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LTETTKHVDYLKRLTADLRRTRRRVAELEDKLSEPVALVGMGCRYPGGADSPESLWEMLTQGRDAVSEFP SDRGWDIDAMFDPDPDARGKTYTRRGGFLADAGDFDAGFFGVGPNEALAMDPQQRLMLEVSWEALERSGI DPTTLRGSATGVFVGVIHAGYGGEVKGELEGYGLTGSTLSVASGRVAYVLGLEGPAVSVDTACSSSLVAL HLAAQSLRSRECDLALVGGVTVMATPAAFVEFSRQRALAADGLCKAYAGAADGTTWSEGAGVLVVERLAD AQRLGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRAALASARLGVADVDVVEGHGTGTVLGDPIEA QAILATYGQDRTEPLWLGSIKSNIGHTSAAAGVAGLIKMVLAMQHGVLPQTLHVDVPTPHVDWSAGAVSL LTESRPWPDLGRPRRAGVSSFGISGTNAHVILEQAPTAEHDLAEPDRGAPTVPWVLSARSAPALANQAQR LLSWAEEHPDLDPVDVGWSLAATRSLFEHRAVVVGTDRTQLMDGLAGVVAGEPGAGVVVGRARSTGKTVF VFPGQGAQYLGMGRVLYERFSAFSTAFDAAAAELDAHLRLPLRQVMWGTDEGLLESTEFAQPALFAVEVA LAALLSQLGVVPDLVLGHSVGEISAAHVAGVLSLPDAARLVAARGRLMAGLAAGGAMVAVAASEQEVTPL LGSGVAVAAVNGPDSVVISGPEAAVGEVVDRIAALGRRTHRLAVSHAFHSELMDPMLPDFAEVLKGVSAS QPRISLVSNVTGQLAEAGYGSAAYWVEHVRKPVRFADSVALAESLGAAAFVEVGPSGGLTALVEQSLTRE TPAVPLLIKDRPENDALLLGLGQLFADGRALDWREAFAGLGAQRTDLPTYGFVRRRYWLKELGVDQTKLT GAGLTGVGHPLLGAVVERPDVGGLVLTGVLSPELHPWLRDHTVDGVVLFPGAGFVELALRAGDEVGCPLV QELTLLAPLALPQTGTVRMQLVVGGADESGRRTVSVFSSTADGDSWVLHAEGVLRASGVGHGVDLSVWPP VGASAVDVSDVYDRFAARGYGYGPAFRGLRSVWRRGREIYAEVVAPEDATVQGFGIHPAVLDAALHAWGF ATATDQLMLPFSWQGVSLHAAGAARLRVRITPADAGSVSLELADPRGLPVLSVKQLVVRAVSGEALSAAV IAAGGTISGRLLEVAWPPTSPELSASDSARDVVVWESGSADGDVAVGQRVNEALAKLQSWLAGDDPGVLV VLTRGAVGLAGEGVTDLAGAAVWGLTRSAQAEHPGRVVLVDTDDSVDIADAVACGEPQLVVRSGVVHGAR LRFIDSGSGLELPEGPWRLAVGGGGTLEDVLVQPCPRADLAAGQVRVAVGAAGVNFRDVLVALGMYPGGG ALGAEGAGVVVEVGPGVEGLAVGDAVMGLVGVVGSEAVVDERLVTTVPAGWSLAQAAGVPVVFLTAFYGL SVLAGLKAGERVLIHAGAGGVGMAAVALAKYWGAEIFVTASRGKWDTLRAMGFDDEHIGDSRSLEFEEKF RKTSGGAGVDVVLNSLAGEFTDASLRLLVSGGRFIEMGKTDLRDPQAVADEYPGVSYRAFDLMEAGPDAI ARMLSEVVGLLQEGILKAPPLKLFDVRSAQQAYRYVSQARHIGKVVLTLPQGPAAQSVLSGGTVLITGGT GMAGAAVARHLVQRYGVGHVVLVSRAGTQAPGIADLVAELQQGGAQVSVTACDVADRDAVAALLAQLPDR YPLKGIFHAAGVLDDAVLASLTPDRVEPVLRAKAAGAWNLHELTHGMDLAAFVMFSSLAGIAGAPGQGNY AAANAFLDGLAAYRRGQDLPAVSIAWGLWEQPSTMTQHLGDRDLARMRQVGLDPLSTEHALHLLDAALLG ERPGVVAAQLNVAALSANPEVPPIWRDLVTRSVRRVVDANDNSASMTALISRLHTLSPEQRSRELVDMIC TNAATVLGNASVDIDANKPFQDLGFDSLTAVELRNRLKSSTGLTLSPTLIFDYPTPAALAEHLSTQLSSL SPAAADEQPNRLARFDAVARELDSMINEPDWTAEDRERVSNRLHGLLADLTSPQSRGEDHSHDDDISSAS ESELFAILDEELGP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_2472 | pks8 | - | 100% (2114) | polyketide synthase, Pks8 |
M. marinum M | MMAR_2471 | pks7 | 0.0 | 62.34% (2135) | polyketide synthase Pks7 |
M. marinum M | MMAR_1762 | pks15/1 | 0.0 | 60.64% (2078) | polyketide synthase Pks15/1 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1689 | pks7 | 0.0 | 63.29% (2141) | polyketide synthase pks7 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 38.68% (2143) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv1661 | pks7 | 0.0 | 63.33% (2141) | polyketide synthase pks7 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 59.66% (2085) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 37.97% (2178) | polyketide synthase |
M. avium 104 | MAV_3108 | - | 0.0 | 66.81% (2136) | erythronolide synthase, modules 3 and 4 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 38.25% (2136) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 34.87% (1844) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2005 | pks15/1 | 0.0 | 60.44% (2078) | polyketide synthase Pks15/1 |
M. vanbaalenii PYR-1 | Mvan_0269 | - | 0.0 | 38.18% (2132) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 MDSAENPIESTPRFAIIGYAARFPGAADAEEFWDVLREGRDAISEVPADR Mvan_0269|M.vanbaalenii_PYR-1 MGSAEHPNGPAPRFAIVGYAARFPGAPDADAFWDVLREGRDAISDVPRDR Mflv_0405|M.gilvum_PYR-GCK MGSAAHQGESAHRFAIVGYAGRFPGARDAESFWELLADGRDAISEVPEDR MSMEG_0408|M.smegmatis_MC2_155 MVSAEHPIEPTPSFAIIGYAARFPGAASAEEYWALLRDGREAISDVPKDR TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 WDAEEFFDPEPGAPGKVVTRRAGFVEDVTGFDAPFFGMSTREVRLMDPQH Mvan_0269|M.vanbaalenii_PYR-1 WDAEEFFDPEPGAPGKVVTRRAGFVDDVTGFDAPFFGMSTREVRMMDPQH Mflv_0405|M.gilvum_PYR-GCK WDVEAFFDPDPSTPGKVVTRRAGFVDDVSGFDAPFFGMSTREVRLMDPQH MSMEG_0408|M.smegmatis_MC2_155 WDIEEFFDPDPSTPGKVVTRRAGFVDDVTGFDAPFFGMSAREVRLMDPQH TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RLLLETAWRAVEHSGIAPTDLAETNSGVFVGLATHDYLGMASDELTFPEI Mvan_0269|M.vanbaalenii_PYR-1 RLLLETAWRAVEHSGTAPTALAGSNTGVFVGLATHDYLGMASDELTYPEI Mflv_0405|M.gilvum_PYR-GCK RLLLETAWRAIEHSGTAPSELANTNTGVFVGLATHDYLGMASDELSYPEI MSMEG_0408|M.smegmatis_MC2_155 RILMETAWRAVEHSGIAPTSLANSNTGVFVGLATHDYLGMASDELTYPEI TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EAYMAIGTSNAAAAGRISYRLGLQGPSVAVDTACSSSLVAIHQACQALQL Mvan_0269|M.vanbaalenii_PYR-1 EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL Mflv_0405|M.gilvum_PYR-GCK EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL MSMEG_0408|M.smegmatis_MC2_155 EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GECDLALAGGANVLLTPATMITFSHAHMLAPDGKCKTFDAAADGYVRGEG Mvan_0269|M.vanbaalenii_PYR-1 GECDLALAGGANVLLTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG Mflv_0405|M.gilvum_PYR-GCK GECDLALAGGANVILTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG MSMEG_0408|M.smegmatis_MC2_155 NECDLALAGGANVLLTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SGVIVIKRLEDAIRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA Mvan_0269|M.vanbaalenii_PYR-1 CGVIVIKRLEDAVRDGDRIRAVIRGSSINQDGASGGLTVPNGVAQQRVIA Mflv_0405|M.gilvum_PYR-GCK CGVIVIKRLEDAVRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIG MSMEG_0408|M.smegmatis_MC2_155 CGVVVVKRLEDAVRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DALKRAGVAPSEVGYLEAHGTGTSLGDPIEAQAAGAAYGIGRETNDPLLI Mvan_0269|M.vanbaalenii_PYR-1 DALKRSDLEPKDVGYLEAHGTGTSLGDPIEAQAAGAVLGAGREPSRPLLI Mflv_0405|M.gilvum_PYR-GCK DALSRAGLAPGDVDYLEAHGTGTSLGDPIEAQAAGAALGPGREPQRPLLI MSMEG_0408|M.smegmatis_MC2_155 DALKRAGLRPADVGYLEAHGTGTSLGDPIEAQAAGEVLGAGRAPEEPLLI TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GSAKTNIGHLEAAAGIAGVIKVILSLENELLPQHRNFQNPSPHIPWDRLP Mvan_0269|M.vanbaalenii_PYR-1 GSAKTNIGHLEAAAGIAGVIKVILSLEHRTLPKHLNFENPSPHIPWDRLA Mflv_0405|M.gilvum_PYR-GCK GSAKTNIGHLEAAAGIAGVIKVVLSLEHETLPKHLNFENPSPHIPWDRLP MSMEG_0408|M.smegmatis_MC2_155 GSAKTNIGHLEAAAGIAGVIKVVMALENETLPKHLNFETPSPHIPWERLP TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VEVVREARPWGRN---GRPRIAGVSSFGFAGTNAHVILEEAPVVSRDAVE Mvan_0269|M.vanbaalenii_PYR-1 VEVVKETIPWERD---GGPRIAGVSSFGFAGTNAHVILEEAP--EQAAAP Mflv_0405|M.gilvum_PYR-GCK VEVVKESIPWRRGQRGGRPRIAGVSSFGFAGTNAHVILEEAP---LAAEP MSMEG_0408|M.smegmatis_MC2_155 IEVVRETVPWQRN---GKPRIAGVSSFGFAGTNAHVILEEAPAVGTPATT TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PPAPAGGRKFSILPLSARTPAALAQLADKYRAWLNAHPEAALADLCFTAG Mvan_0269|M.vanbaalenii_PYR-1 GPVQQPDRRFSLLPLSARTPAALTQLAGQYRDWWTAHPEATLADVCFTAG Mflv_0405|M.gilvum_PYR-GCK AQESVDDGRFTLLPLSARTPAALMAVADRYRDWLVANPDATLADLCFTAG MSMEG_0408|M.smegmatis_MC2_155 EPVE-DPRRYSVLPLSARTPEALVRLAGEYRDWLRAHPQARLADVSHTAG TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VGRAHLEHRAALVVNTREAAVELLSAVADDRPAPGLGRGESHDTPKTAWL Mvan_0269|M.vanbaalenii_PYR-1 AGRAHLEHRAALVVNSAESAVELLGALADDRPAPGLVRGESHDTPKTAWL Mflv_0405|M.gilvum_PYR-GCK TARSHLEHRAALVVNTREAALDLLGALADDRPAPGLVRGESHDTPKTAWL MSMEG_0408|M.smegmatis_MC2_155 TARAHLEQRAALVVNSRESAIELLGALADDRPAPGLVRGESHEAPKTAWL TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 FTGQGSQYPGMARELFETEPVFADTLNRCAAAVADVLEKPLLDVIFDVD- Mvan_0269|M.vanbaalenii_PYR-1 