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MPFDHRQLRDKWYSAGWYSDRTCLDAFEAGAVEHKDVPLTFVIGDSVSSPTVCEIHDRAVALAASLQRLG VRDGDAVAVQLTNRVECAVAYQAVLLCGAVLVPIVHIYGMAEVAFVLDQSAAKVLIMPERHGSIVYSKRL QDLSRIDSLQHVVMLDAEPGEGYLAWSQLDTPAARYRRPAVAADDVCLLLYTSGTTSAPKGVQHTNNTVL AEQRTMPALLAGKPDDVSLVTFPPGHIAGVGSMLRPLLSGARTVFMDGWDPARAVEVVHRFGVTCTAGTP FHLAGILDLGDTGDKLASLREFLVGAAPVAEEIGRRAAQAGISTFRSYGATEHPTVTGEHEGQPQWARLG TDGKPLPGSEIRIVGSDGTDCPIGIGGEVVVRGPDQFIGYQDSALNTEAFTDDGWFRTGDLGHLDAHGRL TITDRIKDVIIRGGETISSGQVEEVLNAHPAVADGVAVAAPDSRYGDVVAAVVVLKPGYALNLDDLRAHF AASGLARQKTPERLAIVDELPRTSLGKVRKAQLRSDHFGAARR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2638 | - | - | 100% (533) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_1957 | - | 0.0 | 66.54% (526) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_2116 | - | 1e-71 | 35.38% (489) | AMP-binding enzyme, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 1e-54 | 33.05% (475) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_2523 | - | 3e-82 | 39.71% (486) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 1e-54 | 33.05% (475) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-40 | 27.29% (491) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4569c | - | 1e-56 | 31.83% (509) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_0303 | - | 2e-56 | 31.87% (524) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4774 | - | 2e-90 | 40.41% (532) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_2816 | - | 1e-91 | 40.61% (527) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 3e-50 | 33.81% (488) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4135 | - | 3e-84 | 39.59% (533) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2523|M.gilvum_PYR-GCK ----------------------MRRIPEELVRRYEQEGYWTPETLGELLA
Mvan_4135|M.vanbaalenii_PYR-1 ----------------------MRRIPAQLVERYQREGYWTQETLGDMLA
MSMEG_4774|M.smegmatis_MC2_155 ----------------------MRDIPAELTKRYVEEGWWTPETLGQMLA
TH_2816|M.thermoresistible__bu ----------------------MRSIPAELRRRYEENGWWTQESLGDLLA
MAV_2638|M.avium_104 ----------------------MPFDHRQLRDKWYSAGWYSDRTCLDAFE
MMAR_0303|M.marinum_M -------MGGPKVPQRRLIDGRWVRWDADRAAGAYAHRWWVRRTLADALR
Mb2533c|M.bovis_AF2122/97 ------------------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANL
Rv2505c|M.tuberculosis_H37Rv ------------------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANL
MUL_4126|M.ulcerans_Agy99 ----------------------MTSDPR----------------TVPTAL
MAB_4569c|M.abscessus_ATCC_199 -----------------------MTDTIDATVQSAGLAQPYRARRQNWCN
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
Mflv_2523|M.gilvum_PYR-GCK RGLDSAPGAGFHVHSAVRPYAGTFAEVERDARRLAAGLRERGVAAGDVVA
Mvan_4135|M.vanbaalenii_PYR-1 RGLAGSPEAGFCVHSSIRPYRGTFGEVERDARRLAAGLRERGVGPGDVVA
MSMEG_4774|M.smegmatis_MC2_155 EGLAAGPDVVFCVHSEVRPYTGTFGEVETLARRLAAGLRARGVGPGDVIA
TH_2816|M.thermoresistible__bu EGLRAAPDAGFRVHSDVRPYTGTFADVEERARRLAAGLRARGVGPGDVIA
MAV_2638|M.avium_104 AGAVEHKDVPLTFVIGDSVSSPTVCEIHDRAVALAASLQRLGVRDGDAVA
MMAR_0303|M.marinum_M EAAQSTPQRVALVDADR---QLDCQELHRQAMALAQHLRSR-MPAGSVVS
