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RVGFIGLGSQGGPMARRIVEGGYPTTLWARRPATLEVFADTDAKVAGSPAELAAASDLVCLCVIGDADID ELTDGEHGLLSAMQPGGVIAVHSTVHPDTCRKLAKRAAALGVSVVDAPVSGGGGAAAEGRLLVMAGGDAD VVERCRPVFETYADPVVHLGELGSGQTTKLLNNLLFTANLATAATALSLAEQLGVRPERLTEVVSRSSGN SFALNALGGIGGLDQLAGVAGALLRKDVRLVVDLAEQAGAAGGAVLDAADAALALMGHPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0917 | - | - | 100% (271) | 6-phosphogluconate dehydrogenase |
| M. avium 104 | MAV_1928 | - | 5e-42 | 37.90% (248) | 6-phosphogluconate dehydrogenase |
| M. avium 104 | MAV_2635 | - | 4e-38 | 36.59% (276) | 3-hydroxyisobutyrate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0793 | - | 3e-34 | 36.32% (223) | dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_2481 | - | 5e-94 | 62.87% (272) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0770 | - | 5e-35 | 36.77% (223) | dehydrogenase/reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1220 | - | 3e-27 | 31.93% (238) | dehydrogenase/reductase |
| M. marinum M | MMAR_4926 | - | 3e-34 | 35.02% (237) | dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_4816 | - | 2e-96 | 65.44% (272) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. thermoresistible (build 8) | TH_2512 | - | 3e-96 | 63.97% (272) | PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 1e-27 | 29.10% (268) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_4173 | - | 8e-96 | 63.60% (272) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0793|M.bovis_AF2122/97 MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFVEGG
Rv0770|M.tuberculosis_H37Rv MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFVEGG
MMAR_4926|M.marinum_M MSEH---PKLGYIGLGNQGAPMAKRLLDWPGGLVVYDVRAEAMTPLAEAG
MAB_1220|M.abscessus_ATCC_1997 MTQQ--AMKLGYIGLGNMGAPMARRLVDWPGGLTVFDLRAEAVAPLVEEG
Mflv_2481|M.gilvum_PYR-GCK -------MRVGFIGLGSQGGPMARRIAEGGFETTLWARRQASLEPYSDTP
Mvan_4173|M.vanbaalenii_PYR-1 -------MRVGFIGLGSQGGPMARRIAEGGFETTLWARRPASLEPYADTP
TH_2512|M.thermoresistible__bu -------MRVGFIGLGSQGGPMARRIAENGYETTLWARRAATLEPFADTP
MSMEG_4816|M.smegmatis_MC2_155 -------MRVGFIGLGSQGAPMARRIVEGGFETTLWARRPASLEPFADTA
MAV_0917|M.avium_104 -------MRVGFIGLGSQGGPMARRIVEGGYPTTLWARRPATLEVFADTD
MUL_0835|M.ulcerans_Agy99 ---MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATAAKG
::.::*** *.**: .: : :
Mb0793|M.bovis_AF2122/97 ATAAASVSDVAEA-DIISITVFDDAQVSSVITADNGLATHAKPGTIVAIH
Rv0770|M.tuberculosis_H37Rv ATAAASVSDVAEA-DIISITVFDDAQVSSVITADNGLATHAKPGTIVAIH
MMAR_4926|M.marinum_M ASAAASVAEVAGA-DIISVTVLNDAQVREVITGANGLAAHARAGTIIAIH
MAB_1220|M.abscessus_ATCC_1997 AVGASDVADIADA-DLISVTVLDDAQVRQVVG---QVAPKAKPGTIIAIH
Mflv_2481|M.gilvum_PYR-GCK AKTASTPAELGAASDLVCLCVVGDDDVREVLYGEQGVLAGLAEGGIIAIH
Mvan_4173|M.vanbaalenii_PYR-1 AKTAATPAELGANSDLVCLCVVGDDDVREVLYGESGVLAGLAEGGIIAIH
TH_2512|M.thermoresistible__bu AKTAGSPAELGAASDLVCLCVVGDDDVREVLYGDTGVLAGLAPGGVVAIH
MSMEG_4816|M.smegmatis_MC2_155 AKVAGTPAELAAASDLVCLCVVGDDDVREVLDGETGVLAGLAPGGIIAIH
MAV_0917|M.avium_104 AKVAGSPAELAAASDLVCLCVIGDADIDELTDGEHGLLSAMQPGGVIAVH
MUL_0835|M.ulcerans_Agy99 ATMFDSAAEAVARADVVITMLPNGAVVKRCYA---EVLPAARSGALFIDS
* :: *:: : .. : : . * :.