FTGQGSQYPGMARELYDTEPVFAETLNRCAEAVADVLEKPLLDVIFDAE- Mflv_0405|M.gilvum_PYR-GCK FTGQGSQYPGMSRELFDTEPLFAETLRECAAAVDGMLEKPLLDVIFDTDG MSMEG_0408|M.smegmatis_MC2_155 FTGQGSQYPGMARELFDTEPVFAETVRKCAEAVADILEKPLLDVIFDAD- TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 --GPEAEETLRQTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYS Mvan_0269|M.vanbaalenii_PYR-1 --ADDAEKTLQNTCYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYS Mflv_0405|M.gilvum_PYR-GCK VLDTDSNETLRHTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYA MSMEG_0408|M.smegmatis_MC2_155 ELDGDTESPLRHTTYAQPALFAVELGLARLWQSWGFEPDVVVGHSVGQYS TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AACVAEVFSLEDGARLIAERGRLFSSLPAGGRMAAVFTDAERAERLTDEF Mvan_0269|M.vanbaalenii_PYR-1 AACVAGVFSLTDGARLMAERGRLFGSLPEGGRMVAVFTTAERAEAMTDEF Mflv_0405|M.gilvum_PYR-GCK AACVAGVLSLRDGARLMAERGRLFGSLPSGGRMAAVFAAAERVEALTDEY MSMEG_0408|M.smegmatis_MC2_155 AACVAGVFDVEDGARLIAERGRLFGSLPAGGRMAAVFTAPERAERLTDEY TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PSLSVAAYNGANTVLSGPAQDLEKAIAALVADGVRCDFLETSHAFHSALL Mvan_0269|M.vanbaalenii_PYR-1 PSLSVAAYNGTNTVLSGPAGDLEKAVATLSADGVRCDWLDTSHAFHSALL Mflv_0405|M.gilvum_PYR-GCK PALSVAAYNGANTVLSGPATDLERAVAGLVADGVRCDWLETSHAFHSALL MSMEG_0408|M.smegmatis_MC2_155 PSLSVAAYNGANTVLSGPAKDLESAVATLVADGVRCDWLDTSHAFHSALL TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DPILDEFEAYANQFNYKTPQRILIDNRTGTALGRSVKLDGAYWRRHARQP Mvan_0269|M.vanbaalenii_PYR-1 DPILDDFESYANQFDFAAPQRILIDNRTGTALGRSVQLDGTYWRRHARQP Mflv_0405|M.gilvum_PYR-GCK DPILDDFESYARGITFTAPQRILIDNRTGAALGRSVTLDAAYWRRHARQP MSMEG_0408|M.smegmatis_MC2_155 DPILDDFESFAQKLEYREPQRILIDNRTGSALGRSTRLDGAYWRRHARQP TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VEFAKSVRTLADMNCKVLLEIGPQPVLTAAALRAWPDPATAPRAIASLRR Mvan_0269|M.vanbaalenii_PYR-1 VEFAKSVRTLAEMNCKLLVEIGPRPVLTAAALGAWPDPATAPRVIASLRR Mflv_0405|M.gilvum_PYR-GCK VEFAKSVHTLADMNCKLLVEIGPRPVLTAAALSAWPDPATSPRVIASLRR MSMEG_0408|M.smegmatis_MC2_155 VEFAKSVRTLADMNCRVLLEIGPRPVLTATALAAWPDPATTPQVLASLRP TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 NTADHRQITEAAADAYVLGHLPDFGAFQHAPARKLDLPTYPFERRQYWFS Mvan_0269|M.vanbaalenii_PYR-1 TAADHRQITEAVADAYVLGHLPEFGAFRDAGARKLDLPTYPFEHRQYWFR Mflv_0405|M.gilvum_PYR-GCK TTADQRQITEAVADAYVLGHLPRFAAFRRDGARVLDLPTYPFEHRQYWFS MSMEG_0408|M.smegmatis_MC2_155 TTADHRQITEAVAAAYAAGHLPDFRAFRQPDARKLDLPTYPFEHRQFWFS TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DKRDGDNRDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVDGDQQTL Mvan_0269|M.vanbaalenii_PYR-1 DNQDPD----GSEALQPRTPSTEAVRLLEDGRIEELATLLDGAAGDQQTL Mflv_0405|M.gilvum_PYR-GCK DSREPV------AAAPQRGARTETVRLLEDGRIEELAALLGGTVDDPFTF MSMEG_0408|M.smegmatis_MC2_155 DNRAIDRDTQTASAGSVTPHRTQAVRLLEDGQIEELAALIDGETVDEQTL TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 NVLTKLAAQHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVA Mvan_0269|M.vanbaalenii_PYR-1 DVLSRLAAQHNQQRSSQSITNDRYEIRWEQSAAALSGAETDEVSSWILVG Mflv_0405|M.gilvum_PYR-GCK DVLNRLAAQHNQQRSTESIADDRYQIRWETAAEPPVGADAADGITWLLVG MSMEG_0408|M.smegmatis_MC2_155 RVLNKLAARHNQQRSTHVDPDARYEIRWDAIAS--AAASTGAAADWILVG TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DAAGAAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAADEDSALR Mvan_0269|M.vanbaalenii_PYR-1 DDTEATRPLVDVLSARGQRYRIFGLPVSDADEEQLGEALRLAAAEDSTLR Mflv_0405|M.gilvum_PYR-GCK DDTDATRPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAADATDLR MSMEG_0408|M.smegmatis_MC2_155 DDTAAVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAG--ELY TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 IVHVAALAGQ----GSSSAQSLLRIQHQVLGGTRRLFRAAAAAELRAPIW Mvan_0269|M.vanbaalenii_PYR-1 IVHVGGLDSDPDPGTAPSMRSLLRMQHRILGGTRRLFRAAAAAELRTPIW Mflv_0405|M.gilvum_PYR-GCK IVHVAALDAA---ESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQLRSPMW MSMEG_0408|M.smegmatis_MC2_155 VVHIAAGDGA-----AAPMRDLLRVQHRTLGGLRRLFRAANDAELRSPIW TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 IVTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLSDAGTDE Mvan_0269|M.vanbaalenii_PYR-1 VVTRRAQHVTATDTVAPDQSCLWGFGRAAALELPQLWGGLADLADGTADE Mflv_0405|M.gilvum_PYR-GCK LVTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLGGGTSDE MSMEG_0408|M.smegmatis_MC2_155 LVTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLSG-ADTE TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 WAQFIGRVSVSGEASTREDQLALRGQAVHVPRLVRREELPSGKPLEVRSD Mvan_0269|M.vanbaalenii_PYR-1 WSRLLNRITAPHGPAVREDQIALRDHAVYVPRLVRRAGRPAGKPLQLRDD Mflv_0405|M.gilvum_PYR-GCK WSRLLNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDTLPSGKPLHLRAD MSMEG_0408|M.smegmatis_MC2_155 WPRLIARITSPRD---GEDQIALRGDAVYAPRLVRRTGEPSDTPLPVRED TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ATYLVTGGLGSIGLEIAGYLAGRGAKHLVLTSRREPGEAARQRIDALAAQ Mvan_0269|M.vanbaalenii_PYR-1 ATYLVTGGLGSIGLEIAGYLAAHGARHLVLTSRRAPGDATQQRIDALGAQ Mflv_0405|M.gilvum_PYR-GCK ATYLVTGGLGSLGLEIAGYLAANGAGHLVLTSRRTPDEAAASRIEALRER MSMEG_0408|M.smegmatis_MC2_155 RTYLVTGGLGAIGLEVAGYLASHGAGHVVLTSRREPGDDARRRLDGLREQ TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 G-CEVRAVTADVADGHDVARLLAGIQAELPPLAGIVHAAGEIGTTPLSDL Mvan_0269|M.vanbaalenii_PYR-1 HSCQIRVVAADVADAHDVARLLAAVAAELPPLAGIVHAAGEIGTTPLVSL Mflv_0405|M.gilvum_PYR-GCK HGCEVRVVTADVADAHAVARLLATVQAEMPPLAGIVHAAGEIGTTPLADL MSMEG_0408|M.smegmatis_MC2_155 YACDVRVITADVADAHDVARLMTTVAAELPPLAGIVHAAGEIGTTPLSGL TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EDAEVDRVFAGKVWGAWHLSEAAAGLK--LDFFINTSSIAAVWGGYGQTA Mvan_0269|M.vanbaalenii_PYR-1 EDSEVDRVFAGKVWGAWHLSEAAADLQ--LDFFLGTSSIASVWGGYGQTA Mflv_0405|M.gilvum_PYR-GCK DDAEVDRVFAGKVWGAWHLSEATSDLQ--LDFFISTSSIASVWGGFGQAA MSMEG_0408|M.smegmatis_MC2_155 DDAEVDRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSSIASVWGGFGQTA TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 YSAANAFLDGLAWRLREQGIAGTSVNFGPWSAGMADAESRARLEQRGIKT Mvan_0269|M.vanbaalenii_PYR-1 YGAANAFLDGLAWRLREQGISGVSINFGPWSAGMADAESRARLDQRGVRT Mflv_0405|M.gilvum_PYR-GCK YGAANAFLDGLAWRLREQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKT MSMEG_0408|M.smegmatis_MC2_155 YGAANAFLDGLAWRLRERGVTAVSVNFGPWAAGMADAESRARLEQRGVRT TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LSPTDALAGLADVVAASGS-NAVQGVIARIDWARFLPLYQQAGKRGFLAE Mvan_0269|M.vanbaalenii_PYR-1 LSPADALAGLADVVTAAEAPGPAQGIVARIDWERFLPLYQQAGRRAFLAE Mflv_0405|M.gilvum_PYR-GCK LSPADALAGLSDAVISAAP----HPVVARVDWSRFLPLYQQAGRRGFLAE MSMEG_0408|M.smegmatis_MC2_155 LSPAEALAGMADVVAGPVQ-----GVVAKIDWSRFLPLYQQAGRRAFLSE TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M --------------------------------MTET-TKHVDYLKRLTAD MAV_3108|M.avium_104 --------------------------------MPGT-EQHLDYLKRLTAD Mb1689|M.bovis_AF2122/97 --------------------------------MNSTPEDLVKALRRSLKQ Rv1661|M.tuberculosis_H37Rv --------------------------------MNSTPEDLVKALRRSLKQ MLBr_00135|M.leprae_Br4923 -------------------------MTASVEGADQKSEKLISYLKKVVVE MUL_2005|M.ulcerans_Agy99 -------------------------MTTSGESADQQNDKLFRYLKKVAVE MAB_0939|M.abscessus_ATCC_1997 LDREVPSHLAGV--AGAQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAE Mvan_0269|M.vanbaalenii_PYR-1 LEREVPDTAP----AATPSGRTELVERLTNAPVQQRKKLLTDYLRTAVAE Mflv_0405|M.gilvum_PYR-GCK LERELPAAPAQQGPAVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAE MSMEG_0408|M.smegmatis_MC2_155 LESELPAAATGAAAPATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAE TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M LR------------------------RTRRRVAE---------------- MAV_3108|M.avium_104 LR------------------------RTRRRVAE---------------- Mb1689|M.bovis_AF2122/97 NE------------------------RLKRENRD---------------- Rv1661|M.tuberculosis_H37Rv NE------------------------RLKRENRD---------------- MLBr_00135|M.leprae_Br4923 LD------------------------ETRARLRE---------------- MUL_2005|M.ulcerans_Agy99 LD------------------------EARARLRE---------------- MAB_0939|M.abscessus_ATCC_1997 VTRVDVSEIREDAGFFDLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPR Mvan_0269|M.vanbaalenii_PYR-1 ITRVDATEIREDAGFFDLGMDSLMAVELRRRIEQGVGREIPATLAMDHPR Mflv_0405|M.gilvum_PYR-GCK VTRVDAAEIREDAGFFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPR MSMEG_0408|M.smegmatis_MC2_155 VTRVDADEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPR TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M ------------------------------LEDKLSEPVALVGMGCRYPG MAV_3108|M.avium_104 ------------------------------LEGRLSEPVAVVGMACRYAG Mb1689|M.bovis_AF2122/97 ------------------------------LLARTTEPVAVVGMGCRYPG Rv1661|M.tuberculosis_H37Rv ------------------------------LLARTTEPVAVVGMGCRYPG MLBr_00135|M.leprae_Br4923 ------------------------------YEQRATEPVAVVGIGCRFPG MUL_2005|M.ulcerans_Agy99 ------------------------------YEQRATEPVAVVGIGCRFPG MAB_0939|M.abscessus_ATCC_1997 ISDVADYLLGDVLGLAEQA--KPAAQLASAVTGRTDEPIAIVAVSCRFPG Mvan_0269|M.vanbaalenii_PYR-1 LSDVADYLLGEVLGLAEQAPAKAGSQPASAAANRTDEPIAIVAVSCRFPG Mflv_0405|M.gilvum_PYR-GCK LSDAADYLLGDVLGLTEAA---TAPKAATVVSTAADEPIAIVAVSCRFPG MSMEG_0408|M.smegmatis_MC2_155 LSDAADYLLVEVLGLGEQT----NVRQASTVTARTDDPIAVVAVSCRFPG TH_4621|M.thermoresistible__bu ---------------------------VNIVGDTPVNAVAVIGMACRLPG :.:*::.:.** .* MMAR_2472|M.marinum_M GADSPESLWEMLTQGRDAVSEFPSDRGWDIDAMFDPDPDARGKTYTRRGG MAV_3108|M.avium_104 GVDSPEALWDLVIEGRDTVSDFPVDRGWDVEGLYDPDPDAKGKMYTRQGS Mb1689|M.bovis_AF2122/97 GVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGG Rv1661|M.tuberculosis_H37Rv GVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGG MLBr_00135|M.leprae_Br4923 GVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTYTRWGA MUL_2005|M.ulcerans_Agy99 GADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAEGKTYTRWGA MAB_0939|M.abscessus_ATCC_1997 APD-PEAFWDVLSGGVDAIREVPEDR-FDIDEFYDPDPEVAGKTYTRFGG Mvan_0269|M.vanbaalenii_PYR-1 APD-PEAFWEVLAGGVDAIREVPEDR-FDIDEFYDPDPDAAGKTYTRFGG Mflv_0405|M.gilvum_PYR-GCK APN-PEAFWDLLSGGVDAIREVPEDR-FDIDEFYDPDPDAAGKTYTRYGG MSMEG_0408|M.smegmatis_MC2_155 APD-PESFWELLAGGVDAIREVPEDR-WDIDEFYDPDPDTPGKTYTRFGG TH_4621|M.thermoresistible__bu GIDSPQRLWEALLRGDDMVTEIPVDR-WDADDYFDPEPGVPGRTVSRWGA . : *: :*: : * : :.* ** :* :**:* . *: :* *. MMAR_2472|M.marinum_M FLADAGDFDAGFFGVGPNEALAMDPQQRLMLEVSWEALERSGIDPTTLRG MAV_3108|M.avium_104 FLQHAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERAGIDPSALRG Mb1689|M.bovis_AF2122/97 FLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDPITLRG Rv1661|M.tuberculosis_H37Rv FLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDPITLRG MLBr_00135|M.leprae_Br4923 FLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDPLSLRG MUL_2005|M.ulcerans_Agy99 FVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHAGIDPMSLRG MAB_0939|M.abscessus_ATCC_1997 FLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYSPAALRG Mvan_0269|M.vanbaalenii_PYR-1 FLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGLAPADLRG Mflv_0405|M.gilvum_PYR-GCK FLDHIDEFDPEFFGLSPREAVWIEPQQRLMLETVWEGLERAGYAPSALRG MSMEG_0408|M.smegmatis_MC2_155 FLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRG TH_4621|M.thermoresistible__bu FLDDVAGFDPEFFGISEREAISIDPQQRLLLETSWEAMEHAGLTPADVEG *: **. ***: *.: ::****::** **.:* :* * :.* MMAR_2472|M.marinum_M SATGVFVGVIHAGYGG----EVKGELEGYGLTGSTLSVASGRVAYVLGLE MAV_3108|M.avium_104 TATGVFAGVIHAGYGG----EVKGELEGYGLTGSTLSVTSGRVSYVLGLE Mb1689|M.bovis_AF2122/97 SQTGVFAGVFHGSYGGQG--RVPGDLERYGLRGSTLSVASGRVAYVLGLQ Rv1661|M.tuberculosis_H37Rv SQTGVFAGVFHGSYGGQG--RVPGDLERYGLRGSTLSVASGRVAYVLGLQ MLBr_00135|M.leprae_Br4923 SATGVFTGIFAPSYGS----RDTGGLQGYGLTGTAVSVASGRVSYVLGLE MUL_2005|M.ulcerans_Agy99 SSTGVFTGIFAPSYGG----KDVGALQGYGLTGSPVSVASGRVAYVLGLE MAB_0939|M.abscessus_ATCC_1997 SRTGIFAGVGANEYAHLLSSESIDKIEPYFITGNALNAISGRVAFALGFE Mvan_0269|M.vanbaalenii_PYR-1 SRTGIFVGVAANEYAHLLSSESIEKIEPHFITGNALNAISGRVAFALGLE Mflv_0405|M.gilvum_PYR-GCK SRTGVFVGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGLE MSMEG_0408|M.smegmatis_MC2_155 SRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGFE TH_4621|M.thermoresistible__bu SSTGVFVGLSHDDYALLTS-DAGALEEAYGFTGSAFSMASGRIAYRLGVH : **:*.*: *. : : : *.... ***::: **.. MMAR_2472|M.marinum_M GPAVSVDTACSSSLVALHLAAQSLRSRECDLALVGGVTVMATPAAFVEFS MAV_3108|M.avium_104 GPAVSVDTACSSSLVAMHLAAQSLRSGECDLALAGGVTVMATPAAFVEFS Mb1689|M.bovis_AF2122/97 GPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFS Rv1661|M.tuberculosis_H37Rv GPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFS MLBr_00135|M.leprae_Br4923 GPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFS MUL_2005|M.ulcerans_Agy99 GPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMGLPSIFVGFS MAB_0939|M.abscessus_ATCC_1997 GPAVAVDTACSSALVAVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAAS Mvan_0269|M.vanbaalenii_PYR-1 GPAVAVDTACSSALVAVHQACQALHSGDCDLALAGGVNVLLSPVTSVAAS Mflv_0405|M.gilvum_PYR-GCK GPAVAVDTACSSSLVAVHQATQALRSGDCDMALAGGVNVLLSPVTVVAAS MSMEG_0408|M.smegmatis_MC2_155 GPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVVAAS TH_4621|M.thermoresistible__bu GPAVTVDTACSSSLLAVHMACRSLQVGESDLALAGGAMVMLEPRKYTSAS ***::*******:*:*:* * :*: :.*:**.**. *: * * MMAR_2472|M.marinum_M RQRALAADGLCKAYAGAADGTTWSEGAGVLVVERLADAQRLGHPVLAVVR MAV_3108|M.avium_104 RQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVWAVLR Mb1689|M.bovis_AF2122/97 RQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVR Rv1661|M.tuberculosis_H37Rv RQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVR MLBr_00135|M.leprae_Br4923 RQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGHTVLAVVR MUL_2005|M.ulcerans_Agy99 RQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRNGHNVLAVVR MAB_0939|M.abscessus_ATCC_1997 RARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIP Mvan_0269|M.vanbaalenii_PYR-1 RARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLGDAVRDGDRVCAVIP Mflv_0405|M.gilvum_PYR-GCK RARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAVRDGDRVCAVIA MSMEG_0408|M.smegmatis_MC2_155 RARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIP TH_4621|M.thermoresistible__bu GLGMLSPTGRCHAFDVAADGFVRSEGSVMLLLKRLPDALRDNDRILAVVR *:. * *:.: :*** .**. :::: ** ** * .. : *:: MMAR_2472|M.marinum_M GSAVNQDGASNGLTAPNGPSQQRVIRAALASARLGVADVDVVEGHGTGTV MAV_3108|M.avium_104 GSAVNQDGASNGLTAPNGPSQQRVIRAALANAGLSAVDVDVVEGHGTGTV Mb1689|M.bovis_AF2122/97 GSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTT Rv1661|M.tuberculosis_H37Rv GSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTT MLBr_00135|M.leprae_Br4923 GSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVEAHGTATT MUL_2005|M.ulcerans_Agy99 GSAINQDGASNGLTAPNGLTQQRVIQAALANCGLTSADVDVVEAHGTATT MAB_0939|M.abscessus_ATCC_1997 GSAVNQDGASSGLTVPNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTP Mvan_0269|M.vanbaalenii_PYR-1 SSAVNQDGASSGLTVPNGGAQQRLIGMALARAGLSGGDVDYLEAHGTGTP Mflv_0405|M.gilvum_PYR-GCK GSAVNQDGASSGLTVPNGGAQQRLIGTVLARAGITGGEVDYLEAHGTGTP MSMEG_0408|M.smegmatis_MC2_155 ASSVNQDGASSGLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTP TH_4621|M.thermoresistible__bu GTAANQDGRTENISTPSIQAQADVYRSALAVAGVDPATVGMVEAHGTGTP .:: **** :..::.