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MSSPKAVAAGFDHSDLRDRWYREGWYSRRTLVDALEQGSAEHGDTPVVFVVDGVETTSTPAEIFQRSRDV AAGLQALGVGPGDAVAVQLTNRLECAVAYEAVLMCGATLVPIIHIYGPSEVAFILVESGAKALIMPARFR SISYVDRIAEFSAIPTLQHVVVVDAPPGDGYLSWPDLTAGRYRRTSPSADDVAVLIYTSGTTSVPKGVQQ SHNSMLAEQQTLPDLVTGDDVVQLVTFPPGHIAGVGSLLRPLISGARSVFVDGWDPPTAVELIHRHRITA TAGTPFHLEGLLDLGDTGQKLTTLREFLVGAATVTEELGRRAAAAGINTYRCYGSTEHPTITSARSTDAA PARMGTDGLPMRGVTVRIIGPDGDEQPVGVDGEVVTQGPDQFIGYRDPVLDADAFTADGWFRTGDLGHLD TDGRLTITDRIKDVIIRAGETISSGQVEDVLNAHPAVAEGAVVAAPHHRYGDVVAAVVALKPGAALDLDE LRRHFAASGLARQKTPERLAFVESLPRTPMGKIRKAELRKEHFENP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1957 | - | - | 100% (536) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_2638 | - | 0.0 | 66.54% (526) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_2116 | - | 5e-70 | 35.89% (496) | AMP-binding enzyme, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 1e-59 | 32.38% (488) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_2523 | - | 3e-80 | 36.60% (530) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 1e-59 | 32.38% (488) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-39 | 28.27% (481) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4569c | - | 5e-59 | 32.92% (480) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_0303 | - | 7e-61 | 33.08% (520) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4774 | - | 9e-88 | 39.66% (527) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_2816 | - | 9e-91 | 39.66% (522) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 2e-49 | 34.61% (497) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4135 | - | 5e-83 | 37.88% (528) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2523|M.gilvum_PYR-GCK ------------MRRIPE-----ELVRRYEQE--------GYWTPETLGE
Mvan_4135|M.vanbaalenii_PYR-1 ------------MRRIPA-----QLVERYQRE--------GYWTQETLGD
MSMEG_4774|M.smegmatis_MC2_155 ------------MRDIPA-----ELTKRYVEE--------GWWTPETLGQ
TH_2816|M.thermoresistible__bu ------------MRSIPA-----ELRRRYEEN--------GWWTQESLGD
MAV_1957|M.avium_104 ---------MSSPKAVAAGFDHSDLRDRWYRE--------GWYSRRTLVD
MMAR_0303|M.marinum_M ----------MGGPKVPQRRLIDGRWVRWDADRAAGAYAHRWWVRRTLAD
Mb2533c|M.bovis_AF2122/97 ----------MAAAEVVDPNRLSYDRGPSAPS----------LLESTIGA
Rv2505c|M.tuberculosis_H37Rv ----------MAAAEVVDPNRLSYDRGPSAPS----------LLESTIGA
MUL_4126|M.ulcerans_Agy99 --------------MTSDPR--------------------------TVPT
MAB_4569c|M.abscessus_ATCC_199 -----------MTDTIDATVQSAGLAQPYRAR------------RQNWCN
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
Mflv_2523|M.gilvum_PYR-GCK LLARGLDSAPGAGFHVHSAVRPYAGTFAEVERDARRLAAGLRERGVAAGD
Mvan_4135|M.vanbaalenii_PYR-1 MLARGLAGSPEAGFCVHSSIRPYRGTFGEVERDARRLAAGLRERGVGPGD
MSMEG_4774|M.smegmatis_MC2_155 MLAEGLAAGPDVVFCVHSEVRPYTGTFGEVETLARRLAAGLRARGVGPGD
TH_2816|M.thermoresistible__bu LLAEGLRAAPDAGFRVHSDVRPYTGTFADVEERARRLAAGLRARGVGPGD
MAV_1957|M.avium_104 ALEQGSAEHGDTPVVFVVDGVETTSTPAEIFQRSRDVAAGLQALGVGPGD
MMAR_0303|M.marinum_M ALREAAQSTPQRVALVDADR---QLDCQELHRQAMALAQHLRSR-MPAGS
Mb2533c|M.bovis_AF2122/97 NLAATAARYGHREALVDMVAR-RRFNYSELLTDVHRLATGLVRAGIGPGD
Rv2505c|M.tuberculosis_H37Rv NLAATAARYGHREALVDMVAR-RRFNYSELLTDVHRLATGLVRAGIGPGD
MUL_4126|M.ulcerans_Agy99 ALDRLVRRLPNHDALVTDE---RSFTVSELNDEVYRAAAALIELGVKPAA
MAB_4569c|M.abscessus_ATCC_199 QLARHALMQPDATAIRYLG---HSISWAELHQRVQALADALSRRGVGFGD
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEG---TLTYKELDRAAHALANGLIAKGVRGGD
:: * * : .
