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AGTQGESGQPLPLSNRSDDHLQGHWLLARLGKRVLRPGGVELTRTLLARADVNHADVLELAPGLGRTASE ILARHPRSYVGAEADPDAANLVRTIVAGHGDVRVADAADTGLPDSSADVVIGEAMLTMQGDAAKHAIVAE AARVLRPHGRYAIHELALTPDDVPEEISTEVRQALARSIKVNARPLTVAEWSQLLAGHGLVVSHVATAPM ALLQPRRIIADEGLLGALRFAKNLLTQPAARKRVLMMRSTFRKHRDRMAAVAIVAYKPSASGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2078 | - | - | 100% (274) | methyltransferase |
| M. marinum M | MMAR_1062 | - | 2e-07 | 33.33% (150) | methyltransferase |
| M. marinum M | MMAR_2358 | - | 2e-05 | 32.38% (105) | hypothetical protein MMAR_2358 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2655 | - | 1e-122 | 80.67% (269) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4299 | - | 1e-84 | 61.92% (260) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv2622 | - | 1e-122 | 80.67% (269) | methyltransferase (methylase) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4103c | - | 2e-05 | 31.58% (114) | methyltransferase |
| M. avium 104 | MAV_3501 | - | 1e-111 | 76.58% (269) | SAM-dependent methyltransferase |
| M. smegmatis MC2 155 | MSMEG_5310 | - | 2e-84 | 62.03% (266) | SAM-dependent methyltransferase |
| M. thermoresistible (build 8) | TH_1606 | - | 1e-83 | 62.31% (260) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_3266 | - | 1e-152 | 99.64% (274) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2049 | - | 3e-86 | 62.31% (260) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2078|M.marinum_M MAGTQGESGQ--PLPLSNRSDDHLQ-----------------GHWLLARL
MUL_3266|M.ulcerans_Agy99 MAGTQGESGQ--PLPLSNRSDDHLQ-----------------GHWLLARL
Mb2655|M.bovis_AF2122/97 MANKRGNAGQ--PLPLSDRDDDHMQ-----------------GHWLLARL
Rv2622|M.tuberculosis_H37Rv MANKRGNAGQ--PLPLSDRDDDHMQ-----------------GHWLLARL
MAV_3501|M.avium_104 MAANELRTGSEPPLPGSHRADEAVA-----------------GHWLLARL
Mflv_4299|M.gilvum_PYR-GCK -MADS-------PLPLAERSDADLP-----------------GHWLLARL
Mvan_2049|M.vanbaalenii_PYR-1 -MADS-------PLPLAERSDADLP-----------------GHWLLARL
TH_1606|M.thermoresistible__bu MTAKS-------PLPLANRSDADLP-----------------GHWLLARL
MSMEG_5310|M.smegmatis_MC2_155 MTSKS-------DLPLAQRPDADLP-----------------GHWLLARL
MAB_4103c|M.abscessus_ATCC_199 MQRSRDWVMFKLNAVFTQRVQKFIYRHATRKLETEDVVFLNYGYEEEPAM