Mb2533c|M.bovis_AF2122/97 AATAARYGHREALVDMVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVG
Rv2505c|M.tuberculosis_H37Rv AATAARYGHREALVDMVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVG
MUL_4126|M.ulcerans_Agy99 DRLVRRLPNHDALVTDE--RSFTVSELNDEVYRAAAALIELGVKPAARVG
MAB_4569c|M.abscessus_ATCC_199 QLARHALMQPDATAIRYLGHSISWAELHQRVQALADALSRRGVGFGDRVL
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
:: . * * : . :
Mflv_2523|M.gilvum_PYR-GCK LQLPNWREAAVTFWASAFLGAVVVPVVHFYGRKELAHILTTAKPRVFVTT
Mvan_4135|M.vanbaalenii_PYR-1 MQLPNWREAAVTFWASAFLGAVVVPIVHFYGRRELAHIMATAKPRVFVTA
MSMEG_4774|M.smegmatis_MC2_155 FQLPNWMEAAAAFWATSFLGAVTVPIVHFYGRKELAHILSTAKPKVFLTT
TH_2816|M.thermoresistible__bu FQLPNWVEAAMTFWASAFLGAVVVPVVHFYGRKELGHILRTARPKVFITA
MAV_2638|M.avium_104 VQLTNRVECAVAYQAVLLCGAVLVPIVHIYGMAEVAFVLDQSAAKVLIMP
MMAR_0303|M.marinum_M FMLPNWHEAAVIYLASTLAAMVANPVLPSLREHELRFILEDAGSRMIFAP
Mb2533c|M.bovis_AF2122/97 IWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAV
Rv2505c|M.tuberculosis_H37Rv IWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAV
MUL_4126|M.ulcerans_Agy99 IWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAM
MAB_4569c|M.abscessus_ATCC_199 ILMLNRPEYVESWLAINELGAIAIPVNFRMTPPEVAFLVENSGAKVAITE
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
. * . . . : : : .
Mflv_2523|M.gilvum_PYR-GCK AQFGRLQFHPDVC-AGVPIVALVGDGPDSGADG-GWEPFEDLLAAEPMAG
Mvan_4135|M.vanbaalenii_PYR-1 EEFGRMRYQPDLC-GDVAVVGLVG--AAHPAAG-NEHAFEQLLADEPMAG
MSMEG_4774|M.smegmatis_MC2_155 ERFGRMSFQPDLC-AQVPIVGLVG-----------ESSFTDLLAERPMSG
TH_2816|M.thermoresistible__bu AEFGRMRYQPDLC-ADVPIVGVVG-----------QHGFDDLVADEPMTG
MAV_2638|M.avium_104 ERHGSIVYSKRLQ-DLSRIDSLQHVVMLDAEPGEGYLAWSQLDTPAARYR
MMAR_0303|M.marinum_M ADFRGHDYTSMLRRVAAQLPSRPEVIEVRGQCPDGVSTFQSLLVGRETAA
Mb2533c|M.bovis_AF2122/97 ASFKDADYAAMLAEVGPRCPDLADVILLE--SDRWDALAGAEPDLPALQQ
Rv2505c|M.tuberculosis_H37Rv ASFKDADYAAMLAEVGPRCPDLADVILLE--SDRWDALAGAEPDLPALQQ
MUL_4126|M.ulcerans_Agy99 GHFLGSDRVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETGTDTGAVTA
MAB_4569c|M.abscessus_ATCC_199 TVLAPVAAAVRQQAPALETVIVAGSASEN-----GVLGYEEVIAEPGEPH
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPDEEEP--PGSTDETLAELIARSSSAP
Mflv_2523|M.gilvum_PYR-GCK -TVAADPAGPALIAFTSGTTRDPKGVIHSHQTLSFETR---QLLENYPPD
Mvan_4135|M.vanbaalenii_PYR-1 -TVAADPAAPTLIAFTSGTTRDPKGVIHSHQTLSCETR---QLLENYPPD
MSMEG_4774|M.smegmatis_MC2_155 -TLDTDPAAPALIAFTSGTTRDPKGVIHSHQTLSCETR---QLLANYPPN
TH_2816|M.thermoresistible__bu -TLATDPAGPALIAFTSGTTRDPKGVIHSHQTLTFETR---QLLANYPPD
MAV_2638|M.avium_104 -RPAVAADDVCLLLYTSGTTSAPKGVQHTNNTVLAEQRTMPALLAGKPDD
MMAR_0303|M.marinum_M PLPTADPDAVRMVLYTSGTTGRPKGVLHTHNSIHALICQIRDHWMVEPGD
Mb2533c|M.bovis_AF2122/97 TAARLDGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQD
Rv2505c|M.tuberculosis_H37Rv TAARLDGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQD
MUL_4126|M.ulcerans_Agy99 RAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITADD
MAB_4569c|M.abscessus_ATCC_199 AEVDLPGDTPALIMYTSGTTGRPKGAVLTHLNLSGQAMTYLLSTTVDLNS
MLBr_02546|M.leprae_Br4923 --APKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPFRAHE
: ***** .**. .