Mflv_2523|M.gilvum_PYR-GCK VVALQLPNWREAAVTFWASAFLGAVVVPVVHFYGRKELAHILTTAKPRVF
Mvan_4135|M.vanbaalenii_PYR-1 VVAMQLPNWREAAVTFWASAFLGAVVVPIVHFYGRRELAHIMATAKPRVF
MSMEG_4774|M.smegmatis_MC2_155 VIAFQLPNWMEAAAAFWATSFLGAVTVPIVHFYGRKELAHILSTAKPKVF
TH_2816|M.thermoresistible__bu VIAFQLPNWVEAAMTFWASAFLGAVVVPVVHFYGRKELGHILRTARPKVF
MAV_1957|M.avium_104 AVAVQLTNRLECAVAYEAVLMCGATLVPIIHIYGPSEVAFILVESGAKAL
MMAR_0303|M.marinum_M VVSFMLPNWHEAAVIYLASTLAAMVANPVLPSLREHELRFILEDAGSRMI
Mb2533c|M.bovis_AF2122/97 RVGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMV
Rv2505c|M.tuberculosis_H37Rv RVGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMV
MUL_4126|M.ulcerans_Agy99 RVGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVL
MAB_4569c|M.abscessus_ATCC_199 RVLILMLNRPEYVESWLAINELGAIAIPVNFRMTPPEVAFLVENSGAKVA
MLBr_02546|M.leprae_Br4923 GIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVI
: . * . . . : :
Mflv_2523|M.gilvum_PYR-GCK VTTAQFGRLQFHPDVC-AGVPIVALVGDGPDSGADG-GWEPFEDLLAAEP
Mvan_4135|M.vanbaalenii_PYR-1 VTAEEFGRMRYQPDLC-GDVAVVGLVG--AAHPAAG-NEHAFEQLLADEP
MSMEG_4774|M.smegmatis_MC2_155 LTTERFGRMSFQPDLC-AQVPIVGLVG-----------ESSFTDLLAERP
TH_2816|M.thermoresistible__bu ITAAEFGRMRYQPDLC-ADVPIVGVVG-----------QHGFDDLVADEP
MAV_1957|M.avium_104 IMPARFRSISYVDRIA-EFSAIPTLQHVVVVDAPPGDGYLSWPDLTAGRY
MMAR_0303|M.marinum_M FAPADFRGHDYTSMLRRVAAQLPSRPEVIEVRGQCPDGVSTFQSLLVGRE
Mb2533c|M.bovis_AF2122/97 IAVASFKDADYAAMLAEVGPRCPDLADVILLE--SDRWDALAGAEPDLPA
Rv2505c|M.tuberculosis_H37Rv IAVASFKDADYAAMLAEVGPRCPDLADVILLE--SDRWDALAGAEPDLPA
MUL_4126|M.ulcerans_Agy99 FAMGHFLGSDRVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETGTDTGA
MAB_4569c|M.abscessus_ATCC_199 ITETVLAPVAAAVRQQAPALETVIVAGSASEN-----GVLGYEEVIAEPG
MLBr_02546|M.leprae_Br4923 IYDDEYTKVVSKAEPALGKLRALGVNPDEEEP--PGSTDETLAELIARSS
.
