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MGRVTGKVAVISGAARGQGRSHARMLAAEGADIIAVDLCADIETNEYPLARPEDLDETARLVEKEGQRAI TAVADVRDRVVLSAAIDAGVAEFGHLDIVVANAGICPLTAGLPPQAFADAVDVDLGGVLNLVHASLKHLR AGASIIVIGSNAAFMSSLNTSGAGSGIGGPGGAGYAFAKLAAAHYVNDFALALAPFSIRMNAVHPTNVNT DMLHSPPMYRAFRPDLPAPTREDAEPVFPLVQAMPVPYVEPEDISEAVLFLASDAARYITGQQLRVDAGG FLKVKPWSGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2946 | - | - | 100% (290) | carveol dehydrogenase |
| M. avium 104 | MAV_2598 | - | 3e-92 | 61.84% (283) | carveol dehydrogenase |
| M. avium 104 | MAV_1881 | - | 2e-90 | 59.15% (284) | carveol dehydrogenase ((+)-trans-carveol dehydrogenase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2771 | - | 2e-51 | 44.77% (277) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_2500 | - | 5e-86 | 57.95% (283) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2750 | - | 2e-51 | 44.77% (277) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 2e-14 | 27.64% (275) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_3081 | - | 9e-53 | 43.62% (282) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4754 | - | 3e-63 | 50.00% (286) | short-chain type dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_4801 | - | 8e-87 | 58.51% (282) | carveol dehydrogenase |
| M. thermoresistible (build 8) | TH_3929 | - | 2e-96 | 63.03% (284) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3392 | fabG | 2e-49 | 41.99% (281) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_2006 | - | 2e-98 | 60.55% (289) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3392|M.ulcerans_Agy99 --------------------------------------------------
MAB_3081|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2946|M.avium_104 --------------------------------------------------
Mvan_2006|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3929|M.thermoresistible__bu --------------------------------------------------
Mflv_2500|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4801|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4754|M.marinum_M --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb2771|M.bovis_AF2122/97 ------------------------------------MIDR-------PLE
Rv2750|M.tuberculosis_H37Rv ------------------------------------MIDR-------PLE
MUL_3392|M.ulcerans_Agy99 ---------------------------------MSRPLDG-------PLS
MAB_3081|M.abscessus_ATCC_1997 --------------------------------------MG-------KLD
MAV_2946|M.avium_104 -----------------------------------------MG----RVT
Mvan_2006|M.vanbaalenii_PYR-1 -----------------------------------------MG----KLD
TH_3929|M.thermoresistible__bu -----------------------------------------MN----RLT
Mflv_2500|M.gilvum_PYR-GCK -----------------------------------------MG----RVQ
MSMEG_4801|M.smegmatis_MC2_155 -----------------------------------------MGSAEGRVA
MMAR_4754|M.marinum_M -------------------------------------MTEQLG---GRVA
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
:
Mb2771|M.bovis_AF2122/97 GKVAFITGAARGLGRAHAVRLA----------------------------
Rv2750|M.tuberculosis_H37Rv GKVAFITGAARGLGRAHAVRLA----------------------------
MUL_3392|M.ulcerans_Agy99 GRVAFITGAARGQGRAHALRLA----------------------------
MAB_3081|M.abscessus_ATCC_1997 GKVAFITGAARGQGRAHAIKLA----------------------------
MAV_2946|M.avium_104 GKVAVISGAARGQGRSHARMLA----------------------------
Mvan_2006|M.vanbaalenii_PYR-1 NKVAVVSGAARGQGRSHAVSLA----------------------------
TH_3929|M.thermoresistible__bu GKVVAITGAARGQGRSHAVHMA----------------------------
Mflv_2500|M.gilvum_PYR-GCK GKVAFITGAARGQGRSHAVRLA----------------------------
MSMEG_4801|M.smegmatis_MC2_155 GKVAFITGAARGQGRSHAVRLA----------------------------
MMAR_4754|M.marinum_M GKVAFITGAARGQGRSHAVRLA----------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
. .: *. **. :
Mb2771|M.bovis_AF2122/97 --ADGANIIAVDICEQIAS-------------------------------
Rv2750|M.tuberculosis_H37Rv --ADGANIIAVDICEQIAS-------------------------------
MUL_3392|M.ulcerans_Agy99 --RDGADVIAVDLCDQIAS-------------------------------
MAB_3081|M.abscessus_ATCC_1997 --SEGASIIAVDICAQIPS-------------------------------
MAV_2946|M.avium_104 --AEGADIIAVDLCADIET-------------------------------
Mvan_2006|M.vanbaalenii_PYR-1 --AEGAHIIALDICADLEG-------------------------------
TH_3929|M.thermoresistible__bu --DEGADIIALDICADIAT-------------------------------
Mflv_2500|M.gilvum_PYR-GCK --EEGADIIAVDICRDYDT-------------------------------
MSMEG_4801|M.smegmatis_MC2_155 --EEGADIIAVDLCQDIDS-------------------------------
MMAR_4754|M.marinum_M --QEGADIIAVDVCKPIVEN------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