*. :* : .*: . : *. :*.***.* MMAR_2472|M.marinum_M LGDPIEAQAILATYGQDR--TEPLWLGSIKSNIGHTSAAAGVAGLIKMVL MAV_3108|M.avium_104 LGDPIEAQALLATYGQDRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQ Mb1689|M.bovis_AF2122/97 LGDPIEAQAILATYGQRP-ADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQ Rv1661|M.tuberculosis_H37Rv LGDPIEAQAILATYGQRP-ADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQ MLBr_00135|M.leprae_Br4923 LGDPIEAQALLATYGQGRPADQPLWVGSIKSNMGHTQAAAGVAGVIKMVQ MUL_2005|M.ulcerans_Agy99 LGDPIEAEALLATYGQGRPTDQPLWVGSIKSNMGHTQAAAGVAGVIKMVQ MAB_0939|M.abscessus_ATCC_1997 LGDPIEVQAAAAAYGGSRDADRPLLMGSVKSNIGHTESASGAAGLIKVVL Mvan_0269|M.vanbaalenii_PYR-1 LGDPIEVQAAAAAYGASRDADRPLLMGSVKTNIGHLESASGAAGLIKVVL Mflv_0405|M.gilvum_PYR-GCK LGDPIEVQAAAAAYAGARDADRPLLMGSVKTNIGHTESASGAAGLIKVVL MSMEG_0408|M.smegmatis_MC2_155 LGDPIEVQAAAAAYGAGRDADRPLLMGSVKTNIGHTESASGAAGLIKVVL TH_4621|M.thermoresistible__bu VGDPIEYNSLTQVYGKTG----PCALTSVKTNFGHAESAAGALGMMKAIL :***** :: .*. * : *:*:*:** .:*:*. *::* : MMAR_2472|M.marinum_M AMQHGVLPQTLHVDVPTPHVDWSAGAVSLLTESRPWPD-LGRPRRAGVSS MAV_3108|M.avium_104 ALRHGVMPKTMHVDVPSPHVDWSAGAVSLLTDPRPWPE-HGGPRRAGVSS Mb1689|M.bovis_AF2122/97 AMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHV-PGRPRRAGVSS Rv1661|M.tuberculosis_H37Rv AMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHV-PGRPRRAGVSS MLBr_00135|M.leprae_Br4923 AMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSV-EGRPRRAGVSS MUL_2005|M.ulcerans_Agy99 AMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWPD-AGRPRRAGVSS MAB_0939|M.abscessus_ATCC_1997 SLQNGVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQA-NGRPRRAGVSS Mvan_0269|M.vanbaalenii_PYR-1 SLQHNLLPQSLHFENPSPHIPWDSLPVRVVDKAIPWQA-DGRPRRAGVSS Mflv_0405|M.gilvum_PYR-GCK SLQHETLPQSLHFDTPSPHIPWDSLPVRVVDTAMPWQP-NGRPRRAGVSS MSMEG_0408|M.smegmatis_MC2_155 SLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQT-NGRVRRAGVSS TH_4621|M.thermoresistible__bu ALQHGVVPQNLHFTRLPDEMAAIETNLFVPQATTLWPVREGCPRRAAVSS :::: :* .:*. . .: : : . * * ***.*** MMAR_2472|M.marinum_M FGISGTNAHVILEQAPTAEHDL-----------AEPDRG---APTVPWVL MAV_3108|M.avium_104 FGISGTNAHVIVEQAPAAAETE-----------AAPASSTMPDAVVPWVV Mb1689|M.bovis_AF2122/97 FGISGTNAHVILEEAPAVEPVG-----------AAHGND---PVAVPWVL Rv1661|M.tuberculosis_H37Rv FGISGTNAHVILEEAPAVEPVG-----------AAHGND---PVAVPWVL MLBr_00135|M.leprae_Br4923 FGISGTNAHVILEEAPTPVEASY----------STAD--QQRLSVVPWVV MUL_2005|M.ulcerans_Agy99 FGISGTNAHVILEEAPAPEAVPD----------SESNKGEPSLPVVPWVI MAB_0939|M.abscessus_ATCC_1997 FGFTGTNAHVLIEEAPQPQATP----------DEDDASTPQSAPVSVLPL Mvan_0269|M.vanbaalenii_PYR-1 FGFTGTNAHVLIEEAPLPQAAD----------PVEEPDT-RALPVGVLAL Mflv_0405|M.gilvum_PYR-GCK FGFTGTNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVEVLPL MSMEG_0408|M.smegmatis_MC2_155 FGFTGTNAHVLVEEAPPQLHTADAAP----VEPAATAEAGTDDSPQVLAL TH_4621|M.thermoresistible__bu YGMSGTNVHAVLEQAPEPVQRP------------EESADTDAAGPLVFAL :*::***.*.::*:** : MMAR_2472|M.marinum_M SARSAPALANQAQRLLSWAEEH-PDLDPVDVGWSLAATRSLFEHRAVVVG MAV_3108|M.avium_104 SARSAEALAGQARRLLDHVTAD-AQASPLDVGWSLVSTRAVFEHRAVVVG Mb1689|M.bovis_AF2122/97 SARSAQALTNQARRLLAWVGAD-ENVRPLDVGWSLVNTRSLFDHRAVVVG Rv1661|M.tuberculosis_H37Rv SARSAQALTNQARRLLAWVGAD-ENVRPLDVGWSLVNTRSLFDHRAVVVG MLBr_00135|M.leprae_Br4923 SGRSTAALMAQASRLAFYVQAD-PEVDPVDVGCALAA-RSVFEHRAVVVG MUL_2005|M.ulcerans_Agy99 SARSAEALTAQAGRLLAHVQAD-PQSNPVDIGFSLAG-RSAFEHRAVVVG MAB_0939|M.abscessus_ATCC_1997 SARSPEALAAVAQRYESWLAAH-PDVDLEDVCLTAGRGRSHFEHRAALVV Mvan_0269|M.vanbaalenii_PYR-1 SARSPEALTALAQRYEAWLSAH-PDADLADVCRTAGTGRSHFEHRAALVV Mflv_0405|M.gilvum_PYR-GCK SARSPEALVALAQRYETWLTAH-PEADLADVCRTAGTGRSHFEHRAALVV MSMEG_0408|M.smegmatis_MC2_155 SARSPEALVELARRYDDWLSAT-PGLDIADVCHTAGVGRSHFEYRAALVV TH_4621|M.thermoresistible__bu SSTSAEELRRTAGRLAEWVEAHTDEVVPADLAYTLARRRAHRPVRTTVIA *. *. * * * *: : *: *:.:: MMAR_2472|M.marinum_M TDRTQLMDGLAGVVAGEPGAGVVVGRARSTGKTVFVFPGQGAQYLGMGRV MAV_3108|M.avium_104 RERGALATGLAGLASGRPGPATVVGRARSTGKTVLVFPGQGSQTLGMGRQ Mb1689|M.bovis_AF2122/97 ADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQ Rv1661|M.tuberculosis_H37Rv ADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQ MLBr_00135|M.leprae_Br4923 ESREQLIAGLAGLAVGESGAGVAIGQAAPLGKTVVVFPGQGAQRIGMGRE MUL_2005|M.ulcerans_Agy99 ADRQQLLTGLATLADGAPGAGVVTGQAGSVGKTAVVFPGQGSQRIGMARE MAB_0939|M.abscessus_ATCC_1997 DSIQTAREGLLELAQNRLRPGVVRGEHTNHPTTAWLFTGQGSQYPGMARE Mvan_0269|M.vanbaalenii_PYR-1 DSVAAAREGLAELAQNRLRPGVVRGEHTHHPTTAWLFTGQGSQFPGMARE Mflv_0405|M.gilvum_PYR-GCK DSVESARIALTDLAQNRLRPGVVRGEHLNHPTTAWMFTGQGSQYPGMARE MSMEG_0408|M.smegmatis_MC2_155 DSVERAREGLAALAEGRTPAGVVRGEHVHRPTTAWLFTGQGSQYPGMARE TH_4621|M.thermoresistible__bu DGVEALTAGLREVADGDAPYQPAVGMDDKAP--VWVFSGQGSQWAGMGAE .* :. . . * . :*.***:* **. MMAR_2472|M.marinum_M LYERFSAFSTAFDAAAAELDAHLRLPLRQVMWGTD-------EGLLESTE MAV_3108|M.avium_104 LYERFEVFAGALDEAVAVVDEHSRLSVREVMWGAD-------PELLQSTE Mb1689|M.bovis_AF2122/97 LCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPG------APGLDRVD Rv1661|M.tuberculosis_H37Rv LCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPG------APGLDRVD MLBr_00135|M.leprae_Br4923 LCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGAD-------AGLLDSTE MUL_2005|M.ulcerans_Agy99 LHDQLPVFAEAFDAVADELDRHLRIPLCEVMWGSD-------VALLDSTE MAB_0939|M.abscessus_ATCC_1997 LFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGKAGEALRHTS Mvan_0269|M.vanbaalenii_PYR-1 LFETEPVFADAVTRCADAVKDILPRPLLEVLFAADRESG----EALRHTS Mflv_0405|M.gilvum_PYR-GCK LFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVPPTETLRHTS MSMEG_0408|M.smegmatis_MC2_155 LFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRETA----DLLQHTS TH_4621|M.thermoresistible__bu LLATEQVFAAKIAEIEPLVARESGFSVTEAMTASET---------VTGID * .*: . : .: :.: . : . MMAR_2472|M.marinum_M FAQPALFAVEVALAALLSQLGVVPDLVLGHSVGEISAAHVAGVLSLPDAA MAV_3108|M.avium_104 FAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAACVAGVLSLRDAA Mb1689|M.bovis_AF2122/97 VVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLWDAA Rv1661|M.tuberculosis_H37Rv VVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAA MLBr_00135|M.leprae_Br4923 FAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLAPADAA MUL_2005|M.ulcerans_Agy99 FAQAALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVAGVLTLVDAA MAB_0939|M.abscessus_ATCC_1997 FAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSIEDGA Mvan_0269|M.vanbaalenii_PYR-1 FAQPAIFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSLEDGA Mflv_0405|M.gilvum_PYR-GCK FAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVAGVFSLEDGA MSMEG_0408|M.smegmatis_MC2_155 FAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFSLDDGA TH_4621|M.thermoresistible__bu RVQPTLFAIQVALAATMQSYGVRPGAVIGHSLGEVAAAVVAGALSLEDGV .*.:::.. :.