For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VCADDLDLTLGDIVTDNAVRFGDVPAYKLGSRMVTHAQLHDRAVQLVSAMAAAGVRRQDRVAVLSRNSVE FGEVMAATHLSGVIMATVNFRLSPDEVLDVLKRVSPSMVFCSDEFALVAAGLAPQLASPPLLVSIGGSGR TGMLDFEEFVGGGDGGRLPFAARPDDIACLLFTSGTTGASKCCILGQAELRRVAFTMNVEMRTGSSDRGL INMPMFHVGAMAIVAGLHARGGSVVLQQQFDAGEAVQLITDERITLLHLAPVMLRALLDEITDPRGLDCL RTVIYSAAPMTVHTLRRALSVLPRTGFLNLYGQTEAIVSGLPRELHDADSPDAADALRSVGFPFPGVRVR IVGDDGRDVLPGEAGEIVVRSDSRFRGYWDDPVATLATLRDGWCHTGDVGRFDHRGLLYLVDRKKDVIIT GGENVYSPEVEEVLGGCEGVAACAVVGAPDEKWGEAVCAVVVPTPGATPTLEAVQEFVRSSLAGYKVPRR LVVVSDLPVLASGKVDKKRLRAEIAAAAAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1867 | - | - | 100% (520) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_2587 | - | 0.0 | 72.46% (512) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_3523 | - | 9e-66 | 34.12% (507) | acyl-CoA synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0172 | fadD5 | 8e-65 | 33.60% (500) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 4e-72 | 36.49% (507) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 8e-65 | 33.80% (500) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 8e-44 | 28.86% (492) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 6e-67 | 35.51% (490) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_0409 | fadD5 | 1e-64 | 34.09% (487) | fatty-acid-CoA ligase FadD5 |
| M. smegmatis MC2 155 | MSMEG_4065 | - | 2e-70 | 37.22% (489) | feruloyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2634 | - | 1e-173 | 72.27% (422) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_0650 | fadD8 | 5e-59 | 34.29% (522) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_3993 | - | 3e-68 | 36.99% (492) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1867|M.avium_104 --------------------------------------MCADDLDLTLGD
TH_2634|M.thermoresistible__bu --------------------------------------MTA----LTVGD
MAB_4559|M.abscessus_ATCC_1997 ---------------------------------------------MQFTQ
MSMEG_4065|M.smegmatis_MC2_155 -------------------------------------------MTMYLTQ
Mvan_3993|M.vanbaalenii_PYR-1 -----------------------------------------MSDGMYLTQ
Mb0172|M.bovis_AF2122/97 --------------------MTAQLASHLTRALTLAQQQPYLARRQNWVN
Rv0166|M.tuberculosis_H37Rv --------------------MTAQLASHLTRALTLAQQQPYLARRQNWVN
MMAR_0409|M.marinum_M --------------------MTAELASHLPQAA-HALEQPYLARRQNWVN
Mflv_0027|M.gilvum_PYR-GCK -------------------------------------------MFHNLAD
MUL_0650|M.ulcerans_Agy99 ------------------------------------MSDDLLRNPTHNGH
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
MAV_1867|M.avium_104 IVTDNAVRFGDVPAYKLGSRMVTHAQLHDRAVQLVSAMAAAGVRRQDRVA
TH_2634|M.thermoresistible__bu IVSDNAHRFPDVVAYRMGERTLTHAELYDRATRLVSAMVAAGVRRQDRIA
MAB_4559|M.abscessus_ATCC_1997 WLHRALQQYPDRLITIDQGREHTVEQFADRVARLSAGLRANGVRPGDRVG
MSMEG_4065|M.smegmatis_MC2_155 GLHRAVQQTPGATMTVFGERRRTFLEVADRVARLAGALRALGVRAGDRVA
Mvan_3993|M.vanbaalenii_PYR-1 GLHRSLRATPDATMTICGERVRTFADVGDRVSRLAGGFRSLGASPGDRIA
Mb0172|M.bovis_AF2122/97 QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
Rv0166|M.tuberculosis_H37Rv QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
MMAR_0409|M.marinum_M QLERHAMMQPRATAIRYLGHTVTWADLRYRVAALAGSLSRRGVGFGDRVM
Mflv_0027|M.gilvum_PYR-GCK IVRSHGRNRPDAPALIVGDRTVSYRELDERSNRTAQAFSRTGVGPGDRVA
MUL_0650|M.ulcerans_Agy99 LLVGALERHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTGVTVG
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
: :. .: *. :
MAV_1867|M.avium_104 VLSRNSVEFGEVMAATHLSGVIMATVNFRLSPDEVLDVLKRVSPSMVFCS
TH_2634|M.thermoresistible__bu ILSRNSIEFGEVMAATHLSGIILATVNFRLTGGEVRDVINRVRPKIVFVG
MAB_4559|M.abscessus_ATCC_1997 MLSLNSDRYIEYLTAVPWLGAALNAVNIRWSLAEIGYSLRESGTRVLLVD
MSMEG_4065|M.smegmatis_MC2_155 MLAQNSDRYHEYLLAVPWANGVLNPVNIRWTPAEIAYSLEDSGTKVMFVD
Mvan_3993|M.vanbaalenii_PYR-1 ILSLNSDRYQESLLATVWSGCVTNPVNIRWSAAEIAYALRDSDSRILLID
Mb0172|M.bovis_AF2122/97 ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLTE
Rv0166|M.tuberculosis_H37Rv ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLTE
MMAR_0409|M.marinum_M ILMLNRTEFVESVLAANMLGAIAVPLNFRLTPSEIAFLVEDCAPRLVITE
Mflv_0027|M.gilvum_PYR-GCK FVERNGIEFFDVAFGSAKLGAVAVPVNWRLTAPEMRHVIADCGASVVVVG
MUL_0650|M.ulcerans_Agy99 LLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASALIID
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
.: * . . :: : : . :.