Mflv_2523|M.gilvum_PYR-GCK MAG-TVAADPAGPALIAFTSGTTRDPKGVIHSHQTLSFETRQLLENYPPD
Mvan_4135|M.vanbaalenii_PYR-1 MAG-TVAADPAAPTLIAFTSGTTRDPKGVIHSHQTLSCETRQLLENYPPD
MSMEG_4774|M.smegmatis_MC2_155 MSG-TLDTDPAAPALIAFTSGTTRDPKGVIHSHQTLSCETRQLLANYPPN
TH_2816|M.thermoresistible__bu MTG-TLATDPAGPALIAFTSGTTRDPKGVIHSHQTLTFETRQLLANYPPD
MAV_1957|M.avium_104 RRT-SPSAD--DVAVLIYTSGTTSVPKGVQQSHNSMLAEQQTLPDLVTGD
MMAR_0303|M.marinum_M TAAPLPTADPDAVRMVLYTSGTTGRPKGVLHTHNSIHALICQIRDHWMVE
Mb2533c|M.bovis_AF2122/97 LQQTAARLDGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYT
Rv2505c|M.tuberculosis_H37Rv LQQTAARLDGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYT
MUL_4126|M.ulcerans_Agy99 VTARAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKIT
MAB_4569c|M.abscessus_ATCC_199 EPHAEVDLPGDTPALIMYTSGTTGRPKGAVLTHLNLSGQAMTYLLSTTVD
MLBr_02546|M.leprae_Br4923 SAP--APKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPFR
: ***** .**.
Mflv_2523|M.gilvum_PYR-GCK -RGR-QLTATPVGHFIGMLGAFLIPVLEG-SPIDLCDVWDPGRVLQLMET
Mvan_4135|M.vanbaalenii_PYR-1 -RGR-QLTATPVGHFIGMLGAFLIPVLEG-APIDLCDVWDPGRVLKLIES
MSMEG_4774|M.smegmatis_MC2_155 -RGR-QLTATPVGHFIGMVGAFLIPVLEG-APVDLCDVWDPAKVLRLMES
TH_2816|M.thermoresistible__bu -RGR-QLTATPVGHFIGMVGAFLIPVLEG-APIDLADVWDPGRVLRLMEA
MAV_1957|M.avium_104 -DVV-QLVTFPPGHIAG-VGSLLRPLISG-ARSVFVDGWDPPTAVELIHR
MMAR_0303|M.marinum_M -PGDGFLVASPIAHIGGSIYAFECPLLLG-TTAVLLDRWDADRAVQLMTS
Mb2533c|M.bovis_AF2122/97 -AQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQD
Rv2505c|M.tuberculosis_H37Rv -AQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQD
MUL_4126|M.ulcerans_Agy99 -ADDRHLCINPFFHNFGYKAGILACLQTG-ATLFPHLTFDPLRTLQAIER
MAB_4569c|M.abscessus_ATCC_199 LNSDVGFIGVPMFHIAGVGNMITGLLLGLPTVIHPLGAFDPGALLDVLES
MLBr_02546|M.leprae_Br4923 -AHEVTLLPAPMFHALGYLHATLAMFLGS--TLVLRRRFKPATVLEDIEK
* * * :.. : :
Mflv_2523|M.gilvum_PYR-GCK EGLSIGGGPPYFVTSLLD--HPQCRPEHVRRFKTVGLGGSTVPAAVTRRL
Mvan_4135|M.vanbaalenii_PYR-1 DGLSIGGGPPYFVTSLLD--HPDFRPEHLRRFKTVGLGGSTVPAAVTQRL
MSMEG_4774|M.smegmatis_MC2_155 DGLSIGGGPPYFVTSLLD--HPDFADRHLARIRTVGLGGSTVPAAVTRRL
TH_2816|M.thermoresistible__bu EDISIGGGPPYFVTSLLD--HPDCTPEHLARFKTVGLGGSTVPTTVTRRL
MAV_1957|M.avium_104 HRITATAGTPFHLEGLLD--LGDTG-QKLTTLREFLVGAATVTEELGRRA
MMAR_0303|M.marinum_M KRCTHMAGATPFLEQLLA--AAQRAGTRLPDLKFFVCGGASVSPSLIRCA
Mb2533c|M.bovis_AF2122/97 ERCTSLYGVPTMFIAELG--LPDFTDYELGSLRTGIMAGAACPVEVMRKV