:.* : : *: . :
MMAR_2078|M.marinum_M GKRVLRPG-----GVELTRTLLARADVNHADVLELAPGLGRTASEIL-AR
MUL_3266|M.ulcerans_Agy99 GKRVLRPG-----GVELTRTLLARADVNHADVLELAPGLGRTASEIL-AR
Mb2655|M.bovis_AF2122/97 GKRVLRPG-----GVELTRTLLARAEVTDADVLELAPGLGRTAAEIL-AR
Rv2622|M.tuberculosis_H37Rv GKRVLRPG-----GVELTRTLLARAEVTDADVLELAPGLGRTAAEIL-AR
MAV_3501|M.avium_104 GKRVLRPG-----GVELTRTLLSHAQLTGADVVELAPGLGRTATEIV-AR
Mflv_4299|M.gilvum_PYR-GCK GKRVLRPG-----GLELTTRLLTAARIQGADVVELGPGLGRTATDIV-AE
Mvan_2049|M.vanbaalenii_PYR-1 GKRVLRPG-----GLELTTRLLAAARIGGSDVVELGPGLGRTASDII-AA
TH_1606|M.thermoresistible__bu GKRVLRPG-----GLELTRRLLTAARVTGADVVELGPGLGRTATDIV-AA
MSMEG_5310|M.smegmatis_MC2_155 GKRVLRPG-----GVELTTRLLSAAGITGSDVVELGPGLGRTAVDIA-AA
MAB_4103c|M.abscessus_ATCC_199 GVPLSASDEPDRYSIQLYHSTATQADLGGQRVLEVGCGHGGGASYLVRAL
* : .. .::* : * : *:*:. * * * : *
MMAR_2078|M.marinum_M HPRSYVGAEADPDAANLVRTIVAGHGD----VRVADAADTGLPDSSADVV
MUL_3266|M.ulcerans_Agy99 HPRSYVGAEADPDAANLVRTIVAGRGD----VRVADAADTGLPDSSADVV
Mb2655|M.bovis_AF2122/97 NPRSYVGAESDPNAANLVRHVLAGRGD----VRVTDAADTGLSDASADVV
Rv2622|M.tuberculosis_H37Rv NPRSYVGAESDPNAANLVRHVLAGRGD----VRVTDAADTGLSDASADVV
MAV_3501|M.avium_104 APRSYVGAEADPDAANVVRGVLGDLGAHNAAVRVADAADTGLPDASGDVV
Mflv_4299|M.gilvum_PYR-GCK RPRSYVGVDDTAAATEQVRSIVAPVGG---KVVVADAASTGLPDGSADVV
Mvan_2049|M.vanbaalenii_PYR-1 QPRSYVGVDDTAAATENVKAIVAPVNG---AVVVADASTTGLPDGSADVV
TH_1606|M.thermoresistible__bu GPRSYVGVDDTAAATEAVRRIVEPVDG---KVVVANAADTGLPSGSADVV
MSMEG_5310|M.smegmatis_MC2_155 EPRSYVGVDDNSTTSALLQSAVATSGG---RLVAADAAETGLDTGSADVV
MAB_4103c|M.abscessus_ATCC_199 QPASYTGLDLNPDGISFCRRRHDLPGL---EFVQGDAEDLPFPDESFDAV
* **.* : . : . . :* : * *.*
MMAR_2078|M.marinum_M IGEAMLTMQGDAAKHAIVAEAARVLRPHGRYAIHELALTPDDVPEEISTE
MUL_3266|M.ulcerans_Agy99 IGEAMLTMQGDAAKHAIVAEAARVLRPHGRYAIHELALTPDDVPEEISTE
Mb2655|M.bovis_AF2122/97 IGEAMLTMQGNAAKHTIVAEAARVLRPGGRYAIHELALVPDDVAEQVRTD
Rv2622|M.tuberculosis_H37Rv IGEAMLTMQGNAAKHTIVAEAARVLRPGGRYAIHELALVPDDVAEQVRTD
MAV_3501|M.avium_104 IGEAMLTMQGDAAKRAIVAEAARVLRPGGRYAIHELALTPDTVSAEVSTD
Mflv_4299|M.gilvum_PYR-GCK VGEAMLTMQGEKAKRAIIGEAFRVLRPGGRYAIHELGLSPDDLSQGIKDD
Mvan_2049|M.vanbaalenii_PYR-1 VGEAMLTMQGEKAKRAIIAEAFRVLRPGGRYAIHELGLTPDDLSQDIKDD
