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MSRAEVDDMTLGDIVTDNAARFPDVVAYRYGQRTVTHAQLRDRAVRLVSAMAAAGVRRQDRIAVLSRNSI EFGELNAAAQLGGIIMATINFRLSPPEMDDALRRVAPSIVFCAAEFVPVIGDLIADMPSPPMLVVIGGQA PQGITGYERFVEEGGSGEPEFVARPDDIAYLLFTSGTTGASKCCILGQREMRRVAFTMNNEMRCGSADRG LINMPMFHFGALGIIGGLHARGGTVVLQQQFDAADAVRLIADERITVLHLAPVMLRALLDEVSDRLAVES VRTVVYSAAPMTAAILRRALAVLPDAGFLNLYGQTEVIVSGLPRELHILDDPNAAERLSSVGFPFPDTRV RVVGADGGVLPVGQAGEIVVRSDSMFRGYWQDAAATQATLRDGWCRTGDMGRLDERGLLYLMDRKKDVII SGGENIYSPEVEDAVSAVDGVAACAVVGVPDDKWGEAVCAVVVPRGGASPTLEMVQEGVRQRLARYKVPR RLVLVADLPVLASGKVDKKRLRAELKAAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2587 | - | - | 100% (520) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_1867 | - | 0.0 | 72.46% (512) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_3523 | - | 3e-68 | 33.66% (508) | acyl-CoA synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0172 | fadD5 | 2e-66 | 33.47% (493) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 2e-69 | 35.25% (505) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 2e-66 | 33.47% (493) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 8e-46 | 29.16% (511) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 6e-70 | 33.87% (499) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_0409 | fadD5 | 1e-66 | 34.21% (497) | fatty-acid-CoA ligase FadD5 |
| M. smegmatis MC2 155 | MSMEG_4065 | - | 3e-70 | 35.35% (495) | feruloyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2634 | - | 1e-164 | 68.96% (422) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_0650 | fadD8 | 7e-54 | 32.02% (509) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_3993 | - | 3e-68 | 36.38% (503) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2587|M.avium_104 -------------------------------------MSRAEVDDMTLGD
TH_2634|M.thermoresistible__bu ------------------------------------------MTALTVGD
MAB_4559|M.abscessus_ATCC_1997 ---------------------------------------------MQFTQ
MSMEG_4065|M.smegmatis_MC2_155 -------------------------------------------MTMYLTQ
Mvan_3993|M.vanbaalenii_PYR-1 -----------------------------------------MSDGMYLTQ
Mb0172|M.bovis_AF2122/97 --------------------MTAQLASHLTRALTLAQQQPYLARRQNWVN
Rv0166|M.tuberculosis_H37Rv --------------------MTAQLASHLTRALTLAQQQPYLARRQNWVN
MMAR_0409|M.marinum_M --------------------MTAELASHLPQAA-HALEQPYLARRQNWVN
Mflv_0027|M.gilvum_PYR-GCK -------------------------------------------MFHNLAD
MUL_0650|M.ulcerans_Agy99 ------------------------------------MSDDLLRNPTHNGH
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
MAV_2587|M.avium_104 IVTDNAARFPDVVAYRYGQRTVTHAQLRDRAVRLVSAMAAAGVRRQDRIA
