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SAVGFVGAGRMGAPMVERLVQAGHEVRVLGRSAEKRSAIAGLGATAVATTAEVSGGADVVIVCVFTDDQV AELCLDGDLVTSMSAGATLVLHTTGSPRTAQSVAEKFPHVAVVDAPVSGGPHDIAAGNVTLFVGGAQDVL ARIRPVLGAYGDPILHAGDTGAGQLVKLVNNTMFAAQIGLVAEGVRLGARFGVDEGALLNALTHGSAQSR ALSMIASAGSAETFISRVGEFIGKDVAVVRRTVADLGGTLGDLEPLVNAVAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2480 | - | - | 100% (263) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. gilvum PYR-GCK | Mflv_2481 | - | 1e-38 | 34.87% (238) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. gilvum PYR-GCK | Mflv_1602 | - | 6e-25 | 29.20% (274) | 6-phosphogluconate dehydrogenase, NAD-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0793 | - | 5e-24 | 31.73% (208) | dehydrogenase/reductase |
| M. tuberculosis H37Rv | Rv0770 | - | 8e-25 | 32.21% (208) | dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_02430 | proC | 4e-06 | 24.91% (269) | pyrroline-5-carboxylate reductase |
| M. abscessus ATCC 19977 | MAB_1186c | - | 7e-22 | 30.84% (214) | 3-hydroxyisobutyrate dehydrogenase |
| M. marinum M | MMAR_1077 | mmsB | 2e-26 | 37.25% (204) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. avium 104 | MAV_1928 | - | 3e-49 | 40.64% (251) | 6-phosphogluconate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4817 | - | 1e-90 | 66.80% (259) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. thermoresistible (build 8) | TH_2512 | - | 7e-39 | 35.29% (238) | PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 1e-25 | 36.76% (204) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_4174 | - | 3e-85 | 62.00% (250) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2480|M.gilvum_PYR-GCK ------MSAVGFVGAGRMGAPMVERLVQAG---HEVRVLGRSAEKRSAIA
MSMEG_4817|M.smegmatis_MC2_155 -------MRIGFLGAGRMGAPMVQRLTAAG---HDVHALGRTDEKRTAVA
Mvan_4174|M.vanbaalenii_PYR-1 -----------------MGAPMVTRLVQAG---HDVRALGRSPDKRAAIG
MAV_1928|M.avium_104 -----MAGIVGFLGAGQLGEPMVERLIDAG---HDVLVYARREEARHRLE
TH_2512|M.thermoresistible__bu -------MRVGFIGLGSQGGPMARRIAENG---YETTLWARRAATLEPFA
MMAR_1077|M.marinum_M ---MTKSCQIAFLGLGHMGAPMSANLIGAG---HTVRGFDPVPAAASAAA
MUL_0835|M.ulcerans_Agy99 ---MTKSCQIAFLGLGHMGAPMSANLIGAG---HTVRGFDPVPAAASATA
MAB_1186c|M.abscessus_ATCC_199 ---MTN---IAFIGLGHMGLPMAVNLTKAG---HTVAAFDLSEQARDAAT
Mb0793|M.bovis_AF2122/97 MTAHPETPRLGYIGLGNQGAPMAKRLLDWP---GGLTVFDVRVEAMAPFV
Rv0770|M.tuberculosis_H37Rv MTAHPETPRLGYIGLGNQGAPMAKRLLDWP---GGLTVFDVRVEAMAPFV
MLBr_02430|M.leprae_Br4923 --MLSSMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRARYLA
* .: :
Mflv_2480|M.gilvum_PYR-GCK GLGATAVATTAEVSGGADVVIVCVFTDDQVAELCLDG-DLVTSMSAGATL
