For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MAGIVGFLGAGQLGEPMVERLIDAGHDVLVYARREEARHRLESKGANLAASVADLARGSDVLISCLFSDA QLRETGLGPDGFVANAKPGAVLVSHTTGNLSTLEALRDSSATPPVILDGPVSGTADDIAAGKLTVLLGGP TDAVAAVTPILAAYADPVVATGELGTALALKLINNLLFAANAQLLASAAQLGTQLGIDPDVLLSTLQVCS ANSNAAAHAHRIGGMDRFTELAGPFLRKDIAACREAAAEAGVDLGLLGTAVREGPLTLDDRAAGQN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1928 | - | - | 100% (276) | 6-phosphogluconate dehydrogenase |
| M. avium 104 | MAV_2635 | - | e-123 | 82.90% (269) | 3-hydroxyisobutyrate dehydrogenase |
| M. avium 104 | MAV_0917 | - | 5e-42 | 37.90% (248) | 6-phosphogluconate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0793 | - | 2e-20 | 30.77% (195) | dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_2480 | - | 4e-49 | 40.64% (251) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0770 | - | 3e-21 | 31.28% (195) | dehydrogenase/reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4486 | - | 2e-23 | 29.41% (221) | 3-hydroxyisobutyrate dehydrogenase |
| M. marinum M | MMAR_4926 | - | 4e-23 | 33.33% (195) | dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_4817 | - | 6e-51 | 43.41% (258) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. thermoresistible (build 8) | TH_2512 | - | 9e-38 | 35.02% (257) | PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 3e-18 | 28.91% (211) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_4174 | - | 1e-49 | 45.12% (246) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2480|M.gilvum_PYR-GCK ------MSAVGFVGAGRMGAPMVERLVQAGHEVRVLGRSAEKRSAIAGLG
MSMEG_4817|M.smegmatis_MC2_155 -------MRIGFLGAGRMGAPMVQRLTAAGHDVHALGRTDEKRTAVAGSG
Mvan_4174|M.vanbaalenii_PYR-1 -----------------MGAPMVTRLVQAGHDVRALGRSPDKRAAIGESR
MAV_1928|M.avium_104 -----MAGIVGFLGAGQLGEPMVERLIDAGHDVLVYARREEARHRLESKG
TH_2512|M.thermoresistible__bu -------MRVGFIGLGSQGGPMARRIAENGYETTLWARRAATLEPFADTP
Mb0793|M.bovis_AF2122/97 MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFVEGG
Rv0770|M.tuberculosis_H37Rv MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFVEGG
MMAR_4926|M.marinum_M MSEH---PKLGYIGLGNQGAPMAKRLLDWPGGLVVYDVRAEAMTPLAEAG
MAB_4486|M.abscessus_ATCC_1997 ------MATYGWIGLGNMGGPMAANLVAAGHTVRGFDLSGDALAAAETTG
MUL_0835|M.ulcerans_Agy99 ---MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATAAKG
* ** .:
Mflv_2480|M.gilvum_PYR-GCK ATAVATTAEVSGGADVVIVCVFTDDQVAELCLDG-DLVTSMSAGATLVLH
MSMEG_4817|M.smegmatis_MC2_155 ATPVAAATDAVHGADVVIVCVFTDEQVRTLCTD--TLLDAMAPGAVLVLH
Mvan_4174|M.vanbaalenii_PYR-1 ARAVAALDEVADGADVVVVCVFTDDQVREVCLDG-GLLDAMAPGSVLVVH
MAV_1928|M.avium_104 ANLAASVADLARGSDVLISCLFSDAQLRETGLGPDGFVANAKPGAVLVSH
TH_2512|M.thermoresistible__bu AKTAGSPAELGAASDLVCLCVVGDDDVREVLYGDTGVLAGLAPGGVVAIH
Mb0793|M.bovis_AF2122/97 ATAAASVSDVAE-ADIISITVFDDAQVSSVITADNGLATHAKPGTIVAIH
Rv0770|M.tuberculosis_H37Rv ATAAASVSDVAE-ADIISITVFDDAQVSSVITADNGLATHAKPGTIVAIH
MMAR_4926|M.marinum_M ASAAASVAEVAG-ADIISVTVLNDAQVREVITGANGLAAHARAGTIIAIH
MAB_4486|M.abscessus_ATCC_1997 VTVVEEIAEVLAGAEVVFTMLPKGEHVRSVFEGPYGIWENASPSTLLVDS
MUL_0835|M.ulcerans_Agy99 ATMFDSAAEAVARADVVITMLPNGAVVKRCYA---EVLPAARSGALFIDS
. : :::: : . : . .. .
Mflv_2480|M.gilvum_PYR-GCK TTGSPRTAQSVAEKFPH--VAVVDAPVSGGPHDIAAGNVTLFVGGAQDVL
MSMEG_4817|M.smegmatis_MC2_155 TTGSPRTAEDIAARAADRGVAVVDAPVSGGPHDIAAGSVTVFAGGDADVV
Mvan_4174|M.vanbaalenii_PYR-1 TTGSPRTVEALAARAPA--VAVLDAPVSGGPHDIAAGQITLFVGGDATAV
MAV_1928|M.avium_104 TTGNLSTLEALRDSSATP-PVILDGPVSGTADDIAAGKLTVLLGGPTDAV
TH_2512|M.thermoresistible__bu STVHPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKLLVMVGGDEEVV
Mb0793|M.bovis_AF2122/97 STIADTTAVDLAEKLKPQGIHIVDAPGSGGAAAAAKGELAVMVGADDEAF
Rv0770|M.tuberculosis_H37Rv STIADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGELAVMVGADDEAF
MMAR_4926|M.marinum_M STISDTTAEELARELRPRGIHVIDAPVSGGAGAASKGQLATMVGAGDDVF
MAB_4486|M.abscessus_ATCC_1997 STVDIETSRYCHAESARRGFRFVDAPVSGGISGARAATLCFMLGGELENV
MUL_0835|M.ulcerans_Agy99 STISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSAL
:* :*.* ** . : : *. .