* .: *. *:*** *: :** ***.:: *.. MMAR_2472|M.marinum_M RLVAARGRLMAGLAAGGAMVAVAASE----QEVTPLLGSGVAVAAVNGPD MAV_3108|M.avium_104 RLVAARGALMAALPPGGVMVAVTAGE----SQVGPLLGGGVSIAAVNGPD Mb1689|M.bovis_AF2122/97 AVVALRSRLLVRLGGAGGMVSLACGQPQA-EKLASQWGDRLNIAAVNGVS Rv1661|M.tuberculosis_H37Rv AVVALRSRLLVRLGGAGGMVSLACGQPQA-EKLASQWGDRLNIAAVNGVS MLBr_00135|M.leprae_Br4923 MLVVARGRLMQSMPAGGTMWAVAASE----DEVVSLLGEGVGIAAINAPE MUL_2005|M.ulcerans_Agy99 MLVVARGRLMQALPAGGAMVAVAAAE----DEVLPSLTDGVGIAAINAPK MAB_0939|M.abscessus_ATCC_1997 RLIAERGRLFGGLPAGGRMVAVFSDAKHV-EQIAGEFPR-VSVGAYNGPN Mvan_0269|M.vanbaalenii_PYR-1 RLMAERGRMFGSLPEGGRMVAVFTDAKLV-EEIAGDFPR-VSVGAYNGPN Mflv_0405|M.gilvum_PYR-GCK RLMAERGRLFGSLPEGGRMVAVFADAKRV-EQVAADFPR-VSVGAYNGPN MSMEG_0408|M.smegmatis_MC2_155 RLMAERGRMFGSLPEGGRMVAVFADAEHV-EQVAGEFPR-VSVGAYNGPN TH_4621|M.thermoresistible__bu KVICRRSRLCLRLAGAGAMAAIELPAQAVREFLAARGVDDVVLSVIASPE :: *. : : .* * :: . : : :.. . . MMAR_2472|M.marinum_M SVVISGPEAAVGEVVDRIAALGRRTHRLAVSHAFHSELMDPMLPDFAEVL MAV_3108|M.avium_104 AVVLSGEQEAVAAVADRLAGSGARVHRLAVSHAFHSALMEPMLDGFAAAA Mb1689|M.bovis_AF2122/97 SVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAAL Rv1661|M.tuberculosis_H37Rv SVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAAL MLBr_00135|M.leprae_Br4923 SVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFVRVA MUL_2005|M.ulcerans_Agy99 SVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPMLEEFARIA MAB_0939|M.abscessus_ATCC_1997 -TVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILDEFESYA Mvan_0269|M.vanbaalenii_PYR-1 -TVLSGPGEDLEQIVDRFGDDGVRCTWLQTSHAFHSELLDPVLDEFESYA Mflv_0405|M.gilvum_PYR-GCK -TVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLDEFESYA MSMEG_0408|M.smegmatis_MC2_155 -TVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDEFEAYA TH_4621|M.thermoresistible__bu STVIGGATDTVRELVAAWEAQGVMAREVAVDVASHSPQVDPILDELEEIL .*:.* : * : .. * ** ::.: : MMAR_2472|M.marinum_M KGVSASQPRISLVSNVTGQLAEAG--YGSAAYWVEHVRKPVRFADSVALA MAV_3108|M.avium_104 AGIEPRPPRIPLVSNLTGQLAGPG--YGTPQYWVDHVRRPVRFVDGVRLA Mb1689|M.bovis_AF2122/97 RGIEPRTSTVAFFSTVTGELMDTA--GVNAEYWYRSIRQPVQFERAVRNA Rv1661|M.tuberculosis_H37Rv RGIEPRTSTVAFFSTVTGELMDTA--GVNAEYWYRSIRQPVQFERAVRNA MLBr_00135|M.leprae_Br4923 AQVEVRKPQIGLVSNVTGELAGPD--FGSPQYWGEHVSRAVRFVDSARHL MUL_2005|M.ulcerans_Agy99 AQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAVRFADSARQL MAB_0939|M.abscessus_ATCC_1997 AQVQFAAPTLPLVCNRTGAVLTAQT-PIDGQYWRRHSRQPVQFAESVRTV Mvan_0269|M.vanbaalenii_PYR-1 AQFQFATPTLPLVCNRTGTVLTAQT-PLDAQYWRRHSRQPVQFAESVRTV Mflv_0405|M.gilvum_PYR-GCK AQLQFAAPTLPLVCNRTGAVLTGQT-SLDAQYWRRHSRQPVQFAESVRTV MSMEG_0408|M.smegmatis_MC2_155 AQFQFAAPTLPLVCNRTGAVLTGQT-PLDAQYWRRHSRQPVQFAESVRTV TH_4621|M.thermoresistible__bu ADLQPMTPTVPYYSATSYDPREKP--VCDADYWVDNLRHEVRFAAAVQAA .. . : . : ** : *:* .. MMAR_2472|M.marinum_M ESLGAAAFVEVGPSGGLTALVEQSLT------RETP-AVPLLIKDRPEND MAV_3108|M.avium_104 ESQGAGVFLEVGPGAALTSAVEQSLT------SDRAMSVVTMPKGRPEVD Mb1689|M.bovis_AF2122/97 FDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGVG Rv1661|M.tuberculosis_H37Rv FDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGVG MLBr_00135|M.leprae_Br4923 QTLGATHFIESGPSSGLMGAIEQSLA------PAEAVVVSMMGKDRPELA MUL_2005|M.ulcerans_Agy99 HTLGVTHFVEVGPGSGLTGSIEQSLA------PAEAVVVSMLGKDRPEVA MAB_0939|M.abscessus_ATCC_1997 AALGCSVLMEIGPQPVLTGAAVQVWP----EHLAPPRAIVSLRKGVEDRR Mvan_0269|M.vanbaalenii_PYR-1 AALGCSVLMEIGPQPVLTGSAVQVWP----EHLAAPRAIVSLRKGVSDRR Mflv_0405|M.gilvum_PYR-GCK AALGCSVLMEIGPQPVLTGAAVQVWP----EHLAAPRAIASLRKGVADRR MSMEG_0408|M.smegmatis_MC2_155 AALGCSVLMEIGPQPVLTGAAVQVWP----EHMAAPRAVASLRKGVADRR TH_4621|M.thermoresistible__bu LEDGFRVFGELSPHPLLTRAVEQTARG----LDMPVAALPAMRREQEMPH * : * .* * : : : : MMAR_2472|M.marinum_M ALLLGLGQLFADGRALDWREAFAGLGAQRTDLPTYGFVRRRYWLKELGVD MAV_3108|M.avium_104 SLLTAAARLFTAGADVRWSAAFTGLHARRVDLPTYAFARRRFWLSGDAVG Mb1689|M.bovis_AF2122/97 RFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGAV Rv1661|M.tuberculosis_H37Rv RFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGAV MLBr_00135|M.leprae_Br4923 SVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGTDG MUL_2005|M.ulcerans_Agy99 SVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWEVPGADG MAB_0939|M.abscessus_ATCC_1997 QIADALASAYVSGHRPNFAALQRHPR-RTVELPTYPFQRRRFWPK---SS Mvan_0269|M.vanbaalenii_PYR-1 QITEALAAAYVGGHRPDFGALYRRPG-RAVALPTYPFQRRRFWPK---TS Mflv_0405|M.gilvum_PYR-GCK QIADALAAAYIGGHKPDFAALHEQRG-VRLELPTYPFQRRRFWPK---SA MSMEG_0408|M.smegmatis_MC2_155 QIADALASAYVGGHRPDFAAVHRQPR-RPVELPTYPFQRRRFWPK---AS TH_4621|M.thermoresistible__bu GVRTMVGDLFAAGAAVDFAALYPSGRLVDAPLPTWTRRKLVLSRE----N . . . * : ***: : MMAR_2472|M.marinum_M QTKLTGAGLTGVGHPLLGAVVERPDVGG-LVLTGVLSPELHPWLRDHTVD MAV_3108|M.avium_104 SANIASLGLAEAEHPLLGAVLDRPDSGG-VVLTGRLSTAAQPWLADHAVA Mb1689|M.bovis_AF2122/97 GGDLGGVGLVGAEHGLLAAVVQRPDSGG-VVLTGRISVVAAPWLADHAVG Rv1661|M.tuberculosis_H37Rv GGDLGGVGLVGAEHGLLAAVVQRPDSGG-VVLTGRISVVAAPWLADHAVG MLBr_00135|M.leprae_Br4923 TASVSGLGLGSTEHALLGAVVERPDSGG-VVLTGRLSLANQPWLADHVIG MUL_2005|M.ulcerans_Agy99 PADATGLGLGGAEHALLGAVVERPDSGG-VVLTGRLALADQPWLADHVIG MAB_0939|M.abscessus_ATCC_1997 GTAIEGGGGLPSG--ILGRGED-LASGD-SVYISRLSVRSQPWLSDHVIY Mvan_0269|M.vanbaalenii_PYR-1 GITTDG--PAVSG--ILGSAKD-LASGD-TVYTSRWSVRSQPWLADHVIY Mflv_0405|M.gilvum_PYR-GCK GMAIDGRVGASAGSGILGSGKD-LASGD-SVYTSRLSVKTQPWLSDHVIY MSMEG_0408|M.smegmatis_MC2_155 SIAVDGG-TAASG--ILGSGKD-LASGD-TIYTSRLSVKSQPWLADHVIY TH_4621|M.thermoresistible__bu GEQQTRGGCTITVHPLLGTHVRLPEEPERHVWQADLGTGAQPWLADHQIH :*. : . . *** ** : MMAR_2472|M.marinum_M GVVLFPGAGFVELALRAGDEVG-CPLVQELTLLAPLALPQTGTVRMQLVV MAV_3108|M.avium_104 GTVLFPGAGFVELALRAGDEVG-CPVVEELTLSAPLSLPAGGTVQLQVVV Mb1689|M.bovis_AF2122/97 PVVLFPGTGFVELALRAGDEVG-CSVLQELTLQAPLVLPADG-VRVQVVV Rv1661|M.tuberculosis_H37Rv PVVLFPGTGFVELALRAGDEVG-CSVLQELTLQAPLVLPADG-VRVQVVV MLBr_00135|M.leprae_Br4923 GVVLFPGAGFVELVIRAGDEVG-CAGVEELVLAAPLVLHPGSGVQVQVVV MUL_2005|M.ulcerans_Agy99 GVVLFPGAGFVELAIRAGDEVG-CAVVEELVLAAPLVLHPGMGVQVQVIV MAB_0939|M.abscessus_ATCC_1997 GTVVVPGATYAAMALAAVGTP---ARAKDVFFYEPIILPEKSSREVQLTL Mvan_0269|M.vanbaalenii_PYR-1 GTVVVPGATYAAMALAAVGTP---ARVKDVFFYEPIILPEKASREVQLTL Mflv_0405|M.gilvum_PYR-GCK GTVVVPGATYAAMALAAVGTP---AHAKDVFFYEPIILPEKSSREVQLTV MSMEG_0408|M.smegmatis_MC2_155 GTVVVPGATYAAMALAAVGTP---ARLKDVFFYEPIILPEKASREVQLTL TH_4621|M.thermoresistible__bu TVAALPGAAYCEMALAAAREVIDSDGVEVRDVRFEQMLLLDEQTEVSAVA .. .**: : :.: * : . * .:. MMAR_2472|M.marinum_M GGAD-ESGRRTVSVFSSTADGD---SWVLHAEGVLRASGVGHGVDLS--- MAV_3108|M.avium_104 ADAAGQPGSRSVAVYSRVAQS----EWTLHAEGVLSEAAPAPAAELS--- Mb1689|M.bovis_AF2122/97 GGVE-QSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELS--- Rv1661|M.tuberculosis_H37Rv GGVE-QSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELS--- MLBr_00135|M.leprae_Br4923 AAAD-ESSRRAVSVYSRGDQSHGG--WLLNAEGLLEVDAAEATVDLS--- MUL_2005|M.ulcerans_Agy99 GTAD-DSGNRALSVYSRGDKSED---WLLNAEGMLGVEAASSGADLS--- MAB_0939|M.abscessus_ATCC_1997 HPLE-DGSGSKFQVHSR-PYGERDVDWSLNAEGTVVTGIGDDAEPAPEAA Mvan_0269|M.vanbaalenii_PYR-1 HPSE-DG-GQKFQVHSR-EYGERGTEWSLNAEGTVASGVDENPQ-----A Mflv_0405|M.gilvum_PYR-GCK HPSV-DG-ESKFQVHSR-PYGERGAEWALNAEGVVASGVGDSPAAAG--- MSMEG_0408|M.smegmatis_MC2_155 HPAD-GGSVLSFQIHSR-PYGERGADWSLNAEGTVDTAGSDPDAAAD--- TH_4621|M.thermoresistible__bu SAVEPGTLEFAVETAKDGEHERRATAVLGAADDTEPPQAHDIDALLA--- . . *:. MMAR_2472|M.marinum_M ------VWPPVGASAVDVSDVYDRFAARGYGYGPAFRG-LRSVWRRG--R MAV_3108|M.avium_104 ------VWPPADAEAVDVAGGYDDLAGRGYGYGPAFRG-LRAVWRRG--A Mb1689|M.bovis_AF2122/97 ------VWPPVGARAMDVADGYQVLAARGYGYGPAFRG-LQALWRRG--A Rv1661|M.tuberculosis_H37Rv ------VWPPVGARAMDVADGYQVLAARGYGYGPAFRG-LQALWRRG--A MLBr_00135|M.leprae_Br4923 ------LWPPEGAESVDISDAYPQLAERGYAYGPAFQG-LVAIWRRG--S MUL_2005|M.ulcerans_Agy99 ------VWPPEGAESVDISDGYAQLADRGYAYGPGFQG-LVGVWRRD--S MAB_0939|M.abscessus_ATCC_1997 EPAEPVDAAIERMERMRPMELFEIFADLELAWGPTWSGSLKSLWLGE--G Mvan_0269|M.vanbaalenii_PYR-1 EPSGPVDEAIERLNRMRPQDLFETFADMELAWGPTWSGSLKSLWLGE--G Mflv_0405|M.gilvum_PYR-GCK DLEDPVDEAIERLNRMRPQELFETFADLELAWGPTWSGSLKSLWLGE--G MSMEG_0408|M.smegmatis_MC2_155 EQSDPVDEVIERLERMRPQDLFETFADLELAWGPTWSGSLKSLWLGD--G TH_4621|M.thermoresistible__bu ----------EHPTRIEGDELRQWFDQRGVQFGPAFTGLTAARIPEGTVT : : :** : * . MMAR_2472|M.marinum_M EIYAEVVAPEDATVQG--FGIHPAVLD----AALHAWGFAT----ATDQL MAV_3108|M.avium_104 ETFAEVELPEQAGVSTGRFGIHPVLLD----AALHALGVAD----KRLET Mb1689|M.bovis_AF2122/97 EVFADVTLPEGVPIRG--FGIHPAVLD----AALHAWGIVE----GEQQT Rv1661|M.tuberculosis_H37Rv EVFADVTLPEGVPIRG--FGIHPAVLD----AALHAWGIVE----GEQQT MLBr_00135|M.leprae_Br4923 ELFAEVVAPTGVVVDG--MGMHPALLD----AVLHALGLAIENTQATTEM MUL_2005|M.ulcerans_Agy99 ELFAEVVAPSGVAVDK--MGMHPVVLD----AVLHALGLTAEQNPDSDET MAB_0939|M.abscessus_ATCC_1997 EAIGDVLVGEELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDL Mvan_0269|M.vanbaalenii_PYR-1 EAIGDILVGEELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVSDL Mflv_0405|M.gilvum_PYR-GCK EAIGDILVGAELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDL MSMEG_0408|M.smegmatis_MC2_155 EAVGDILVGAELAEQLGSEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDL TH_4621|M.thermoresistible__bu SVLAEVGLPGQIRSQQAPYGIHPALLD----ACFQSVAAHPDVQGAGSGL . .:: :**.::* . : : MMAR_2472|M.marinum_M MLPFSWQGVSLHAAGAARLRVRITP------ADAGSVSLELADPRGLPVL MAV_3108|M.avium_104 VLPFSWQGVSLHAAGASRVRVRLAP------AGAGAVSVELADASGVPVL Mb1689|M.bovis_AF2122/97 MLPFSWQGVCLHASGAARVRVRLAP------VGRGAVPVELADPQGLPVL Rv1661|M.tuberculosis_H37Rv MLPFSWQGVCLHASGAARVRVRLAP------VGRGAVSVELADPQGLPVL MLBr_00135|M.leprae_Br4923 RLPFCWRGVSLHAGGAGRVRARFTS------AGADAIAVDIADSAGLPVL MUL_2005|M.ulcerans_Agy99 KLPFCWRGVSLHAGGAGRVRARLTM------SGPDSISVEIADAAGLPVL MAB_0939|M.abscessus_ATCC_1997 FLPLRYGQVTLKEKMPRRFYCRARWHESPLDSETQVFDLDYLDRDGRHLG Mvan_0269|M.vanbaalenii_PYR-1 FLPLRYGQVTLRDKMPRRFYCRATWHTSELDSETQVFDLDFLDRDGRHLG Mflv_0405|M.gilvum_PYR-GCK YLPLRYGQVSLQEKMPRRFYCRATWHEAPLDSETQVFDLEYLDRDGRHLG MSMEG_0408|M.smegmatis_MC2_155 FLPLRYGQVTLAEKMPRRFYCRARWHRSALDSETQVFELEFVDLGGRALG TH_4621|M.thermoresistible__bu LLPLGVRRLQAFGPTRGARYCYARVTDAD--GSKAEADLDVLDEHGNVLL **: : :: * * : MMAR_2472|M.marinum_M SVKQLVVRAVSGEALSAAVIAAGGTISGR--------------------- MAV_3108|M.avium_104 SVRELVTRAVSAEQLAAAVAVRSG--SGE--------------------- Mb1689|M.bovis_AF2122/97 SVRQLMVRPVSAAALSRSTAGDRG-------------------------- Rv1661|M.tuberculosis_H37Rv SVRQLMVRPVSAAALSRSTAGDRG-------------------------- MLBr_00135|M.leprae_Br4923 TVRSLVTRAMTAEQLRTAVTAAGG-ALEQG-------------------- MUL_2005|M.ulcerans_Agy99 TVGALVTRAMSAAQLRAAVAEAGGGAPDQG-------------------- MAB_0939|M.abscessus_ATCC_1997 GIREFTVKRAPREALLRGLGGDATRLLYTLGWHEVAVPPVAGEGEESAAS Mvan_0269|M.vanbaalenii_PYR-1 GIREFTVKRAPREALLRGLGGDATRLLYTLGWHEVPAPASG-----DAAL Mflv_0405|M.gilvum_PYR-GCK GVREFTVKRAPREALLRGLGGDATRLLYTLGWHEVPVPESG----DGAAP MSMEG_0408|M.smegmatis_MC2_155 GIREFTVKRAPREALLRGLGGDATRLLYTLGWHEVPPPPSA------DDA TH_4621|M.thermoresistible__bu RVQGLLMGGAAADGDDRDRVLGERLLTIEWQRRDLPEADSAAG-KWLLVS : : . MMAR_2472|M.marinum_M ---LLEVAWPPTSPEL-SASD-------------------S--ARDVVVW MAV_3108|M.avium_104 ---LLDVAWSVIEPRN-SLPD-------------------NPISEGVTVW Mb1689|M.bovis_AF2122/97 ---LLEMIWTPVPLEGGDIGD-------------------DAVVWELPPH Rv1661|M.tuberculosis_H37Rv ---LLEMIWTPVPLEGGDIGD-------------------DAVVWELPPH MLBr_00135|M.leprae_Br4923 ---PMDLVWSPIPLSSDGHGG-GLPSVVSWADYCAG----RGNDTGVVVW MUL_2005|M.ulcerans_Agy99 ---PLDVIWSPIPLSGSGTNGSAQPAVVSWADFCAGGDGGAAGDAGVVVW MAB_0939|M.abscessus_ATCC_1997 IGTWLIAGFDELAAKVPGCIPLNRETDPELLGEVLVAAKERGVPFSGVVW Mvan_0269|M.vanbaalenii_PYR-1 NGNWLIAGFDELAAGVPGCIPFDRSTDPEPLGQLLAQAHERGIGFSGVVW Mflv_0405|M.gilvum_PYR-GCK QGTWLIGGFDELAVSVPGCIPADR-TNPESLRQLLTDAHGRGLPFSGVVW MSMEG_0408|M.smegmatis_MC2_155 VGTWLIAGFDELAAKVPGCVPIDRNTDLQVLGEVLSQAHARGAGFSGVVW TH_4621|M.thermoresistible__bu TSATADVSATRLSDALKQAGAESTSMCWPQQADHADNVDRFRAGIADGVT MMAR_2472|M.marinum_M ES-------GSADGD--VAVGQRVNEALAKLQSWLA-----GDDPGVLVV MAV_3108|M.avium_104 EP-------AAVDGAGPAAVHAATHQALGVLQSRLA-----GEAGGVLVV Mb1689|M.bovis_AF2122/97 AG-------AQAGGDVLAAVYRGVHEVLEVLQSWLA-----SDATGLGVV Rv1661|M.tuberculosis_H37Rv AG-------AQAGGDVLAAVYRGVHEVLEVLQSWLA-----SDATGLGVV MLBr_00135|M.leprae_Br4923 EFGSAS-AGAQAPVDSVAAVYSATHAALQVLQFWFG-----QDRAGTLVV MUL_2005|M.ulcerans_Agy99 EP-------NPAGEDVVGPVYAATHAALEVLQSWFD-----GDRAGTLVV MAB_0939|M.abscessus_ATCC_1997 RAAGPGATES--TTESAARLEGEIAHLLSAVHTVQNSAQNGVKLPGGLWI Mvan_0269|M.vanbaalenii_PYR-1 RAAAPSADES--STAMAARIETEIADLLSAVHTVQN---GAVKLPGGLWI Mflv_0405|M.gilvum_PYR-GCK RAARSDGDES--DAEVAARLEAEIAELLGAVHTVQG---GEVKLPGGLWI MSMEG_0408|M.smegmatis_MC2_155 RCATPGRKESGSASAESARLEAEITNLLSAVHAAQG---PSVKLPGGLWI TH_4621|M.thermoresistible__bu GVVVLTGPKNGNPDDAAARRGSDYVRHLVRITRELA---EIDGDAPRLFV * : : MMAR_2472|M.marinum_M LTRGAVGLAGEGVTDLAGAAVWGLTRSAQAEHPG-RVVLVDTDD---SVD MAV_3108|M.avium_104 STRGAVGLPGEDVADLAGAAVWGLVRSAQAEHPG-RVVLVDTDG---SLD Mb1689|M.bovis_AF2122/97 VTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPG-RVVLVDTDG---SVA Rv1661|M.tuberculosis_H37Rv VTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPG-RVVLVDTDG---SVA MLBr_00135|M.leprae_Br4923 LTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHSG-KIVLIDTDS---AVD MUL_2005|M.ulcerans_Agy99 LTHGAVAMPGENVSDLAGAAVWGIVRSAQAENPG-RIVLVDADA---AVE MAB_0939|M.abscessus_ATCC_1997 VTERAVATESGEPVDPVQAALWGFGRTTINEEPALRAKLVDGDGSPEAVQ Mvan_0269|M.vanbaalenii_PYR-1 VTERAVATESGEPVDPVQAALWGFGRTTINEEPALRCRLVDVDGSPEAVL Mflv_0405|M.gilvum_PYR-GCK VTERAVATESGEPVDPVQAALWGFGRTAINEEPALRCRLVDCDGSPQAVQ MSMEG_0408|M.smegmatis_MC2_155 VTEHGVACESGEPVDPVQAALWGFGRTTINEEPALHCRLVDCDGSSEAVD TH_4621|M.thermoresistible__bu VTRGAQAVLPQDRPNLEQAGLRGLLRVIGAEHPHLRTTQIDIADDADLDR *. . . : *.: *: * *.. : :* MMAR_2472|M.marinum_M IADAVAC----GEPQLVVRSGVVHGARLRF---IDSGSGLELPEGP---W MAV_3108|M.avium_104 LATVIGC----GEPQLVVRDGVAYRARLRP---AGRRALLELPGPPAV-W Mb1689|M.bovis_AF2122/97 VEDAVGFGARSGEPQLVVRRGRVYAARLAP---VAAG--LTLPSASAGGW Rv1661|M.tuberculosis_H37Rv VEDAVGFGARSGEPQLVVRRGRVYAARLAP---VAAG--LTLPSASAGGW MLBr_00135|M.leprae_Br4923 VAVLADL----GESQLLVRCNTVHAARLSP---APQL--LALPVGES-MW MUL_2005|M.ulcerans_Agy99 AAELVAV----GEPQLVVRSGAAHAARLAP---AAPL--LAVPADES-AW MAB_0939|M.abscessus_ATCC_1997 ALARLLVTP-VDEPEIAVRQGKLLASRLLP---WSRTGHLTVPRGSD--Y Mvan_0269|M.vanbaalenii_PYR-1 ALAGLLAAP-VDEPELAVRQGKLLASRLLP---WARSGHLTVPRSAD--Y Mflv_0405|M.gilvum_PYR-GCK ALAALLSTP-VDEPELAVRQGKLLASRLLP---WSRSGHLTVPRGGD--Y MSMEG_0408|M.smegmatis_MC2_155 LLAALLAAPGIQEPEIAVRQGKLLASRLLP---WARSGHLTLPRGGD--F TH_4621|M.thermoresistible__bu VAVQLLGGG--AEDETAWRDGQWYTARLSLSPLRPEERKQAVVDCERDGM * : * . :** : MMAR_2472|M.marinum_M RLAVGGGGTLEDVLVQPCPR--ADLAAGQVRVAVGAAGVNFRDVLVALGM MAV_3108|M.avium_104 RLAAGDAGTLEDLAVQEHPA--AELAPGQVRVRVAAAGVNFRDVLVALGM Mb1689|M.bovis_AF2122/97 RLVAGGGGTLADVVVAPVAP--VELATGQVRVAVGAVGVNFRDVLVALGM Rv1661|M.tuberculosis_H37Rv RLVAGGGGTLADVVVAPVAP--VELATGQVRVAVGAVGVNFRDVLVALGM MLBr_00135|M.leprae_Br4923 RLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNFRDVVAALGM MUL_2005|M.ulcerans_Agy99 RLAAGGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAVGVNFRDVVAALGM MAB_0939|M.abscessus_ATCC_1997 VLAPTERGAIDNLRITEKEVP--APDEGYVQVRVEAAGLNFRDVLNVLGL Mvan_0269|M.vanbaalenii_PYR-1 VLAPTERGAIDNLRLTETDVA--PPAEGYVQVRVEAAGLNFRDVLNVLGL Mflv_0405|M.gilvum_PYR-GCK VLAPTERGAIDNLRLTDSEVP--PPAEGYVQVRVEAAGLNFRDVLNVLGL MSMEG_0408|M.smegmatis_MC2_155 VLAPTERGAIDNLRLTETDVP--EPDEGYVQVRVEAAGLNFRDVLNVLGL TH_4621|M.thermoresistible__bu RLEIRTPGDLETMELAAFDR--VPPGPGQIEVAVTASSINFADVLIAFGR * * : : : * :.