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RDIPAELTKRYVEEGWWTPETLGQMLAEGLAAGPDVVFCVHSEVRPYTGTFGEVETLARRLAAGLRARGV GPGDVIAFQLPNWMEAAAAFWATSFLGAVTVPIVHFYGRKELAHILSTAKPKVFLTTERFGRMSFQPDLC AQVPIVGLVGESSFTDLLAERPMSGTLDTDPAAPALIAFTSGTTRDPKGVIHSHQTLSCETRQLLANYPP NRGRQLTATPVGHFIGMVGAFLIPVLEGAPVDLCDVWDPAKVLRLMESDGLSIGGGPPYFVTSLLDHPDF ADRHLARIRTVGLGGSTVPAAVTRRLADLGIFVFRSYGSTEHPSITGSSPSAPEGKRLYTDGNPRPGVEI RLGPDGEIFSRGPDLCLGYTDDALTAKAFDDEGWYRTGDVGFLDDDGYLTITDRTADLIIRGGENISALE VEEVLLGIPGVIEAIVVAAPDARLGERVAAVLRTRSGAPLPTLDDVRAHFERVGIARQKWPEELHHVPDG QDFPRTASGKVQKYRVRQAVRNPAAVMDIATSAN*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_4774 | - | - | 100% (525) | AMP-dependent synthetase and ligase |
M. smegmatis MC2 155 | MSMEG_5631 | - | 2e-63 | 36.01% (511) | AMP-dependent synthetase and ligase |
M. smegmatis MC2 155 | MSMEG_4112 | - | 2e-60 | 31.07% (531) | cyclohexanecarboxylate-CoA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3591 | fadD3 | 3e-49 | 32.99% (488) | acyl-CoA synthetase |
M. gilvum PYR-GCK | Mflv_2523 | - | 0.0 | 75.05% (521) | AMP-dependent synthetase and ligase |
M. tuberculosis H37Rv | Rv3561 | fadD3 | 8e-50 | 33.20% (488) | acyl-CoA synthetase |
M. leprae Br4923 | MLBr_01051 | xclC | 1e-28 | 29.52% (481) | acyl-CoA synthetase |
M. abscessus ATCC 19977 | MAB_4377c | - | 3e-50 | 31.77% (532) | AMP-binding domain protein |
M. marinum M | MMAR_0303 | - | 1e-61 | 33.46% (511) | acyl-CoA synthetase |
M. avium 104 | MAV_2638 | - | 1e-90 | 40.41% (532) | AMP-dependent synthetase and ligase |
M. thermoresistible (build 8) | TH_2816 | - | 0.0 | 78.68% (516) | PUTATIVE AMP-dependent synthetase and ligase |
M. ulcerans Agy99 | MUL_4126 | fadD3 | 6e-47 | 32.43% (481) | acyl-CoA synthetase |
M. vanbaalenii PYR-1 | Mvan_4135 | - | 0.0 | 77.56% (517) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment Mb3591|M.bovis_AF2122/97 ------------------------------MINDLRTVPAALDRLVRQLP Rv3561|M.tuberculosis_H37Rv ------------------------------MINDLRTVPAALDRLVRQLP MUL_4126|M.ulcerans_Agy99 ------------------------------MTSDPRTVPTALDRLVRRLP MAB_4377c|M.abscessus_ATCC_199 --------------------MKAYDAGATLSPIIEETIGENFERIARAHP MSMEG_4774|M.smegmatis_MC2_155 ---------------MRDIPAELTKRYVEEGWWTPETLGQMLAEGLAAGP TH_2816|M.thermoresistible__bu ---------------MRSIPAELRRRYEENGWWTQESLGDLLAEGLRAAP Mflv_2523|M.gilvum_PYR-GCK ---------------MRRIPEELVRRYEQEGYWTPETLGELLARGLDSAP Mvan_4135|M.vanbaalenii_PYR-1 ---------------MRRIPAQLVERYQREGYWTQETLGDMLARGLAGSP