For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
GRVQGKVAFITGAARGQGRSHAVRLAEEGADIIAVDICRDYDTVGYRMATPEDLEETKNFVEKTGQRIVT AQADVRNEAELRAALEAGLAEFGKVDIVVAQAGIAAMKGQPAMQAWTDGINTNFVGTINAIQVALPHLKE GASIIATASAAALMDAHNKPNPGGDPGGMGYMISKRLISEYVHALATELAVRGIRANVIHPTNCNTDMLQ SEPMYRSFRPDLENPTRADAEPVFGVQQAMKVNFIEPEDISNAVLWLASDESRYVTGMQLRVDAGGYLKW YDYHV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2500 | - | - | 100% (286) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4148 | - | 8e-85 | 54.74% (285) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2430 | - | 7e-65 | 47.55% (286) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2771 | - | 4e-58 | 46.01% (276) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2750 | - | 4e-58 | 46.01% (276) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 7e-11 | 26.55% (275) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_3081 | - | 1e-52 | 42.11% (285) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4754 | - | 5e-62 | 47.20% (286) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_2946 | - | 5e-86 | 57.95% (283) | carveol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4801 | - | 1e-141 | 84.91% (285) | carveol dehydrogenase |
| M. thermoresistible (build 8) | TH_4131 | - | 1e-141 | 84.97% (286) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3392 | fabG | 7e-55 | 43.88% (278) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_4158 | - | 1e-142 | 85.61% (285) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3392|M.ulcerans_Agy99 --------------------------------------------------
MAB_3081|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2500|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4158|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4131|M.thermoresistible__bu --------------------------------------------------
MSMEG_4801|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2946|M.avium_104 --------------------------------------------------
MMAR_4754|M.marinum_M --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb2771|M.bovis_AF2122/97 -------------------------------------------MIDRPLE
Rv2750|M.tuberculosis_H37Rv -------------------------------------------MIDRPLE
MUL_3392|M.ulcerans_Agy99 ----------------------------------------MSRPLDGPLS
MAB_3081|M.abscessus_ATCC_1997 ---------------------------------------------MGKLD
Mflv_2500|M.gilvum_PYR-GCK ---------------------------------------------MGRVQ
Mvan_4158|M.vanbaalenii_PYR-1 ---------------------------------------------MGRVQ
TH_4131|M.thermoresistible__bu ---------------------------------------------VGRVE
MSMEG_4801|M.smegmatis_MC2_155 -----------------------------------------MGSAEGRVA
MAV_2946|M.avium_104 ---------------------------------------------MGRVT
MMAR_4754|M.marinum_M ----------------------------------------MTEQLGGRVA
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
:
Mb2771|M.bovis_AF2122/97 GKVAFITGAARGLGRAHAVRLA----------------------------
Rv2750|M.tuberculosis_H37Rv GKVAFITGAARGLGRAHAVRLA----------------------------
MUL_3392|M.ulcerans_Agy99 GRVAFITGAARGQGRAHALRLA----------------------------
MAB_3081|M.abscessus_ATCC_1997 GKVAFITGAARGQGRAHAIKLA----------------------------
Mflv_2500|M.gilvum_PYR-GCK GKVAFITGAARGQGRSHAVRLA----------------------------
Mvan_4158|M.vanbaalenii_PYR-1 GKVAFITGAARGQGRSHAVRLA----------------------------
TH_4131|M.thermoresistible__bu GKVAFITGAARGQGRSHAVRLA----------------------------
MSMEG_4801|M.smegmatis_MC2_155 GKVAFITGAARGQGRSHAVRLA----------------------------
MAV_2946|M.avium_104 GKVAVISGAARGQGRSHARMLA----------------------------
MMAR_4754|M.marinum_M GKVAFITGAARGQGRSHAVRLA----------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
* .:: *. **. :
Mb2771|M.bovis_AF2122/97 --ADGANIIAVDICE-QIASVP----------------------------
Rv2750|M.tuberculosis_H37Rv --ADGANIIAVDICE-QIASVP----------------------------
MUL_3392|M.ulcerans_Agy99 --RDGADVIAVDLCD-QIASVP----------------------------
MAB_3081|M.abscessus_ATCC_1997 --SEGASIIAVDICA-QIPSVE----------------------------
Mflv_2500|M.gilvum_PYR-GCK --EEGADIIAVDICR-DYDTVG----------------------------
Mvan_4158|M.vanbaalenii_PYR-1 --EEGADIIAVDLCE-NVDTIG----------------------------
TH_4131|M.thermoresistible__bu --EEGADIIAVDICA-DIETIG----------------------------
MSMEG_4801|M.smegmatis_MC2_155 --EEGADIIAVDLCQ-DIDSIG----------------------------
MAV_2946|M.avium_104 --AEGADIIAVDLCA-DIETNE----------------------------
MMAR_4754|M.marinum_M --QEGADIIAVDVCKPIVENTT----------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