TH_2634|M.thermoresistible__bu IVSDNAHRFPDVVAYRMGERTLTHAELYDRATRLVSAMVAAGVRRQDRIA
MAB_4559|M.abscessus_ATCC_1997 WLHRALQQYPDRLITIDQGREHTVEQFADRVARLSAGLRANGVRPGDRVG
MSMEG_4065|M.smegmatis_MC2_155 GLHRAVQQTPGATMTVFGERRRTFLEVADRVARLAGALRALGVRAGDRVA
Mvan_3993|M.vanbaalenii_PYR-1 GLHRSLRATPDATMTICGERVRTFADVGDRVSRLAGGFRSLGASPGDRIA
Mb0172|M.bovis_AF2122/97 QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
Rv0166|M.tuberculosis_H37Rv QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
MMAR_0409|M.marinum_M QLERHAMMQPRATAIRYLGHTVTWADLRYRVAALAGSLSRRGVGFGDRVM
Mflv_0027|M.gilvum_PYR-GCK IVRSHGRNRPDAPALIVGDRTVSYRELDERSNRTAQAFSRTGVGPGDRVA
MUL_0650|M.ulcerans_Agy99 LLVGALERHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTGVTVG
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
: :. .: *. :
MAV_2587|M.avium_104 VLSRNSIEFGELNAAAQLGGIIMATINFRLSPPEMDDALRRVAPSIVFCA
TH_2634|M.thermoresistible__bu ILSRNSIEFGEVMAATHLSGIILATVNFRLTGGEVRDVINRVRPKIVFVG
MAB_4559|M.abscessus_ATCC_1997 MLSLNSDRYIEYLTAVPWLGAALNAVNIRWSLAEIGYSLRESGTRVLLVD
MSMEG_4065|M.smegmatis_MC2_155 MLAQNSDRYHEYLLAVPWANGVLNPVNIRWTPAEIAYSLEDSGTKVMFVD
Mvan_3993|M.vanbaalenii_PYR-1 ILSLNSDRYQESLLATVWSGCVTNPVNIRWSAAEIAYALRDSDSRILLID
Mb0172|M.bovis_AF2122/97 ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLTE
Rv0166|M.tuberculosis_H37Rv ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLTE
MMAR_0409|M.marinum_M ILMLNRTEFVESVLAANMLGAIAVPLNFRLTPSEIAFLVEDCAPRLVITE
Mflv_0027|M.gilvum_PYR-GCK FVERNGIEFFDVAFGSAKLGAVAVPVNWRLTAPEMRHVIADCGASVVVVG
MUL_0650|M.ulcerans_Agy99 LLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASALIID
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
.: * . . :: : : . :.
MAV_2587|M.avium_104 AE--FVPVIGDLIADMPSPPMLVVIGG-QAPQGITGYERFVEEGG---SG
TH_2634|M.thermoresistible__bu DE--FAPMVADLAGQLTSTPLLVCVG--DGHSAMTDYEEFVASGR---AG
MAB_4559|M.abscessus_ATCC_1997 DT--FKAAAAPLRAACACLETVIYCGAGPAPQDMIGYEDLLASH----EP
MSMEG_4065|M.smegmatis_MC2_155 DS--FARMLPAIKDAWAELSTVIYAGEASPPAGTLAYEELIDKS----DP
Mvan_3993|M.vanbaalenii_PYR-1 DA--FLPMLPELRREFPGLGDVIHCGDGVAPPECLAFEDLLGVS----DP
Mb0172|M.bovis_AF2122/97 AA--LAPVAIGVRNIQPLLSVIVVAG-GSSQDSVFGYEDLLNEAG---DV
Rv0166|M.tuberculosis_H37Rv AA--LAPVAIGVRNIQPLLSVIVVAG-GSSQDSVFGYEDLLNEAG---DV
MMAR_0409|M.marinum_M EV--LAQVAVGVREIAPALSTIVVAG-GASDPTVVGYDELISETG---DP
Mflv_0027|M.gilvum_PYR-GCK QE--FTGRIEAIADDLD--VEVVVIG---KHRHWPTFDDLLAAAP---AV
MUL_0650|M.ulcerans_Agy99 PNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDRAVDLSAEAAKYQPKP
MLBr_02546|M.leprae_Br4923 DEY-----TKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSS
: : *
MAV_2587|M.avium_104 EPEFVARPDDIAYLLFTSGTTGASKCCILGQR-EMRRVAFTMNNEMRCGS
TH_2634|M.thermoresistible__bu DVALRARPEDIACLIFTSGTTGASKCCILGQT-EHRRVLFTMNNEMRSGS
