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MPNTVGFLGAGQLGEPMVERLLGAGHDVSVYARREEIRRRLEAKGAVAAASVADLARGSDVLISCLFSDA QLRETGFGPEGFIANAKPGAVFVSHTTGTLSTLEALRDSSAAAPIVLDAPVSGTVENIDAGTLTVLIGGP SDAVASVTPILAAYADPVVATGALGSALALKLINNLLFAANAQLLCAATQLGVRLGVDPSVLLSTLQVCS AGSHVAAHAHRIGGMDRFEELAGPFLRKDISACREAAAEAGVELGLLGTAVLEGPLALDVDSATAGSDR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2635 | - | - | 100% (279) | 3-hydroxyisobutyrate dehydrogenase |
| M. avium 104 | MAV_1928 | - | e-123 | 82.90% (269) | 6-phosphogluconate dehydrogenase |
| M. avium 104 | MAV_0917 | - | 4e-38 | 36.59% (276) | 6-phosphogluconate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0773c | mmsB | 2e-18 | 28.64% (206) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. gilvum PYR-GCK | Mflv_2480 | - | 5e-46 | 38.34% (253) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0770 | - | 1e-18 | 29.74% (195) | dehydrogenase/reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4486 | - | 6e-23 | 29.86% (211) | 3-hydroxyisobutyrate dehydrogenase |
| M. marinum M | MMAR_1077 | mmsB | 3e-22 | 32.68% (205) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. smegmatis MC2 155 | MSMEG_4817 | - | 3e-48 | 41.09% (258) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. thermoresistible (build 8) | TH_2512 | - | 2e-36 | 34.63% (257) | PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 2e-21 | 32.20% (205) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_4174 | - | 3e-46 | 43.27% (245) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2480|M.gilvum_PYR-GCK ------MSAVGFVGAGRMGAPMVERLVQAGHEVRVLGRSAEKRSAIAGLG
MSMEG_4817|M.smegmatis_MC2_155 -------MRIGFLGAGRMGAPMVQRLTAAGHDVHALGRTDEKRTAVAGSG
Mvan_4174|M.vanbaalenii_PYR-1 -----------------MGAPMVTRLVQAGHDVRALGRSPDKRAAIGESR
MAV_2635|M.avium_104 -----MPNTVGFLGAGQLGEPMVERLLGAGHDVSVYARREEIRRRLEAKG
TH_2512|M.thermoresistible__bu -------MRVGFIGLGSQGGPMARRIAENGYETTLWARRAATLEPFADTP
MMAR_1077|M.marinum_M ---MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASAAAAKG
MUL_0835|M.ulcerans_Agy99 ---MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATAAKG
Mb0773c|M.bovis_AF2122/97 ---MTT---IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHG
MAB_4486|M.abscessus_ATCC_1997 ---MAT---YGWIGLGNMGGPMAANLVAAGHTVRGFDLSGDALAAAETTG
Rv0770|M.tuberculosis_H37Rv MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFVEGG
* ** .:
Mflv_2480|M.gilvum_PYR-GCK ATAVATTAEVSGGADVVIVCVFTDDQVAELCLDG-DLVTSMSAGATLVLH
MSMEG_4817|M.smegmatis_MC2_155 ATPVAAATDAVHGADVVIVCVFTDEQVRTLCTD--TLLDAMAPGAVLVLH
Mvan_4174|M.vanbaalenii_PYR-1 ARAVAALDEVADGADVVVVCVFTDDQVREVCLDG-GLLDAMAPGSVLVVH
MAV_2635|M.avium_104 AVAAASVADLARGSDVLISCLFSDAQLRETGFGPEGFIANAKPGAVFVSH
TH_2512|M.thermoresistible__bu AKTAGSPAELGAASDLVCLCVVGDDDVREVLYGDTGVLAGLAPGGVVAIH
MMAR_1077|M.marinum_M ATMFDSAAEAVAGADVVITMLPNGAVVKRCYA---EVLPAARSGALFIDS
MUL_0835|M.ulcerans_Agy99 ATMFDSAAEAVARADVVITMLPNGAVVKRCYA---EVLPAARSGALFIDS
Mb0773c|M.bovis_AF2122/97 VAVFRSAPEAVAEADVVITMLPTGEVVRRCYT---DVLAAARPATLFIDS
MAB_4486|M.abscessus_ATCC_1997 VTVVEEIAEVLAGAEVVFTMLPKGEHVRSVFEGPYGIWENASPSTLLVDS
Rv0770|M.tuberculosis_H37Rv ATAAASVSDVA-EADIISITVFDDAQVSSVITADNGLATHAKPGTIVAIH
. : :::: : . : . .. .
Mflv_2480|M.gilvum_PYR-GCK TTGSPRTAQSVAEKFPH--VAVVDAPVSGGPHDIAAGNVTLFVGGAQDVL
MSMEG_4817|M.smegmatis_MC2_155 TTGSPRTAEDIAARAADRGVAVVDAPVSGGPHDIAAGSVTVFAGGDADVV
Mvan_4174|M.vanbaalenii_PYR-1 TTGSPRTVEALAARAPA--VAVLDAPVSGGPHDIAAGQITLFVGGDATAV
MAV_2635|M.avium_104 TTGTLSTLEALRDSSAA-APIVLDAPVSGTVENIDAGTLTVLIGGPSDAV
TH_2512|M.thermoresistible__bu STVHPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKLLVMVGGDEEVV
MMAR_1077|M.marinum_M STISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSAL
MUL_0835|M.ulcerans_Agy99 STISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSAL
Mb0773c|M.bovis_AF2122/97 STISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTL
MAB_4486|M.abscessus_ATCC_1997 STVDIETSRYCHAESARRGFRFVDAPVSGGISGARAATLCFMLGGELENV
Rv0770|M.tuberculosis_H37Rv STIADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGELAVMVGADDEAF
:* :****** . : .: *. .
