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MATYGWIGLGNMGGPMAANLVAAGHTVRGFDLSGDALAAAETTGVTVVEEIAEVLAGAEVVFTMLPKGEH VRSVFEGPYGIWENASPSTLLVDSSTVDIETSRYCHAESARRGFRFVDAPVSGGISGARAATLCFMLGGE LENVGAATDYIKPMAGRVIHAGDGGAGVAAKICNNMMLFIDMMANSEGSQLAERLGLDPQVFWEICSVSS ARSWAQQTWYPVPGIIESAAANRNFDATFTVDLAHKDARLALAAGEATGVNLPAATLVTEQFQQLIDEGL GGKDCSLIVKYATPDGSPRGYTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4486 | - | - | 100% (303) | 3-hydroxyisobutyrate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1186c | - | 2e-56 | 43.82% (283) | 3-hydroxyisobutyrate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1220 | - | 4e-26 | 32.36% (275) | dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0773c | mmsB | 5e-59 | 44.87% (263) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. gilvum PYR-GCK | Mflv_5012 | - | 2e-60 | 42.41% (290) | 3-hydroxyisobutyrate dehydrogenase |
| M. tuberculosis H37Rv | Rv0751c | mmsB | 5e-59 | 44.87% (263) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. leprae Br4923 | MLBr_02065 | gnd | 1e-07 | 26.36% (220) | 6-phosphogluconate dehydrogenase |
| M. marinum M | MMAR_1077 | mmsB | 6e-56 | 42.64% (265) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. avium 104 | MAV_4419 | mmsB | 2e-58 | 42.81% (285) | 3-hydroxyisobutyrate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1496 | mmsB | 2e-59 | 41.72% (290) | 3-hydroxyisobutyrate dehydrogenase |
| M. thermoresistible (build 8) | TH_0328 | mmsB | 3e-59 | 42.70% (281) | PROBABLE 3-HYDROXYISOBUTYRATE DEHYDROGENASE MMSB (HIBADH) |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 5e-54 | 41.51% (265) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_1360 | - | 3e-59 | 42.41% (290) | 3-hydroxyisobutyrate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1496|M.smegmatis_MC2_155 ------MAT---IAFLGLGHMGGPMAANLAAAGHTVRGFDPMPASREAAE
TH_0328|M.thermoresistible__bu --------------------MGGPMAANLVAAGHTVRGFDPVAESRAAAA
Mflv_5012|M.gilvum_PYR-GCK ------MTT---IAFLGLGNMGGPMAANLVAAGHTVHAFDVVPELRDAAE
Mvan_1360|M.vanbaalenii_PYR-1 ------MTT---IAFLGLGNMGGPMAANLVAAGQTVHAFDLVTELKEAAK
Mb0773c|M.bovis_AF2122/97 ------MTT---IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAA
Rv0751c|M.tuberculosis_H37Rv ------MTT---IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAA
MMAR_1077|M.marinum_M ------MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASAAA
MUL_0835|M.ulcerans_Agy99 ------MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATA
MAV_4419|M.avium_104 ----------MVVAFLGLGNMGAPMAANLVAAQHAVRGFDPVPAALSAAT
MAB_4486|M.abscessus_ATCC_1997 ------MAT---YGWIGLGNMGGPMAANLVAAGHTVRGFDLSGDALAAAE
