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MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFVEGGATAAASVSDVAEADIISITV FDDAQVSSVITADNGLATHAKPGTIVAIHSTIADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGELAV MVGADDEAFQRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQRLAEACGLDLVALGKV VRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEHTRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAA GLGVPHPDTEPAKET
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0770 | - | - | 100% (295) | PROBABLE DEHYDROGENASE/REDUCTASE |
| M. tuberculosis H37Rv | Rv0751c | mmsB | 4e-24 | 31.01% (287) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. tuberculosis H37Rv | Rv1122 | gnd2 | 6e-08 | 24.57% (232) | 6-phosphogluconate dehydrogenase-like protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0793 | - | 1e-164 | 99.66% (295) | dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_1602 | - | 1e-104 | 67.63% (278) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1220 | - | 1e-107 | 67.86% (280) | dehydrogenase/reductase |
| M. marinum M | MMAR_4926 | - | 1e-110 | 70.11% (281) | dehydrogenase/reductase |
| M. avium 104 | MAV_0715 | - | 1e-107 | 69.12% (285) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_5857 | - | 1e-104 | 68.71% (278) | oxidoreductase |
| M. thermoresistible (build 8) | TH_1259 | - | 1e-99 | 66.91% (278) | putative oxidoreductase |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 2e-22 | 30.21% (288) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_5155 | - | 1e-102 | 65.38% (286) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1602|M.gilvum_PYR-GCK -----MST--DDLKLGYIGLGNQGAPMAKRLVDWPGGLVVFDVRTEAMTP
Mvan_5155|M.vanbaalenii_PYR-1 -----MSERADELRVGYIGLGNQGAPMAKRLVDWPGGLIVFDVRTEAMTP
MSMEG_5857|M.smegmatis_MC2_155 -----MSG----VKLGYIGLGNQGAPMAKRLADWPGGLTVFDVRAEAMAP
TH_1259|M.thermoresistible__bu -----MSD----LKLGYIGLGNMGAPMAKRLVDWPGGLIVYDVRTEAMTP
MAV_0715|M.avium_104 -MTTNAAHTTEQLKLGYIGLGNMGAPMATRMTEWPGGVTVYDIRIEAMTP
Rv0770|M.tuberculosis_H37Rv -----MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAP
Mb0793|M.bovis_AF2122/97 -----MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAP
MMAR_4926|M.marinum_M -----MSEH---PKLGYIGLGNQGAPMAKRLLDWPGGLVVYDVRAEAMTP
MAB_1220|M.abscessus_ATCC_1997 -----MTQQ--AMKLGYIGLGNMGAPMARRLVDWPGGLTVFDLRAEAVAP
MUL_0835|M.ulcerans_Agy99 MTKS--------CQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASA
::.::***: ****: .: : :* * :.
Mflv_1602|M.gilvum_PYR-GCK LVELGATLADSVADVAAADVISVTVLNDAQVRDVVA---ELAAHAEPGTV
Mvan_5155|M.vanbaalenii_PYR-1 LVEMGASAADDVAGVSAADVISVTVLNDAQVRDVVG---ELAAHAEPGTV
MSMEG_5857|M.smegmatis_MC2_155 LVELGAEAADSVAAVATADVISVTVLNDAQVRDVVG---QLAEHAKPGTV
TH_1259|M.thermoresistible__bu LAEVGANLADSVADVAKADIISVTVLDDEQVRAVVD---ELAAGAGPGTV
MAV_0715|M.avium_104 LAEAGATLADSVADVAAADLIHITVLDDAQVREVVG---ELAGHAKPGTV
Rv0770|M.tuberculosis_H37Rv FVEGGATAAASVSDVAEADIISITVFDDAQVSSVITADNGLATHAKPGTI
Mb0793|M.bovis_AF2122/97 FVEGGATAAASVSDVAEADIISITVFDDAQVSSVITADNGLATHAKPGTI
MMAR_4926|M.marinum_M LAEAGASAAASVAEVAGADIISVTVLNDAQVREVITGANGLAAHARAGTI
MAB_1220|M.abscessus_ATCC_1997 LVEEGAVGASDVADIADADLISVTVLDDAQVRQVVG---QVAPKAKPGTI
MUL_0835|M.ulcerans_Agy99 TAAKGATMFDSAAEAVARADVVITMLPNGAVVKRCY--AEVLPAARSGAL
. ** ..: : :*:: : * : * .*::
Mflv_1602|M.gilvum_PYR-GCK IAIHSTIEPATAGELAEQLRPKGIHIVDAPVSGGAGAAEKGELAVMVGAD
Mvan_5155|M.vanbaalenii_PYR-1 IAIHSTIEPDTAPELAEQLRPKGIHIVDAPVSGGAGAADKGELAVMVGAD
MSMEG_5857|M.smegmatis_MC2_155 VAIHSTIEPGTAPELAEQLRPKGIHIVDAPVSGGAGAADKGELAVMVGAD
TH_1259|M.thermoresistible__bu IAIHSTIRPETAVELAEQLRPKDIHLVDAPVSGGGGAAEKGELAVMVGAD
MAV_0715|M.avium_104 IAIHSTISDTTAVELARDLKARDIHIVDAPVSGGAAAAARGELATMVGAD
Rv0770|M.tuberculosis_H37Rv VAIHSTIADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGELAVMVGAD
Mb0793|M.bovis_AF2122/97 VAIHSTIADTTAVDLAEKLKPQGIHIVDAPGSGGAAAAAKGELAVMVGAD
MMAR_4926|M.marinum_M IAIHSTISDTTAEELARELRPRGIHVIDAPVSGGAGAASKGQLATMVGAG
MAB_1220|M.abscessus_ATCC_1997 IAIHSTISDTTAVELAQAWRPRDIHVIDAPVSGGAPGAHKGELATMVGAD
MUL_0835|M.ulcerans_Agy99 FIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGD
. *** * :: ..:.: :*** *** .* * ** ***..
