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VKWVTYQGDDGERVGVLRDDTIYAMGSGVTLLDLIARGAEGLRHAGEEAQRSPAATVPAARARLLAPIPR PPSIRDSLCFLDHMRNCQAALGAGRVLADTWYRVPAFYFACPATVLGPYDDAPTAPGSAWQDFELEIAAV IGTGGKDLSVEQAEQAIIGYTIFNDWSARDLQQLDSQLGIGQAKGKDSGVTLGPYLVTPDELEPYRRNGK LDLRVTASVNDTVIGSGSTAQMDWTFGEVISYASRGVTLVPGDVIGSGTVPTCTLVEHLDPAALESFPGW LHDGDVVTLRVEGLGETRQTVRASGAPHPLAARPNPDAPPAAPRVNRAAARVPYTRGLHQVGDRVWAWTL PDGGYGWSNAGLIAGDGASLLVDTLFDLALTREMLTAMRPITASAPITDAVITHSNGDHTHGNQLLDPAV RIIAAHGTAEEIAHGMAPEMLAMAQTANLGPVATRYTRERFGHFDFSNITLRNADETFDRSLAVEVGGRR VDVLNLGPAHTAADSVVHVPDAGVLFGGDLLFIGCTPIVWAGPIANWVAACDAMIALDAPTVVPGHGPVT DPDGIRAVRGYLVHIAEQAEAAYRKGLSWPEAADTIDLGEYATWLDAERVVVNVYQRYRELDPHTPQLEV MALLVMQAEWLAKRS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1057 | - | - | 100% (645) | fumarylacetoacetate hydrolase family protein, putative |
| M. avium 104 | MAV_3844 | - | 3e-22 | 33.73% (249) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. avium 104 | MAV_2782 | - | 3e-12 | 30.18% (222) | metallo-beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0964 | - | 0.0 | 81.96% (643) | bifunctional 2-hydroxyhepta-2,4-diene-1,7-dioate |
| M. gilvum PYR-GCK | Mflv_4230 | - | 2e-20 | 31.05% (248) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
| M. tuberculosis H37Rv | Rv0939 | - | 0.0 | 81.96% (643) | bifunctional 2-hydroxyhepta-2,4-diene-1,7-dioate |
| M. leprae Br4923 | MLBr_01689 | - | 5e-21 | 31.85% (248) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2020c | - | 6e-40 | 33.33% (315) | bifunctional HHDD isomerase/cyclase/dehydrase |
| M. marinum M | MMAR_4572 | - | 0.0 | 79.35% (644) | bifunctional enzyme: 2-hydroxyhepta-2,4-diene- 1,7-dioate |
| M. smegmatis MC2 155 | MSMEG_6588 | - | 9e-20 | 30.20% (202) | fumarylacetoacetate |
| M. thermoresistible (build 8) | TH_0259 | - | 0.0 | 76.29% (620) | POSSIBLE BIFUNCTIONAL ENZYME: |
| M. ulcerans Agy99 | MUL_1956 | - | 9e-19 | 31.60% (250) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. vanbaalenii PYR-1 | Mvan_2132 | - | 4e-20 | 31.85% (248) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0964|M.bovis_AF2122/97 MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRTAGERAV
Rv0939|M.tuberculosis_H37Rv MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRTAGERAV
MMAR_4572|M.marinum_M MKWVTYRSADGERVGVLSDGSIYAMAPGVALLDLIKRGADGLREAGENVL
MAV_1057|M.avium_104 MKWVTYQGDDGERVGVLRDDTIYAMGSGVTLLDLIARGAEGLRHAGEEAQ
TH_0259|M.thermoresistible__bu ------------------------MPPGTELIDLVALGADGLRDAGERAL
MAB_2020c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4230|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2132|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01689|M.leprae_Br4923 --------------------------------------------------