MSMEG_4817|M.smegmatis_MC2_155 GSGATPVAAATDAVHGADVVIVCVFTDEQVRTLCTD--TLLDAMAPGAVL
Mvan_4174|M.vanbaalenii_PYR-1 ESRARAVAALDEVADGADVVVVCVFTDDQVREVCLDG-GLLDAMAPGSVL
MAV_1928|M.avium_104 SKGANLAASVADLARGSDVLISCLFSDAQLRETGLGPDGFVANAKPGAVL
TH_2512|M.thermoresistible__bu DTPAKTAGSPAELGAASDLVCLCVVGDDDVREVLYGDTGVLAGLAPGGVV
MMAR_1077|M.marinum_M AKGATMFDSAAEAVAGADVVIT-MLPNG--AVVKRCYAEVLPAARSGALF
MUL_0835|M.ulcerans_Agy99 AKGATMFDSAAEAVARADVVIT-MLPNG--AVVKRCYAEVLPAARSGALF
MAB_1186c|M.abscessus_ATCC_199 QAGVPLAESGAAAASTADVVIT-MLPKG--AHVLAAYEDLLPAARPGTLF
Mb0793|M.bovis_AF2122/97 EGGATAAASVSDVAEADIISIT-VFDDAQVSSVITADNGLATHAKPGTIV
Rv0770|M.tuberculosis_H37Rv EGGATAAASVSDVAEADIISIT-VFDDAQVSSVITADNGLATHAKPGTIV
MLBr_02430|M.leprae_Br4923 DTYSVLVTSVTDAVENAMFVVVAVKPTD-VESVMGDLVQAAAVANDSAEQ
: . : .
Mflv_2480|M.gilvum_PYR-GCK VLHTTGSPRTAQSVAEKFPH--VAVVDAPVSGGPHDIAAGNVTLFVGGAQ
MSMEG_4817|M.smegmatis_MC2_155 VLHTTGSPRTAEDIAARAADRGVAVVDAPVSGGPHDIAAGSVTVFAGGDA
Mvan_4174|M.vanbaalenii_PYR-1 VVHTTGSPRTVEALAARAPA--VAVLDAPVSGGPHDIAAGQITLFVGGDA
MAV_1928|M.avium_104 VSHTTGNLSTLEALRDSSATP-PVILDGPVSGTADDIAAGKLTVLLGGPT
TH_2512|M.thermoresistible__bu AIHSTVHPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKLLVMVGGDE
MMAR_1077|M.marinum_M IDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQ
MUL_0835|M.ulcerans_Agy99 IDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQ
MAB_1186c|M.abscessus_ATCC_199 IDSSTVDVADARAAHEAATAAGHRFADAPVSGGVPGATAATLTFMVGADD
Mb0793|M.bovis_AF2122/97 AIHSTIADTTAVDLAEKLKPQGIHIVDAPGSGGAAAAAKGELAVMVGADD
Rv0770|M.tuberculosis_H37Rv AIHSTIADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGELAVMVGADD
MLBr_02430|M.leprae_Br4923 VLVTVAAGVTITYLESKLPAGTPVVRAMP---NAAALVGAGVTVLAKGRF
:. * . : .: .
Mflv_2480|M.gilvum_PYR-GCK DVLARIRPVLGAYGDP-ILHAGDTGAGQLVKLVNNTMFAAQIGLVAEGVR
MSMEG_4817|M.smegmatis_MC2_155 DVVERVRPALVAYAEP-LLHVGPLGSGQRVKLVNNTMFAAQIGVVAEGVR
Mvan_4174|M.vanbaalenii_PYR-1 TAVERARPVLAAYGDP-ILRVGELGAGQWVKLINNTLFAAQLGMLREAAS
MAV_1928|M.avium_104 DAVAAVTPILAAYADP-VVATGELGTALALKLINNLLFAANAQLLASAAQ
TH_2512|M.thermoresistible__bu EVVERCRPVFASYADP-IVHLGPLGSGQVTKILNNLLFTANLGSALSTLE
MMAR_1077|M.marinum_M SALAQARPVLEPMAGK-IIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFV
MUL_0835|M.ulcerans_Agy99 SALAQARPVLEPMAGK-IIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFV
MAB_1186c|M.abscessus_ATCC_199 AVFVAAEPILDAMGKR-VVHCGGPGVGQAAKICNNMILGVSMIAISEAFV
Mb0793|M.bovis_AF2122/97 EAFQRIKEPFSRWASL-LIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQR
Rv0770|M.tuberculosis_H37Rv EAFQRIKEPFSRWASL-LIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQR
MLBr_02430|M.leprae_Br4923 VTGQQFEDVLAMFDAVGGVLTVPESQMDAVTAVSGSGPAYFFLLVEALVD
. : : . . .