** : * :.
Mb2771|M.bovis_AF2122/97 --YPLSTADDLAATVELVEDAGGGIVARQGDVRDRA----------SLSV
Rv2750|M.tuberculosis_H37Rv --YPLSTADDLAATVELVEDAGGGIVARQGDVRDRA----------SLSV
MUL_3392|M.ulcerans_Agy99 --YPLGTAEELATTVKLVEDTGARIVASQADVRDRE----------ALAA
MAB_3081|M.abscessus_ATCC_1997 --YPMATTEDLDLTVKEVDALGRAISAHETDVRDRE----------ALQA
Mflv_2500|M.gilvum_PYR-GCK --YRMATPEDLEETKNFVEKTGQRIVTAQADVRNEA----------ELRA
Mvan_4158|M.vanbaalenii_PYR-1 --YPMATAEDLEETAAFVEKTGQRIVTAKADVRDAA----------QLKK
TH_4131|M.thermoresistible__bu --YSMAKPEDLEETAKLVEKTGRGVYTAQADVRNAD----------QLRT
MSMEG_4801|M.smegmatis_MC2_155 --YSLATPEDLEETARYVEKAGRRIVTAQADVRDAA----------QLKE
MAV_2946|M.avium_104 --YPLARPEDLDETARLVEKEGQRAITAVADVRDRV----------VLSA
MMAR_4754|M.marinum_M --IPASTPEDLAETADLVKGHNRRIFTAEADVRDYD----------ALKA
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
* . * : :*
Mb2771|M.bovis_AF2122/97 ALQAGLDEFG---------------------------RLDIVVANAGIA-
Rv2750|M.tuberculosis_H37Rv ALQAGLDEFG---------------------------RLDIVVANAGIA-
MUL_3392|M.ulcerans_Agy99 ALQAGIDELG---------------------------QVDIVVANAGIA-
MAB_3081|M.abscessus_ATCC_1997 AFDAGVHDLG---------------------------PVDIVVANAGIA-
Mflv_2500|M.gilvum_PYR-GCK ALEAGLAEFG---------------------------KVDIVVAQAGIA-
Mvan_4158|M.vanbaalenii_PYR-1 ALEDGIAQLG---------------------------GVDIVVAQAGIA-
TH_4131|M.thermoresistible__bu ALEGGLKEFG---------------------------KVDIVVAQAGVA-
MSMEG_4801|M.smegmatis_MC2_155 ALERGVSELG---------------------------KLDIVVAQAGIA-
MAV_2946|M.avium_104 AIDAGVAEFG---------------------------HLDIVVANAGIC-
MMAR_4754|M.marinum_M AVDAGVDELG---------------------------RLDIIVANAGIGN
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
*.: .* **:* :**:
Mb2771|M.bovis_AF2122/97 --MMQ--AGDDGWRDVIDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSA
Rv2750|M.tuberculosis_H37Rv --MMQ--AGDDGWRDVIDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSA
MUL_3392|M.ulcerans_Agy99 --PMQ--SGDDGWRDVIDVNLSGAYYTVEVAIPTMIEQGRGGSIVLISSA
MAB_3081|M.abscessus_ATCC_1997 --TLTPECGDDGWRDVLDVNLTGVYHTIEVARPSMVQRGAGGSIVLTSSV
Mflv_2500|M.gilvum_PYR-GCK --AMKGQPAMQAWTDGINTNFVGTINAIQVALPHLKEG--ASIIATASAA
Mvan_4158|M.vanbaalenii_PYR-1 --GMKGNPPMQAWTDVINTNLVGTINAIQVALPHLKEG--AAIVATGSTA
TH_4131|M.thermoresistible__bu --GMKGQPPLQAWTDVMNTNLVGTMNAIQVALPHLKEG--ASIIATASAA
MSMEG_4801|M.smegmatis_MC2_155 --AMKGNPPLQAWTDGINTNLVGTINAIQVALPHLSEG--ASIVATASAA
MAV_2946|M.avium_104 --PLTAGLPPQAFADAVDVDLGGVLNLVHASLKHLRAG--ASIIVIGSNA
MMAR_4754|M.marinum_M GGATLDKTSEHDWQEMIDVNLSGVWKSVKAAVPHLIAGGNGGSIVLTSSV
MLBr_02565|M.leprae_Br4923 -DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMA
: ::.:: . . . :. * .