MAV_1867|M.avium_104 DE--FALVAAGLAPQLASPPLLVSIGG-SGRTGMLDFEEFVGGGD---GG
TH_2634|M.thermoresistible__bu DE--FAPMVADLAGQLTSTPLLVCVG--DGHSAMTDYEEFVASGR---AG
MAB_4559|M.abscessus_ATCC_1997 DT--FKAAAAPLRAACACLETVIYCGAGPAPQDMIGYEDLLASH----EP
MSMEG_4065|M.smegmatis_MC2_155 DS--FARMLPAIKDAWAELSTVIYAGEASPPAGTLAYEELIDKS----DP
Mvan_3993|M.vanbaalenii_PYR-1 DA--FLPMLPELRREFPGLGDVIHCGDGVAPPECLAFEDLLGVS----DP
Mb0172|M.bovis_AF2122/97 AA--LAPVAIGVRNIQPLLSVIVVAG-GSSQDSVFGYEDLLNEAG---DV
Rv0166|M.tuberculosis_H37Rv AA--LAPVAIGVRNIQPLLSVIVVAG-GSSQDSVFGYEDLLNEAG---DV
MMAR_0409|M.marinum_M EV--LAQVAVGVREIAPALSTIVVAG-GASDPTVVGYDELISETG---DP
Mflv_0027|M.gilvum_PYR-GCK QE--FTGRIEAIADDLD--VEVVVIG---KHRHWPTFDDLLAAAP---AV
MUL_0650|M.ulcerans_Agy99 PNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDRAVDLSAEAAKYQPKP
MLBr_02546|M.leprae_Br4923 DEY-----TKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSS
: : *
MAV_1867|M.avium_104 RLPFAARPDDIACLLFTSGTTGASKCCILGQAELR-RVAFTMNVEMRTGS
TH_2634|M.thermoresistible__bu DVALRARPEDIACLIFTSGTTGASKCCILGQTEHR-RVLFTMNNEMRSGS
MAB_4559|M.abscessus_ATCC_1997 IDDTRTGGDSLLGVFYTGGTTGNPKGVMLSHNNVLASAMGSLSTGNFLTR
MSMEG_4065|M.smegmatis_MC2_155 VDDARRGGDELAGLFYTGGTTGFPKGVMLSHANLLTSTYGLLTPGFAFRP
Mvan_3993|M.vanbaalenii_PYR-1 VTDAHRSGSDLAGVFYTGGTSGHPKGVMLTHDNLMTSAMGALASGFFLTS
Mb0172|M.bovis_AF2122/97 HEPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSGANIN
Rv0166|M.tuberculosis_H37Rv HEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGANIN
MMAR_0409|M.marinum_M PEPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLTGQVMTALYTGGANIN
Mflv_0027|M.gilvum_PYR-GCK DPGVVTGPDDLVFLMYTSGTTGAPKGVMLSNANVVCKTAGVGGP-WKFDA
MUL_0650|M.ulcerans_Agy99 LVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNIT--AMTSIQLAEWEWP
MLBr_02546|M.leprae_Br4923 SAPAPKVRKRASIIILTSGTTGTPKGANR-NTPASLAPLGGILSKVPFRA
. : *.**:* .*
MAV_1867|M.avium_104 SDRGLINMPMFHVGAMAIVAGLHARGGSVVLQQQ--FDAGEAVQLITDER
TH_2634|M.thermoresistible__bu DDQILINMPMFHIGAMAMLGGMHARGGTVVLQQQ--FDPDEAVRLIAEHR
MAB_4559|M.abscessus_ATCC_1997 GGRLLHSAPMFHMADFSAVLAGNLSGSTHVIVPS--FSPQGVLDAIVAHD
MSMEG_4065|M.smegmatis_MC2_155 GGICLHAAPMFHLADLMSWSAGLLQGGRHVFIPS--FEPVTVMQAIAQHQ
Mvan_3993|M.vanbaalenii_PYR-1 GGPLLHAAPMFHLADLAIWLEQVIRGGTHVFIPS--FKPEGVLDALQRHR
Mb0172|M.bovis_AF2122/97 SDVGFVGVPLFHIAGIGNMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEK
Rv0166|M.tuberculosis_H37Rv SDVGFVGVPLFHIAGIGNMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEK
MMAR_0409|M.marinum_M SDVGFIGVPFFHIAGIGNMLSGMLLGVPTVIYPLGAFNPGQLLDVLEAER
Mflv_0027|M.gilvum_PYR-GCK DSVSLAVMPLFHMAGFGWALAGLWEGAVTVVLRD--VDPGAILDAVARHR
MUL_0650|M.ulcerans_Agy99 EHPRFLMCTPLSHAGAAFFTPTLVKGGEMIVLAK--FDPGEVLRVIEEQR
MLBr_02546|M.leprae_Br4923 HEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRR--FKPATVLEDIEKHQ
: . : * :. ... : : .