Mflv_2480|M.gilvum_PYR-GCK LGARFGVDEGALLNALTHGSAQSRALSMIASAG-SAETFISR--------
MSMEG_4817|M.smegmatis_MC2_155 LARELGVDEPTVLSALTHGSAASRALSGIAATG-SAEDFKAR--------
Mvan_4174|M.vanbaalenii_PYR-1 FGARVGVDEAGLLGAIGHGSGASRAAEIVGTRG-SVQSFIES--------
MAV_1928|M.avium_104 LGTQLGIDPDVLLSTLQVCSANSNAAAHAHRIG-GMDRFTEL--------
TH_2512|M.thermoresistible__bu LGESLGIPRVKLAEVLNGGSATSKALGSISVFGGTVEGLAPI--------
MMAR_1077|M.marinum_M LAENLGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPAN-NDFKPGF
MUL_0835|M.ulcerans_Agy99 LAENLGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPAN-NDFKPGF
MAB_1186c|M.abscessus_ATCC_199 LGEKLGLSHQALFDVAANASGQCWALTSNCPVPGPVPTSPAN-RDYAPGF
Mb0793|M.bovis_AF2122/97 LAEACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEH
Rv0770|M.tuberculosis_H37Rv LAEACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEH
MLBr_02430|M.leprae_Br4923 AGVAVGLTRQVATELAAQTMAGSAAMLLERMDQDRHSAEVAP--------
. *: . .
Mflv_2480|M.gilvum_PYR-GCK VGEFIGKDVAVVRRTVADLGGTLGDLEPLVNAVAP---------------
MSMEG_4817|M.smegmatis_MC2_155 VGEFIGKDVAVVRATAADLGADLGLLDHAVDAALR---------------
Mvan_4174|M.vanbaalenii_PYR-1 VGEFLGKDVAVVREVAAETGSDLGLLEGLLDVVVGAPSG-----------
MAV_1928|M.avium_104 AGPFLRKDIAACREAAAEAGVDLGLLGTAVREGPLTLDDRAAGQN-----
TH_2512|M.thermoresistible__bu AGALLQKDVRHAANIAASASVPEGTVFTVADTALTAMGHARR--------
MMAR_1077|M.marinum_M ATALMNKDLGLAMDAVTSTGSAAPLGSHAAEIYAKF-AADHADQDFSAVI
MUL_0835|M.ulcerans_Agy99 ATALMNKDLGLAMDAVTSTASAAPLGSHAAEIYAKF-ATDHADQDFSAVI
MAB_1186c|M.abscessus_ATCC_199 AVALMAKDLGLAANAVRANGVDAQLGLAAAHIYDDFNSTGGSGLDFSAIF
Mb0793|M.bovis_AF2122/97 TRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET
Rv0770|M.tuberculosis_H37Rv TRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET
MLBr_02430|M.leprae_Br4923 LGAQVDVPAAQLRATITSPGGTTAAALRELERGGLRMVVDAAVQAAKIRS
.
Mflv_2480|M.gilvum_PYR-GCK --------
MSMEG_4817|M.smegmatis_MC2_155 --------
Mvan_4174|M.vanbaalenii_PYR-1 --------
MAV_1928|M.avium_104 --------
TH_2512|M.thermoresistible__bu --------
MMAR_1077|M.marinum_M EMLRGS--
MUL_0835|M.ulcerans_Agy99 EMLRGS--
MAB_1186c|M.abscessus_ATCC_199 SRIQGAS-
Mb0793|M.bovis_AF2122/97 --------
Rv0770|M.tuberculosis_H37Rv --------
MLBr_02430|M.leprae_Br4923 EQLRITSE