* * * .:** **: .:* MMAR_2472|M.marinum_M YP---GGGA-LGAEGAGVVVEVGPGVEGLAVGDAVMG--LVGVVGSEAVV MAV_3108|M.avium_104 YP---GAAQ-LGAEGAGVVTEVGAGVTDVAVGDAVMG--IFGLVGSEAAV Mb1689|M.bovis_AF2122/97 YP---GGGE-LGVDGAGVVVEVGPGVTGLAVGDRVMG--LLGLVGSEAVV Rv1661|M.tuberculosis_H37Rv YP---GGGE-LGVDGAGVVVEVGPGVTGLAVGDRVMG--LLGLVGSEAVV MLBr_00135|M.leprae_Br4923 YP---GQAPPLGAEGAGVVIEIGPEVTGVAVGDAVMG--FLGGAGPLAVV MUL_2005|M.ulcerans_Agy99 YP---GAAPPLGAEGAGVVLEVGPQVSGVAVGDSVMG--FLGGAGPLSVV MAB_0939|M.abscessus_ATCC_1997 YP---GDPGPIGGDFAGIVTQLGEGVTGVEVGQRVYGS-MQGAFGSRFNV Mvan_0269|M.vanbaalenii_PYR-1 YP---GDPGPIGGDFAGTVTQLGSGVTGLEVGQRVYGF-MQGAFASRFNV Mflv_0405|M.gilvum_PYR-GCK YP---GDPGPIGGDFAGTVTQLGEGVTGLDVGQRVYGS-MQGAFASRFNV MSMEG_0408|M.smegmatis_MC2_155 YP---GDPGPIGGDFAGTVTQLGAGVSGLEIGQRVYGS-MQGAFASRFNV TH_4621|M.thermoresistible__bu YPTFDGRRPQLGTDFAGVVTAVGPDVTSHRVGDRVGGLSPNGCWSTFVTC ** * :* : ** * :* * . :*: * * * .. MMAR_2472|M.marinum_M DERLVTTVPAGWSLAQAAGVPVVFLTAFYGLSVLAGLKAGERVLIHAGAG MAV_3108|M.avium_104 DRRLVTRVPPGWSMAQAAGIPVVFLTAYYGLSVLAGLRAGQRVLVHAATG Mb1689|M.bovis_AF2122/97 DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTG Rv1661|M.tuberculosis_H37Rv DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTG MLBr_00135|M.leprae_Br4923 HQQLITQMPQGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLIHAGTG MUL_2005|M.ulcerans_Agy99 DQQLITRMPQGWSFAQAAAVPVVFLTALFGLQDLAKIQPGESVLIHAGTG MAB_0939|M.abscessus_ATCC_1997 PAQFLAPIPDGISGVEAATIPAAALTVRLSF-DWAQLKPGDKVLIHAASG Mvan_0269|M.vanbaalenii_PYR-1 PAQLLAPIPDGIGAVDAATIPAAALTARLAF-DWAQLKPGDRVLIHAASG Mflv_0405|M.gilvum_PYR-GCK PGQFLAPIPDGVSAVEAATIPAAALTVRLSF-DWAQVKSGDKVLIHAASG MSMEG_0408|M.smegmatis_MC2_155 PAQFLAPIPDGIGAVEAATIPAAALTVRLAF-DWAQLKPGDKVLIHAASG TH_4621|M.thermoresistible__bu DADLAVPLPDGLTEGQAAAVSTAHATAWYGLHDLARLGAGEKVLIHSATG : . :* * :** :... *. .: * : .*: **:*:.:* MMAR_2472|M.marinum_M GVGMAAVALAKYWGAEIFVTASR-GKWDTLRAMGFDDEHIGDSRSLEFEE MAV_3108|M.avium_104 GVGMAAVQLARHWGAEVFATASR-GKWDTLRAMGFDDAHIADSRTLDFEQ Mb1689|M.bovis_AF2122/97 GVGMAAVSLARYWGAEVFVTASR-AKWDTLRAMGFDDIHISDSRSLEFEE Rv1661|M.tuberculosis_H37Rv GVGMAAVSLARYWGAEVFVTASR-AKWDTLRAMGFDDIHISDSRSLEFEE MLBr_00135|M.leprae_Br4923 GVGMAAVQFARHWGVEIFVTASR-GKWDTLRDMGFDDDHIGDSRTLEFEE MUL_2005|M.ulcerans_Agy99 GVGMAAVQLARHWGVEIFVTASR-GKWDTLRAMGFDDDHIGDSRTLDFEE MAB_0939|M.abscessus_ATCC_1997 GVGLAAIQMAQQFGAEVFATAST-FKRATLRKLGVK--YVYDSRTTDFAD Mvan_0269|M.vanbaalenii_PYR-1 GVGLAAIQMAQQHGAVVFATAST-YKRATLRKLGVD--HVYDSRTTEFAD Mflv_0405|M.gilvum_PYR-GCK GVGLAAVQMAQQCGAEVYATAST-FKRATLRKLGVK--HVYDSRTTDFAE MSMEG_0408|M.smegmatis_MC2_155 GVGLAAIQMAQQSGAEVFATAST-FKRSTLRRLGVK--YVYDSRTTDFAD TH_4621|M.thermoresistible__bu GVGLAAIAIARSVGAQIYATAGSPARRDLLRDMGIE--HVYDSRSTAFAD ***:**: :*: *. ::.**. : ** :*.. :: ***: * : MMAR_2472|M.marinum_M KFRKTSGGAGVDVVLNSLAGE-FTDASLRLLVSGGRFIEMGKTDLRDPQA MAV_3108|M.avium_104 KFGAAPG--GMDVVLNSLAGE-FNDASLRLLGPGGRFIEMGKTDLRDPDV Mb1689|M.bovis_AF2122/97 AFLRATEGSGVDVVLNSLAGE-FTDASLRLLPSGGRFIELGKTDIRDGQT Rv1661|M.tuberculosis_H37Rv AFLRATEGSGVDVVLNSLAGE-FTDASLRLLPSGGRFIELGKTDIRDGQT MLBr_00135|M.leprae_Br4923 KFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDIRDAQE MUL_2005|M.ulcerans_Agy99 KFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDIRDADK MAB_0939|M.abscessus_ATCC_1997 QILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDIWTTEQ Mvan_0269|M.vanbaalenii_PYR-1 QILADTDGEGVDVVLNSLTNEGFIEATVRATAQNGRFAEIAKRDIWTPEQ Mflv_0405|M.gilvum_PYR-GCK QILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDIWTVEQ MSMEG_0408|M.smegmatis_MC2_155 QILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDIWSHEQ TH_4621|M.thermoresistible__bu EIRRDTDGYGVDVVLNSLPGA-AQRAGLELLSFGGRFIEIGKRDIYGDTR : . *:****:**.. * :. *** *:.* *: MMAR_2472|M.marinum_M VADE--YPGVSYRAFDLMEAG---PDAIARMLSEVVGLLQEG------IL MAV_3108|M.avium_104 VARA--HPGVRYRAFDLMEAG---PDRIAAMLAEVMELFAAG------AL Mb1689|M.bovis_AF2122/97 VAER--HRGVRYRAFDLVEAG---PDRIAAMLSEVVGLLAAG------VL Rv1661|M.tuberculosis_H37Rv VAER--HRGVRYRAFDLVEAG---PDRIAAMLSEVVGLLAAG------VL MLBr_00135|M.leprae_Br4923 IAAN--YPGVQYRAFDLSEAG---PVRMQEMLCEVRELFDTQ------VL MUL_2005|M.ulcerans_Agy99 IAAN--YPGVWYRAFDLSEAG---PVRMQEMLAEVRELFDTA------VL MAB_0939|M.abscessus_ATCC_1997 MAQS--RPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKG------EW Mvan_0269|M.vanbaalenii_PYR-1 MAAA--RPDIAYEIVALDTVTLLEPERIRGLLGEVSDGLGKADGSSRAEW Mflv_0405|M.gilvum_PYR-GCK MAAA--RPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDG------AW MSMEG_0408|M.smegmatis_MC2_155 MAEA--RPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARG------EW TH_4621|M.thermoresistible__bu LGLFPFRRNLAFHGVDLGLMADSHPHKIRELLETVYRLTADG------VL :. .: :. . * * : :* * MMAR_2472|M.marinum_M KAPPLKLFDVRSAQQAYRYVSQARHIGKVVLTLPQG---------PAAQS MAV_3108|M.avium_104 TPLPVKAFDARCAADAYRFVSAARHIGKVVLTMPDG---------PAG-- Mb1689|M.bovis_AF2122/97 ARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDG---------PGGQS Rv1661|M.tuberculosis_H37Rv ARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDG---------PGGQS MLBr_00135|M.leprae_Br4923 HRLPVTSWDVRCAPAAFRFMSQARHIGKVVLTMPSA---------LADG- MUL_2005|M.ulcerans_Agy99 HRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSA---------LADG- MAB_0939|M.abscessus_ATCC_1997 TPLPAEIYPLTEARTAFRRMQQARHIGKIVCQMPNP---------LAPR- Mvan_0269|M.vanbaalenii_PYR-1 VPLPAEIYPLTEARAAFRRMQQARHVGKIVLQMPKP---------LQPR- Mflv_0405|M.gilvum_PYR-GCK TPLPAEVYPLTEARAAFRRMQQARHIGKIVVQIPNP---------LQPQ- MSMEG_0408|M.smegmatis_MC2_155 TPLPAEIYPITEARSAFRRMQQARHIGKIVLQVPKP---------LQPQ- TH_4621|M.thermoresistible__bu PMPQSTHYPLAEAATAIRVMSAAEHVGKLVLDVPHTGRADVVVPPEQASP : * * * :. *.*:**:* :* MMAR_2472|M.marinum_M VLSGGTVLITGGTGMAGAAVARHLVQRYGVGHVVLVSRAGTQAPGIADLV MAV_3108|M.avium_104 -LSGGTALITGATGMAGAALARHLVARHRVPHLMLVGRRGEAAPGMAELA Mb1689|M.bovis_AF2122/97 GLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVA Rv1661|M.tuberculosis_H37Rv GLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVA MLBr_00135|M.leprae_Br4923 -LAEGTVLITGASGAIGGVLARHMVSAYGVRHLVLASRRGDRAEGAVELA MUL_2005|M.ulcerans_Agy99 -LADATVLITGATGAVGAVLARHMLDGYGVRHLVLASRRGDRAEGAAELA MAB_0939|M.abscessus_ATCC_1997 --PDRTYLITGGLGAIGLHTAAYLAQ-LGAGDIVLTSRRAPDTDAQRVIG Mvan_0269|M.vanbaalenii_PYR-1 --ADRSYLITGGLGAIGLHTAAYLAQ-LGAGDLVLTSRRAPDADARRAIE Mflv_0405|M.gilvum_PYR-GCK --PDRSYLITGGLGAIGLHTAGYLAQ-LGAGDIVLTSRRAPDAAAQQAIA MSMEG_0408|M.smegmatis_MC2_155 --QDRSYLITGGLGAIGLHTAAYLAQ-LGAGDIVLTSRRDPDESAQRAID TH_4621|M.thermoresistible__bu FRSDGAYIVTGGMGGLGLYLAGEMAA-AGAGCIVLNGRSAPSGEALRTIE : ::**. * * * : . ::* .