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M. smegmatis MC2 155 MSMEG_4774 (-)

annotation: AMP-dependent synthetase and ligase
coordinates: 4876225 - 4877802
length: 525

RDIPAELTKRYVEEGWWTPETLGQMLAEGLAAGPDVVFCVHSEVRPYTGTFGEVETLARRLAAGLRARGV
GPGDVIAFQLPNWMEAAAAFWATSFLGAVTVPIVHFYGRKELAHILSTAKPKVFLTTERFGRMSFQPDLC
AQVPIVGLVGESSFTDLLAERPMSGTLDTDPAAPALIAFTSGTTRDPKGVIHSHQTLSCETRQLLANYPP
NRGRQLTATPVGHFIGMVGAFLIPVLEGAPVDLCDVWDPAKVLRLMESDGLSIGGGPPYFVTSLLDHPDF
ADRHLARIRTVGLGGSTVPAAVTRRLADLGIFVFRSYGSTEHPSITGSSPSAPEGKRLYTDGNPRPGVEI
RLGPDGEIFSRGPDLCLGYTDDALTAKAFDDEGWYRTGDVGFLDDDGYLTITDRTADLIIRGGENISALE
VEEVLLGIPGVIEAIVVAAPDARLGERVAAVLRTRSGAPLPTLDDVRAHFERVGIARQKWPEELHHVPDG
QDFPRTASGKVQKYRVRQAVRNPAAVMDIATSAN*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_4774--100% (525)AMP-dependent synthetase and ligase
M. smegmatis MC2 155MSMEG_5631-2e-6336.01% (511) AMP-dependent synthetase and ligase
M. smegmatis MC2 155MSMEG_4112-2e-6031.07% (531) cyclohexanecarboxylate-CoA ligase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3591fadD33e-4932.99% (488) acyl-CoA synthetase
M. gilvum PYR-GCKMflv_2523-0.075.05% (521) AMP-dependent synthetase and ligase
M. tuberculosis H37RvRv3561fadD38e-5033.20% (488) acyl-CoA synthetase
M. leprae Br4923MLBr_01051xclC1e-2829.52% (481) acyl-CoA synthetase
M. abscessus ATCC 19977MAB_4377c-3e-5031.77% (532) AMP-binding domain protein
M. marinum MMMAR_0303-1e-6133.46% (511) acyl-CoA synthetase
M. avium 104MAV_2638-1e-9040.41% (532) AMP-dependent synthetase and ligase
M. thermoresistible (build 8)TH_2816-0.078.68% (516) PUTATIVE AMP-dependent synthetase and ligase
M. ulcerans Agy99MUL_4126fadD36e-4732.43% (481) acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_4135-0.077.56% (517) AMP-dependent synthetase and ligase

CLUSTAL 2.0.9 multiple sequence alignment


Mb3591|M.bovis_AF2122/97            ------------------------------MINDLRTVPAALDRLVRQLP
Rv3561|M.tuberculosis_H37Rv         ------------------------------MINDLRTVPAALDRLVRQLP
MUL_4126|M.ulcerans_Agy99           ------------------------------MTSDPRTVPTALDRLVRRLP
MAB_4377c|M.abscessus_ATCC_199      --------------------MKAYDAGATLSPIIEETIGENFERIARAHP
MSMEG_4774|M.smegmatis_MC2_155      ---------------MRDIPAELTKRYVEEGWWTPETLGQMLAEGLAAGP
TH_2816|M.thermoresistible__bu      ---------------MRSIPAELRRRYEENGWWTQESLGDLLAEGLRAAP
Mflv_2523|M.gilvum_PYR-GCK          ---------------MRRIPEELVRRYEQEGYWTPETLGELLARGLDSAP
Mvan_4135|M.vanbaalenii_PYR-1       ---------------MRRIPAQLVERYQREGYWTQETLGDMLARGLAGSP
MAV_2638|M.avium_104                ---------------MPFDHRQLRDKWYSAGWYSDRTCLDAFEAGAVEHK
MMAR_0303|M.marinum_M               MGGPKVPQRRLIDGRWVRWDADRAAGAYAHRWWVRRTLADALREAAQSTP
MLBr_01051|M.leprae_Br4923          ------------------------------------MLLASLNPSVVTAT
                                                                             :        