MAV_2638|M.avium_104 ---------------MPFDHRQLRDKWYSAGWYSDRTCLDAFEAGAVEHK MMAR_0303|M.marinum_M MGGPKVPQRRLIDGRWVRWDADRAAGAYAHRWWVRRTLADALREAAQSTP MLBr_01051|M.leprae_Br4923 ------------------------------------MLLASLNPSVVTAT : Mb3591|M.bovis_AF2122/97 DHTALIAE---DRRFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTW Rv3561|M.tuberculosis_H37Rv DHTALIAE---DRRFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTW MUL_4126|M.ulcerans_Agy99 NHDALVTD---ERSFTVSELNDEVYRAAAALIELGVKPAARVGIWSPNTW MAB_4377c|M.abscessus_ATCC_199 DVGALVDVSG-DRRWTYRELDAEINRVARGLMSLGVAAGDRVGIWAPNCA MSMEG_4774|M.smegmatis_MC2_155 DVVFCVHSEVRPYTGTFGEVETLARRLAAGLRARGVGPGDVIAFQLPNWM TH_2816|M.thermoresistible__bu DAGFRVHSDVRPYTGTFADVEERARRLAAGLRARGVGPGDVIAFQLPNWV Mflv_2523|M.gilvum_PYR-GCK GAGFHVHSAVRPYAGTFAEVERDARRLAAGLRERGVAAGDVVALQLPNWR Mvan_4135|M.vanbaalenii_PYR-1 EAGFCVHSSIRPYRGTFGEVERDARRLAAGLRERGVGPGDVVAMQLPNWR MAV_2638|M.avium_104 DVPLTFVIGDSVSSPTVCEIHDRAVALAASLQRLGVRDGDAVAVQLTNRV MMAR_0303|M.marinum_M QRVALVDADR---QLDCQELHRQAMALAQHLRSR-MPAGSVVSFMLPNWH MLBr_01051|M.leprae_Br4923 DIADAVCVDG-------VVLSRSGLVGAATSVAERVGGARLVAVLATPTA . : * : . :.. . Mb3591|M.bovis_AF2122/97 HWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLGAD Rv3561|M.tuberculosis_H37Rv HWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLGAD MUL_4126|M.ulcerans_Agy99 HWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAMGHFLGSD MAB_4377c|M.abscessus_ATCC_199 EWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKSSD MSMEG_4774|M.smegmatis_MC2_155 EAAAAFWATSFLGAVTVPIVHFYGRKELAHILSTAKPKVFLTTERFGRMS TH_2816|M.thermoresistible__bu EAAMTFWASAFLGAVVVPVVHFYGRKELGHILRTARPKVFITAAEFGRMR Mflv_2523|M.gilvum_PYR-GCK EAAVTFWASAFLGAVVVPVVHFYGRKELAHILTTAKPRVFVTTAQFGRLQ Mvan_4135|M.vanbaalenii_PYR-1 EAAVTFWASAFLGAVVVPIVHFYGRRELAHIMATAKPRVFVTAEEFGRMR MAV_2638|M.avium_104 ECAVAYQAVLLCGAVLVPIVHIYGMAEVAFVLDQSAAKVLIMPERHGSIV MMAR_0303|M.marinum_M EAAVIYLASTLAAMVANPVLPSLREHELRFILEDAGSRMIFAPADFRGHD MLBr_01051|M.leprae_Br4923 STVLAITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPSADSA . . . : * : : . Mb3591|M.bovis_AF2122/97 RAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVAARAAAVA Rv3561|M.tuberculosis_H37Rv RAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVAARAAAVA MUL_4126|M.ulcerans_Agy99 RVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETGT-DTGAVTARAAAVS MAB_4377c|M.abscessus_ATCC_199 YVA-MASQVMPDAPGLRDVVFIGTSDWTELVAGAERVTETALRARMSQLS MSMEG_4774|M.smegmatis_MC2_155 