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MGAPMVTRLVQAGHDVRALGRSPDKRAAIGESRARAVAALDEVADGADVVVVCVFTDDQVREVCLDGGLL DAMAPGSVLVVHTTGSPRTVEALAARAPAVAVLDAPVSGGPHDIAAGQITLFVGGDATAVERARPVLAAY GDPILRVGELGAGQWVKLINNTLFAAQLGMLREAASFGARVGVDEAGLLGAIGHGSGASRAAEIVGTRGS VQSFIESVGEFLGKDVAVVREVAAETGSDLGLLEGLLDVVVGAPSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4174 | - | - | 100% (256) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. vanbaalenii PYR-1 | Mvan_4173 | - | 3e-36 | 33.20% (256) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. vanbaalenii PYR-1 | Mvan_5155 | - | 1e-20 | 31.48% (270) | 6-phosphogluconate dehydrogenase, NAD-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0773c | mmsB | 1e-21 | 30.77% (260) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. gilvum PYR-GCK | Mflv_2480 | - | 2e-85 | 62.00% (250) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0751c | mmsB | 1e-21 | 30.77% (260) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1186c | - | 1e-17 | 30.65% (199) | 3-hydroxyisobutyrate dehydrogenase |
| M. marinum M | MMAR_1077 | mmsB | 9e-22 | 35.00% (200) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. avium 104 | MAV_1928 | - | 1e-49 | 45.12% (246) | 6-phosphogluconate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4817 | - | 2e-81 | 60.47% (253) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. thermoresistible (build 8) | TH_2512 | - | 6e-38 | 34.38% (256) | PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 5e-21 | 34.50% (200) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2480|M.gilvum_PYR-GCK ---MSAVGFVGAGRMGAPMVERLVQAGHEVRVLGRSAEKRSAIAGLGATA
MSMEG_4817|M.smegmatis_MC2_155 ----MRIGFLGAGRMGAPMVQRLTAAGHDVHALGRTDEKRTAVAGSGATP
Mvan_4174|M.vanbaalenii_PYR-1 --------------MGAPMVTRLVQAGHDVRALGRSPDKRAAIGESRARA
MAV_1928|M.avium_104 --MAGIVGFLGAGQLGEPMVERLIDAGHDVLVYARREEARHRLESKGANL
TH_2512|M.thermoresistible__bu ----MRVGFIGLGSQGGPMARRIAENGYETTLWARRAATLEPFADTPAKT
Mb0773c|M.bovis_AF2122/97 MTT---IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAV
Rv0751c|M.tuberculosis_H37Rv MTT---IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAV
MMAR_1077|M.marinum_M MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASAAAAKGATM
MUL_0835|M.ulcerans_Agy99 MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATAAKGATM
MAB_1186c|M.abscessus_ATCC_199 MTN---IAFIGLGHMGLPMAVNLTKAGHTVAAFDLSEQARDAATQAGVPL
* ** .: *: . .
Mflv_2480|M.gilvum_PYR-GCK VATTAEVSGGADVVIVCVFTDDQVAELCLDG-DLVTSMSAGATLVLHTTG
MSMEG_4817|M.smegmatis_MC2_155 VAAATDAVHGADVVIVCVFTDEQVRTLCTD--TLLDAMAPGAVLVLHTTG
Mvan_4174|M.vanbaalenii_PYR-1 VAALDEVADGADVVVVCVFTDDQVREVCLDG-GLLDAMAPGSVLVVHTTG
MAV_1928|M.avium_104 AASVADLARGSDVLISCLFSDAQLRETGLGPDGFVANAKPGAVLVSHTTG
TH_2512|M.thermoresistible__bu AGSPAELGAASDLVCLCVVGDDDVREVLYGDTGVLAGLAPGGVVAIHSTV
Mb0773c|M.bovis_AF2122/97 FRSAPEAVAEADVVITMLPTGEVVRRCYTD---VLAAARPATLFIDSSTI
Rv0751c|M.tuberculosis_H37Rv FRSAPEAVAEADVVITMLPTGEVVRRCYTD---VLAAARPATLFIDSSTI
MMAR_1077|M.marinum_M FDSAAEAVAGADVVITMLPNGAVVKRCYAE---VLPAARSGALFIDSSTI
MUL_0835|M.ulcerans_Agy99 FDSAAEAVARADVVITMLPNGAVVKRCYAE---VLPAARSGALFIDSSTI
MAB_1186c|M.abscessus_ATCC_199 AESGAAAASTADVVITMLPKGAHVLAAYED---LLPAARPGTLFIDSSTV
: :*:: : . : .: .. . :*
Mflv_2480|M.gilvum_PYR-GCK SPRTAQSVAEKFPH--VAVVDAPVSGGPHDIAAGNVTLFVGGAQDVLARI
MSMEG_4817|M.smegmatis_MC2_155 SPRTAEDIAARAADRGVAVVDAPVSGGPHDIAAGSVTVFAGGDADVVERV
Mvan_4174|M.vanbaalenii_PYR-1 SPRTVEALAARAPA--VAVLDAPVSGGPHDIAAGQITLFVGGDATAVERA
MAV_1928|M.avium_104 NLSTLEALRDSSATP-PVILDGPVSGTADDIAAGKLTVLLGGPTDAVAAV
TH_2512|M.thermoresistible__bu HPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKLLVMVGGDEEVVERC
Mb0773c|M.bovis_AF2122/97 SVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRA
Rv0751c|M.tuberculosis_H37Rv SVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRA
MMAR_1077|M.marinum_M SVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSALAQA
MUL_0835|M.ulcerans_Agy99 SVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSALAQA
MAB_1186c|M.abscessus_ATCC_199 DVADARAAHEAATAAGHRFADAPVSGGVPGATAATLTFMVGADDAVFVAA
. *.**** . : .: *. ..