Mb3591|M.bovis_AF2122/97            DHTALIAE---DRRFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTW
Rv3561|M.tuberculosis_H37Rv         DHTALIAE---DRRFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTW
MUL_4126|M.ulcerans_Agy99           NHDALVTD---ERSFTVSELNDEVYRAAAALIELGVKPAARVGIWSPNTW
MAB_4377c|M.abscessus_ATCC_199      DVGALVDVSG-DRRWTYRELDAEINRVARGLMSLGVAAGDRVGIWAPNCA
MSMEG_4774|M.smegmatis_MC2_155      DVVFCVHSEVRPYTGTFGEVETLARRLAAGLRARGVGPGDVIAFQLPNWM
TH_2816|M.thermoresistible__bu      DAGFRVHSDVRPYTGTFADVEERARRLAAGLRARGVGPGDVIAFQLPNWV
Mflv_2523|M.gilvum_PYR-GCK          GAGFHVHSAVRPYAGTFAEVERDARRLAAGLRERGVAAGDVVALQLPNWR
Mvan_4135|M.vanbaalenii_PYR-1       EAGFCVHSSIRPYRGTFGEVERDARRLAAGLRERGVGPGDVVAMQLPNWR
MAV_2638|M.avium_104                DVPLTFVIGDSVSSPTVCEIHDRAVALAASLQRLGVRDGDAVAVQLTNRV
MMAR_0303|M.marinum_M               QRVALVDADR---QLDCQELHRQAMALAQHLRSR-MPAGSVVSFMLPNWH
MLBr_01051|M.leprae_Br4923          DIADAVCVDG-------VVLSRSGLVGAATSVAERVGGARLVAVLATPTA
                                         .             :       *       :  .  :..  .   

Mb3591|M.bovis_AF2122/97            HWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLGAD
Rv3561|M.tuberculosis_H37Rv         HWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLGAD
MUL_4126|M.ulcerans_Agy99           HWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAMGHFLGSD
MAB_4377c|M.abscessus_ATCC_199      EWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKSSD
MSMEG_4774|M.smegmatis_MC2_155      EAAAAFWATSFLGAVTVPIVHFYGRKELAHILSTAKPKVFLTTERFGRMS
TH_2816|M.thermoresistible__bu      EAAMTFWASAFLGAVVVPVVHFYGRKELGHILRTARPKVFITAAEFGRMR
Mflv_2523|M.gilvum_PYR-GCK          EAAVTFWASAFLGAVVVPVVHFYGRKELAHILTTAKPRVFVTTAQFGRLQ
Mvan_4135|M.vanbaalenii_PYR-1       EAAVTFWASAFLGAVVVPIVHFYGRRELAHIMATAKPRVFVTAEEFGRMR
MAV_2638|M.avium_104                ECAVAYQAVLLCGAVLVPIVHIYGMAEVAFVLDQSAAKVLIMPERHGSIV
MMAR_0303|M.marinum_M               EAAVIYLASTLAAMVANPVLPSLREHELRFILEDAGSRMIFAPADFRGHD
MLBr_01051|M.leprae_Br4923          STVLAITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPSADSA
                                      .    .    .     :       *    :  :     .         

Mb3591|M.bovis_AF2122/97            RAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVAARAAAVA
Rv3561|M.tuberculosis_H37Rv         RAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVAARAAAVA
MUL_4126|M.ulcerans_Agy99           RVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETGT-DTGAVTARAAAVS
MAB_4377c|M.abscessus_ATCC_199      YVA-MASQVMPDAPGLRDVVFIGTSDWTELVAGAERVTETALRARMSQLS
MSMEG_4774|M.smegmatis_MC2_155      FQPDLC-AQVPIV-GLVG-----------ESSFTDLLAERPMSG-TLDTD
TH_2816|M.thermoresistible__bu      YQPDLC-ADVPIV-GVVG-----------QHGFDDLVADEPMTG-TLATD
Mflv_2523|M.gilvum_PYR-GCK          FHPDVC-AGVPIV-ALVGDGPDSGADG-GWEPFEDLLAAEPMAG-TVAAD
Mvan_4135|M.vanbaalenii_PYR-1       YQPDLC-GDVAVV-GLVG--AAHPAAG-NEHAFEQLLADEPMAG-TVAAD
MAV_2638|M.avium_104                YSKRLQ-DLSRID-SLQHVVMLDAEPGEGYLAWSQLDTPAARYR-RPAVA
MMAR_0303|M.marinum_M               YTSMLRRVAAQLP-SRPEVIEVRGQCPDGVSTFQSLLVGRETAAPLPTAD
MLBr_01051|M.leprae_Br4923          PDG---------------------------LPHIPVQLDARSWNRYPEPS
                                                                                      