Rv2505c|M.tuberculosis_H37Rv ERCTSLYGVPTMFIAELG--LPDFTDYELGSLRTGIMAGAACPVEVMRKV
MUL_4126|M.ulcerans_Agy99 HRITVLPGPPTIYQTLLD--HPARDDYDLSSLRFAVTGAATVPVVLVERM
MAB_4569c|M.abscessus_ATCC_199 EGVTGIFLVPAQWQAVCA--AQQANPRKVR-LKTLSWGAAPATDVLLRTM
MLBr_02546|M.leprae_Br4923 HQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRA
. : . : :: ..: :
Mflv_2523|M.gilvum_PYR-GCK SDLG--MFVFRSYGSTEHP-SITGSRPSAPEDKRLFTDGDARPGVEIK--
Mvan_4135|M.vanbaalenii_PYR-1 TDLG--LFVFRSYGSTEHP-SITGSRPDAPEVKRLFTDGNVRPGVEIR--
MSMEG_4774|M.smegmatis_MC2_155 ADLG--IFVFRSYGSTEHP-SITGSSPSAPEGKRLYTDGNPRPGVEIR--
TH_2816|M.thermoresistible__bu AELG--MFVFRSYGSTEHP-SITGSGPAAPEEKRLYTDGNPRPGVEIR--
MAV_1957|M.avium_104 AAAG--INTYRCYGSTEHP-TITSARSTDAAPARMGTDGLPMRGVTVRII
MMAR_0303|M.marinum_M TDYFDKAVVTRVYGSTEVP-VTTIGAPDSSAHAAATDGRVGAADVKLV--
Mb2533c|M.bovis_AF2122/97 ISRMHMPGVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVV
Rv2505c|M.tuberculosis_H37Rv ISRMHMPGVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVV
MUL_4126|M.ulcerans_Agy99 QSELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFADFELRIG
MAB_4569c|M.abscessus_ATCC_199 SETFPDARILAAFGQTEMS-PVTCMLMGDDAIRKMGSVGRVIPTVSARVV
MLBr_02546|M.leprae_Br4923 LEELG-PVIYNMYGSTEIAFATIAGPKD--LQINSATVGPVVKGVKVKIL
:* ** .
Mflv_2523|M.gilvum_PYR-GCK --------LGPDGEIFSR---------GPDLCLGYV-DDDLTAQAFDEDG
Mvan_4135|M.vanbaalenii_PYR-1 --------LGEDGEIFSR---------GPDLCLGYT-DDELTARAFDDDG
MSMEG_4774|M.smegmatis_MC2_155 --------LGPDGEIFSR---------GPDLCLGYT-DDALTAKAFDDEG
TH_2816|M.thermoresistible__bu --------IAEDGEILSR---------GPDLCLGYT-DDALTARAFDDDG
MAV_1957|M.avium_104 GPDGDEQPVGVDGEVVTQ---------GPDQFIGYR-DPVLDADAFTADG
MMAR_0303|M.marinum_M -----------AGEIRVR---------GPQMLVGYR-HPEDEAGSFDAQG
Mb2533c|M.bovis_AF2122/97 D--------PATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADG
Rv2505c|M.tuberculosis_H37Rv D--------PATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADG
MUL_4126|M.ulcerans_Agy99 ---------PDTGEVLLR---------GPNVMLGYLDDPRATAAAIDADG
MAB_4569c|M.abscessus_ATCC_199 DDNMNDVPVGEVGEIVYR---------APTLMQGYWNNPEATADAFAG-G
MLBr_02546|M.leprae_Br4923 DDSGKEVPRGQVGRIFVG---------NAFPFEGYT----GGGGKQIIDG
*. ** . *
Mflv_2523|M.gilvum_PYR-GCK WYHTGDIGVLDEDGYLTITDRKADVIIRGGENISALEVEEILLGMPAVAE
Mvan_4135|M.vanbaalenii_PYR-1 WYRTGDVGVLDDDGYLTITDRKADVIIRGGENISALEVEEVLLAMPAVAE
MSMEG_4774|M.smegmatis_MC2_155 WYRTGDVGFLDDDGYLTITDRTADLIIRGGENISALEVEEVLLGIPGVIE