Mb0793|M.bovis_AF2122/97 STIADTTAVDLAEKLKPQGIHIVDAPGSGGAAAAAKGELAVMVGADDEAF
Rv0770|M.tuberculosis_H37Rv STIADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGELAVMVGADDEAF
MMAR_4926|M.marinum_M STISDTTAEELARELRPRGIHVIDAPVSGGAGAASKGQLATMVGAGDDVF
MAB_1220|M.abscessus_ATCC_1997 STISDTTAVELAQAWRPRDIHVIDAPVSGGAPGAHKGELATMVGADGETF
Mflv_2481|M.gilvum_PYR-GCK STVHPQTCQEIAEKGAAQGVSVIDAPVSGGGPAVEQGTLLVMVGGDEEVA
Mvan_4173|M.vanbaalenii_PYR-1 STVHPDTCREIAEKSAAQGISVIDAPVSGGGPAVEQGTLLVMVGGDEEVA
TH_2512|M.thermoresistible__bu STVHPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKLLVMVGGDEEVV
MSMEG_4816|M.smegmatis_MC2_155 STVHPDTCTEIAEQVAEKGISLIDAPVSGGEPAAKAGTLLVMAGGDEDIV
MAV_0917|M.avium_104 STVHPDTCRKLAKRAAALGVSVVDAPVSGGGGAAAEGRLLVMAGGDADVV
MUL_0835|M.ulcerans_Agy99 STISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSAL
**: . .: : :*** *** .. * * *.*.. .
Mb0793|M.bovis_AF2122/97 QRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQRLAEA
Rv0770|M.tuberculosis_H37Rv QRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQRLAEA
MMAR_4926|M.marinum_M ARVKEPFSCWASLVVHAGPPGAGTRMKLARNMLTFTIYAAVGEAWKLAEA
MAB_1220|M.abscessus_ATCC_1997 ARVKEAFSKWASLVIHAGAPGAGTRMKLARNLLHFVAFTAAGEAQRLAES
Mflv_2481|M.gilvum_PYR-GCK ERCRPVFATYADPIVHLGPLGSGQNTKILNNLLFSANLGSAVSTLELGES
Mvan_4173|M.vanbaalenii_PYR-1 QRCRPVFATYADPIVHLGPLGSGQNTKILNNLLFSANLGAAVSTLELGES
TH_2512|M.thermoresistible__bu ERCRPVFASYADPIVHLGPLGSGQVTKILNNLLFTANLGSALSTLELGES
MSMEG_4816|M.smegmatis_MC2_155 DKVRPVFATYADPVVRLGGVGSGQVAKILNNLLFSANLGAAMSALELGEA
MAV_0917|M.avium_104 ERCRPVFETYADPVVHLGELGSGQTTKLLNNLLFTANLATAATALSLAEQ
MUL_0835|M.ulcerans_Agy99 AQARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFVLAEN
: : : *. ::: * *:* *: .*:: . : : *.*
Mb0793|M.bovis_AF2122/97 CGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEHTRGL
Rv0770|M.tuberculosis_H37Rv CGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEHTRGL
MMAR_4926|M.marinum_M SGVNLQDLGNVVRHTDKLTSGAGSIMFRDNTKDLEPGHFLYDGFVHARDL
MAB_1220|M.abscessus_ATCC_1997 CGLDITDLGKVVRHTDAITGGPGAIMLRDTTEPVTPDSFWLPIFTHVRGL
Mflv_2481|M.gilvum_PYR-GCK LGIPRAKLVEVLSKGSATSKAVSSISMFGGTLDGLAP--------IAGGL
Mvan_4173|M.vanbaalenii_PYR-1 LGIPRQKLVEVLNRGSATSKAVASISMFGGTLEGLAP--------IAGAL
TH_2512|M.thermoresistible__bu LGIPRVKLAEVLNGGSATSKALGSISVFGGTVEGLAP--------IAGAL
MSMEG_4816|M.smegmatis_MC2_155 LGVPRSALCEVITRGSANSKALGSIAMFGGTLDNLAP--------IAGAL
MAV_0917|M.avium_104 LGVRPERLTEVVSRSSGNSFALNALGGIGG-LDQLAG--------VAGAL
MUL_0835|M.ulcerans_Agy99 LGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG-FATAL
*: * .*: . : . . *
Mb0793|M.bovis_AF2122/97 GEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET----
Rv0770|M.tuberculosis_H37Rv GEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET----
MMAR_4926|M.marinum_M GEKDLGLALALGEALSVDLPLARLALERLAPGLGVPHTQKDA--------
MAB_1220|M.abscessus_ATCC_1997 GEKDLSLALALGEEQSVDLPLATLAREQLAASLGVPHEEGASNG------
Mflv_2481|M.gilvum_PYR-GCK LQKDVRHAASLAAAAKAPEGAVFTAADAALEAMDHRR-------------
Mvan_4173|M.vanbaalenii_PYR-1 LQKDVRHAASLAASAEAAEGAVFTAADAALEAMDHRR-------------
TH_2512|M.thermoresistible__bu LQKDVRHAANIAASASVPEGTVFTVADTALTAMGHARR------------
MSMEG_4816|M.smegmatis_MC2_155 LQKDCRHAASLADAASASQGAVFGAADEALRLMNVPR-------------
MAV_0917|M.avium_104 LRKDVRLVVDLAEQAGAAGGAVLDAADAALALMGHPR-------------
MUL_0835|M.ulcerans_Agy99 MNKDLGLAMDAVTSTASAAPLGSHAAEIYAKFATDHADQDFSAVIEMLRG
.** . . :
Mb0793|M.bovis_AF2122/97 -
Rv0770|M.tuberculosis_H37Rv -
MMAR_4926|M.marinum_M -
MAB_1220|M.abscessus_ATCC_1997 -
Mflv_2481|M.gilvum_PYR-GCK -
Mvan_4173|M.vanbaalenii_PYR-1 -
TH_2512|M.thermoresistible__bu -
MSMEG_4816|M.smegmatis_MC2_155 -
MAV_0917|M.avium_104 -
MUL_0835|M.ulcerans_Agy99 S