Mb3591|M.bovis_AF2122/97            PQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDD--RYLC
Rv3561|M.tuberculosis_H37Rv         PQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDD--RYLC
MUL_4126|M.ulcerans_Agy99           PDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITADD--RHLC
MAB_4377c|M.abscessus_ATCC_199      NTDPINIQYTSGTTGYPKGATLSHRNVLNNGFFVAESIQLQAGD--RLCI
MSMEG_4774|M.smegmatis_MC2_155      PAAPALIAFTSGTTRDPKGVIHSHQTLSCETR---QLLANYPPNRGRQLT
TH_2816|M.thermoresistible__bu      PAGPALIAFTSGTTRDPKGVIHSHQTLTFETR---QLLANYPPDRGRQLT
Mflv_2523|M.gilvum_PYR-GCK          PAGPALIAFTSGTTRDPKGVIHSHQTLSFETR---QLLENYPPDRGRQLT
Mvan_4135|M.vanbaalenii_PYR-1       PAAPTLIAFTSGTTRDPKGVIHSHQTLSCETR---QLLENYPPDRGRQLT
MAV_2638|M.avium_104                ADDVCLLLYTSGTTSAPKGVQHTNNTVLAEQRTMPALLAGKPDD--VSLV
MMAR_0303|M.marinum_M               PDAVRMVLYTSGTTGRPKGVLHTHNSIHALICQIRDHWMVEPGD--GFLV
MLBr_01051|M.leprae_Br4923          PDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTADD--VLVH
                                          : :*****  .**.  :..                . :      

Mb3591|M.bovis_AF2122/97            INPFFHNFGYKAGILACLQTGATLIPHVT-FDPLHALRAIERHRITVLPG
Rv3561|M.tuberculosis_H37Rv         INPFFHNFGYKAGILACLQTGATLIPHVT-FDPLHALRAIERHRITVLPG
MUL_4126|M.ulcerans_Agy99           INPFFHNFGYKAGILACLQTGATLFPHLT-FDPLRTLQAIERHRITVLPG
MAB_4377c|M.abscessus_ATCC_199      PVPFYHCFGMVMGNLGCTTHGATIVMPAPGFDPGRTLEAIERERCVGVYG
MSMEG_4774|M.smegmatis_MC2_155      ATPVGHFIGMVGAFLIPVLEGAPVDLCDV-WDPAKVLRLMESDGLSIGGG
TH_2816|M.thermoresistible__bu      ATPVGHFIGMVGAFLIPVLEGAPIDLADV-WDPGRVLRLMEAEDISIGGG
Mflv_2523|M.gilvum_PYR-GCK          ATPVGHFIGMLGAFLIPVLEGSPIDLCDV-WDPGRVLQLMETEGLSIGGG
Mvan_4135|M.vanbaalenii_PYR-1       ATPVGHFIGMLGAFLIPVLEGAPIDLCDV-WDPGRVLKLIESDGLSIGGG
MAV_2638|M.avium_104                TFPPGHIAG-VGSMLRPLLSGARTVFMDG-WDPARAVEVVHRFGVTCTAG
MMAR_0303|M.marinum_M               ASPIAHIGGSIYAFECPLLLGTTAVLLDR-WDADRAVQLMTSKRCTHMAG
MLBr_01051|M.leprae_Br4923          GLPLFHVHGLVLGLLGSLRIGNRFVHTGK-PTPTAYAQACSEAGGSLYFG
                                      *  *  *   .       *           .    .           *