MAB_4559|M.abscessus_ATCC_1997 IDDTRTGGDSLLGVFYTGGTTGNPKGVMLSHNNVLASAMGSLSTGNFLTR
MSMEG_4065|M.smegmatis_MC2_155 VDDARRGGDELAGLFYTGGTTGFPKGVMLSHANLLTSTYGLLTPGFAFRP
Mvan_3993|M.vanbaalenii_PYR-1 VTDAHRSGSDLAGVFYTGGTSGHPKGVMLTHDNLMTSAMGALASGFFLTS
Mb0172|M.bovis_AF2122/97 HEPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSGANIN
Rv0166|M.tuberculosis_H37Rv HEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGANIN
MMAR_0409|M.marinum_M PEPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLTGQVMTALYTGGANIN
Mflv_0027|M.gilvum_PYR-GCK DPGVVTGPDDLVFLMYTSGTTGAPKGVMLSNANVVCKTAGVGGP-WKFDA
MUL_0650|M.ulcerans_Agy99 LVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNITAMTS-IQLAEWEWPE
MLBr_02546|M.leprae_Br4923 SAPAPKVRKRASIIILTSGTTGTPKGAN-RNTPASLAPLGGILSKVPFRA
. : *.**:* .*
MAV_2587|M.avium_104 ADRGLINMPMFHFGALGIIGGLHARGGTVVLQQQ--FDAADAVRLIADER
TH_2634|M.thermoresistible__bu DDQILINMPMFHIGAMAMLGGMHARGGTVVLQQQ--FDPDEAVRLIAEHR
MAB_4559|M.abscessus_ATCC_1997 GGRLLHSAPMFHMADFSAVLAGNLSGSTHVIVPS--FSPQGVLDAIVAHD
MSMEG_4065|M.smegmatis_MC2_155 GGICLHAAPMFHLADLMSWSAGLLQGGRHVFIPS--FEPVTVMQAIAQHQ
Mvan_3993|M.vanbaalenii_PYR-1 GGPLLHAAPMFHLADLAIWLEQVIRGGTHVFIPS--FKPEGVLDALQRHR
Mb0172|M.bovis_AF2122/97 SDVGFVGVPLFHIAGIGNMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEK
Rv0166|M.tuberculosis_H37Rv SDVGFVGVPLFHIAGIGNMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEK
MMAR_0409|M.marinum_M SDVGFIGVPFFHIAGIGNMLSGMLLGVPTVIYPLGAFNPGQLLDVLEAER
Mflv_0027|M.gilvum_PYR-GCK DSVSLAVMPLFHMAGFGWALAGLWEGAVTVVLRD--VDPGAILDAVARHR
MUL_0650|M.ulcerans_Agy99 HPRFLMCTPLSHAG-AAFFTPTLVKGGEMIVLAK--FDPGEVLRVIEEQR
MLBr_02546|M.leprae_Br4923 HEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRR--FKPATVLEDIEKHQ
: *: * * :. ... : : .
MAV_2587|M.avium_104 ITVLHLAPVMLRALLD--EVSDR-LAVESVRTVVYSAAPMTAAILRRALA
TH_2634|M.thermoresistible__bu ITVLHLAPVMLSALLD--AVTDT-GSLESLHTVVYAAAPMTMNILERALA
MAB_4559|M.abscessus_ATCC_1997 VQDMLLVPTMIQMLVD--HPGAAQLDLSGIRSITYGASVISEAVLQRATR
MSMEG_4065|M.smegmatis_MC2_155 VTDALLVPTMIQKLID--HPDINRYDLTSFRALFYAASAIPQALLERAMK
Mvan_3993|M.vanbaalenii_PYR-1 VSDLLLVPTMVQMLVD--HPALPVYDTSALQMVMYGGSPIAAALLERASK
Mb0172|M.bovis_AF2122/97 VTGIFLVPAQWQAVCT--EQQARPRDLR-LRVLSWGAAPAPDALLRQMSA
Rv0166|M.tuberculosis_H37Rv VTGIFLVPAQWQAVCT--EQQARPRDLR-LRVLSWGAAPAPDALLRQMSA
MMAR_0409|M.marinum_M VSGIFLVPAQWQAVCA--EQQARPRELS-LRVMSWGAAPAPDALLRQMSE
Mflv_0027|M.gilvum_PYR-GCK VTNMLLVPAVIQFLLD--TTGLDDTDLSRLRIVVYGASPITDDVLMRGID
MUL_0650|M.ulcerans_Agy99 ITATMLVPSMLYALMD--HPDPHTRDLSSLETVYYGASAINPVRLAEAID
MLBr_02546|M.leprae_Br4923 ATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRALE
:.* : .. : ..: .