MAV_1867|M.avium_104 ITLLHLAPVMLRALLD--EITD-PRGLDCLRTVIYSAAPMTVHTLRRALS
TH_2634|M.thermoresistible__bu ITVLHLAPVMLSALLD--AVTD-TGSLESLHTVVYAAAPMTMNILERALA
MAB_4559|M.abscessus_ATCC_1997 VQDMLLVPTMIQMLVD--HPGAAQLDLSGIRSITYGASVISEAVLQRATR
MSMEG_4065|M.smegmatis_MC2_155 VTDALLVPTMIQKLID--HPDINRYDLTSFRALFYAASAIPQALLERAMK
Mvan_3993|M.vanbaalenii_PYR-1 VSDLLLVPTMVQMLVD--HPALPVYDTSALQMVMYGGSPIAAALLERASK
Mb0172|M.bovis_AF2122/97 VTGIFLVPAQWQAVCT--EQQARPRDLR-LRVLSWGAAPAPDALLRQMSA
Rv0166|M.tuberculosis_H37Rv VTGIFLVPAQWQAVCT--EQQARPRDLR-LRVLSWGAAPAPDALLRQMSA
MMAR_0409|M.marinum_M VSGIFLVPAQWQAVCA--EQQARPRELS-LRVMSWGAAPAPDALLRQMSE
Mflv_0027|M.gilvum_PYR-GCK VTNMLLVPAVIQFLLD--TTGLDDTDLSRLRIVVYGASPITDDVLMRGID
MUL_0650|M.ulcerans_Agy99 ITATMLVPSMLYALMD--HPDPHTRDLSSLETVYYGASAINPVRLAEAID
MLBr_02546|M.leprae_Br4923 ATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRALE
:.* : :. : ..: .
MAV_1867|M.avium_104 VLPRTGFLNLYGQTEAIVSGLPRELHDADSPDAADALRSVGFPFPGVRVR
TH_2634|M.thermoresistible__bu LMPSVGFLNLYGQTEAIVSGLPRELHAGDP----EALRSVGFPFPGNRVR
MAB_4559|M.abscessus_ATCC_1997 VFPNARFTQAYGMTEVSPVATLLLPDDHDDPA---LLRSAGRAAPHCEVR
MSMEG_4065|M.smegmatis_MC2_155 VFPNAEFVQGYGMTELSPLATLLSPDDHQKPR---LLRSAGRAAPSAEVR
Mvan_3993|M.vanbaalenii_PYR-1 RLPTASFVQAYGMTEVSPIATLLSPRDHDDPV---LRRSGGVAAPHSEVR
Mb0172|M.bovis_AF2122/97 TFPETQILAAFGQTEMSPVTCMLLGEDAIAK-----RGSVGRVIPTVAAR
Rv0166|M.tuberculosis_H37Rv TFPETQILAAFGQTEMSPVTCMLLGEDAIAK-----RGSVGRVIPTVAAR
MMAR_0409|M.marinum_M VFPGTQIMAAFGQTEMSPVTCMLLGEDAIRK-----RGSVGKVIPTVSAR
Mflv_0027|M.gilvum_PYR-GCK RFG-GIFAQVYGMTESTGSVTQLDGDEHLPQ----LLRSCGRPYPWVQIR
MUL_0650|M.ulcerans_Agy99 RFG-PIFAQYYGQSEAPMVITYLPKADHDEK----RLTSCGRPTLFARVA
MLBr_02546|M.leprae_Br4923 ELG-PVIYNMYGSTEIAFATIAGPKDLQINS------ATVGPVVKGVKVK
: : :* :* : *
MAV_1867|M.avium_104 IVGDDGRDVLPGEAGEIVVRSDSRFRGYWDDPVATLATLR-DGWCHTGDV
TH_2634|M.thermoresistible__bu IVDDDGADVPVGEAGEIVVQSDSLFRGYWDDQAATLATLR-DGWCHTGDV
MAB_4559|M.abscessus_ATCC_1997 IVDPDDNEVPRGEIGEVIVKGDNVMLGYWELPEESAAAIR-DGWMHTGDA
MSMEG_4065|M.smegmatis_MC2_155 IVDPDGNEVPRRTVGEVAVRGGNVMLGYWNKPQETAAAIR-DGWMHTGDA
Mvan_3993|M.vanbaalenii_PYR-1 IVDEDDVEVPRGDVGEITVRGGHVMAGYWGRPEDTATALR-GGWMHTGDA
Mb0172|M.bovis_AF2122/97 VVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFA-GGWFHSGDL
Rv0166|M.tuberculosis_H37Rv VVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFA-GGWFHSGDL