Mflv_2523|M.gilvum_PYR-GCK RGRQLTATPVGHFIGMLGAFLIPVLEG-SPIDLCDVWDPGRVLQLMETEG
Mvan_4135|M.vanbaalenii_PYR-1 RGRQLTATPVGHFIGMLGAFLIPVLEG-APIDLCDVWDPGRVLKLIESDG
MSMEG_4774|M.smegmatis_MC2_155 RGRQLTATPVGHFIGMVGAFLIPVLEG-APVDLCDVWDPAKVLRLMESDG
TH_2816|M.thermoresistible__bu RGRQLTATPVGHFIGMVGAFLIPVLEG-APIDLADVWDPGRVLRLMEAED
MAV_2638|M.avium_104 --VSLVTFPPGHIAG-VGSMLRPLLSG-ARTVFMDGWDPARAVEVVHRFG
MMAR_0303|M.marinum_M --GFLVASPIAHIGGSIYAFECPLLLG-TTAVLLDRWDADRAVQLMTSKR
Mb2533c|M.bovis_AF2122/97 --RICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDER
Rv2505c|M.tuberculosis_H37Rv --RICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDER
MUL_4126|M.ulcerans_Agy99 --RHLCINPFFHNFGYKAGILACLQTG-ATLFPHLTFDPLRTLQAIERHR
MAB_4569c|M.abscessus_ATCC_199 -DVGFIGVPMFHIAGVGNMITGLLLGLPTVIHPLGAFDPGALLDVLESEG
MLBr_02546|M.leprae_Br4923 --VTLLPAPMFHALGYLHATLAMFLGS--TLVLRRRFKPATVLEDIEKHQ
* * * :.. : :
Mflv_2523|M.gilvum_PYR-GCK LSIGGGPPYFVTSLLD--HPQCRPEHVRRFKTVGLGGSTVPAAVTRRLSD
Mvan_4135|M.vanbaalenii_PYR-1 LSIGGGPPYFVTSLLD--HPDFRPEHLRRFKTVGLGGSTVPAAVTQRLTD
MSMEG_4774|M.smegmatis_MC2_155 LSIGGGPPYFVTSLLD--HPDFADRHLARIRTVGLGGSTVPAAVTRRLAD
TH_2816|M.thermoresistible__bu ISIGGGPPYFVTSLLD--HPDCTPEHLARFKTVGLGGSTVPTTVTRRLAE
MAV_2638|M.avium_104 VTCTAGTPFHLAGILD--LGDTG-DKLASLREFLVGAAPVAEEIGRRAAQ
MMAR_0303|M.marinum_M CTHMAGATPFLEQLLA--AAQRAGTRLPDLKFFVCGGASVSPSLIRCATD
Mb2533c|M.bovis_AF2122/97 CTSLYGVPTMFIAELG--LPDFTDYELGSLRTGIMAGAACPVEVMRKVIS
Rv2505c|M.tuberculosis_H37Rv CTSLYGVPTMFIAELG--LPDFTDYELGSLRTGIMAGAACPVEVMRKVIS
MUL_4126|M.ulcerans_Agy99 ITVLPGPPTIYQTLLD--HPARDDYDLSSLRFAVTGAATVPVVLVERMQS
MAB_4569c|M.abscessus_ATCC_199 VTGIFLVPAQWQAVCA--AQQANPRKVR-LKTLSWGAAPATDVLLRTMSE
MLBr_02546|M.leprae_Br4923 ATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRALE
: . : :: ..: : .