* : MMAR_2472|M.marinum_M AELQQGGAQVSVTACDVADRDAVAALLAQLPDRYP-LKGIFHAAGVLDDA MAV_3108|M.avium_104 AELRGAGASVSVLSCDVGDRDAVAAMLAQVPARYP-LRSVFHAAGVLDDA Mb1689|M.bovis_AF2122/97 ALLREGGAQVAVVSCDVADRDALAALLAGLDPRYP-LKGVFHAAGVLDDA Rv1661|M.tuberculosis_H37Rv ALLREGGAQVAVVSCDVADRDALAALLAGLDPRYP-LKGVFHAAGVLDDA MLBr_00135|M.leprae_Br4923 AELVGAGAKIQVVACDVADNDAVRGLFAQLSREFPPVRGVIHAAGVLDDG MUL_2005|M.ulcerans_Agy99 AELSEAGANVQVVACDVADRDAVEAMLARLSGEYPPVRGVIHAAGVLDDA MAB_0939|M.abscessus_ATCC_1997 EITERSKTRIHVFTADVGAESEVAGLLERIRAELPPLAGVAHLAGVLDDA Mvan_0269|M.vanbaalenii_PYR-1 EITERYKCRVHTFCADVGDESQVAELLARIRAELPPLAGVAHLAGVLDDA Mflv_0405|M.gilvum_PYR-GCK DIADRTKARLHVFTADVGVEADVAALLERIRAELPPLAGVAHLAGVLDDA MSMEG_0408|M.smegmatis_MC2_155 EITERHKCRIHTYAADVGDEAQVADLLARIRAELPPLAGIAHLAGVLDDA TH_4621|M.thermoresistible__bu QLRAAGTEVIVECGXXX--------------------RGQPVEVAVPTEL : . ..* : MMAR_2472|M.marinum_M VLASLTPDRVEPVLRAKAAG-AWNLHELTHGMDLAAFVMFSSLAGIAGAP MAV_3108|M.avium_104 VIASLTPARIDTVLRAKVDG-AWNLHELTKDLDLSAFVVFSSMAGIVGAP Mb1689|M.bovis_AF2122/97 VITGLTPDRVDTVLRAKVDG-AWNLHELTEDMDLSAFVVFSSMAGIVGTP Rv1661|M.tuberculosis_H37Rv VITGLTPDRVDTVLRAKVDG-AWNLHELTEDMDLSAFVVFSSMAGIVGTP MLBr_00135|M.leprae_Br4923 AITSLTPDRVDTVLRAKVDA-AWNLHEATRDLDLLMFVLCSSIAATVGSP MUL_2005|M.ulcerans_Agy99 VISSLTPERIDTVLRAKVDA-AWNLHEATLDLDLSMFVLCSSIAATVGSP MAB_0939|M.abscessus_ATCC_1997 LLGQQSVERFRTTLAPKAFG-AEYLDRLTKGDDLDFFIVSSSVSSLFGSP Mvan_0269|M.vanbaalenii_PYR-1 LLSQQSLERFRTTLAPKAFG-ACHLDRLTAGDDLDFFIMSSSVSSLFGSP Mflv_0405|M.gilvum_PYR-GCK LLSQQSVERFRTALAPKAFG-AVHLDRLTRVDDLDFFLVSSSVSSLFGSP MSMEG_0408|M.smegmatis_MC2_155 LLSAQNPERFRTTLAPKAYG-ASHLDRLTRDDDLDFFIVSSSVSSLFGSP TH_4621|M.thermoresistible__bu RHADEHPDRRGAQLCDEFARGEQGAQRNQHRTDAGEGQRDAHPPGAVGHD * . * : .. * : .. * MMAR_2472|M.marinum_M GQGNYAAANAFLDGLAAYRRGQDLPAVSIAWGLWEQPSTMTQHLGDRDLA MAV_3108|M.avium_104 GQGNYAAANSFLDALAIHRHAHGLPALSVAWGMWEEPSAMTAHLEERDKA Mb1689|M.bovis_AF2122/97 AQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRA Rv1661|M.tuberculosis_H37Rv AQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRA MLBr_00135|M.leprae_Br4923 GQGNYSAANAFLDGLAAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSRDLA MUL_2005|M.ulcerans_Agy99 GQGNYSAANSFLDGLAAHRQAAGLAGISVAWGLWEQSGGMAAHLSSRDLA MAB_0939|M.abscessus_ATCC_1997 GQSNYATANALLDGLIAQRRAQGLPATGINFGPWGQGGMASSEAATAN-- Mvan_0269|M.vanbaalenii_PYR-1 GQANYATANALLDGLTAHRRARGLPATGVNFGPWAQGGMASSEAATAN-- Mflv_0405|M.gilvum_PYR-GCK GQSNYATANAFLDGLVAQRRAQGLPATGVNFGPWARGGMASSEAAAAN-- MSMEG_0408|M.smegmatis_MC2_155 GQANYATANAMLDGLVAKRRAQGLVATGINFGPWGQGGMASSEAATAN-- TH_4621|M.thermoresistible__bu QPDPGALSDTGLD-----ERGGQFPGVGVQIPVADPG------------- : ::: ** .:. : . .: MMAR_2472|M.marinum_M RMRQVGLDPLSTEHALHLLDAALLGE--RPGVVAAQLNVAALSAN---PE MAV_3108|M.avium_104 RMSRAGLSALSTRQALDLLDDALLGE--QPLVVGTRLDRAALAQHR--AA Mb1689|M.bovis_AF2122/97 RMTQAGLAPLTTEQALGFLDTALQAD--RAVVVAARLDRAALAGAG--AA Rv1661|M.tuberculosis_H37Rv RMTQAGLAPLTTEQALGFLDTALQAD--RAVVVAARLDRAALAGAG--AA MLBr_00135|M.leprae_Br4923 RISRSGLAPMNPAQALELFDAALVID--HPFMVTALLDRAALDAQAQAGA MUL_2005|M.ulcerans_Agy99 RMSRSGLAPMNPEQAVGLLDAVLAIN--HPLMVATLLDRPALEARAQAGG MAB_0939|M.abscessus_ATCC_1997 -ISAQGLIPLDPSAALAALAEVVANGTGQATILKANWQRAAKVLGS---S Mvan_0269|M.vanbaalenii_PYR-1 -IGAQGLVPLEPSAALGALAEVLANGTGQAAVLKANWQRAAKVLGS---S Mflv_0405|M.gilvum_PYR-GCK -ISAQGLIPLEPSAALTAMAEVVANGTAQATVLKANWQRAAKVLGS---S MSMEG_0408|M.smegmatis_MC2_155 -ITAQGLIPLDPSAALHALAEVIANGSGQATVLKANWQRAAKVLGS---A TH_4621|M.thermoresistible__bu -------VGIDHRGAVRVDSGVPAQQGVDGEVVRHRTLSSVRSGRS---- : *: . :: .. MMAR_2472|M.marinum_M VPPIWRDLVTRSVRRVVD-ANDNSASMTALISRLHTLSPEQRSRELVDMI MAV_3108|M.avium_104 LPPLLSELAGRPARRMLE-HTD-MVSLTGLRARLAGMNPEQRQAELVELV Mb1689|M.bovis_AF2122/97 LPALFSQLAAGPTRRRID-AADTAVSMSGLVSRLHALTPERRQRELTDLV Rv1661|M.tuberculosis_H37Rv LPALFSQLAAGPTRRRID-AADTAVSMSGLVSRLHALTPERRQRELTDLV MLBr_00135|M.leprae_Br4923 LPPLFSRLVRRSRRRQIEDPGDATQSKLALVQRLQGLAANRQLELLVGVV MUL_2005|M.ulcerans_Agy99 LPPLFAGVVRRPRRRQIEDTGDAAQSKSALAERLNGLSAGERQDALVGLV MAB_0939|M.abscessus_ATCC_1997 RPPILDLVLPSAVGEVTG--------DSELLKQLMEIPVPQRAGFVTEFL Mvan_0269|M.vanbaalenii_PYR-1 RPPILDLVLPRPEGEVAG--------DSELLRQLQEIPVAQRAGFVTEFL Mflv_0405|M.gilvum_PYR-GCK RPPILDLVLPSAVGEITG--------DSELLKQLQEIPVPQRAGFVTEFL MSMEG_0408|M.smegmatis_MC2_155 RPPILDLVLPSAAGEATG--------DSELLKQLMEIPIPQRAGFVTEFL TH_4621|M.thermoresistible__bu -----SRWTAPGSRCGSG-------------RRYGGESCRRTTGPAAGAA : . . MMAR_2472|M.marinum_M CTNAATVLG-NASVDIDANKPFQDLGFDSLTAVELRNRLKSSTG--LTLS MAV_3108|M.avium_104 CGNAAAVLG-HSTADVDPGDAFSDLGFDSLTAVELRNRLKIATG--LTLS Mb1689|M.bovis_AF2122/97 ISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATG--LTLS Rv1661|M.tuberculosis_H37Rv ISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATG--LTLS MLBr_00135|M.leprae_Br4923 CLQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAVELRNRLKSATG--LTLP MUL_2005|M.ulcerans_Agy99 CLQAAAVLGRPSPEDIDPEAGFQDLGFDSLTAVELRNRFKSATG--LTLP MAB_0939|M.abscessus_ATCC_1997 QREVQNFLRLAQPP--AATSRFLDLGTDSLMAIELRNRLHSQFGGKFTIN Mvan_0269|M.vanbaalenii_PYR-1 QREVQNFLRLAQPP--AATSRFLDLGTDSLMAIELRNRLHSQFGGAFTIN Mflv_0405|M.gilvum_PYR-GCK QKEVQNFLRLAQPP--AATSRFLDLGTDSLMAIELRNRLHSQFGGAFTIN MSMEG_0408|M.smegmatis_MC2_155 QREVQNFLRLASPP--AASSRFLDLGTDSLMAIELRNRLHSQFGGKFTIN TH_4621|M.thermoresistible__bu ARRGRTRRRRRPRRPPPPPDRVRHRAGPAHGPVRR--------------- . . . . . : .:. MMAR_2472|M.marinum_M PTLIFDYPTPAALAEHLSTQLSSLSPAAAD-----EQPNRLARFDAVARE MAV_3108|M.avium_104 PTVIFDHPTPAALAEHLGGQLTSAGPTPAAPAETAAPPDRSSRIDEVVSE Mb1689|M.bovis_AF2122/97 PTLIFDYPTPATLAEHLDSRLVTASGSDQQ--------SLSDRVDDITRE Rv1661|M.tuberculosis_H37Rv PTLIFDYPTPATLAEHLDSRLVTASGSDQQ--------SLSDRVDDITRE MLBr_00135|M.leprae_Br4923 PTVIFDHPTPTAVAEYVAQQMLKSRPAESG--------------DETSQA MUL_2005|M.ulcerans_Agy99 PTVIFDHPTPTAIAEYVGRQIPDSQATQAE--------------EE--KL MAB_0939|M.abscessus_ATCC_1997 ATAVFDYPTIGGLAEYLVGQLPDADA----------------ESAEAPPA Mvan_0269|M.vanbaalenii_PYR-1 ATAVFDYPTIGGLAEYLVGQLPDSDA----------------AAGETPAT Mflv_0405|M.gilvum_PYR-GCK ATAVFDYPTIGGLAEYLVAQLPD---------------------AETPQA MSMEG_0408|M.smegmatis_MC2_155 ATAVFDYPTIGGLAEYLVGQLPD---------------------AEAPET TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M LDSMINEPDWTAEDRERVSNRLHGLLADLTSPQSRGE--DHSHDDDISSA MAV_3108|M.avium_104 LQTLLTQPGLSPGDRAQLVTRLQSLLSTPPQPSGHPEFPEDAFDDDIATA Mb1689|M.bovis_AF2122/97 LVVLLDQPDLSANVKAHLRTRLQTMLTSLTTE-----------DDDIAAA Rv1661|M.tuberculosis_H37Rv LVVLLDQPDLSANVKAHLRTRLQTMLTSLTTE-----------DDDIAAA MLBr_00135|M.leprae_Br4923 VEPKVEEVSVHA-------------------------------------- MUL_2005|M.ulcerans_Agy99 PESDGEMVSVTA-------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VESAEAESGAGPAAASDAVSELKE-------------------------- Mvan_0269|M.vanbaalenii_PYR-1 ETSPIDHNHPDREADSPG-------------------------------- Mflv_0405|M.gilvum_PYR-GCK APQSESEPGPDVTE------------------------------------ MSMEG_0408|M.smegmatis_MC2_155 A------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_2472|M.marinum_M SESELFAILDEELGP MAV_3108|M.avium_104 TDSQLFAILDDEAGP Mb1689|M.bovis_AF2122/97 TESQLFAILDEELGS Rv1661|M.tuberculosis_H37Rv TESQLFAILDEELGS MLBr_00135|M.leprae_Br4923 --------------- MUL_2005|M.ulcerans_Agy99 --------------- MAB_0939|M.abscessus_ATCC_1997 --------------- Mvan_0269|M.vanbaalenii_PYR-1 --------------- Mflv_0405|M.gilvum_PYR-GCK --------------- MSMEG_0408|M.smegmatis_MC2_155 --------------- TH_4621|M.thermoresistible__bu ---------------