MUL_1956|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6588|M.smegmatis_MC2_155 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 RSPAAVVALDEVTLAAPIPRPPSIRDSLCFLDHMRNCQEAMGGGRVLMDT
Rv0939|M.tuberculosis_H37Rv RSPAAVVALDEVTLAAPIPRPPSIRDSLCFLDHMRNCQEAMGGGRVLMDT
MMAR_4572|M.marinum_M RSPSEVVALDEVTLAAPIPRPPSIRDSLCFLDHMRNCQEAVGGGRVLMDT
MAV_1057|M.avium_104 RSPAATVPAARARLLAPIPRPPSIRDSLCFLDHMRNCQAALGAGRVLADT
TH_0259|M.thermoresistible__bu RDPSEVVPLSDVVLRAPIPRPPAIRDCLCFLDHMRNCQEALGGGRVLKDA
MAB_2020c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4230|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2132|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01689|M.leprae_Br4923 --------------------------------------------------
MUL_1956|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6588|M.smegmatis_MC2_155 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 WYRIPAFYFACPSTVLGPYDDAPTAPGSAWQDFELEIAAVIGTSGKDLTV
Rv0939|M.tuberculosis_H37Rv WYRIPAFYFACPSTVLGPYDDAPTAPGSAWQDFELEIAAVIGTSGKDLTV
MMAR_4572|M.marinum_M WYRIPAFYFACPATVLGPYDDAPMAPGSAWQDFELEIAAVIGTGGQDLSV
MAV_1057|M.avium_104 WYRVPAFYFACPATVLGPYDDAPTAPGSAWQDFELEIAAVIGTGGKDLSV
TH_0259|M.thermoresistible__bu WYRIPAFYFANPSAVFGPYDDVPTAPGSAWQDFELEIAAVIGTGGADLTV
MAB_2020c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4230|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2132|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01689|M.leprae_Br4923 --------------------------------------------------
MUL_1956|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6588|M.smegmatis_MC2_155 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 EQAERSIIGYTIFNDWSARDLQMLEGQLRIGQAKGKDSGITLGPYLVTPD
Rv0939|M.tuberculosis_H37Rv EQAERSIIGYTIFNDWSARDLQMLEGQLRIGQAKGKDSGITLGPYLVTPD
MMAR_4572|M.marinum_M EQAEQSIIGYTIFNDWSARDLQQLEGQLRIGQAKGKDSGVTLGPYLVTAD
MAV_1057|M.avium_104 EQAEQAIIGYTIFNDWSARDLQQLDSQLGIGQAKGKDSGVTLGPYLVTPD
TH_0259|M.thermoresistible__bu AEAEQAIIGYTIFNDWSARDLQSLESQLGIGQAKGKDSGITLGPYLVTPD
MAB_2020c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4230|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2132|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01689|M.leprae_Br4923 --------------------------------------------------
MUL_1956|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6588|M.smegmatis_MC2_155 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 ELEPYCRGGKLSLRVIALVNGTVIGSGSTAQMDWSFGEVIAYASRGVTLT
Rv0939|M.tuberculosis_H37Rv ELEPYCRGGKLSLRVIALVNGTVIGSGSTAQMDWSFGEVIAYASRGVTLT
MMAR_4572|M.marinum_M ELQAYRRDGKLSLQVSALVNDTVIGSGSTATMDWTFGEVISYVSRGVMLA
MAV_1057|M.avium_104 ELEPYRRNGKLDLRVTASVNDTVIGSGSTAQMDWTFGEVISYASRGVTLV
TH_0259|M.thermoresistible__bu ELDEFRTDGRLDLTVTALVNGEVIGSGSTAAMDWTFAEVISYASRGVFLH