Mb3591|M.bovis_AF2122/97            PPTIYQSLLDHPARKDFDLSSLRFAVTGAATVPVVLVERMQSELDIDIVL
Rv3561|M.tuberculosis_H37Rv         PPTIYQSLLDHPARKDFDLSSLRFAVTGAATVPVVLVERMQSELDIDIVL
MUL_4126|M.ulcerans_Agy99           PPTIYQTLLDHPARDDYDLSSLRFAVTGAATVPVVLVERMQSELDIDIVL
MAB_4377c|M.abscessus_ATCC_199      VPTMFIAMLADPGFAHRDLSTLRTGIMAGSVCPVEVMKRCIDEMHMAGVA
MSMEG_4774|M.smegmatis_MC2_155      PPYFVTSLLDHPDFADRHLARIRTVGLGGSTVPAAVTRRLADLG--IFVF
TH_2816|M.thermoresistible__bu      PPYFVTSLLDHPDCTPEHLARFKTVGLGGSTVPTTVTRRLAELG--MFVF
Mflv_2523|M.gilvum_PYR-GCK          PPYFVTSLLDHPQCRPEHVRRFKTVGLGGSTVPAAVTRRLSDLG--MFVF
Mvan_4135|M.vanbaalenii_PYR-1       PPYFVTSLLDHPDFRPEHLRRFKTVGLGGSTVPAAVTQRLTDLG--LFVF
MAV_2638|M.avium_104                TPFHLAGILDLGDTG-DKLASLREFLVGAAPVAEEIGRRAAQAG--ISTF
MMAR_0303|M.marinum_M               ATPFLEQLLAAAQRAGTRLPDLKFFVCGGASVSPSLIRCATDYFDKAVVT
MLBr_01051|M.leprae_Br4923          VPTVWSRLVAD-EAVARALRPARLLVSGSASLPVPVFDRLAHLTG-HRPI
                                     .     ::         :   :    ..:  .  :              

Mb3591|M.bovis_AF2122/97            TAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELRIADD--------
Rv3561|M.tuberculosis_H37Rv         TAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELRIADD--------
MUL_4126|M.ulcerans_Agy99           TAYGLTEANGMGTMCRADDDALTVATTCGRPFADFELRIGPDT-------
MAB_4377c|M.abscessus_ATCC_199      IAYGMTETSPVSCQTLFDDDLDRRTATVGRAHPHIEIKIVDPNSGETVQR
MSMEG_4774|M.smegmatis_MC2_155      RSYGSTEHPSITGSS-PSAPEGKRLYTDGNPRPGVEIRLGPD--------
TH_2816|M.thermoresistible__bu      RSYGSTEHPSITGSG-PAAPEEKRLYTDGNPRPGVEIRIAED--------
Mflv_2523|M.gilvum_PYR-GCK          RSYGSTEHPSITGSR-PSAPEDKRLFTDGDARPGVEIKLGPD--------
Mvan_4135|M.vanbaalenii_PYR-1       RSYGSTEHPSITGSR-PDAPEVKRLFTDGNVRPGVEIRLGED--------
MAV_2638|M.avium_104                RSYGATEHPTVTGEH-EGQPQWARLGTDGKPLPGSEIRIVGSD-GTDCPI
MMAR_0303|M.marinum_M               RVYGSTEVPVTTIGA-PDSS-AHAAATDGRVG-AADVKLVAG--------
MLBr_01051|M.leprae_Br4923          ERYGSTESLITLSTL---ADGERRAGWVGLPLAGVQTRLVDESGGPVPYD
                                      ** **                     *      : ::           

Mb3591|M.bovis_AF2122/97            ----GEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLR
Rv3561|M.tuberculosis_H37Rv         ----GEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLR
MUL_4126|M.ulcerans_Agy99           ----GEVLLRGPNVMLGYLDDPRATAAAIDADGWLHTGDIGVLDEAGNLR
MAB_4377c|M.abscessus_ATCC_199      -GQSGELCTRGYSVMLGYWNDEAHTREVLDTDGWMHTGDLAVMRDDGYCT
MSMEG_4774|M.smegmatis_MC2_155      ----GEIFSRGPDLCLGYTDD-ALTAKAFDDEGWYRTGDVGFLDDDGYLT
TH_2816|M.thermoresistible__bu      ----GEILSRGPDLCLGYTDD-ALTARAFDDDGWYHTGDIGVLDDDGYLT
Mflv_2523|M.gilvum_PYR-GCK          ----GEIFSRGPDLCLGYVDD-DLTAQAFDEDGWYHTGDIGVLDEDGYLT
Mvan_4135|M.vanbaalenii_PYR-1       ----GEIFSRGPDLCLGYTDD-ELTARAFDDDGWYRTGDVGVLDDDGYLT
MAV_2638|M.avium_104                -GIGGEVVVRGPDQFIGYQDS-ALNTEAFTDDGWFRTGDLGHLDAHGRLT
MMAR_0303|M.marinum_M               -----EIRVRGPQMLVGYRHP-EDEAGSFDAQGYFRTGDLGHWVDDEYLV
MLBr_01051|M.leprae_Br4923          GETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHR
                                         .:  *.     ** .        :  :*: :***:.         