MLBr_02065|M.leprae_Br4923 MSAPESKTAIAQIGVTGLAVMGSNIARNFARHGYTVALHNRSIAKTDTLL
**. :: *: .* .:
MSMEG_1496|M.smegmatis_MC2_155 AKG--------IKVFGTGAEAASEAEVVITSLPNGDIVKSCYA---EVLP
TH_0328|M.thermoresistible__bu DKG--------VQTFDSGAEAVAGAEVVITSLPNGDIVKQCYA---EVLP
Mflv_5012|M.gilvum_PYR-GCK AKG--------ANVFDSAAAAVADADVVVTSLPNGAVVKAVYD---EVVP
Mvan_1360|M.vanbaalenii_PYR-1 AKG--------AKVFDSGAAAVADADVVITSLPNGNIVKAVYD---EVVP
Mb0773c|M.bovis_AF2122/97 AHG--------VAVFRSAPEAVAEADVVITMLPTGEVVRRCYT---DVLA
Rv0751c|M.tuberculosis_H37Rv AHG--------VAVFRSAPEAVAEADVVITMLPTGEVVRRCYT---DVLA
MMAR_1077|M.marinum_M AKG--------ATMFDSAAEAVAGADVVITMLPNGAVVKRCYA---EVLP
MUL_0835|M.ulcerans_Agy99 AKG--------ATMFDSAAEAVARADVVITMLPNGAVVKRCYA---EVLP
MAV_4419|M.avium_104 ASG--------VTGFDTATDAVTGADVVITMLPNGEVVKRCYA---EILP
MAB_4486|M.abscessus_ATCC_1997 TTG--------VTVVEEIAEVLAGAEVVFTMLPKGEHVRSVFEGPYGIWE
MLBr_02065|M.leprae_Br4923 KEHGSEGNFVRTETIPEFLAALQTPRRVLIMVKAGDATDAVIN---ELAD
. . . *. : * . :
MSMEG_1496|M.smegmatis_MC2_155 AAPTGTLFIDTSTISVDDARTVHTQALEKGHAQLDAPVSGGVKGATAGTL
TH_0328|M.thermoresistible__bu AATSGALFIDTSTISVDDARTVHAQATGRGFAQVDAPVSGGVKGAVAGTL
Mflv_5012|M.gilvum_PYR-GCK AAKAGALLIDTSTISVDDARAIHEQATAGGLAQIDAPVSGGIKGATAGTL
Mvan_1360|M.vanbaalenii_PYR-1 AAKAGALLIDTSTISVDDARAIHDQATEKGLAQIDAPVSGGIKGATAGTL
Mb0773c|M.bovis_AF2122/97 AARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATL
Rv0751c|M.tuberculosis_H37Rv AARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATL
MMAR_1077|M.marinum_M AARSGALFIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTL
MUL_0835|M.ulcerans_Agy99 AARSGALFIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTL
MAV_4419|M.avium_104 AARPGALFIDSSTISVADAREVHAQAQSHGVAQLDAPVSGGVKGAVAGTL
MAB_4486|M.abscessus_ATCC_1997 NASPSTLLVDSSTVDIETSRYCHAESARRGFRFVDAPVSGGISGARAATL
MLBr_02065|M.leprae_Br4923 VMEPSDIIIDGGNSLFTDTIRREKAMRERGLHFVGAGISGGEEGALNG-P
.. :::* .. . : . * :.* :*** .** .
MSMEG_1496|M.smegmatis_MC2_155 AFMVGGEDDAVERARPILDPMAGKII------HCGGSGTGQAAKLCNNMV
TH_0328|M.thermoresistible__bu AFMVGGDAEAVERARPVLEPMAGKII------HCGASGTGQAAKLCNNMV
Mflv_5012|M.gilvum_PYR-GCK AFMVGGDDEAFERAKPVLEPMAGKII------HCGASGAGQAAKLCNNMV
Mvan_1360|M.vanbaalenii_PYR-1 AFMVGGEDEAFERAKPVLEPMAGKII------HCGASGAGQAAKLCNNMV
Mb0773c|M.bovis_AF2122/97 AFMVGGDESTLRRARPVLEPMAGKII------HCGAAGAGQAAKVCNNMV
Rv0751c|M.tuberculosis_H37Rv AFMVGGDESTLRRARPVLEPMAGKII------HCGAAGAGQAAKVCNNMV
MMAR_1077|M.marinum_M AFMVGGDQSALAQARPVLEPMAGKII------HCGAAGAGQAAKVCNNMV
MUL_0835|M.ulcerans_Agy99 AFMVGGDQSALAQARPVLEPMAGKII------HCGAAGAGQAAKVCNNMV
MAV_4419|M.avium_104 AFMVGGEPEALERARPVLEPMAGKII------HCGAAGAGQAAKVCNNMV