Mflv_2480|M.gilvum_PYR-GCK ARIRPVLGAYGDPILHAGDTGAGQLVKLVNNTMFAAQIGLVAEGVRLGAR
MSMEG_4817|M.smegmatis_MC2_155 ERVRPALVAYAEPLLHVGPLGSGQRVKLVNNTMFAAQIGVVAEGVRLARE
Mvan_4174|M.vanbaalenii_PYR-1 ERARPVLAAYGDPILRVGELGAGQWVKLINNTLFAAQLGMLREAASFGAR
MAV_1928|M.avium_104 AAVTPILAAYADPVVATGELGTALALKLINNLLFAANAQLLASAAQLGTQ
TH_2512|M.thermoresistible__bu ERCRPVFASYADPIVHLGPLGSGQVTKILNNLLFTANLGSALSTLELGES
Mb0793|M.bovis_AF2122/97 QRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQRLAEA
Rv0770|M.tuberculosis_H37Rv QRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQRLAEA
MMAR_4926|M.marinum_M ARVKEPFSCWASLVVHAGPPGAGTRMKLARNMLTFTIYAAVGEAWKLAEA
MAB_4486|M.abscessus_ATCC_1997 GAATDYIKPMAGRVIHAGDGGAGVAAKICNNMMLFIDMMANSEGSQLAER
MUL_0835|M.ulcerans_Agy99 AQARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFVLAEN
: . :: * *:. *: .* : . :.
Mflv_2480|M.gilvum_PYR-GCK FGVDEGALLNALTHGSAQSRALSMIASAG-SAETFISR--------VGEF
MSMEG_4817|M.smegmatis_MC2_155 LGVDEPTVLSALTHGSAASRALSGIAATG-SAEDFKAR--------VGEF
Mvan_4174|M.vanbaalenii_PYR-1 VGVDEAGLLGAIGHGSGASRAAEIVGTRG-SVQSFIES--------VGEF
MAV_1928|M.avium_104 LGIDPDVLLSTLQVCSANSNAAAHAHRIG-GMDRFTEL--------AGPF
TH_2512|M.thermoresistible__bu LGIPRVKLAEVLNGGSATSKALGSISVFGGTVEGLAPI--------AGAL
Mb0793|M.bovis_AF2122/97 CGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEHTRGL
Rv0770|M.tuberculosis_H37Rv CGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEHTRGL
MMAR_4926|M.marinum_M SGVNLQDLGNVVRHTDKLTSGAGSIMFRDNTKDLEPGHFLYDGFVHARDL
MAB_4486|M.abscessus_ATCC_1997 LGLDPQVFWEICSVSSARSWAQQTWYPVPGIIESAAAN-RNFDATFTVDL
MUL_0835|M.ulcerans_Agy99 LGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPAN-NDFKPGFATAL
*: . . . :
Mflv_2480|M.gilvum_PYR-GCK IGKDVAVVRRTVADLGGTLGDLEPLVNAVAP-------------------
MSMEG_4817|M.smegmatis_MC2_155 IGKDVAVVRATAADLGADLGLLDHAVDAALR-------------------
Mvan_4174|M.vanbaalenii_PYR-1 LGKDVAVVREVAAETGSDLGLLEGLLDVVVGAPSG---------------
MAV_1928|M.avium_104 LRKDIAACREAAAEAGVDLGLLGTAVREGPLTLDDRAAGQN---------
TH_2512|M.thermoresistible__bu LQKDVRHAANIAASASVPEGTVFTVADTALTAMGHARR------------
Mb0793|M.bovis_AF2122/97 GEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET----
Rv0770|M.tuberculosis_H37Rv GEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET----
MMAR_4926|M.marinum_M GEKDLGLALALGEALSVDLPLARLALERLAPGLGVPHTQKDA--------
MAB_4486|M.abscessus_ATCC_1997 AHKDARLALAAGEATGVNLPAATLVTEQFQQLIDEGLGGKDCSLIVKYAT
MUL_0835|M.ulcerans_Agy99 MNKDLGLAMDAVTSTASAAPLGSHAAEIYAKFATD-HADQDFSAVIEMLR
** .
Mflv_2480|M.gilvum_PYR-GCK ----------
MSMEG_4817|M.smegmatis_MC2_155 ----------
Mvan_4174|M.vanbaalenii_PYR-1 ----------
MAV_1928|M.avium_104 ----------
TH_2512|M.thermoresistible__bu ----------
Mb0793|M.bovis_AF2122/97 ----------
Rv0770|M.tuberculosis_H37Rv ----------
MMAR_4926|M.marinum_M ----------
MAB_4486|M.abscessus_ATCC_1997 PDGSPRGYTP
MUL_0835|M.ulcerans_Agy99 --GS------