MAB_2020c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4230|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2132|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01689|M.leprae_Br4923 --------------------------------------------------
MUL_1956|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6588|M.smegmatis_MC2_155 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 PGDVFGSGTVPTCTLVEHLRPP--ESFPGWLHDGDVVTLQVEGLGETRQT
Rv0939|M.tuberculosis_H37Rv PGDVFGSGTVPTCTLVEHLRPP--ESFPGWLHDGDVVTLQVEGLGETRQT
MMAR_4572|M.marinum_M PGDVIGSGTVPTCTLVEHLTNP--DSFPGWLRDGDVVTLEVEGLGQTRQR
MAV_1057|M.avium_104 PGDVIGSGTVPTCTLVEHLDPAALESFPGWLHDGDVVTLRVEGLGETRQT
TH_0259|M.thermoresistible__bu PGEVFGSGTVPTCTLVEHLDMTDLAGFRGWLSDGDEVTLQVQGLGETRQT
MAB_2020c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4230|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2132|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01689|M.leprae_Br4923 --------------------------------------------------
MUL_1956|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6588|M.smegmatis_MC2_155 -------MKLRRVRTAADLRVESLDADGNWVPHDDVAPLGGR--------
Mb0964|M.bovis_AF2122/97 VRTSGTPFPLALRPNPDAEPDRRGVNPAPTRVPFTRGLHEVADRVWAWTL
Rv0939|M.tuberculosis_H37Rv VRTSGTPFPLALRPNPDAEPDRRGVNPAPTRVPFTRGLHEVADRVWAWTL
MMAR_4572|M.marinum_M VCATPPPQPLAPRVDPNAAPEAARVNPAPPLVPYTRGLHQVADRVWAWTL
MAV_1057|M.avium_104 VRASGAPHPLAARPNPDAPPAAPRVNRAAARVPYTRGLHQVGDRVWAWTL
TH_0259|M.thermoresistible__bu VRHRPAPTLLPPRPNPDAAPAPARVNPAPAKVPYRRGLHQVGENVWAWTL
MAB_2020c|M.abscessus_ATCC_199 ---------------------------MAQDFAFQKGLVPLGGGAHVFLS
Mflv_4230|M.gilvum_PYR-GCK ------MRLGRIASPDGVAFVAVEGPPDDPAAAVAREIAEHPFGTPTFTG
Mvan_2132|M.vanbaalenii_PYR-1 ------MRLGRIASPDGVAFVAIEGPPDDPGGAVAREIAEHPFGNPTFTG
MLBr_01689|M.leprae_Br4923 --------------------------------MFARELAEYPFGELTFTG
MUL_1956|M.ulcerans_Agy99 --------------------------------MTAREIAEDPFGTPNFTG
MSMEG_6588|M.smegmatis_MC2_155 --------------VFDAEWLAAAADRQLQHSPHLLPFQPVSFRDFMLYE
:
Mb0964|M.bovis_AF2122/97 PDGGYGFSNAGLVAGDGASLLVDTLFDLALTREMLAAMKPVTERAPITDA
Rv0939|M.tuberculosis_H37Rv PDGGYGFSNAGLVAGDGASLLVDTLFDLALTREMLAAMKPVTERAPITDA
MMAR_4572|M.marinum_M PDGGFGWSNAGLVAGDGASLLVDTLFDLALTREMLDAMRPITDAAPITDA
MAV_1057|M.avium_104 PDGGYGWSNAGLIAGDGASLLVDTLFDLALTREMLTAMRPITASAPITDA
TH_0259|M.thermoresistible__bu PDGGYGWSNAGLVAGEGASLLVDTLFDLTLTREMLDAMQSITQRAPITDM
MAB_2020c|M.abscessus_ATCC_199 GDEGFGLANAGLVVSDDESLVVDTLYDVRHAREMLDEFGRHTATAPVRYV
Mflv_4230|M.gilvum_PYR-GCK --RQWPLADVRLLAPILASKVVCMGKNYAAHIEEMGGGT---FEDPIIFL
Mvan_2132|M.vanbaalenii_PYR-1 --RQWPLADVRLLAPILASKVVCMGKNYAAHIEEMGGGT---FEDPIIFL
MLBr_01689|M.leprae_Br4923 --RSWPLADVRLLAPMLASKVVCIGKNYADHIVEMGGQTGLASADPVIFL
