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MRIGFLGAGRMGAPMVQRLTAAGHDVHALGRTDEKRTAVAGSGATPVAAATDAVHGADVVIVCVFTDEQV RTLCTDTLLDAMAPGAVLVLHTTGSPRTAEDIAARAADRGVAVVDAPVSGGPHDIAAGSVTVFAGGDADV VERVRPALVAYAEPLLHVGPLGSGQRVKLVNNTMFAAQIGVVAEGVRLARELGVDEPTVLSALTHGSAAS RALSGIAATGSAEDFKARVGEFIGKDVAVVRATAADLGADLGLLDHAVDAALR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4817 | - | - | 100% (263) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. smegmatis MC2 155 | MSMEG_4816 | - | 1e-44 | 35.34% (266) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. smegmatis MC2 155 | MSMEG_5477 | - | 2e-29 | 33.33% (213) | 2-hydroxy-3-oxopropionate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0773c | mmsB | 1e-30 | 32.83% (265) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. gilvum PYR-GCK | Mflv_2480 | - | 8e-91 | 66.80% (259) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0751c | mmsB | 1e-30 | 32.83% (265) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. leprae Br4923 | MLBr_02065 | gnd | 6e-07 | 24.09% (220) | 6-phosphogluconate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1220 | - | 1e-23 | 29.60% (223) | dehydrogenase/reductase |
| M. marinum M | MMAR_1077 | mmsB | 9e-31 | 31.95% (266) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. avium 104 | MAV_1928 | - | 5e-51 | 43.41% (258) | 6-phosphogluconate dehydrogenase |
| M. thermoresistible (build 8) | TH_2512 | - | 7e-43 | 36.23% (265) | PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 1e-29 | 36.45% (203) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_4174 | - | 2e-81 | 60.47% (253) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4817|M.smegmatis_MC2_155 ----------MRIGFLGAGRMGAPMVQRLTAAGHDVHALGRTDEKRTAVA
Mflv_2480|M.gilvum_PYR-GCK ---------MSAVGFVGAGRMGAPMVERLVQAGHEVRVLGRSAEKRSAIA
Mvan_4174|M.vanbaalenii_PYR-1 --------------------MGAPMVTRLVQAGHDVRALGRSPDKRAAIG
MAV_1928|M.avium_104 --------MAGIVGFLGAGQLGEPMVERLIDAGHDVLVYARREEARHRLE
TH_2512|M.thermoresistible__bu ----------MRVGFIGLGSQGGPMARRIAENGYETTLWARRAATLEPFA
Mb0773c|M.bovis_AF2122/97 ------MTT---IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAA
Rv0751c|M.tuberculosis_H37Rv ------MTT---IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAA
MMAR_1077|M.marinum_M ------MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASAAA
MUL_0835|M.ulcerans_Agy99 ------MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATA
MAB_1220|M.abscessus_ATCC_1997 -----MTQQAMKLGYIGLGNMGAPMARRLVDWPGGLTVFDLRAEAVAPLV
MLBr_02065|M.leprae_Br4923 MSAPESKTAIAQIGVTGLAVMGSNIARNFARHGYTVALHNRSIAKTDTLL
* : .:
MSMEG_4817|M.smegmatis_MC2_155 GSGATPVAAATDAVH-------GADVVIVCVFTDEQVRTLCTD--TLLDA
Mflv_2480|M.gilvum_PYR-GCK GLGATAVATTAEVSG-------GADVVIVCVFTDDQVAELCLDG-DLVTS
Mvan_4174|M.vanbaalenii_PYR-1 ESRARAVAALDEVAD-------GADVVVVCVFTDDQVREVCLDG-GLLDA
MAV_1928|M.avium_104 SKGANLAASVADLAR-------GSDVLISCLFSDAQLRETGLGPDGFVAN
TH_2512|M.thermoresistible__bu DTPAKTAGSPAELGA-------ASDLVCLCVVGDDDVREVLYGDTGVLAG
Mb0773c|M.bovis_AF2122/97 AHGVAVFRSAPEAVA-------EADVVITMLPTGEVVRRCYTD---VLAA
Rv0751c|M.tuberculosis_H37Rv AHGVAVFRSAPEAVA-------EADVVITMLPTGEVVRRCYTD---VLAA
MMAR_1077|M.marinum_M AKGATMFDSAAEAVA-------GADVVITMLPNGAVVKRCYAE---VLPA
MUL_0835|M.ulcerans_Agy99 AKGATMFDSAAEAVA-------RADVVITMLPNGAVVKRCYAE---VLPA
MAB_1220|M.abscessus_ATCC_1997 EEG-AVGASDVADIA-------DADLISVTVLDDAQVRQVVGQ---VAPK
MLBr_02065|M.leprae_Br4923 KEHGSEGNFVRTETIPEFLAALQTPRRVLIMVKAGDATDAVIN--ELADV
: : .