** : : :.
Mb2771|M.bovis_AF2122/97 VPYPLSTADDLAATVELVEDAGGGIVARQGDVRDRA----------SLSV
Rv2750|M.tuberculosis_H37Rv VPYPLSTADDLAATVELVEDAGGGIVARQGDVRDRA----------SLSV
MUL_3392|M.ulcerans_Agy99 VPYPLGTAEELATTVKLVEDTGARIVASQADVRDRE----------ALAA
MAB_3081|M.abscessus_ATCC_1997 VEYPMATTEDLDLTVKEVDALGRAISAHETDVRDRE----------ALQA
MAV_2946|M.avium_104 NEYPLARPEDLDETARLVEKEGQRAITAVADVRDRV----------VLSA
Mvan_2006|M.vanbaalenii_PYR-1 NTYPLSRPEDLDETARLAEKEGVRVHTAIVDVRERA----------AVWK
TH_3929|M.thermoresistible__bu NEYPLATREDLEETARLVEKAGRRAITAEVDVRDRA----------RLKQ
Mflv_2500|M.gilvum_PYR-GCK VGYRMATPEDLEETKNFVEKTGQRIVTAQADVRNEA----------ELRA
MSMEG_4801|M.smegmatis_MC2_155 IGYSLATPEDLEETARYVEKAGRRIVTAQADVRDAA----------QLKE
MMAR_4754|M.marinum_M TTIPASTPEDLAETADLVKGHNRRIFTAEADVRDYD----------ALKA
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
* . . : :*
Mb2771|M.bovis_AF2122/97 ALQAGLDEFG---------------------------RLDIVVANAGIAM
Rv2750|M.tuberculosis_H37Rv ALQAGLDEFG---------------------------RLDIVVANAGIAM
MUL_3392|M.ulcerans_Agy99 ALQAGIDELG---------------------------QVDIVVANAGIAP
MAB_3081|M.abscessus_ATCC_1997 AFDAGVHDLG---------------------------PVDIVVANAGIAT
MAV_2946|M.avium_104 AIDAGVAEFG---------------------------HLDIVVANAGICP
Mvan_2006|M.vanbaalenii_PYR-1 AVADGVDALG---------------------------RLDIVVANAGICP
TH_3929|M.thermoresistible__bu VLDDAVAELG---------------------------GLHVVVANAGICP
Mflv_2500|M.gilvum_PYR-GCK ALEAGLAEFG---------------------------KVDIVVAQAGIAA
MSMEG_4801|M.smegmatis_MC2_155 ALERGVSELG---------------------------KLDIVVAQAGIAA
MMAR_4754|M.marinum_M AVDAGVDELG---------------------------RLDIIVANAGIGN
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
.. .* .::* :***
Mb2771|M.bovis_AF2122/97 MQ--A---GDDGWRDVIDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSA
Rv2750|M.tuberculosis_H37Rv MQ--A---GDDGWRDVIDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSA
MUL_3392|M.ulcerans_Agy99 MQ--S---GDDGWRDVIDVNLSGAYYTVEVAIPTMIEQGRGGSIVLISSA
MAB_3081|M.abscessus_ATCC_1997 LTPEC---GDDGWRDVLDVNLTGVYHTIEVARPSMVQRGAGGSIVLTSSV
MAV_2946|M.avium_104 LTAGL---PPQAFADAVDVDLGGVLNLVHASLKHLRAGA---SIIVIGSN
Mvan_2006|M.vanbaalenii_PYR-1 MGRGQ---TIQSWSDAIDTDLVGVFNVIQASLPHVNDGA---SIIATGSL
TH_3929|M.thermoresistible__bu QGNHL---PYKAYIDAFDVDFVGVVNTIHVGLDYLGEGG---SVIVTGSI
Mflv_2500|M.gilvum_PYR-GCK MKGQP---AMQAWTDGINTNFVGTINAIQVALPHLKEGA---SIIATASA
MSMEG_4801|M.smegmatis_MC2_155 MKGNP---PLQAWTDGINTNLVGTINAIQVALPHLSEGA---SIVATASA
MMAR_4754|M.marinum_M GGATLDKTSEHDWQEMIDVNLSGVWKSVKAAVPHLIAGGNGGSIVLTSSV
MLBr_02565|M.leprae_Br4923 DKLLAN-MDDCRWDAVLEVNLLAPQRLTEGLVGNGSISK-GGRVIVLSSM
