For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MLLGLLPDGLATLDPTARTIVTAARTCFTERGFSNTTMQDIADAAGVGVATVYRRFRHKRNLVRLTIIDE SVRLSTLISDVAGRAASAEEGIAEVFAAFVHEASAPKLLTRSIRESPAAGELSAFLTDEHLIAISRTYIA SWLRRWQERGELADDLDTEVVGEMIGRLIISLIETPKSVIPVYNLAEARDFARRYLVPLVLPAPAALPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2883 | - | - | 100% (209) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_1333 | - | 4e-13 | 28.26% (184) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_5227 | - | 1e-11 | 29.03% (186) | TetR-family protein transcriptional regulator, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2534 | - | 8e-09 | 27.44% (164) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2304 | - | 3e-12 | 27.78% (198) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2506 | - | 8e-09 | 27.44% (164) | TetR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1024 | - | 3e-13 | 28.06% (196) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0287 | - | 3e-13 | 27.18% (195) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_0465 | - | 4e-10 | 31.68% (161) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_3720 | - | 7e-12 | 27.51% (189) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4837 | - | 1e-12 | 26.67% (195) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4342 | - | 2e-10 | 26.84% (190) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2304|M.gilvum_PYR-GCK -MSMSVGAFANSAPADQVTSPVADPPVEPKARTVRDRLIDAAEQCLTAKG
Mvan_4342|M.vanbaalenii_PYR-1 -MSMSVGTVPNSAGSNSAASARAEP------GSVRDRLIDAAEQCLTAKG
MMAR_0287|M.marinum_M -MQSRMGTETSTDGVESIT-------------DLDRTILDTARAVFETYG
MUL_4837|M.ulcerans_Agy99 -----MGTETSTDGVESIT-------------DLDRTILDTAHAVFETYG
Mb2534|M.bovis_AF2122/97 ---MTASAPDGRPGQPEATNRRSQLK-----SDRRFQLLAAAERLFAERG
Rv2506|M.tuberculosis_H37Rv ---MTASAPDGRPGQPEATNRRSQLK-----SDRRFQLLAAAERLFAERG
MAV_2883|M.avium_104 ---MLLGLLPDGLATLDPT---------------ARTIVTAARTCFTERG
MAB_1024|M.abscessus_ATCC_1997 -----MSADPDPTG---------------------ERILEAALQTMLSFG
TH_3720|M.thermoresistible__bu --------VTEATALET-----------------REAIIMGAFACFRTYG
MSMEG_0465|M.smegmatis_MC2_155 MKATDSKLRQRTDGRLDRTR--------------DPAILDAALAALAENG
:: * : *
Mflv_2304|M.gilvum_PYR-GCK IRATTVSEVAEVAGVSRGWLYRHFPDKSELLGAAIVRLNDAFWTESRTRL
Mvan_4342|M.vanbaalenii_PYR-1 IRATTVSEVAEVAGVSRGWLYRHFPDKAELLGAAIVRLNDAFWSESRTRL
MMAR_0287|M.marinum_M VRRANIEDVATRAGVSRSTIYRRFPTKDELFERVVRREAELFFAALNQAT
MUL_4837|M.ulcerans_Agy99 VRRANIEDVATRAGVSRSTIYRRFPTKDELFERVVRREAELFFAALNQAT
Mb2534|M.bovis_AF2122/97 FLAVRLEDIGAAAGVSGPAIYRHFPNKESLLVELLVGVSARLLAGARDVT