MSMEG_4817|M.smegmatis_MC2_155 MAPGAVLVLHTTGSPRTAEDIAARAADRGVAVVDAPVSGGPHDIAAGSVT
Mflv_2480|M.gilvum_PYR-GCK MSAGATLVLHTTGSPRTAQSVAEKFPH--VAVVDAPVSGGPHDIAAGNVT
Mvan_4174|M.vanbaalenii_PYR-1 MAPGSVLVVHTTGSPRTVEALAARAPA--VAVLDAPVSGGPHDIAAGQIT
MAV_1928|M.avium_104 AKPGAVLVSHTTGNLSTLEALRDSSATP-PVILDGPVSGTADDIAAGKLT
TH_2512|M.thermoresistible__bu LAPGGVVAIHSTVHPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKLL
Mb0773c|M.bovis_AF2122/97 ARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLA
Rv0751c|M.tuberculosis_H37Rv ARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLA
MMAR_1077|M.marinum_M ARSGALFIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLA
MUL_0835|M.ulcerans_Agy99 ARSGALFIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLA
MAB_1220|M.abscessus_ATCC_1997 AKPGTIIAIHSTISDTTAVELAQAWRPRDIHVIDAPVSGGAPGAHKGELA
MLBr_02065|M.leprae_Br4923 MEPSDIIIDGGNSLFTDTIRREKAMRERGLHFVGAGISGGEEGALNG-PS
.. . . :.. :** .
MSMEG_4817|M.smegmatis_MC2_155 VFAGGDADVVERVRPALVAYAEPLL------HVGPLGSGQRVKLVNNTMF
Mflv_2480|M.gilvum_PYR-GCK LFVGGAQDVLARIRPVLGAYGDPIL------HAGDTGAGQLVKLVNNTMF
Mvan_4174|M.vanbaalenii_PYR-1 LFVGGDATAVERARPVLAAYGDPIL------RVGELGAGQWVKLINNTLF
MAV_1928|M.avium_104 VLLGGPTDAVAAVTPILAAYADPVV------ATGELGTALALKLINNLLF
TH_2512|M.thermoresistible__bu VMVGGDEEVVERCRPVFASYADPIV------HLGPLGSGQVTKILNNLLF
Mb0773c|M.bovis_AF2122/97 FMVGGDESTLRRARPVLEPMAGKII------HCGAAGAGQAAKVCNNMVL
Rv0751c|M.tuberculosis_H37Rv FMVGGDESTLRRARPVLEPMAGKII------HCGAAGAGQAAKVCNNMVL
MMAR_1077|M.marinum_M FMVGGDQSALAQARPVLEPMAGKII------HCGAAGAGQAAKVCNNMVL
MUL_0835|M.ulcerans_Agy99 FMVGGDQSALAQARPVLEPMAGKII------HCGAAGAGQAAKVCNNMVL
MAB_1220|M.abscessus_ATCC_1997 TMVGADGETFARVKEAFSKWASLVI------HAGAPGAGTRMKLARNLLH
MLBr_02065|M.leprae_Br4923 IMPGGPAESYTSLGPLLEEISAHVDGVSCCTHIGPGGSGHFVKMVHNGIE
: *. : . : * *:. *: .* :
MSMEG_4817|M.smegmatis_MC2_155 AAQIGVVAEGVRLARE-LGVDEPTVLSALTHGSAASRALSGIAATG----
Mflv_2480|M.gilvum_PYR-GCK AAQIGLVAEGVRLGAR-FGVDEGALLNALTHGSAQSRALSMIASAG----
Mvan_4174|M.vanbaalenii_PYR-1 AAQLGMLREAASFGAR-VGVDEAGLLGAIGHGSGASRAAEIVGTRG----
MAV_1928|M.avium_104 AANAQLLASAAQLGTQ-LGIDPDVLLSTLQVCSANSNAAAHAHRIG----
TH_2512|M.thermoresistible__bu TANLGSALSTLELGES-LGIPRVKLAEVLNGGSATSKALGSISVFGG---
Mb0773c|M.bovis_AF2122/97 AVQQIAIAEAFVLAEK-LGLSAQSLFDVITGATGNCWAVHTNCPVPGPVP
Rv0751c|M.tuberculosis_H37Rv AVQQIAIAEAFVLAEK-LGLSAQSLFDVITGATGNCWAVHTNCPVPGPVP
MMAR_1077|M.marinum_M AVQQIAIGEAFVLAEN-LGLDAQSLFDVITGATGNCWAVHTNCPVPGPVP
MUL_0835|M.ulcerans_Agy99 AVQQIAIGEAFVLAEN-LGLDAQSLFDVITGATGNCWAVHTNCPVPGPVP
MAB_1220|M.abscessus_ATCC_1997 FVAFTAAGEAQRLAES-CGLDITDLGKVVRHTDAITGGPGAIMLRDTTEP
MLBr_02065|M.leprae_Br4923 YSDMQLIGEAYQLLRDGLGMSAPQIADVFTEWNRGDLNSYLVEITAEVLR
. : *: : ..