MAB_4486|M.abscessus_ATCC_1997 CFMLGGELENVGAATDYIKPMAGRVI------HAGDGGAGVAAKICNNMM
MLBr_02065|M.leprae_Br4923 SIMPGGPAESYTSLGPLLEEISAHVDGVSCCTHIGPGGSGHFVKMVHNGI
.:* ** . :. ::.:: * * .*:* .*: :* :
MSMEG_1496|M.smegmatis_MC2_155 LAVQQIAIGEAFVLAEK-LGLSAQSLFDVITGATG---NCWSVHTNCPVP
TH_0328|M.thermoresistible__bu LAVQQIAIGEAFVLAEK-LGLSAQSLFDVITGATG---NCWAVHTNCPVP
Mflv_5012|M.gilvum_PYR-GCK LAVQQIAIGEAFVLAEK-LGLPAQSLFDVITGATG---NCWSVHTNCPVP
Mvan_1360|M.vanbaalenii_PYR-1 LAVQQIAIGEAFVLAEK-LGLPAQSLFDVITGATG---NCWAVHTNCPVP
Mb0773c|M.bovis_AF2122/97 LAVQQIAIAEAFVLAEK-LGLSAQSLFDVITGATG---NCWAVHTNCPVP
Rv0751c|M.tuberculosis_H37Rv LAVQQIAIAEAFVLAEK-LGLSAQSLFDVITGATG---NCWAVHTNCPVP
MMAR_1077|M.marinum_M LAVQQIAIGEAFVLAEN-LGLDAQSLFDVITGATG---NCWAVHTNCPVP
MUL_0835|M.ulcerans_Agy99 LAVQQIAIGEAFVLAEN-LGLDAQSLFDVITGATG---NCWAVHTNCPVP
MAV_4419|M.avium_104 LAVQQIAIGEAFILAEK-LGLSAQSLFDVITGATG---NCWAVHTNCPVP
MAB_4486|M.abscessus_ATCC_1997 LFIDMMANSEGSQLAER-LGLDPQVFWEICSVSSA---RSWAQQTWYPVP
MLBr_02065|M.leprae_Br4923 EYSDMQLIGEAYQLLRDGLGMSAPQIADVFTEWNRGDLNSYLVEITAEVL
: .*. * . **: . : :: : . ..: . *
MSMEG_1496|M.smegmatis_MC2_155 -----------------------------------GPVPTSPANNDFKPG
TH_0328|M.thermoresistible__bu -----------------------------------GPVPTSPANNDFKPG
Mflv_5012|M.gilvum_PYR-GCK -----------------------------------GPVPTSPANNDFKPG
Mvan_1360|M.vanbaalenii_PYR-1 -----------------------------------GPVPTSPANNDFKPG
Mb0773c|M.bovis_AF2122/97 -----------------------------------GPVPTSPANNDFKPG
Rv0751c|M.tuberculosis_H37Rv -----------------------------------GPVPTSPANNDFKPG
MMAR_1077|M.marinum_M -----------------------------------GPVPTSPANNDFKPG
MUL_0835|M.ulcerans_Agy99 -----------------------------------GPVPTSPANNDFKPG
MAV_4419|M.avium_104 -----------------------------------GPVPTSPANNDFKPG
MAB_4486|M.abscessus_ATCC_1997 -----------------------------------GIIESAAANRNFDAT
MLBr_02065|M.leprae_Br4923 RQTDIKTGRPLVDVILDKAEQKGTGRWTVQSALDLGVPITGIAEAVFARA
* :. *: *
MSMEG_1496|M.smegmatis_MC2_155 FATSLMNKDLGLAMAAVSSTGASAPLGSHAAEIYAKFN---EEHADKDFS
TH_0328|M.thermoresistible__bu FATALMNKDLGLAMDAVKSSGASAPLGSHAAEIYAEFIRAADGNADKDFS
Mflv_5012|M.gilvum_PYR-GCK FATALMNKDLGLAMAAVESSGAKAPLGTHAAEIYSDFA---KEHAGKDFS
Mvan_1360|M.vanbaalenii_PYR-1 FATALMNKDLGLAMAAVSSTGSSAPLGTHAAEIYAEFN---KEHADKDFS
Mb0773c|M.bovis_AF2122/97 FSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFA---ADHADLDFS
Rv0751c|M.tuberculosis_H37Rv FSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFA---ADHADLDFS
MMAR_1077|M.marinum_M FATALMNKDLGLAMDAVTSTGSAAPLGSHAAEIYAKFA---ADHADQDFS
MUL_0835|M.ulcerans_Agy99 FATALMNKDLGLAMDAVTSTASAAPLGSHAAEIYAKFA---TDHADQDFS
