHLATGSATDLREALNADDGSYD
: : . * . : * :*
Mb3064c|M.bovis_AF2122/97 LVVGHAVLHHIPDVELSLREVVRVLKPGGRFVFAGEPTTVGDGYARTLST
Rv3038c|M.tuberculosis_H37Rv LVVGHAVLHHIPDVELSLREVVRVLKPGGRFVFAGEPTTVGDGYARTLST
MUL_1900|M.ulcerans_Agy99 LVVGHAVLHHIPDVELSLREVMRVLKPGGRFVFAGEPTTVGNEYARTLST
MLBr_01723|M.leprae_Br4923 LVVGHAVLHHIPDVELSLREVLRVLKPGGRFVFAGEPTDVGNRYARVFAD
Mflv_4269|M.gilvum_PYR-GCK LVVGHAVLHHIPDVELSLREVVRVLKPGGRFVFAGEPTTVGNRYARELST
TH_2189|M.thermoresistible__bu LVVGHAVLHHIPDVELSLREVVRVLRPGGRFVFAGEPTTVGNSYARALST
MMAR_4799|M.marinum_M VVHAHQVLQHVADPVQALREMKRVCAPGG-LVAARDADYAG---------
MAV_0854|M.avium_104 VVHAHQVLQHLSDPVAALREMRRVCRPGG-IVAVRDADYAG---------
MAB_2961|M.abscessus_ATCC_1997 VAFLASVIGEVPDKAACVRSLAQVLKPGGRLVFH----------------
MSMEG_0098|M.smegmatis_MC2_155 AATSLAVFQLIPDPVAAVSEIVRVLKPGGRVAIMVPTAG-----------
Mvan_3244|M.vanbaalenii_PYR-1 AVFDFGIIHHIPDWRAAVAEAARVLIPGGRFYFEEVTAHALS--------
. :: :.* .: . :* *** .
Mb3064c|M.bovis_AF2122/97 LTWRVVTNATKLPGLRGWRRPQGELDESSRAAALEALVDLHTFTPQDLQR
Rv3038c|M.tuberculosis_H37Rv LTWRVVTNATKLPGLRGWRRPQGELDESSRAAALEALVDLHTFTPQDLQR
MUL_1900|M.ulcerans_Agy99 LTWRIATNVTKLPGLGGWRRPQEELDESSRAAALEAIVDLHTFAPEDLER
MLBr_01723|M.leprae_Br4923 LTWKVTIRVVQLPGLSAWRRTQVEIDENSRAAALEWVVDLHTFEPKVLET
Mflv_4269|M.gilvum_PYR-GCK LTWHAATNIMKLPMLSDWRRPQAELDESSRAAALEAVVDLHTFDPADLER
TH_2189|M.thermoresistible__bu LTWHVATTVTRLPGLQGWRRPQAELDESSRAAALEAVVDLHTFEPSDLER
MMAR_4799|M.marinum_M FIWYP-----QLPALDHWLKLYQRAARANGGEPDAGRRLLSWARQAGFAD
MAV_0854|M.avium_104 FIWYP-----ELPALDLWRDLYRRVARANRGEPDAGRRLLSWARQAGFDD
MAB_2961|M.abscessus_ATCC_1997 ---------------EIFLDPDR-----------LGISELRSLVEPAGFT
MSMEG_0098|M.smegmatis_MC2_155 ---------------------------AVKPVTFLARGGARIFGDDELGD
Mvan_3244|M.vanbaalenii_PYR-1 ---------------------------RPTYRLLFDHPTDDRFTAEDFLD
Mb3064c|M.bovis_AF2122/97 IAHNAGAVEVQTATEEFTAAMLGWPLRTFECTVPPGRLGWGWARFAFTSW
Rv3038c|M.tuberculosis_H37Rv IAHNAGAVEVQTATEEFTAAMLGWPLRTFECTVPPGRLGWGWARFAFTSW
MUL_1900|M.ulcerans_Agy99 MAKNAGAIRVETASEEFSAAMFGWPVRTFESSVPPGRLGWNWARFAFNGW
MLBr_01723|M.leprae_Br4923 MATNAGAVQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWARFAFTSW
Mflv_4269|M.gilvum_PYR-GCK MAANAGAVEVRTASEEFTAAMLGWPVRTFEAAVPPGRLGWGWAKFAFGSW
TH_2189|M.thermoresistible__bu MARNAGAVEVATASEEFTAAMLGWPVRTFEAAVPPGKLGWNWAKFAFGSW
MMAR_4799|M.marinum_M ITP-TGSMWCYATDEMRAWWGGMWAERILRSDLSAQLLGSGMASAADLEA
MAV_0854|M.avium_104 ITP-TGSLWCYATPETRDWWGGMWADRILHSTVARDLVSLGLAAREQLEE
MAB_2961|M.abscessus_ATCC_1997 FAAATGSRWRDIVEFART--------------------------------
MSMEG_0098|M.smegmatis_MC2_155 IFENVGLVGVRVKTHGFIQWVRGTKL------------------------
Mvan_3244|M.vanbaalenii_PYR-1 ELGRHGLVILGSVTRIQGDYLLGVAAKPLAADGGR---------------
*
Mb3064c|M.bovis_AF2122/97 KTLGWVDANVWRHVVPKGWFYNVMITGVKPS
Rv3038c|M.tuberculosis_H37Rv KTLGWVDANVWRHVVPKGWFYNVMITGVKPS
MUL_1900|M.ulcerans_Agy99 KALGWMDANVWRHVAPKGWFYNVMVTGVKPS
MLBr_01723|M.leprae_Br4923 KTLSWVDANVWRRVIPKSWFYNIIITGVKPS
Mflv_4269|M.gilvum_PYR-GCK TTLSWVDANVWRRIVPKGWFYNVMVTGVKPS
TH_2189|M.thermoresistible__bu TALSWVDANVWRRVMPKGWFYNVMVTGVKPS
MMAR_4799|M.marinum_M ISQAWRDW----AAAPDGWLGIPNGEILCRV
MAV_0854|M.avium_104 ISAAWREW----AAAPDGWIAIPHGEIICRA
MAB_2961|M.abscessus_ATCC_1997 -------------------------------
MSMEG_0098|M.smegmatis_MC2_155 -------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 -------------------------------