MSMEG_4817|M.smegmatis_MC2_155 -SAEDFKARVG----EFIGKDVAVVRATAADLGADLGLLDHAVDAALR--
Mflv_2480|M.gilvum_PYR-GCK -SAETFISRVG----EFIGKDVAVVRRTVADLGGTLGDLEPLVNAVAP--
Mvan_4174|M.vanbaalenii_PYR-1 -SVQSFIESVG----EFLGKDVAVVREVAAETGSDLGLLEGLLDVVVGAP
MAV_1928|M.avium_104 -GMDRFTELAG----PFLRKDIAACREAAAEAGVDLGLLGTAVREGPLTL
TH_2512|M.thermoresistible__bu -TVEGLAPIAG----ALLQKDVRHAANIAASASVPEGTVFTVADTALTAM
Mb0773c|M.bovis_AF2122/97 TSPANNDFKPG-FSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFA
Rv0751c|M.tuberculosis_H37Rv TSPANNDFKPG-FSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFA
MMAR_1077|M.marinum_M TSPANNDFKPG-FATALMNKDLGLAMDAVTSTGSAAPLGSHAAEIYAKFA
MUL_0835|M.ulcerans_Agy99 TSPANNDFKPG-FATALMNKDLGLAMDAVTSTASAAPLGSHAAEIYAKFA
MAB_1220|M.abscessus_ATCC_1997 VTPDSFWLPIFTHVRGLGEKDLSLALALGEEQSVDLPLATLAREQLAASL
MLBr_02065|M.leprae_Br4923 QTDIKTGRPLVDVILDKAEQKGTGRWTVQSALDLGVPITGIAEAVFARAL
:.
MSMEG_4817|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2480|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4174|M.vanbaalenii_PYR-1 SG------------------------------------------------
MAV_1928|M.avium_104 DDRAAGQN------------------------------------------
TH_2512|M.thermoresistible__bu GHARR---------------------------------------------
Mb0773c|M.bovis_AF2122/97 ADHADLDFSAVIHTLRARADA-----------------------------
Rv0751c|M.tuberculosis_H37Rv ADHADLDFSAVIHTLRARADA-----------------------------
MMAR_1077|M.marinum_M ADHADQDFSAVIEMLRGS--------------------------------
MUL_0835|M.ulcerans_Agy99 TDHADQDFSAVIEMLRGS--------------------------------
MAB_1220|M.abscessus_ATCC_1997 GVPHEEGASNG---------------------------------------
MLBr_02065|M.leprae_Br4923 SGSVLQRKAAIGLASGKLGNKPTDRETFIEDVRQALYASKIVAYAQGFNH
MSMEG_4817|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2480|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4174|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1928|M.avium_104 --------------------------------------------------
TH_2512|M.thermoresistible__bu --------------------------------------------------
Mb0773c|M.bovis_AF2122/97 --------------------------------------------------
Rv0751c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1077|M.marinum_M --------------------------------------------------
MUL_0835|M.ulcerans_Agy99 --------------------------------------------------
MAB_1220|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02065|M.leprae_Br4923 IQTGSTEFGWNITPGDLATIWRGGCIIRAKFLNRIKEAFDAAPDLASLIV
MSMEG_4817|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2480|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4174|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1928|M.avium_104 --------------------------------------------------
TH_2512|M.thermoresistible__bu --------------------------------------------------
Mb0773c|M.bovis_AF2122/97 --------------------------------------------------
Rv0751c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1077|M.marinum_M --------------------------------------------------
MUL_0835|M.ulcerans_Agy99 --------------------------------------------------
MAB_1220|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02065|M.leprae_Br4923 APYFRSAVESAIDSWRRVVSTATQLGIPNPGFSSALSYYDALRTERLPAA
MSMEG_4817|M.smegmatis_MC2_155 ------------------------------------
Mflv_2480|M.gilvum_PYR-GCK ------------------------------------
Mvan_4174|M.vanbaalenii_PYR-1 ------------------------------------
MAV_1928|M.avium_104 ------------------------------------
TH_2512|M.thermoresistible__bu ------------------------------------
Mb0773c|M.bovis_AF2122/97 ------------------------------------
Rv0751c|M.tuberculosis_H37Rv ------------------------------------
MMAR_1077|M.marinum_M ------------------------------------
MUL_0835|M.ulcerans_Agy99 ------------------------------------
MAB_1220|M.abscessus_ATCC_1997 ------------------------------------
MLBr_02065|M.leprae_Br4923 LTQAQRDFFGAHSYGRVDARGKFHTLWSEDRSEVTV