Mflv_2480|M.gilvum_PYR-GCK RPVLGAYGDPILHAGDTGAGQLVKLVNNTMFAAQIGLVAEGVRLGARFGV
MSMEG_4817|M.smegmatis_MC2_155 RPALVAYAEPLLHVGPLGSGQRVKLVNNTMFAAQIGVVAEGVRLARELGV
Mvan_4174|M.vanbaalenii_PYR-1 RPVLAAYGDPILRVGELGAGQWVKLINNTLFAAQLGMLREAASFGARVGV
MAV_1928|M.avium_104 TPILAAYADPVVATGELGTALALKLINNLLFAANAQLLASAAQLGTQLGI
TH_2512|M.thermoresistible__bu RPVFASYADPIVHLGPLGSGQVTKILNNLLFTANLGSALSTLELGESLGI
Mb0773c|M.bovis_AF2122/97 RPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGL
Rv0751c|M.tuberculosis_H37Rv RPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGL
MMAR_1077|M.marinum_M RPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFVLAENLGL
MUL_0835|M.ulcerans_Agy99 RPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFVLAENLGL
MAB_1186c|M.abscessus_ATCC_199 EPILDAMGKRVVHCGGPGVGQAAKICNNMILGVSMIAISEAFVLGEKLGL
* : . . :: * * . *: ** :: .. . :. .*:
Mflv_2480|M.gilvum_PYR-GCK DEGALLNALTHGSAQSRALSMIASAG-SAETFISR-------VGEFIGKD
MSMEG_4817|M.smegmatis_MC2_155 DEPTVLSALTHGSAASRALSGIAATG-SAEDFKAR-------VGEFIGKD
Mvan_4174|M.vanbaalenii_PYR-1 DEAGLLGAIGHGSGASRAAEIVGTRG-SVQSFIES-------VGEFLGKD
MAV_1928|M.avium_104 DPDVLLSTLQVCSANSNAAAHAHRIG-GMDRFTEL-------AGPFLRKD
TH_2512|M.thermoresistible__bu PRVKLAEVLNGGSATSKALGSISVFGGTVEGLAPI-------AGALLQKD
Mb0773c|M.bovis_AF2122/97 SAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNKD
Rv0751c|M.tuberculosis_H37Rv SAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNKD
MMAR_1077|M.marinum_M DAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATALMNKD
MUL_0835|M.ulcerans_Agy99 DAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATALMNKD
MAB_1186c|M.abscessus_ATCC_199 SHQALFDVAANASGQCWALTSNCPVPGPVPTSPANRDYAPGFAVALMAKD
: . :. . * :: **
Mflv_2480|M.gilvum_PYR-GCK VAVVRRTVADLGGTLGDLEPLVNAVAP-----------------------
MSMEG_4817|M.smegmatis_MC2_155 VAVVRATAADLGADLGLLDHAVDAALR-----------------------
Mvan_4174|M.vanbaalenii_PYR-1 VAVVREVAAETGSDLGLLEGLLDVVVGAPSG-------------------
MAV_1928|M.avium_104 IAACREAAAEAGVDLGLLGTAVREGPLTLDDRAAGQN-------------
TH_2512|M.thermoresistible__bu VRHAANIAASASVPEGTVFTVADTALTAMGHARR----------------
Mb0773c|M.bovis_AF2122/97 LGLAMDAVAATGATAPLGSHAADIYAKF-AADHADLDFSAVIHTLRARAD
Rv0751c|M.tuberculosis_H37Rv LGLAMDAVAATGATAPLGSHAADIYAKF-AADHADLDFSAVIHTLRARAD
MMAR_1077|M.marinum_M LGLAMDAVTSTGSAAPLGSHAAEIYAKF-AADHADQDFSAVIEMLRGS--
MUL_0835|M.ulcerans_Agy99 LGLAMDAVTSTASAAPLGSHAAEIYAKF-ATDHADQDFSAVIEMLRGS--
MAB_1186c|M.abscessus_ATCC_199 LGLAANAVRANGVDAQLGLAAAHIYDDFNSTGGSGLDFSAIFSRIQGAS-
: . .
Mflv_2480|M.gilvum_PYR-GCK -
MSMEG_4817|M.smegmatis_MC2_155 -
Mvan_4174|M.vanbaalenii_PYR-1 -
MAV_1928|M.avium_104 -
TH_2512|M.thermoresistible__bu -
Mb0773c|M.bovis_AF2122/97 A
Rv0751c|M.tuberculosis_H37Rv A
MMAR_1077|M.marinum_M -
MUL_0835|M.ulcerans_Agy99 -
MAB_1186c|M.abscessus_ATCC_199 -