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RRHGWSGDIPADDEEAVARILTATRRAIDERGTVSVSQVASTLGVTRQTIYRYFPTHEALLGATALSAVE GFLDRLAAHLGSITDPTEAVVEGIAYTFEQLAHDRYLSLVFQPGKASAFTAGVTSDIAISFGRSILQRFE VDWGAAGFADAGLDELVEVMLRTLQSLIVDPGRPPRTGAELRRFLQDWVAPAVRAHAISR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1115 | - | - | 100% (201) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_2960 | - | 9e-56 | 51.28% (195) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_4189 | - | 5e-38 | 41.62% (197) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1606 | - | 9e-57 | 56.41% (195) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1255c | - | 9e-07 | 25.00% (188) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_01070 | - | 2e-05 | 29.51% (122) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4765 | - | 6e-44 | 46.43% (196) | putative regulatory protein TetR |
| M. marinum M | MMAR_0226 | - | 7e-40 | 43.15% (197) | hypothetical protein MMAR_0226 |
| M. smegmatis MC2 155 | MSMEG_5854 | - | 4e-64 | 59.69% (196) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1262 | - | 4e-60 | 56.41% (195) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4888 | - | 2e-33 | 40.88% (181) | hypothetical protein MUL_4888 |
| M. vanbaalenii PYR-1 | Mvan_4911 | - | 1e-78 | 73.10% (197) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1115|M.avium_104 ------------MRRHGWSGDIPADDEEAVARILTATRRAIDERGT--VS
Mvan_4911|M.vanbaalenii_PYR-1 ------------MRRHGWAGNIPVDDDEAVSRIVAAARASIDARGT--VS
MSMEG_5854|M.smegmatis_MC2_155 ------------MRTHGWSGSAPATDEEAIARILAAAGKAIDERGAD-FS
TH_1262|M.thermoresistible__bu ------------MRTHGWGGSAPASDEEAIARILEAAKRTIEERGAE-FS
Mflv_1606|M.gilvum_PYR-GCK ------MAYSAFVRTHGWSGAKPASDDEAVARILEAAGKAIEERGAD-FS
MMAR_0226|M.marinum_M -----------MARRRGWNGAPPASDEEASRRIVDTAVRLIAETGSD-VS
MUL_4888|M.ulcerans_Agy99 -----------MVSRPKRRGVSRIG------RGVRRHRRGIAETGSD-VS
MAB_4765|M.abscessus_ATCC_1997 -----------MARRRGWDGQPPSSDEEAAERIVAAAVKLIGETGSA-VS
Rv1255c|M.tuberculosis_H37Rv ------------MAGTDWLS--ARRTELAADRILDAAERLFTQRDPASIG
MLBr_01070|M.leprae_Br4923 MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFS
: : ..
MAV_1115|M.avium_104 VSQVASTLGVTRQTIYRYFPTHEALLGATALSA---VEGFLDRLAAHLGS
Mvan_4911|M.vanbaalenii_PYR-1 VSEVATELGITRQTVYRYFPTLDALLTGTALSA---VGGFLDRLAQDLAS
MSMEG_5854|M.smegmatis_MC2_155 IADVARTLGVTRQTVYRYFPSTDALLVAAAVHA---ASGFLDRLAAHLSG
TH_1262|M.thermoresistible__bu IADVARAVGVTRQTVYRYFPSTDALLVAAAMHA---AGDFLDRLAVHLQG
Mflv_1606|M.gilvum_PYR-GCK ISDVARTVGVTRQTVYRYFSSTEALLVAAAVHA---VDGFLDRLAAHLVG