: .:.:: . . :: .*
Mb2771|M.bovis_AF2122/97 AGLVGIGSSD--------PGSLGYAAAKHGVVGLMRAYANHLAPQNIRVN
Rv2750|M.tuberculosis_H37Rv AGLVGIGSSD--------PGSLGYAAAKHGVVGLMRAYANHLAPQNIRVN
MUL_3392|M.ulcerans_Agy99 AGLVGISSAD--------AGAIGYVASKHALVGLMRVYANLLAPHSIRVN
MAB_3081|M.abscessus_ATCC_1997 AGLTGMVMDN--------PGGLAYTAAKHGLVGLMRSYANMLAPHNIRVN
MAV_2946|M.avium_104 AAFMSSLNTSGAGSGIGGPGGAGYAFAKLAAAHYVNDFALALAPFSIRMN
Mvan_2006|M.vanbaalenii_PYR-1 AAQLGSATNQ-------GPGGSAYSLAKQVVAHYVNDLSIQLAKRMIRVN
TH_3929|M.thermoresistible__bu AGLVDQKDMANGG-GPSGPGGAGYGMAKKMVRDYTKALALTLAPHKIRIN
Mflv_2500|M.gilvum_PYR-GCK AALMDAHNKPNPG---GDPGGMGYMISKRLISEYVHALATELAVRGIRAN
MSMEG_4801|M.smegmatis_MC2_155 AALMDAHNKPNPG---ADPGGMGYMVSKRMISEYVHYLATELTPLGIRAN
MMAR_4754|M.marinum_M GGMKAY------------PHCGNYVAAKHGVVGLMRSFAVELGQHMIRVN
MLBr_02565|M.leprae_Br4923 AGIAGN------------RGQTNYATAKAGVIGLTQALAPGLAEKGITIN
.. * :* . : * * *
Mb2771|M.bovis_AF2122/97 SVHPCGVDTPMINN-EFFQQWLT------TADMDAPHNLGNALPVELVQP
Rv2750|M.tuberculosis_H37Rv SVHPCGVDTPMINN-EFFQQWLT------TADMDAPHNLGNALPVELVQP
MUL_3392|M.ulcerans_Agy99 SLHPSGVDPPMINN-EFIRHWLADL----VAETGSGPGAGNALPVQILQA
MAB_3081|M.abscessus_ATCC_1997 TIHPSGVATPMLIN-PVTEKLFAD------GSPEGMSDTGNALPVVLMEP
MAV_2946|M.avium_104 AVHPTNVNTDMLHSPPMYRAFRPDLPAPTREDAEPVFPLVQAMPVPYVEP
Mvan_2006|M.vanbaalenii_PYR-1 AIHPTNVNTDMLHNEGLYRVFRPDLKEPTREEAEEAFPAMQAMPIPYIEP
TH_3929|M.thermoresistible__bu AVHPTNVNTDMLHNMSMYRVFRPDLTEPTREDAEVVFPLLQAMPIPYVEP
Mflv_2500|M.gilvum_PYR-GCK VIHPTNCNTDMLQSEPMYRSFRPDLENPTRADAEPVFGVQQAMKVNFIEP
MSMEG_4801|M.smegmatis_MC2_155 VIHPTNCNTDMLQSEPMYRSFRPDLEHPTRADAEPVFYVQQAMKVPWVEP
MMAR_4754|M.marinum_M SVHPTHVRTPMLHNEGTFKMFRPDLENPGPDDMAPICQLFHTLPIPWVEA
MLBr_02565|M.leprae_Br4923 AVAPGFIETQMTAAIPLAT----------REVGRRLNSLLQGG-----LP
: * . * : .
Mb2771|M.bovis_AF2122/97 TDIANAVAWLASEEARYVTGVTLPVDAGFVNKR------
Rv2750|M.tuberculosis_H37Rv TDIANAVAWLASEEARYVTGVTLPVDAGFVNKR------
MUL_3392|M.ulcerans_Agy99 DDIAGALAWLVSDEARYITGVALPVDAGCVNKR------
MAB_3081|M.abscessus_ATCC_1997 EDMANTVAWLVSEDARYITGVALPVDAGFTNRR------
MAV_2946|M.avium_104 EDISEAVLFLASDAARYITGQQLRVDAGGFLKVKPWSGG
Mvan_2006|M.vanbaalenii_PYR-1 RDVSNAVVFLAGDDSRYITGTQLRIDAGGYVKAVPWKG-
TH_3929|M.thermoresistible__bu DDVSHAVVYLASDESRYVTGQQLFVDAGAGLKMGV----
Mflv_2500|M.gilvum_PYR-GCK EDISNAVLWLASDESRYVTGMQLRVDAGGYLKWYDYHV-
MSMEG_4801|M.smegmatis_MC2_155 SDISNAVLWLASDESRFVTGMQLRVDAGGYLKWYDYHV-
MMAR_4754|M.marinum_M EDISNAVLFLASDESRYITGVTLPVDAGGCLK-------
MLBr_02565|M.leprae_Br4923 VDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA------
*:: :: ::. :. :** : : .