Mb2771|M.bovis_AF2122/97 AGLVGIGSSDPGS-------LGYAAAKHGVVGLMRAYANHLAPQNIRVNS
Rv2750|M.tuberculosis_H37Rv AGLVGIGSSDPGS-------LGYAAAKHGVVGLMRAYANHLAPQNIRVNS
MUL_3392|M.ulcerans_Agy99 AGLVGISSADAGA-------IGYVASKHALVGLMRVYANLLAPHSIRVNS
MAB_3081|M.abscessus_ATCC_1997 AGLTGMVMDNPGG-------LAYTAAKHGLVGLMRSYANMLAPHNIRVNT
Mflv_2500|M.gilvum_PYR-GCK ALMDAHNKPNPGG---DPGGMGYMISKRLISEYVHALATELAVRGIRANV
Mvan_4158|M.vanbaalenii_PYR-1 ALMDAHNKPNPGN---DPGGMAYMTSKRLLSQYVHDLATELAVRGIRANV
TH_4131|M.thermoresistible__bu ALMDAHQKPNPGA---DPGGMAYMSSKRLLAQYVHDLATELAVRGIRANV
MSMEG_4801|M.smegmatis_MC2_155 ALMDAHNKPNPGA---DPGGMGYMVSKRMISEYVHYLATELTPLGIRANV
MAV_2946|M.avium_104 AFMSSLNTSGAGSGIGGPGGAGYAFAKLAAAHYVNDFALALAPFSIRMNA
MMAR_4754|M.marinum_M GGMKAY--PHCGN---------YVAAKHGVVGLMRSFAVELGQHMIRVNS
MLBr_02565|M.leprae_Br4923 G-----IAGNRGQ-------TNYATAKAGVIGLTQALAPGLAEKGITINA
. * * :* . * * * *
Mb2771|M.bovis_AF2122/97 VHPCGVDTPMINN-EFFQQWLT------TADMDAPHNLGNALPVELVQPT
Rv2750|M.tuberculosis_H37Rv VHPCGVDTPMINN-EFFQQWLT------TADMDAPHNLGNALPVELVQPT
MUL_3392|M.ulcerans_Agy99 LHPSGVDPPMINN-EFIRHWLADL----VAETGSGPGAGNALPVQILQAD
MAB_3081|M.abscessus_ATCC_1997 IHPSGVATPMLIN-PVTEKLFAD------GSPEGMSDTGNALPVVLMEPE
Mflv_2500|M.gilvum_PYR-GCK IHPTNCNTDMLQSEPMYRSFRPDLENPTRADAEPVFGVQQAMKVNFIEPE
Mvan_4158|M.vanbaalenii_PYR-1 VHPTNCNTDMLQSPPMYKSFRPDLENPTRADAEPVFGVQQAMKVNFIEPE
TH_4131|M.thermoresistible__bu IHPTNCNTDMLQSEPMYRSFRPDLENPTRADAEPVFGVQQAMRVPYVEPE
MSMEG_4801|M.smegmatis_MC2_155 IHPTNCNTDMLQSEPMYRSFRPDLEHPTRADAEPVFYVQQAMKVPWVEPS
MAV_2946|M.avium_104 VHPTNVNTDMLHSPPMYRAFRPDLPAPTREDAEPVFPLVQAMPVPYVEPE
MMAR_4754|M.marinum_M VHPTHVRTPMLHNEGTFKMFRPDLENPGPDDMAPICQLFHTLPIPWVEAE
MLBr_02565|M.leprae_Br4923 VAPGFIETQMTAAIPLAT---------------REVGRRLNSLLQGGLPV
: * . * : .
Mb2771|M.bovis_AF2122/97 DIANAVAWLASEEARYVTGVTLPVDAGFVNKR------
Rv2750|M.tuberculosis_H37Rv DIANAVAWLASEEARYVTGVTLPVDAGFVNKR------
MUL_3392|M.ulcerans_Agy99 DIAGALAWLVSDEARYITGVALPVDAGCVNKR------
MAB_3081|M.abscessus_ATCC_1997 DMANTVAWLVSEDARYITGVALPVDAGFTNRR------
Mflv_2500|M.gilvum_PYR-GCK DISNAVLWLASDESRYVTGMQLRVDAGGYLKWYDYHV-
Mvan_4158|M.vanbaalenii_PYR-1 DISNAILWLVSDEARYVTGMQLRVDAGGYLKWYDYHA-
TH_4131|M.thermoresistible__bu DISNAVLWLASEEARYVTGMQLRVDAGGYLKWYDYHV-
MSMEG_4801|M.smegmatis_MC2_155 DISNAVLWLASDESRFVTGMQLRVDAGGYLKWYDYHV-
MAV_2946|M.avium_104 DISEAVLFLASDAARYITGQQLRVDAGGFLKVKPWSGG
MMAR_4754|M.marinum_M DISNAVLFLASDESRYITGVTLPVDAGGCLK-------
MLBr_02565|M.leprae_Br4923 DVAETIAYFAIPASNAVTGNVIRVCGQAMLGA------
*:: :: ::. :. :** : * .