Mflv_2480|M.gilvum_PYR-GCK ARIRPVLGAYGDPILHAGDTGAGQLVKLVNNTMFAAQIGLVAEGVRLGAR
MSMEG_4817|M.smegmatis_MC2_155 ERVRPALVAYAEPLLHVGPLGSGQRVKLVNNTMFAAQIGVVAEGVRLARE
Mvan_4174|M.vanbaalenii_PYR-1 ERARPVLAAYGDPILRVGELGAGQWVKLINNTLFAAQLGMLREAASFGAR
MAV_2635|M.avium_104 ASVTPILAAYADPVVATGALGSALALKLINNLLFAANAQLLCAATQLGVR
TH_2512|M.thermoresistible__bu ERCRPVFASYADPIVHLGPLGSGQVTKILNNLLFTANLGSALSTLELGES
MMAR_1077|M.marinum_M AQARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFVLAEN
MUL_0835|M.ulcerans_Agy99 AQARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFVLAEN
Mb0773c|M.bovis_AF2122/97 RRARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEK
MAB_4486|M.abscessus_ATCC_1997 GAATDYIKPMAGRVIHAGDGGAGVAAKICNNMMLFIDMMANSEGSQLAER
Rv0770|M.tuberculosis_H37Rv QRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQRLAEA
: . :: * *:. *: .* : . :.
Mflv_2480|M.gilvum_PYR-GCK FGVDEGALLNALTHGSAQSRALSMIASAG-SAETFISR--------VGEF
MSMEG_4817|M.smegmatis_MC2_155 LGVDEPTVLSALTHGSAASRALSGIAATG-SAEDFKAR--------VGEF
Mvan_4174|M.vanbaalenii_PYR-1 VGVDEAGLLGAIGHGSGASRAAEIVGTRG-SVQSFIES--------VGEF
MAV_2635|M.avium_104 LGVDPSVLLSTLQVCSAGSHVAAHAHRIG-GMDRFEEL--------AGPF
TH_2512|M.thermoresistible__bu LGIPRVKLAEVLNGGSATSKALGSISVFGGTVEGLAPI--------AGAL
MMAR_1077|M.marinum_M LGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANND-FKPGFATAL
MUL_0835|M.ulcerans_Agy99 LGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANND-FKPGFATAL
Mb0773c|M.bovis_AF2122/97 LGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANND-FKPGFSTAL
MAB_4486|M.abscessus_ATCC_1997 LGLDPQVFWEICSVSSARSWAQQTWYPVPGIIESAAANRN-FDATFTVDL
Rv0770|M.tuberculosis_H37Rv CGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEHTRGL
*: . . :
Mflv_2480|M.gilvum_PYR-GCK IGKDVAVVRRTVADLGGTLGDL-----EPLVNAVAP--------------
MSMEG_4817|M.smegmatis_MC2_155 IGKDVAVVRATAADLGADLGLL-----DHAVDAALR--------------
Mvan_4174|M.vanbaalenii_PYR-1 LGKDVAVVREVAAETGSDLGLL-----EGLLDVVVGAPSG----------
MAV_2635|M.avium_104 LRKDISACREAAAEAGVELGLLGTAVLEGPLALDVDSATAGSDR------
TH_2512|M.thermoresistible__bu LQKDVRHAANIAASASVPEGTVFTVADTALTAMGHARR------------
MMAR_1077|M.marinum_M MNKDLGLAMDAVTSTGSAAPLGSHAAEIYAKFAAD-HADQDFSAVIEMLR
MUL_0835|M.ulcerans_Agy99 MNKDLGLAMDAVTSTASAAPLGSHAAEIYAKFATD-HADQDFSAVIEMLR
Mb0773c|M.bovis_AF2122/97 MNKDLGLAMDAVAATGATAPLGSHAADIYAKFAAD-HADLDFSAVIHTLR
MAB_4486|M.abscessus_ATCC_1997 AHKDARLALAAGEATGVNLPAATLVTEQFQQLIDEGLGGKDCSLIVKYAT
Rv0770|M.tuberculosis_H37Rv GEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET----
** .
Mflv_2480|M.gilvum_PYR-GCK ----------
MSMEG_4817|M.smegmatis_MC2_155 ----------
Mvan_4174|M.vanbaalenii_PYR-1 ----------
MAV_2635|M.avium_104 ----------
TH_2512|M.thermoresistible__bu ----------
MMAR_1077|M.marinum_M GS--------
MUL_0835|M.ulcerans_Agy99 GS--------
Mb0773c|M.bovis_AF2122/97 ARADA-----
MAB_4486|M.abscessus_ATCC_1997 PDGSPRGYTP
Rv0770|M.tuberculosis_H37Rv ----------