MUL_1956|M.ulcerans_Agy99 --RSWPLADVRLLAPILASKVVCVGKNYTGHIAEMGGQTGPTPADPVIFL
MSMEG_6588|M.smegmatis_MC2_155 QHNIDAARGLIRRFHPGLYRATSAFERLTGRPVPQFKPKPLFYRQPIYYM
. . *:
Mb0964|M.bovis_AF2122/97 LITHSNGDHTHGTQLLDRSVRIIAAKGTSEEIEHGPAPEMLARIQTADLG
Rv0939|M.tuberculosis_H37Rv LITHSNGDHTHGTQLLDRSVRIIAAKGTSEEIEHGPAPEMLARIQTADLG
MMAR_4572|M.marinum_M LITHSNGDHTHGNQLLSPSVRIIAAKGTAEEIAEDTGPTLLTAMQTIDLG
MAV_1057|M.avium_104 VITHSNGDHTHGNQLLDPAVRIIAAHGTAEEIAHGMAPEMLAMAQTANLG
TH_0259|M.thermoresistible__bu VITHCNGDHTHGNQLLDPSVRIIAAKETKDEIDHEMAPSMLALAQTGDLG
MAB_2020c|M.abscessus_ATCC_199 FNTHTDGDHFFGNQVFADDVEIITTEAARALMVQEHADLTAELLGGSSDP
Mflv_4230|M.gilvum_PYR-GCK KPNTAIIGPYTPIQLPADADPVHFEGELAAVIGRPCKDVPASRAAENILG
Mvan_2132|M.vanbaalenii_PYR-1 KPNTAIIGPNTPIQLPADANPVHFEGELAAVIGRPCKDVPASRAAENILG
MLBr_01689|M.leprae_Br4923 KPNTAIIGPNVPIRLPANASPVHFEGELALVVGRSCKDVPAVQAVDCILG
MUL_1956|M.ulcerans_Agy99 KSNTAIVGPNVPIRLPANASPVHFEGELAIVIGRPCKDVSAAQAVDNILG
MSMEG_6588|M.smegmatis_MC2_155 SNAQTFVPTGTPVPVPDYSQALDFELEIGFVLAAPLFNATPNEATAAIGA
: : :
Mb0964|M.bovis_AF2122/97 PVATRYLRDRFGH---FDFSGIKLRNADLTFDRDLAIELGGRR-VDLLNL
Rv0939|M.tuberculosis_H37Rv PVATRYLRDRFGH---FDFSGIKLRNADLTFDRDLAIELGGRR-VDLLNL
MMAR_4572|M.marinum_M PVATRFMRDRFGH---FDFSGIRLRNADQTFDHELTIDVGGRR-VDLINL
MAV_1057|M.avium_104 PVATRYTRERFGH---FDFSNITLRNADETFDRSLAVEVGGRR-VDVLNL
TH_0259|M.thermoresistible__bu PIATTYARDRFGH---FDFSGITIRNADHTFDKRLDLEVGGRQ-VTLLNL
MAB_2020c|M.abscessus_ATCC_199 ASNMHVLAPLAKP---FHFNEVRVRPADTTFSGERALRVGKLD-VELHEL
Mflv_4230|M.gilvum_PYR-GCK YTIANDVSARDQQ---KKDGQWMRAKGHDTFCPVGPWIVTDI---DPSDL
Mvan_2132|M.vanbaalenii_PYR-1 YTIANDVSARDQQ---QKDGQWMRAKGHDTFCPVGPWIVTDL---DPSDL
MLBr_01689|M.leprae_Br4923 YTIGNDMSARDQQ---RADGQWTRAKGHDTFCPVGPWIVTDLGPLDPADL
MUL_1956|M.ulcerans_Agy99 YTIGNDVSARDQQ---KSDGQWTRAKGHDTFCPVGPWIVTDV---DPAGL
MSMEG_6588|M.smegmatis_MC2_155 FVVLNDFSARDVQRAEMTSGFGPQKSKHFASSMSDTAVTADEVLPRIDAL
. . : *
Mb0964|M.bovis_AF2122/97 GPAHTTADSVVHVADAGVLFAGDLLFIGCTPIVWAGPIANWVAACDAMIA
Rv0939|M.tuberculosis_H37Rv GPAHTTADSVVHVADAGVLFAGDLLFIGCTPIVWAGPIANWVAACDAMIA
MMAR_4572|M.marinum_M GPAHTAADSVVHVPDAGVLFAGDLLFIGCTPIVWNGPIANWIAACDAMIA
MAV_1057|M.avium_104 GPAHTAADSVVHVPDAGVLFGGDLLFIGCTPIVWAGPIANWVAACDAMIA
TH_0259|M.thermoresistible__bu GPAHTAADTVIHIPDAGVLFGGDLLFIGCTPIVWGGPIANWIAACDTMLA
MAB_2020c|M.abscessus_ATCC_199 GPAHTVGDAVAFLPEHRVLFSGDLLTRGIVKVVWSGSIPNWIVALERIRA
Mflv_4230|M.gilvum_PYR-GCK EIRTEVNGELKQHSRTSLMIHD------------IGAIIEWISSVMTLLP
Mvan_2132|M.vanbaalenii_PYR-1 EIRTEVNGDVKQRSRTSLMIHD------------IGAIIEWISAVMTLLP
MLBr_01689|M.leprae_Br4923 ELRTAVNGEVKQHSRTSLMIHG------------IGAIMEWISAVMTLLP
MUL_1956|M.ulcerans_Agy99 ELRTEVNGAVKQHARTSLMIHD------------VGAIVEWISAVMTLLP
MSMEG_6588|M.smegmatis_MC2_155 TGSVAVNGEIVSTVDSAGMQHS------------LGEVLAHASRCEPLYP
. . : : . * : : .