MAV_4419|M.avium_104 FAAALMNKDLGLAMDAVTSTGAAAPLGRHAAEIYAKFA---ASHGDKDFS
MAB_4486|M.abscessus_ATCC_1997 FTVDLAHKDARLALAAGEATGVNLPAATLVTEQFQQLID--EGLGGKDCS
MLBr_02065|M.leprae_Br4923 LSGSVLQRKAAIGLASGKLGNKPTDRETFIEDVRQALYASKIVAYAQGFN
:: : ::. :.: : : : . .
MSMEG_1496|M.smegmatis_MC2_155 AVIELLRG------------------------------------------
TH_0328|M.thermoresistible__bu AVIELLRNS-----------------------------------------
Mflv_5012|M.gilvum_PYR-GCK AIIEALRD------------------------------------------
Mvan_1360|M.vanbaalenii_PYR-1 AIIEALRG------------------------------------------
Mb0773c|M.bovis_AF2122/97 AVIHTLRARADA--------------------------------------
Rv0751c|M.tuberculosis_H37Rv AVIHTLRARADA--------------------------------------
MMAR_1077|M.marinum_M AVIEMLRGS-----------------------------------------
MUL_0835|M.ulcerans_Agy99 AVIEMLRGS-----------------------------------------
MAV_4419|M.avium_104 AVIEMLRGAC----------------------------------------
MAB_4486|M.abscessus_ATCC_1997 LIVKYATPDGSPRGYTP---------------------------------
MLBr_02065|M.leprae_Br4923 HIQTGSTEFGWNITPGDLATIWRGGCIIRAKFLNRIKEAFDAAPDLASLI
:
MSMEG_1496|M.smegmatis_MC2_155 --------------------------------------------------
TH_0328|M.thermoresistible__bu --------------------------------------------------
Mflv_5012|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1360|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0773c|M.bovis_AF2122/97 --------------------------------------------------
Rv0751c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1077|M.marinum_M --------------------------------------------------
MUL_0835|M.ulcerans_Agy99 --------------------------------------------------
MAV_4419|M.avium_104 --------------------------------------------------
MAB_4486|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02065|M.leprae_Br4923 VAPYFRSAVESAIDSWRRVVSTATQLGIPNPGFSSALSYYDALRTERLPA
MSMEG_1496|M.smegmatis_MC2_155 -------------------------------------
TH_0328|M.thermoresistible__bu -------------------------------------
Mflv_5012|M.gilvum_PYR-GCK -------------------------------------
Mvan_1360|M.vanbaalenii_PYR-1 -------------------------------------
Mb0773c|M.bovis_AF2122/97 -------------------------------------
Rv0751c|M.tuberculosis_H37Rv -------------------------------------
MMAR_1077|M.marinum_M -------------------------------------
MUL_0835|M.ulcerans_Agy99 -------------------------------------
MAV_4419|M.avium_104 -------------------------------------
MAB_4486|M.abscessus_ATCC_1997 -------------------------------------
MLBr_02065|M.leprae_Br4923 ALTQAQRDFFGAHSYGRVDARGKFHTLWSEDRSEVTV