MAV_2587|M.avium_104 VLPDAGFLNLYGQTEVIVSGLPRELHILDDPNAAERLSSVGFPFPDTRVR
TH_2634|M.thermoresistible__bu LMPSVGFLNLYGQTEAIVSGLPRELHAGD----PEALRSVGFPFPGNRVR
MAB_4559|M.abscessus_ATCC_1997 VFPNARFTQAYGMTEVSP---VATLLLPDDHDDPALLRSAGRAAPHCEVR
MSMEG_4065|M.smegmatis_MC2_155 VFPNAEFVQGYGMTELSP---LATLLSPDDHQKPRLLRSAGRAAPSAEVR
Mvan_3993|M.vanbaalenii_PYR-1 RLPTASFVQAYGMTEVSP---IATLLSPRDHDDPVLRRSGGVAAPHSEVR
Mb0172|M.bovis_AF2122/97 TFPETQILAAFGQTEMSP---VTCMLLGEDAIAK--RGSVGRVIPTVAAR
Rv0166|M.tuberculosis_H37Rv TFPETQILAAFGQTEMSP---VTCMLLGEDAIAK--RGSVGRVIPTVAAR
MMAR_0409|M.marinum_M VFPGTQIMAAFGQTEMSP---VTCMLLGEDAIRK--RGSVGKVIPTVSAR
Mflv_0027|M.gilvum_PYR-GCK RFG-GIFAQVYGMTESTG---SVTQLDGDEHLPQ-LLRSCGRPYPWVQIR
MUL_0650|M.ulcerans_Agy99 RFG-PIFAQYYGQSEAPM---VITYLPKADHDEK-RLTSCGRPTLFARVA
MLBr_02546|M.leprae_Br4923 ELG-PVIYNMYGSTEIAF----ATIAGPKDLQIN--SATVGPVVKGVKVK
: : :* :* : *
MAV_2587|M.avium_104 VVGADGGVLPVGQAGEIVVRSDSMFRGYWQDAAATQATLR-DGWCRTGDM
TH_2634|M.thermoresistible__bu IVDDDGADVPVGEAGEIVVQSDSLFRGYWDDQAATLATLR-DGWCHTGDV
MAB_4559|M.abscessus_ATCC_1997 IVDPDDNEVPRGEIGEVIVKGDNVMLGYWELPEESAAAIR-DGWMHTGDA
MSMEG_4065|M.smegmatis_MC2_155 IVDPDGNEVPRRTVGEVAVRGGNVMLGYWNKPQETAAAIR-DGWMHTGDA
Mvan_3993|M.vanbaalenii_PYR-1 IVDEDDVEVPRGDVGEITVRGGHVMAGYWGRPEDTATALR-GGWMHTGDA
Mb0172|M.bovis_AF2122/97 VVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFA-GGWFHSGDL
Rv0166|M.tuberculosis_H37Rv VVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFA-GGWFHSGDL
MMAR_0409|M.marinum_M VVDDEMNDVPIGQVGEIVYRAPTLMSGYWNNPDATAEAFA-GGWFHSGDL
Mflv_0027|M.gilvum_PYR-GCK VVDPTGRDVAPGTVGEVWTRSDQNMLGYWNNPEATAATLTPDGWLRTGDA
MUL_0650|M.ulcerans_Agy99 LLGEDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFR-DGWLHTGDM
MLBr_02546|M.leprae_Br4923 ILDDSGKEVPRGQVGRIFVGNAFPFEGYTGG----GGKQIIDGLLSSGDV
::. :. *.: * .* :**
MAV_2587|M.avium_104 GRLDERGLLYLMDRKKDVIISGGENIYSPEVEDAVSAVDGVAACAVVGVP
TH_2634|M.thermoresistible__bu GRFDERGLLYLVDRKKDVIITGGENVYSPEGRTPFCG-------------
MAB_4559|M.abscessus_ATCC_1997 GRMDDRGYVYIVDRIKDMVVTGGENVYSAEVENALAKHPAVAACAVIGIP
MSMEG_4065|M.smegmatis_MC2_155 AYMDDDGYIYVVDRIKDMIITGGENVYSAEVENAVVQHPSVAACAVIGVP
Mvan_3993|M.vanbaalenii_PYR-1 GYMDERGYVFVVDRIKDMIVSGGENVYSVEVENALARHPAVAACAVIGVP
Mb0172|M.bovis_AF2122/97 VRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRA
Rv0166|M.tuberculosis_H37Rv VRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRA
MMAR_0409|M.marinum_M VRMDEDGYVWVVDRKKDMIISGGENVYCAEVENVLASHPSIVEVAVIGRA
Mflv_0027|M.gilvum_PYR-GCK GYLDRDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTDVAVIGIP
MUL_0650|M.ulcerans_Agy99 AREDEDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGAP
MLBr_02546|M.leprae_Br4923 GYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVD
* . :: .* .:::::*. *:: * . .