TH_2816|M.thermoresistible__bu WYHTGDIGVLDDDGYLTITDRKADLIIRGGENISALEVEEVLLGMPAVAE
MAV_1957|M.avium_104 WFRTGDLGHLDTDGRLTITDRIKDVIIRAGETISSGQVEDVLNAHPAVAE
MMAR_0303|M.marinum_M YFRTGDLGHWVDDEYLVVTGRAKDIIIRNGENISPKEIEDILITHPGIAD
Mb2533c|M.bovis_AF2122/97 WMHTGDLAEMDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVD
Rv2505c|M.tuberculosis_H37Rv WMHTGDLAEMDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVD
MUL_4126|M.ulcerans_Agy99 WLHTGDIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVAD
MAB_4569c|M.abscessus_ATCC_199 WFHSGDLVRQDEDGFVWVVDRKKDMIISGGENIYCAEVENALAEHEQIAE
MLBr_02546|M.leprae_Br4923 LLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVE
:**: : : .* :: : * .: ::*: : : :
Mflv_2523|M.gilvum_PYR-GCK AVVVAAPDERLGEHTAAVLRIRDGHVMPSLDDVRAHFRAAGAATQKWPEE
Mvan_4135|M.vanbaalenii_PYR-1 AVVVAAPDARLGEHTAAVLRIREGQSMPALGDVREHFKQAGVATQKWPEE
MSMEG_4774|M.smegmatis_MC2_155 AIVVAAPDARLGERVAAVLRTRSGAPLPTLDDVRAHFERVGIARQKWPEE
TH_2816|M.thermoresistible__bu AVVVAAPDPRLGERTAAVVRVKPGHAMPTLDEVRDHFERTGVARQKWPEE
MAV_1957|M.avium_104 GAVVAAPHHRYGDVVAAVVALKPGAAL-DLDELRRHFAASGLARQKTPER
MMAR_0303|M.marinum_M VAIVGLPDDRTGERACAVIVA-AADPPPGLPGVRAFLEGAGVARFKIPEQ
Mb2533c|M.bovis_AF2122/97 GHVIGVPDAKYGEELMAVVKLRNDAPELTIERLREYCMGR-IARFKIPRY
Rv2505c|M.tuberculosis_H37Rv GHVIGVPDAKYGEELMAVVKLRNDAPELTIERLREYCMGR-IARFKIPRY
MUL_4126|M.ulcerans_Agy99 VAVIGIPDHRLGEVGRAFIVAR-PGFNLDEKSVIDYTREH-LANFKAPRS
MAB_4569c|M.abscessus_ATCC_199 VAVIGRPHEKWGEVPVAVAAIHGAALTLAELDG---FLTARLARYKHPKD
MLBr_02546|M.leprae_Br4923 ATAIGVDDKEWGARLRAFVVKK-QDATIDEDAIKAYVRDH-LARYKVPRE
:. . . * *. * * *.
Mflv_2523|M.gilvum_PYR-GCK LHRVPEGQDFPRTASGKVQKYVIRQQVAAGMHGVVAASQK-
Mvan_4135|M.vanbaalenii_PYR-1 LHRVPEGQDFPRTASGKVQKFVIRQQLAAGELSAIATGQE-
MSMEG_4774|M.smegmatis_MC2_155 LHHVPDGQDFPRTASGKVQKYRVRQAVRNPAAVMDIATSAN
TH_2816|M.thermoresistible__bu LHEVS---DYPRTASGKVQKYRVRQSIAEIAAAQQ------
MAV_1957|M.avium_104 LAFVES---LPRTPMGKIRKAELRKEHFENP----------
MMAR_0303|M.marinum_M VVIWDH---LPKNHAGKIVKHRIKAALMKAEQ---------
Mb2533c|M.bovis_AF2122/97 LWIVDE---FPMTVTGKVRKVEMRQQALEYLRGQQ------
Rv2505c|M.tuberculosis_H37Rv LWIVDE---FPMTVTGKVRKVEMRQQALEYLRGQQ------
MUL_4126|M.ulcerans_Agy99 VRFVDT---LPRNAGGKVVKPQLRELA--------------
MAB_4569c|M.abscessus_ATCC_199 LVIVDA---LPRNPSGKVLKTELRQRFGIAD----------
MLBr_02546|M.leprae_Br4923 VIFLEE---LPRNPTGKVLKRELRDFEVH------------
: * . **: * ::