FQPDLC-AQVPIV-GLVG-----------ESSFTDLLAERPMSG-TLDTD TH_2816|M.thermoresistible__bu YQPDLC-ADVPIV-GVVG-----------QHGFDDLVADEPMTG-TLATD Mflv_2523|M.gilvum_PYR-GCK FHPDVC-AGVPIV-ALVGDGPDSGADG-GWEPFEDLLAAEPMAG-TVAAD Mvan_4135|M.vanbaalenii_PYR-1 YQPDLC-GDVAVV-GLVG--AAHPAAG-NEHAFEQLLADEPMAG-TVAAD MAV_2638|M.avium_104 YSKRLQ-DLSRID-SLQHVVMLDAEPGEGYLAWSQLDTPAARYR-RPAVA MMAR_0303|M.marinum_M YTSMLRRVAAQLP-SRPEVIEVRGQCPDGVSTFQSLLVGRETAAPLPTAD MLBr_01051|M.leprae_Br4923 PDG---------------------------LPHIPVQLDARSWNRYPEPS Mb3591|M.bovis_AF2122/97 PQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDD--RYLC Rv3561|M.tuberculosis_H37Rv PQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDD--RYLC MUL_4126|M.ulcerans_Agy99 PDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITADD--RHLC MAB_4377c|M.abscessus_ATCC_199 NTDPINIQYTSGTTGYPKGATLSHRNVLNNGFFVAESIQLQAGD--RLCI MSMEG_4774|M.smegmatis_MC2_155 PAAPALIAFTSGTTRDPKGVIHSHQTLSCETR---QLLANYPPNRGRQLT TH_2816|M.thermoresistible__bu PAGPALIAFTSGTTRDPKGVIHSHQTLTFETR---QLLANYPPDRGRQLT Mflv_2523|M.gilvum_PYR-GCK PAGPALIAFTSGTTRDPKGVIHSHQTLSFETR---QLLENYPPDRGRQLT Mvan_4135|M.vanbaalenii_PYR-1 PAAPTLIAFTSGTTRDPKGVIHSHQTLSCETR---QLLENYPPDRGRQLT MAV_2638|M.avium_104 ADDVCLLLYTSGTTSAPKGVQHTNNTVLAEQRTMPALLAGKPDD--VSLV MMAR_0303|M.marinum_M PDAVRMVLYTSGTTGRPKGVLHTHNSIHALICQIRDHWMVEPGD--GFLV MLBr_01051|M.leprae_Br4923 PDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTADD--VLVH : :***** .**. :.. . : Mb3591|M.bovis_AF2122/97 INPFFHNFGYKAGILACLQTGATLIPHVT-FDPLHALRAIERHRITVLPG Rv3561|M.tuberculosis_H37Rv INPFFHNFGYKAGILACLQTGATLIPHVT-FDPLHALRAIERHRITVLPG MUL_4126|M.ulcerans_Agy99 INPFFHNFGYKAGILACLQTGATLFPHLT-FDPLRTLQAIERHRITVLPG MAB_4377c|M.abscessus_ATCC_199 PVPFYHCFGMVMGNLGCTTHGATIVMPAPGFDPGRTLEAIERERCVGVYG MSMEG_4774|M.smegmatis_MC2_155 ATPVGHFIGMVGAFLIPVLEGAPVDLCDV-WDPAKVLRLMESDGLSIGGG TH_2816|M.thermoresistible__bu ATPVGHFIGMVGAFLIPVLEGAPIDLADV-WDPGRVLRLMEAEDISIGGG Mflv_2523|M.gilvum_PYR-GCK ATPVGHFIGMLGAFLIPVLEGSPIDLCDV-WDPGRVLQLMETEGLSIGGG Mvan_4135|M.vanbaalenii_PYR-1 ATPVGHFIGMLGAFLIPVLEGAPIDLCDV-WDPGRVLKLIESDGLSIGGG MAV_2638|M.avium_104 TFPPGHIAG-VGSMLRPLLSGARTVFMDG-WDPARAVEVVHRFGVTCTAG MMAR_0303|M.marinum_M ASPIAHIGGSIYAFECPLLLGTTAVLLDR-WDADRAVQLMTSKRCTHMAG MLBr_01051|M.leprae_Br4923 GLPLFHVHGLVLGLLGSLRIGNRFVHTGK-PTPTAYAQACSEAGGSLYFG * * * . * . . * Mb3591|M.bovis_AF2122/97 PPTIYQSLLDHPARKDFDLSSLRFAVTGAATVPVVLVERMQSELDIDIVL Rv3561|M.tuberculosis_H37Rv PPTIYQSLLDHPARKDFDLSSLRFAVTGAATVPVVLVERMQSELDIDIVL