MAV_2587|M.avium_104 DDKWGEAVCAVVVPRGGASPTLE----------MVQEGVRQRLARYKVPR
TH_2634|M.thermoresistible__bu --------------------------------------------------
MAB_4559|M.abscessus_ATCC_1997 DEQWGERVHAVVVKQAQSEC---CDG-------DLQEHCREHIANYKVPR
MSMEG_4065|M.smegmatis_MC2_155 DADWGERVHAVVVLQPGAEL---AAC-------QIREHAKRLIAGYKCPR
Mvan_3993|M.vanbaalenii_PYR-1 DERWGERVHAVVVPSAEGGA---DARNLD--PEELREFCRSLIGGYKVPR
Mb0172|M.bovis_AF2122/97 DEKWGEVPIAVAAVTNDDLR---IED--------LGEFLTDRLARYKHPK
Rv0166|M.tuberculosis_H37Rv DEKWGEVPIAVAAVTNDDLR---IED--------LGEFLTDRLARYKHPK
MMAR_0409|M.marinum_M DEKWGEVPIAVAAVTKDHLR---IED--------LDEYLTERLARYKHPK
Mflv_0027|M.gilvum_PYR-GCK DTRWGEAVKAVVVAGAPVTE---AEL---------IAFAREQLAGFKLPK
MUL_0650|M.ulcerans_Agy99 DEKWGEAVTAVVVLRADAAR---DDAAIETMTAEIQAAVKQRKGSVQSPK
MLBr_02546|M.leprae_Br4923 DKEWGARLRAFVVKKQDATID----------EDAIKAYVRDHLARYKVPR
MAV_2587|M.avium_104 RLVLVADLPVLASGKVDKKRLRAEL-------------KAAAG-------
TH_2634|M.thermoresistible__bu --------------------------------------------------
MAB_4559|M.abscessus_ATCC_1997 SFEFVDELPLSGAGKI----LKRVLRQKY-----WESRDAGVS-------
MSMEG_4065|M.smegmatis_MC2_155 SIEFVNALPLSGAGKV----LKRELRERH-----LGARERDRGSLP----
Mvan_3993|M.vanbaalenii_PYR-1 TVEVVAALPLSAAGKV----LKRELRARY-----WEGSDRSVG-------
Mb0172|M.bovis_AF2122/97 ALEIVDALPRNPAGKV----LKTELRLRYGACVNVERRSASAGFTERREN
Rv0166|M.tuberculosis_H37Rv ALEIVDALPRNPAGKV----LKTELRLRYGACVNVERRSASAGFTERREN
MMAR_0409|M.marinum_M ALEIVDALPRNPSGKV----LKTELRLRYGVGVYSESRSVSRSFEFREGS
Mflv_0027|M.gilvum_PYR-GCK SVDFVDALPRNPSGKL----LKRQLREPY-----WTDEDRHIG-------
MUL_0650|M.ulcerans_Agy99 QVVVVDSLPLTGLGKP----DKKAVRARF-----WEGAGRAVG-------
MLBr_02546|M.leprae_Br4923 EVIFLEELPRNPTGKV----LKRELRDFEVH-------------------
MAV_2587|M.avium_104 ----
TH_2634|M.thermoresistible__bu ----
MAB_4559|M.abscessus_ATCC_1997 ----
MSMEG_4065|M.smegmatis_MC2_155 ----
Mvan_3993|M.vanbaalenii_PYR-1 ----
Mb0172|M.bovis_AF2122/97 RQKL
Rv0166|M.tuberculosis_H37Rv RQKL
MMAR_0409|M.marinum_M ----
Mflv_0027|M.gilvum_PYR-GCK ----
MUL_0650|M.ulcerans_Agy99 ----
MLBr_02546|M.leprae_Br4923 ----