TH_1606|M.thermoresistible__bu IGEAMLTMQGDRDKRAIVNEAFRVLRPGGRYAIHELGLQPDSLPQDTKDQ
MSMEG_5310|M.smegmatis_MC2_155 VGEAMLTMQGEKAKKAIVDEAFRVLRPGGRYAIHELGLMPDDLSDGIKDD
MAB_4103c|M.abscessus_ATCC_199 INVESSHLYPHFP--VFLTEVARVLRPGGNFLYTDARSVQDVAGWKVALA
:. : . .:: *. ***** *.: : *
MMAR_2078|M.marinum_M ---VRQALARSIKVNARPLTVAEWSQLLAGHGLVVSHVATAPMALLQPRR
MUL_3266|M.ulcerans_Agy99 ---VRQALARSIKVNARPLTVAEWSQLLAGHGLVVSHVATAPMALLQPRR
Mb2655|M.bovis_AF2122/97 ---LRQSLARALKVNARPLTVAEWSHLLAGHGLVVEHVVTASMALLQPRR
Rv2622|M.tuberculosis_H37Rv ---LRQSLARALKVNARPLTVAEWSHLLAGHGLVVEHVVTASMALLQPRR
MAV_3501|M.avium_104 ---IRRALARAIKVNARPLTVAEWSALLAEHGLVVDHVATAPMALLQPRR
Mflv_4299|M.gilvum_PYR-GCK ---IRRDMSRAIKVNARPLTSAEWTALLTDAGFKIESVDHAPMALLNPAR
Mvan_2049|M.vanbaalenii_PYR-1 ---IRREMSRAIKVNARPLTIAEWTALLTEAGFQVETVDQAPMALLSPAR
TH_1606|M.thermoresistible__bu ---IRKDMARAIKVNARPLTASEWVNLLTDAGFEVVSVDHAKMALLNPGR
MSMEG_5310|M.smegmatis_MC2_155 ---IRKEMARAIKVNARPLTVAEWTDLLTSAGFEVRSVDLAPMALLQPKR
MAB_4103c|M.abscessus_ATCC_199 NAPLRMVSERGINAEVR----RGMEKNLARWRYVIDRATPAPLRGIVR-R
:* *.::.:.* *: : . * : : *
MMAR_2078|M.marinum_M IIADEGLLGALRFAKNLLTQPAARKRVLMMRSTFRKHRDRMAAVAIVAYK
MUL_3266|M.ulcerans_Agy99 IIADEGLLGALRFAKNLLTQPAARKRVLMMRSTFRKHRDRMAAVAIVAYK
Mb2655|M.bovis_AF2122/97 VIADEGLLGALRFAGNLLIHRAARRRVLLMRHTFRRHRERLTAVAIVAHK
Rv2622|M.tuberculosis_H37Rv VIADEGLLGALRFAGNLLIHRAARRRVLLMRHTFRRHRERLTAVAIVAHK
MAV_3501|M.avium_104 LVSDEGLFGALRFARNVLVHRDARKRVLTMRRTFRKHRRQLAAVAIVAHK
Mflv_4299|M.gilvum_PYR-GCK VLADEGPLGALRIVGNLIRRPAARKRVIGMRKTFQRYRRSLTAVAVVGVV
Mvan_2049|M.vanbaalenii_PYR-1 VLADEGLFGALRIVGNMIRRPAARRRVLGMRATFARYRRSLTAVAVVGVV
TH_1606|M.thermoresistible__bu VLADEGLFGALRIVGNLIRRPAARKRVIGMRKTFQRYRHSLTAIAVVGVV
MSMEG_5310|M.smegmatis_MC2_155 VVADEGFLGALRIVFNALTHPAARKRVLGMRRTFNRYRDELTAVAIVAVV
MAB_4103c|M.abscessus_ATCC_199 FAPAQRAYDDLRAGG---------------SVEYRMYRFVKA--------
. . : . ** : :* :
MMAR_2078|M.marinum_M PSASGS-
MUL_3266|M.ulcerans_Agy99 PSASGS-
Mb2655|M.bovis_AF2122/97 PHVDS--
Rv2622|M.tuberculosis_H37Rv PHVDS--
MAV_3501|M.avium_104 PTASQTG
Mflv_4299|M.gilvum_PYR-GCK PGQ----
Mvan_2049|M.vanbaalenii_PYR-1 PGQ----
TH_1606|M.thermoresistible__bu PEK----
MSMEG_5310|M.smegmatis_MC2_155 PTESK--
MAB_4103c|M.abscessus_ATCC_199 -------