MUL_4126|M.ulcerans_Agy99 PPTIYQTLLDHPARDDYDLSSLRFAVTGAATVPVVLVERMQSELDIDIVL MAB_4377c|M.abscessus_ATCC_199 VPTMFIAMLADPGFAHRDLSTLRTGIMAGSVCPVEVMKRCIDEMHMAGVA MSMEG_4774|M.smegmatis_MC2_155 PPYFVTSLLDHPDFADRHLARIRTVGLGGSTVPAAVTRRLADLG--IFVF TH_2816|M.thermoresistible__bu PPYFVTSLLDHPDCTPEHLARFKTVGLGGSTVPTTVTRRLAELG--MFVF Mflv_2523|M.gilvum_PYR-GCK PPYFVTSLLDHPQCRPEHVRRFKTVGLGGSTVPAAVTRRLSDLG--MFVF Mvan_4135|M.vanbaalenii_PYR-1 PPYFVTSLLDHPDFRPEHLRRFKTVGLGGSTVPAAVTQRLTDLG--LFVF MAV_2638|M.avium_104 TPFHLAGILDLGDTG-DKLASLREFLVGAAPVAEEIGRRAAQAG--ISTF MMAR_0303|M.marinum_M ATPFLEQLLAAAQRAGTRLPDLKFFVCGGASVSPSLIRCATDYFDKAVVT MLBr_01051|M.leprae_Br4923 VPTVWSRLVAD-EAVARALRPARLLVSGSASLPVPVFDRLAHLTG-HRPI . :: : : ..: . : Mb3591|M.bovis_AF2122/97 TAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELRIADD-------- Rv3561|M.tuberculosis_H37Rv TAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELRIADD-------- MUL_4126|M.ulcerans_Agy99 TAYGLTEANGMGTMCRADDDALTVATTCGRPFADFELRIGPDT------- MAB_4377c|M.abscessus_ATCC_199 IAYGMTETSPVSCQTLFDDDLDRRTATVGRAHPHIEIKIVDPNSGETVQR MSMEG_4774|M.smegmatis_MC2_155 RSYGSTEHPSITGSS-PSAPEGKRLYTDGNPRPGVEIRLGPD-------- TH_2816|M.thermoresistible__bu RSYGSTEHPSITGSG-PAAPEEKRLYTDGNPRPGVEIRIAED-------- Mflv_2523|M.gilvum_PYR-GCK RSYGSTEHPSITGSR-PSAPEDKRLFTDGDARPGVEIKLGPD-------- Mvan_4135|M.vanbaalenii_PYR-1 RSYGSTEHPSITGSR-PDAPEVKRLFTDGNVRPGVEIRLGED-------- MAV_2638|M.avium_104 RSYGATEHPTVTGEH-EGQPQWARLGTDGKPLPGSEIRIVGSD-GTDCPI MMAR_0303|M.marinum_M RVYGSTEVPVTTIGA-PDSS-AHAAATDGRVG-AADVKLVAG-------- MLBr_01051|M.leprae_Br4923 ERYGSTESLITLSTL---ADGERRAGWVGLPLAGVQTRLVDESGGPVPYD ** ** * : :: Mb3591|M.bovis_AF2122/97 ----GEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLR Rv3561|M.tuberculosis_H37Rv ----GEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLR MUL_4126|M.ulcerans_Agy99 ----GEVLLRGPNVMLGYLDDPRATAAAIDADGWLHTGDIGVLDEAGNLR MAB_4377c|M.abscessus_ATCC_199 -GQSGELCTRGYSVMLGYWNDEAHTREVLDTDGWMHTGDLAVMRDDGYCT MSMEG_4774|M.smegmatis_MC2_155 ----GEIFSRGPDLCLGYTDD-ALTAKAFDDEGWYRTGDVGFLDDDGYLT TH_2816|M.thermoresistible__bu ----GEILSRGPDLCLGYTDD-ALTARAFDDDGWYHTGDIGVLDDDGYLT Mflv_2523|M.gilvum_PYR-GCK ----GEIFSRGPDLCLGYVDD-DLTAQAFDEDGWYHTGDIGVLDEDGYLT Mvan_4135|M.vanbaalenii_PYR-1 ----GEIFSRGPDLCLGYTDD-ELTARAFDDDGWYRTGDVGVLDDDGYLT MAV_2638|M.avium_104 -GIGGEVVVRGPDQFIGYQDS-ALNTEAFTDDGWFRTGDLGHLDAHGRLT MMAR_0303|M.marinum_M -----EIRVRGPQMLVGYRHP-EDEAGSFDAQGYFRTGDLGHWVDDEYLV MLBr_01051|M.leprae_Br4923 GETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHR .: *. ** . : :*: :***:. Mb3591|M.bovis_AF2122/97 INDR-LKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGR Rv3561|M.tuberculosis_H37Rv ITDR-LKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGR MUL_4126|M.ulcerans_Agy99 ITDR-LKDMYICGGFNVYPAEVEQVLARLDGVADVAVIGIPDHRLGEVGR MAB_4377c|M.abscessus_ATCC_199 IIGR-LKDMVIRGGENIYPREIEEFLLTHPDIEDVHVVGVPDEKYGEELC MSMEG_4774|M.smegmatis_MC2_155 ITDR-TADLIIRGGENISALEVEEVLLGIPGVIEAIVVAAPDARLGERVA TH_2816|M.thermoresistible__bu ITDR-KADLIIRGGENISALEVEEVLLGMPAVAEAVVVAAPDPRLGERTA Mflv_2523|M.gilvum_PYR-GCK ITDR-KADVIIRGGENISALEVEEILLGMPAVAEAVVVAAPDERLGEHTA Mvan_4135|M.vanbaalenii_PYR-1 ITDR-KADVIIRGGENISALEVEEVLLAMPAVAEAVVVAAPDARLGEHTA MAV_2638|M.avium_104 ITDR-IKDVIIRGGETISSGQVEEVLNAHPAVADGVAVAAPDSRYGDVVA MMAR_0303|M.marinum_M VTGR-AKDIIIRNGENISPKEIEDILITHPGIADVAIVGLPDDRTGERAC MLBr_01051|M.leprae_Br4923 IVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQRIV : .* *: .* : . ::* * : : :. ** *: Mb3591|M.bovis_AF2122/97 AFVVARPG-TGLDEASVIAYTREH-LANFKTPRSVRFVD---VLPRNAAG Rv3561|M.tuberculosis_H37Rv AFVVARPG-TGLDEASVIAYTREH-LANFKTPRSVRFVD---VLPRNAAG MUL_4126|M.ulcerans_Agy99 AFIVARPG-FNLDEKSVIDYTREH-LANFKAPRSVRFVD---TLPRNAGG MAB_4377c|M.abscessus_ATCC_199 AWVRMRPDRVVIDAVAIRAFASGR-LAHYKIPRYVHVVE---SFPMTVTG MSMEG_4774|M.smegmatis_MC2_155 AVLRTRSGAPLPTLDDVRAHFERVGIARQKWPEELHHVPDGQDFPRTASG TH_2816|M.thermoresistible__bu AVVRVKPGHAMPTLDEVRDHFERTGVARQKWPEELHEVS---DYPRTASG Mflv_2523|M.gilvum_PYR-GCK AVLRIRDGHVMPSLDDVRAHFRAAGAATQKWPEELHRVPEGQDFPRTASG Mvan_4135|M.vanbaalenii_PYR-1 AVLRIREGQSMPALGDVREHFKQAGVATQKWPEELHRVPEGQDFPRTASG MAV_2638|M.avium_104 AVVVLKPGYALN-LDDLRAHFAASGLARQKTPERLAIVD---ELPRTSLG MMAR_0303|M.marinum_M AVIVAAAD-PPPGLPGVRAFLEGAGVARFKIPEQVVIWD---HLPKNHAG MLBr_01051|M.leprae_Br4923 AFVVGAEA---LDADELINYVAQQ-LSIHKRPREVRFVD---ALPRNAMG * : : . : * *. : * . * Mb3591|M.bovis_AF2122/97 KVSKPQLRELG--------------- Rv3561|M.tuberculosis_H37Rv KVSKPQLRELG--------------- MUL_4126|M.ulcerans_Agy99 KVVKPQLRELA--------------- MAB_4377c|M.abscessus_ATCC_199 KVRKIEMRQQTIQIFGLPEPGRTDEQ MSMEG_4774|M.smegmatis_MC2_155 KVQKYRVRQAVRNPAAVMDIATSAN- TH_2816|M.thermoresistible__bu KVQKYRVRQSIAEIAAAQQ------- Mflv_2523|M.gilvum_PYR-GCK KVQKYVIRQQVAAGMHGVVAASQK-- Mvan_4135|M.vanbaalenii_PYR-1 KVQKFVIRQQLAAGELSAIATGQE-- MAV_2638|M.avium_104 KVRKAQLRSDHFGAARR--------- MMAR_0303|M.marinum_M KIVKHRIKAALMKAEQ---------- MLBr_01051|M.leprae_Br4923 KVLKKQLLFEG--------------- *: * :