MMAR_0226|M.marinum_M LAQVAASLGVIRQTVYRYYPTADALMRAAAIAS---VDGFLDRLTEAVRG
MUL_4888|M.ulcerans_Agy99 LAQVAASLGVIRQTVYRYYPTADALMRAAAIAS---VDGFLDRLTEAVRG
MAB_4765|M.abscessus_ATCC_1997 LADVAAELGVIRQTVYRYFPTADALMHAASLAS---VDGFLDRLTHVVRG
Rv1255c|M.tuberculosis_H37Rv MNEIAKAAGCSRATLYRYFDSREALRTAYVHRE---TRRLGREIMVKIAD
MLBr_01070|M.leprae_Br4923 VDELAKGAGISRPTFYFYFPSKNAVLLSLLDDLNMKSRSAVEALAEQLP-
: ::* * * *.* *: : :*: . : :
MAV_1115|M.avium_104 ITDPTEAVVEGIAYTFEQLAHDRYLSLVFQPGKASAFTAGVT-SDIAISF
Mvan_4911|M.vanbaalenii_PYR-1 ITDPAEAVVEGIAYTLEQLPHDRYLGLVMQPGKASAFAAGVT-SDVAISF
MSMEG_5854|M.smegmatis_MC2_155 ITDPVEAVTEAIATALEWVPQDKHLGLLISPGRADAHTESVT-SDVAVDF
TH_1262|M.thermoresistible__bu ITDPVEAVAEAIATTLEWLPEDTHIGLLVAPGRPTAHTESVT-SDVAIDF
Mflv_1606|M.gilvum_PYR-GCK VTDPPEAVTEAVATALEWLPREKYIGLIMAPG-GSTHVQSVT-SDIALRF
MMAR_0226|M.marinum_M MRDPAEAMAEAVMFTLRDVVRTPHLGILIAQPYAHTHPENLT-SEEAQVF
MUL_4888|M.ulcerans_Agy99 MRDPAEAMAEAVMFTLRDVVRTPHLGILIAQPYAHTHPENLT-SEEAQVF
MAB_4765|M.abscessus_ATCC_1997 ITDPAEALTEGVLYTLEEVTRTPHLGIMMSEPYAHSHTSDMT-SDEAQAF
Rv1255c|M.tuberculosis_H37Rv VVEPAERLLVSITTTLRMVRDNPALAAWFTTTRPPIGGEMAGRSEVIAAL
MLBr_01070|M.leprae_Br4923 -ADPAAVWRSAITAFFEVCGTHRAVAVAGAAAKATSPEVRRLWSTVMQQW
:* .: :. :. *
MAV_1115|M.avium_104 GRSILQRFEVDWGAAGFADAGLD-ELVEVMLRTLQSLIVDPGR-PPRTGA
Mvan_4911|M.vanbaalenii_PYR-1 GRSILERLNVDWAGAGFSGQSLD-ELVEFMLRTLQSFILDPGG-PDRHRG
MSMEG_5854|M.smegmatis_MC2_155 ARAMLRKFDVDWAGLGFGDDDLD-ELAEHLLRIIQSFIIDPGR-PPRTGA
TH_1262|M.thermoresistible__bu ANRMLRRFDVDWAAVGYSDADLD-ELAEHLLRVIQSFVIDPGR-PPRDGQ
Mflv_1606|M.gilvum_PYR-GCK ARDMVGRLDVDWTAAGFDEAELD-QLSEHLLRIIQSFVLDPGR-PPRRGD
MMAR_0226|M.marinum_M GVRMLERFDVDWAEYGFADESARHDLVEFLLRVLLSFFVAPNV-PSRSDD
MUL_4888|M.ulcerans_Agy99 GVRMLERFDVDWAEYGFADESARHDLVEFLLRVLLSFFVAPNV-PSRSDD
MAB_4765|M.abscessus_ATCC_1997 GLRMLDRFDVDWVQYGY-DDAAKRELVEFALRIMLSFFVSPNE-ATRSRD
Rv1255c|M.tuberculosis_H37Rv AAAFLN-------SLGPDDPTTVERRARWVVRMLTSLLMFPGRDEADERA
MLBr_01070|M.leprae_Br4923 IDYNTAAIQAER-KCGVAPDTIPAEDLAVALQLMTERVMAATFSDEKPLI
* :: : . .: .
MAV_1115|M.avium_104 ELRRFLQDWVAPAVRAHAISR-----
Mvan_4911|M.vanbaalenii_PYR-1 ELRAFLHRWVAPAVELHHRSGFPEQA
MSMEG_5854|M.smegmatis_MC2_155 TLRSYLRRWVGAAVKPAQASVQSPRV
TH_1262|M.thermoresistible__bu SLRAYLRRWVGAAVTGAR--------
Mflv_1606|M.gilvum_PYR-GCK ELRSYLRRWVGNALLRR---------
MMAR_0226|M.marinum_M ELKSFIKRWVGGAILAQKR-------
MUL_4888|M.ulcerans_Agy99 ELKSFIRRWVGGAIVAQKR-------
MAB_4765|M.abscessus_ATCC_1997 ELRGFLKRWLGGAVLAQGR-------
Rv1255c|M.tuberculosis_H37Rv MIAEFVVPIVTPASAAARKAGHPGPE
MLBr_01070|M.leprae_Br4923 PDKKVIDTLVHIWLASIYGS------
: :