Mflv_1602|M.gilvum_PYR-GCK EHAYERVKPVFKKWASMVVRAGEPGAGTRMKLARNMLTFIGFTAACEAMR
Mvan_5155|M.vanbaalenii_PYR-1 EHAYDRVKPVFKQWASMVVRAGEPGAGTRMKLARNMLTFVGFTAACEAMR
MSMEG_5857|M.smegmatis_MC2_155 DDAYAAVKPVFKKWASLVVRAGEPGAGTRMKLARNMLTFIGFAASCEAMK
TH_1259|M.thermoresistible__bu RDVYERIKPAFKRFASLVVHAGEPGAGTRMKLARNMLTFTSYVAACEAME
MAV_0715|M.avium_104 REVYERIKPAFKHWAAVVIHAGEPGAGTRMKLARNMLTFTSYAAACEAMK
Rv0770|M.tuberculosis_H37Rv DEAFQRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQR
Mb0793|M.bovis_AF2122/97 DEAFQRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQR
MMAR_4926|M.marinum_M DDVFARVKEPFSCWASLVVHAGPPGAGTRMKLARNMLTFTIYAAVGEAWK
MAB_1220|M.abscessus_ATCC_1997 GETFARVKEAFSKWASLVIHAGAPGAGTRMKLARNLLHFVAFTAAGEAQR
MUL_0835|M.ulcerans_Agy99 QSALAQARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFV
. : :. *. :::.* .*** *:..*:: * **
Mflv_1602|M.gilvum_PYR-GCK LAEASGIDLQKLGRVVRHSDAQSGGPGAIMVRDDMKALTPDHFLHDMFVH
Mvan_5155|M.vanbaalenii_PYR-1 LAEAAGIDLQKLGRVVRHSDAQSGGPGAIMVRDDMLPLAPEHFLYDMFVH
MSMEG_5857|M.smegmatis_MC2_155 LAEAAGIDLQKLGRVVRHSDAQSGGPGAIIVRDDTKPLTPDHWLYDMFVH
TH_1259|M.thermoresistible__bu LAEAAGLSLQALGRVVRHSDAQSGGPGAIIVREDMRDLEPDHWLYEAFTH
MAV_0715|M.avium_104 LAEAAGLDLQALGRVVRHTDALTGGPGAIMVRDNMKDLEPDNFLYQPFLH
Rv0770|M.tuberculosis_H37Rv LAEACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEH
Mb0793|M.bovis_AF2122/97 LAEACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEH
MMAR_4926|M.marinum_M LAEASGVNLQDLGNVVRHTDKLTSGAGSIMFRDNTKDLEPGHFLYDGFVH
MAB_1220|M.abscessus_ATCC_1997 LAESCGLDITDLGKVVRHTDAITGGPGAIMLRDTTEPVTPDSFWLPIFTH
MUL_0835|M.ulcerans_Agy99 LAENLGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFA
*** *:. * *: : . : *
Mflv_1602|M.gilvum_PYR-GCK TRGLAEKDLKLALALGDETGVDLPLARIALQDLAAGLGVPHTKE------
Mvan_5155|M.vanbaalenii_PYR-1 TRGLGEKDLRLALGLGESTGVELPLAEIALRDLAAGLGVPHTTSTTEE--
MSMEG_5857|M.smegmatis_MC2_155 TRGLAEKDLTLALGLGESVGVELPLAHIALERLADGLGVPHSKEQE----
TH_1259|M.thermoresistible__bu TRGLGEKDLSLALDLGRQTGVDLPLARIALQNLAAALGVPHTKE------
MAV_0715|M.avium_104 TRGLGEKDLSLALALGEAVSVDLPLARLAYEGLAAGLGVPHKEKEA----
Rv0770|M.tuberculosis_H37Rv TRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET
Mb0793|M.bovis_AF2122/97 TRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET
MMAR_4926|M.marinum_M ARDLGEKDLGLALALGEALSVDLPLARLALERLAPGLGVPHTQKDA----
MAB_1220|M.abscessus_ATCC_1997 VRGLGEKDLSLALALGEEQSVDLPLATLAREQLAASLGVPHEEGASNG--
MUL_0835|M.ulcerans_Agy99 T-ALMNKDLGLAMDAVTSTASAAPLGSHAAEIYAK-FATDHADQDFSAVI
. * :*** **: . **. * . * :.. *
Mflv_1602|M.gilvum_PYR-GCK ------
Mvan_5155|M.vanbaalenii_PYR-1 ------
MSMEG_5857|M.smegmatis_MC2_155 ------
TH_1259|M.thermoresistible__bu ------
MAV_0715|M.avium_104 ------
Rv0770|M.tuberculosis_H37Rv ------
Mb0793|M.bovis_AF2122/97 ------
MMAR_4926|M.marinum_M ------
MAB_1220|M.abscessus_ATCC_1997 ------
MUL_0835|M.ulcerans_Agy99 EMLRGS