Mb3591|M.bovis_AF2122/97            INDR-LKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGR
Rv3561|M.tuberculosis_H37Rv         ITDR-LKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGR
MUL_4126|M.ulcerans_Agy99           ITDR-LKDMYICGGFNVYPAEVEQVLARLDGVADVAVIGIPDHRLGEVGR
MAB_4377c|M.abscessus_ATCC_199      IIGR-LKDMVIRGGENIYPREIEEFLLTHPDIEDVHVVGVPDEKYGEELC
MSMEG_4774|M.smegmatis_MC2_155      ITDR-TADLIIRGGENISALEVEEVLLGIPGVIEAIVVAAPDARLGERVA
TH_2816|M.thermoresistible__bu      ITDR-KADLIIRGGENISALEVEEVLLGMPAVAEAVVVAAPDPRLGERTA
Mflv_2523|M.gilvum_PYR-GCK          ITDR-KADVIIRGGENISALEVEEILLGMPAVAEAVVVAAPDERLGEHTA
Mvan_4135|M.vanbaalenii_PYR-1       ITDR-KADVIIRGGENISALEVEEVLLAMPAVAEAVVVAAPDARLGEHTA
MAV_2638|M.avium_104                ITDR-IKDVIIRGGETISSGQVEEVLNAHPAVADGVAVAAPDSRYGDVVA
MMAR_0303|M.marinum_M               VTGR-AKDIIIRNGENISPKEIEDILITHPGIADVAIVGLPDDRTGERAC
MLBr_01051|M.leprae_Br4923          IVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQRIV
                                    : .*   *:   .*  : . ::*  *     : :   :. **   *:   

Mb3591|M.bovis_AF2122/97            AFVVARPG-TGLDEASVIAYTREH-LANFKTPRSVRFVD---VLPRNAAG
Rv3561|M.tuberculosis_H37Rv         AFVVARPG-TGLDEASVIAYTREH-LANFKTPRSVRFVD---VLPRNAAG
MUL_4126|M.ulcerans_Agy99           AFIVARPG-FNLDEKSVIDYTREH-LANFKAPRSVRFVD---TLPRNAGG
MAB_4377c|M.abscessus_ATCC_199      AWVRMRPDRVVIDAVAIRAFASGR-LAHYKIPRYVHVVE---SFPMTVTG
MSMEG_4774|M.smegmatis_MC2_155      AVLRTRSGAPLPTLDDVRAHFERVGIARQKWPEELHHVPDGQDFPRTASG
TH_2816|M.thermoresistible__bu      AVVRVKPGHAMPTLDEVRDHFERTGVARQKWPEELHEVS---DYPRTASG
Mflv_2523|M.gilvum_PYR-GCK          AVLRIRDGHVMPSLDDVRAHFRAAGAATQKWPEELHRVPEGQDFPRTASG
Mvan_4135|M.vanbaalenii_PYR-1       AVLRIREGQSMPALGDVREHFKQAGVATQKWPEELHRVPEGQDFPRTASG
MAV_2638|M.avium_104                AVVVLKPGYALN-LDDLRAHFAASGLARQKTPERLAIVD---ELPRTSLG
MMAR_0303|M.marinum_M               AVIVAAAD-PPPGLPGVRAFLEGAGVARFKIPEQVVIWD---HLPKNHAG
MLBr_01051|M.leprae_Br4923          AFVVGAEA---LDADELINYVAQQ-LSIHKRPREVRFVD---ALPRNAMG
                                    * :             :  .      :  * *. :         * .  *

Mb3591|M.bovis_AF2122/97            KVSKPQLRELG---------------
Rv3561|M.tuberculosis_H37Rv         KVSKPQLRELG---------------
MUL_4126|M.ulcerans_Agy99           KVVKPQLRELA---------------
MAB_4377c|M.abscessus_ATCC_199      KVRKIEMRQQTIQIFGLPEPGRTDEQ
MSMEG_4774|M.smegmatis_MC2_155      KVQKYRVRQAVRNPAAVMDIATSAN-
TH_2816|M.thermoresistible__bu      KVQKYRVRQSIAEIAAAQQ-------
Mflv_2523|M.gilvum_PYR-GCK          KVQKYVIRQQVAAGMHGVVAASQK--
Mvan_4135|M.vanbaalenii_PYR-1       KVQKFVIRQQLAAGELSAIATGQE--
MAV_2638|M.avium_104                KVRKAQLRSDHFGAARR---------
MMAR_0303|M.marinum_M               KIVKHRIKAALMKAEQ----------
MLBr_01051|M.leprae_Br4923          KVLKKQLLFEG---------------
                                    *: *  :