Mflv_2523|M.gilvum_PYR-GCK LG--MFVFRSYGSTEHP-SITGSRPSAPEDKRLFTDGDARPGVEIKLGPD
Mvan_4135|M.vanbaalenii_PYR-1 LG--LFVFRSYGSTEHP-SITGSRPDAPEVKRLFTDGNVRPGVEIRLGED
MSMEG_4774|M.smegmatis_MC2_155 LG--IFVFRSYGSTEHP-SITGSSPSAPEGKRLYTDGNPRPGVEIRLGPD
TH_2816|M.thermoresistible__bu LG--MFVFRSYGSTEHP-SITGSGPAAPEEKRLYTDGNPRPGVEIRIAED
MAV_2638|M.avium_104 AG--ISTFRSYGATEHP-TVTGEHEGQPQWARLGTDGKPLPGSEIRIVGS
MMAR_0303|M.marinum_M YFDKAVVTRVYGSTEVP-VTTIGAPDSS-AHAAATDGRVG-AADVKLVAG
Mb2533c|M.bovis_AF2122/97 RMHMPGVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVVDP
Rv2505c|M.tuberculosis_H37Rv RMHMPGVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVVDP
MUL_4126|M.ulcerans_Agy99 ELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFADFELRIG-P
MAB_4569c|M.abscessus_ATCC_199 TFPDARILAAFGQTEMS-PVTCMLMGDDAIRKMGSVGRVIPTVSARVVDD
MLBr_02546|M.leprae_Br4923 ELG-PVIYNMYGSTEIAFATIAG--PKDLQINSATVGPVVKGVKVKILDD
:* ** : * . ::
Mflv_2523|M.gilvum_PYR-GCK -----------GEIFSRGPDLCLGYVDDDL-TAQAFDEDGWYHTGDIGVL
Mvan_4135|M.vanbaalenii_PYR-1 -----------GEIFSRGPDLCLGYTDDEL-TARAFDDDGWYRTGDVGVL
MSMEG_4774|M.smegmatis_MC2_155 -----------GEIFSRGPDLCLGYTDDAL-TAKAFDDEGWYRTGDVGFL
TH_2816|M.thermoresistible__bu -----------GEILSRGPDLCLGYTDDAL-TARAFDDDGWYHTGDIGVL
MAV_2638|M.avium_104 DGTDCPIG-IGGEVVVRGPDQFIGYQDSAL-NTEAFTDDGWFRTGDLGHL
MMAR_0303|M.marinum_M ------------EIRVRGPQMLVGYRHPED-EAGSFDAQGYFRTGDLGHW
Mb2533c|M.bovis_AF2122/97 ATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEM
Rv2505c|M.tuberculosis_H37Rv ATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEM
MUL_4126|M.ulcerans_Agy99 DTGEVLLR---------GPNVMLGYLDDPRATAAAIDADGWLHTGDIGVL
MAB_4569c|M.abscessus_ATCC_199 NMNDVPVG-EVGEIVYRAPTLMQGYWNNPEATADAFAG-GWFHSGDLVRQ
MLBr_02546|M.leprae_Br4923 SGKEVPRG-QVGRIFVGNAFPFEGYTGGGG----KQIIDGLLSSGDVGYF
** * :**:
Mflv_2523|M.gilvum_PYR-GCK DEDGYLTITDRKADVIIRGGENISALEVEEILLGMPAVAEAVVVAAPDER
Mvan_4135|M.vanbaalenii_PYR-1 DDDGYLTITDRKADVIIRGGENISALEVEEVLLAMPAVAEAVVVAAPDAR
MSMEG_4774|M.smegmatis_MC2_155 DDDGYLTITDRTADLIIRGGENISALEVEEVLLGIPGVIEAIVVAAPDAR
TH_2816|M.thermoresistible__bu DDDGYLTITDRKADLIIRGGENISALEVEEVLLGMPAVAEAVVVAAPDPR
MAV_2638|M.avium_104 DAHGRLTITDRIKDVIIRGGETISSGQVEEVLNAHPAVADGVAVAAPDSR
MMAR_0303|M.marinum_M VDDEYLVVTGRAKDIIIRNGENISPKEIEDILITHPGIADVAIVGLPDDR
Mb2533c|M.bovis_AF2122/97 DPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAK
Rv2505c|M.tuberculosis_H37Rv DPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAK
MUL_4126|M.ulcerans_Agy99 DEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVAVIGIPDHR
MAB_4569c|M.abscessus_ATCC_199 DEDGFVWVVDRKKDMIISGGENIYCAEVENALAEHEQIAEVAVIGRPHEK
MLBr_02546|M.leprae_Br4923 DEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDDKE
: : .* :: : .* .: ::*: : : : :. . .