Mb0964|M.bovis_AF2122/97 LDAPTVVP--GHGPVTGPDGIRAVRG----YLAHIAEQAEAAYRKGLSLP
Rv0939|M.tuberculosis_H37Rv LDAPTVVP--GHGPVTGPDGIRAVRG----YLAHIAEQAEAAYRKGLSLP
MMAR_4572|M.marinum_M LDAPIVVP--GHGPVTDPDGIRAVRG----YFEHVNEQAEAAYRKGLSLA
MAV_1057|M.avium_104 LDAPTVVP--GHGPVTDPDGIRAVRG----YLVHIAEQAEAAYRKGLSWP
TH_0259|M.thermoresistible__bu LDAPTVVP--GHGPITGPEGIHAVRD----YFEYITEQADDAHRRGLSFI
MAB_2020c|M.abscessus_ATCC_199 FGAKIVVP--GHGPLLVDAEVDAAIDRGIAFWSDLHEQANRLYDQGVPAQ
Mflv_4230|M.gilvum_PYR-GCK GDLILTGTPEGVGPLEHGDTVSITVEG-------IGTLSNPVVRKGKS--
Mvan_2132|M.vanbaalenii_PYR-1 GDLILTGTPEGVGPLEHGDSVSITVEG-------IGTLTNPVVRKGRS--
MLBr_01689|M.leprae_Br4923 GDLILTGTPAGVGPVEDGDIVSITVEG-------IGTLTNPVVRKGKS--
MUL_1956|M.ulcerans_Agy99 GDLILTGTPAGVGPIEDGDTVSITIEG-------IDTLTNPVVRKGKS--
MSMEG_6588|M.smegmatis_MC2_155 GELFGTGTLPGGSGMETGHWLRPGDT--------LTLILDDIGRIEHTIG
. . * . : : : : .
Mb0964|M.bovis_AF2122/97 EAVETIDLGEYASWLDSERVVVNVYQRYRELDPDTPRQDLLALLVMQAEW
Rv0939|M.tuberculosis_H37Rv EAVETIDLGEYASWLDSERVVVNVYQRYRELDPDTPRQDLLALLVMQAEW
MMAR_4572|M.marinum_M EAIETVELGDYAAWLDSERIVVNIYQRYRELDPHTPEVERLALLVMQAEW
MAV_1057|M.avium_104 EAADTIDLGEYATWLDAERVVVNVYQRYRELDPHTPQLEVMALLVMQAEW
TH_0259|M.thermoresistible__bu EAADTIDLGPYANWLDAERVVVNVYQRYRELDPDTPQLGVITLLTMQAEW
MAB_2020c|M.abscessus_ATCC_199 DATALIDIAKYPEAMVT--LPIIVTAIYHERNPEIPFQSLTQALESISGQ
Mflv_4230|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2132|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01689|M.leprae_Br4923 --------------------------------------------------
MUL_1956|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6588|M.smegmatis_MC2_155 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 AARHCT---
Rv0939|M.tuberculosis_H37Rv AARHCT---
MMAR_4572|M.marinum_M AAKRV----
MAV_1057|M.avium_104 LAKRS----
TH_0259|M.thermoresistible__bu HAKRGAR--
MAB_2020c|M.abscessus_ATCC_199 LAKAAAGPK
Mflv_4230|M.gilvum_PYR-GCK ---------
Mvan_2132|M.vanbaalenii_PYR-1 ---------
MLBr_01689|M.leprae_Br4923 ---------
MUL_1956|M.ulcerans_Agy99 ---------
MSMEG_6588|M.smegmatis_MC2_155 ---------