Rv2506|M.tuberculosis_H37Rv FLAVRLEDIGAAAGVSGPAIYRHFPNKESLLVELLVGVSARLLAGARDVT
MAV_2883|M.avium_104 FSNTTMQDIADAAGVGVATVYRRFRHKRNLVRLTIIDESVRLSTLISDVA
MAB_1024|M.abscessus_ATCC_1997 IRRATVDEIARRAGVSHMTVYRRWSNKTDLVLAVLMREAQAIFTSVDAEI
TH_3720|M.thermoresistible__bu LRKTTIVDIARKAEVSRSTVYEYFPDKAAIVEACAEAASERFYRNMAKVV
MSMEG_0465|M.smegmatis_MC2_155 YAGTNMDDIASRAGVGKAAIYRRWSSKAALITDALVYWKPALLIDDIPDT
. : ::. * *. :*. : * :. :
Mflv_2304|M.gilvum_PYR-GCK DSVTGLDEQIAAGVALARKESETPGALVLKLRQEEPEAFTACVGLGVRGL
Mvan_4342|M.vanbaalenii_PYR-1 DAVAGLDQQIAVGVELARKESETPGALVLKLRQEEPEAFTACVGLGVRGL
MMAR_0287|M.marinum_M NGHNPREAVIEAFTLGVRLIQDSP--LYSRIAESEPELFGMFS----RSH
MUL_4837|M.ulcerans_Agy99 NGHNPREAVIEAFTLGVRLIRDSP--LYSRIAESEPELFGMFS----RSH
Mb2534|M.bovis_AF2122/97 TRSANLAAALDG-LIEFHLDFALGEADLIRIQDRDLAHLPAVA---ERQV
Rv2506|M.tuberculosis_H37Rv TRSANLAAALDG-LIEFHLDFALGEADLIRIQDRDLAHLPAVA---ERQV
MAV_2883|M.avium_104 GRAASAEEGIAEVFAAFVHEASAPKLLTRSIRES-PAAGELSAFLTDEHL
MAB_1024|M.abscessus_ATCC_1997 AALDSPEEKLVAGFTGIYWHVHTHPLMRRAVETDPESVLPVMT-----SG
TH_3720|M.thermoresistible__bu NRGEDLEDKLVRACVFVTQARRVVQGEKYFDEEEVSILLTRDS----AVL
MSMEG_0465|M.smegmatis_MC2_155 GSLEGDLNEIAERAARNADERITYDLILRVAVEAMNDSQLASA--LDDLT
:
Mflv_2304|M.gilvum_PYR-GCK IPEIAAFWEPYIQAAVDRGEIHADTDRAEAAEWIARITMSLATVPGEQCD
Mvan_4342|M.vanbaalenii_PYR-1 IPEIAAFWVPYIQAAVDRGEIHPDTNSAEAAEWIARIMMSLATVPGEQCN
MMAR_0287|M.marinum_M VFPIGQFADGIAHTLRRCGADAPDADLANIADILLRVAVGIIMFPTERLD
MUL_4837|M.ulcerans_Agy99 VFPIGQFADGIAHTLRRCGADAPDADLANIADILLRVAVGIIMFPTERLD
Mb2534|M.bovis_AF2122/97 RKAQRQYVEVWVGVLRELNPGLAEAD----ARLMAHAVFGLLNSTPHSMK
Rv2506|M.tuberculosis_H37Rv RKAQRQYVEVWVGVLRELNPGLAEAD----ARLMAHAVFGLLNSTPHSMK
MAV_2883|M.avium_104 IAISRTYIASWLRRWQERGELADDLDTEVVGEMIGRLIISLIETPKSVIP
MAB_1024|M.abscessus_ATCC_1997 AGPALDMATTYLAGHVSQSAGDLVDDPYGIAEVFVRLTHSLILAPSPRRE
TH_3720|M.thermoresistible__bu LKECADFIAPYLSAGRVTGEVRKDLDIPKASEWVARILFSLFNTPSPTID
MSMEG_0465|M.smegmatis_MC2_155 LLRGRRTMTAILKNATARGEIAPDTDWS----LVPDVLTAMLLMRAIRGE
. : . .:
Mflv_2304|M.gilvum_PYR-GCK VDDHESVLRHARRYIVAAFRSDPAGT-------
Mvan_4342|M.vanbaalenii_PYR-1 VDDHDSVLRHARRYIVAALRSDPNQ--------
MMAR_0287|M.marinum_M TSDDAAVREYAARYLIPIITL------------
MUL_4837|M.ulcerans_Agy99 TSDDAAVREYAARYLIPIITL------------
Mb2534|M.bovis_AF2122/97 AADSKPARTVRARAVLRAMTVAALSAADRCL--
Rv2506|M.tuberculosis_H37Rv AADSKPARTVRARAVLRAMTVAALSAADRCL--
MAV_2883|M.avium_104 VYNLAEARDFARRYLVPLVLPAPAALPG-----
MAB_1024|M.abscessus_ATCC_1997 LATREDAQQYARRYILPIAQALVPAASPAVR--
TH_3720|M.thermoresistible__bu MSDDGAVADFVRSFVLRGFVDDRPHRGRRSSAG
MSMEG_0465|M.smegmatis_MC2_155 RVDANYVRKVIDTVIVPAVRATAY---------
. ::