Mflv_2523|M.gilvum_PYR-GCK LGEHTAAVLRIRDGHVMPSLDDVRAHFRAAGAATQKWPEELHRVPEGQDF
Mvan_4135|M.vanbaalenii_PYR-1 LGEHTAAVLRIREGQSMPALGDVREHFKQAGVATQKWPEELHRVPEGQDF
MSMEG_4774|M.smegmatis_MC2_155 LGERVAAVLRTRSGAPLPTLDDVRAHFERVGIARQKWPEELHHVPDGQDF
TH_2816|M.thermoresistible__bu LGERTAAVVRVKPGHAMPTLDEVRDHFERTGVARQKWPEELHEVS---DY
MAV_2638|M.avium_104 YGDVVAAVVVLKPGYALN-LDDLRAHFAASGLARQKTPERLAIVD---EL
MMAR_0303|M.marinum_M TGERACAVIVAAAD-PPPGLPGVRAFLEGAGVARFKIPEQVVIWD---HL
Mb2533c|M.bovis_AF2122/97 YGEELMAVVKLRNDAPELTIERLREYCMGR-IARFKIPRYLWIVD---EF
Rv2505c|M.tuberculosis_H37Rv YGEELMAVVKLRNDAPELTIERLREYCMGR-IARFKIPRYLWIVD---EF
MUL_4126|M.ulcerans_Agy99 LGEVGRAFIVAR-PGFNLDEKSVIDYTREH-LANFKAPRSVRFVD---TL
MAB_4569c|M.abscessus_ATCC_199 WGEVPVAVAAIHGAALTLAELDG---FLTARLARYKHPKDLVIVD---AL
MLBr_02546|M.leprae_Br4923 WGARLRAFVVKKQD--ATIDEDAIKAYVRDHLARYKVPREVIFLE---EL
* *. * * *. :
Mflv_2523|M.gilvum_PYR-GCK PRTASGKVQKYVIRQQVAAGMHGVVAASQK-
Mvan_4135|M.vanbaalenii_PYR-1 PRTASGKVQKFVIRQQLAAGELSAIATGQE-
MSMEG_4774|M.smegmatis_MC2_155 PRTASGKVQKYRVRQAVRNPAAVMDIATSAN
TH_2816|M.thermoresistible__bu PRTASGKVQKYRVRQSIAEIAAAQQ------
MAV_2638|M.avium_104 PRTSLGKVRKAQLRSDHFGAARR--------
MMAR_0303|M.marinum_M PKNHAGKIVKHRIKAALMKAEQ---------
Mb2533c|M.bovis_AF2122/97 PMTVTGKVRKVEMRQQALEYLRGQQ------
Rv2505c|M.tuberculosis_H37Rv PMTVTGKVRKVEMRQQALEYLRGQQ------
MUL_4126|M.ulcerans_Agy99 PRNAGGKVVKPQLRELA--------------
MAB_4569c|M.abscessus_ATCC_199 PRNPSGKVLKTELRQRFGIAD----------
MLBr_02546|M.leprae_Br4923 PRNPTGKVLKRELRDFEVH------------
* . **: * ::