MMAR_0409|M.marinum_M VVDDEMNDVPIGQVGEIVYRAPTLMSGYWNNPDATAEAFA-GGWFHSGDL
Mflv_0027|M.gilvum_PYR-GCK VVDPTGRDVAPGTVGEVWTRSDQNMLGYWNNPEATAATLTPDGWLRTGDA
MUL_0650|M.ulcerans_Agy99 LLGEDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFR-DGWLHTGDM
MLBr_02546|M.leprae_Br4923 ILDDSGKEVPRGQVGRIFVGNAFPFEGYTGG----GGKQIIDGLLSSGDV
::. * *.: * .* :**
MAV_1867|M.avium_104 GRFDHRGLLYLVDRKKDVIITGGENVYSPEVEEVLGGCEGVAACAVVGAP
TH_2634|M.thermoresistible__bu GRFDERGLLYLVDRKKDVIITGGENVYSPEGRTPFCG-------------
MAB_4559|M.abscessus_ATCC_1997 GRMDDRGYVYIVDRIKDMVVTGGENVYSAEVENALAKHPAVAACAVIGIP
MSMEG_4065|M.smegmatis_MC2_155 AYMDDDGYIYVVDRIKDMIITGGENVYSAEVENAVVQHPSVAACAVIGVP
Mvan_3993|M.vanbaalenii_PYR-1 GYMDERGYVFVVDRIKDMIVSGGENVYSVEVENALARHPAVAACAVIGVP
Mb0172|M.bovis_AF2122/97 VRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRA
Rv0166|M.tuberculosis_H37Rv VRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRA
MMAR_0409|M.marinum_M VRMDEDGYVWVVDRKKDMIISGGENVYCAEVENVLASHPSIVEVAVIGRA
Mflv_0027|M.gilvum_PYR-GCK GYLDRDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTDVAVIGIP
MUL_0650|M.ulcerans_Agy99 AREDEDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGAP
MLBr_02546|M.leprae_Br4923 GYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVD
* . :: .* .:::::*. *:: * . .
MAV_1867|M.avium_104 DEKWGEAVCAVVVPTPGATPTLEA-----------VQEFVRSSLAGYKVP
TH_2634|M.thermoresistible__bu --------------------------------------------------
MAB_4559|M.abscessus_ATCC_1997 DEQWGERVHAVVVKQAQSEC----CDG-------DLQEHCREHIANYKVP
MSMEG_4065|M.smegmatis_MC2_155 DADWGERVHAVVVLQPGAEL----AAC-------QIREHAKRLIAGYKCP
Mvan_3993|M.vanbaalenii_PYR-1 DERWGERVHAVVVPSAEGGA----DARNLD--PEELREFCRSLIGGYKVP
Mb0172|M.bovis_AF2122/97 DEKWGEVPIAVAAVTNDDLR----IED--------LGEFLTDRLARYKHP
Rv0166|M.tuberculosis_H37Rv DEKWGEVPIAVAAVTNDDLR----IED--------LGEFLTDRLARYKHP
MMAR_0409|M.marinum_M DEKWGEVPIAVAAVTKDHLR----IED--------LDEYLTERLARYKHP
Mflv_0027|M.gilvum_PYR-GCK DTRWGEAVKAVVVAGAPVTE----AEL---------IAFAREQLAGFKLP
MUL_0650|M.ulcerans_Agy99 DEKWGEAVTAVVVLRADAAR----DDAAIETMTAEIQAAVKQRKGSVQSP
MLBr_02546|M.leprae_Br4923 DKEWGARLRAFVVKKQDATID-----------EDAIKAYVRDHLARYKVP
MAV_1867|M.avium_104 RRLVVVSDLPVLASGKVDKKRLRAEIAAAAAD------------------
TH_2634|M.thermoresistible__bu --------------------------------------------------
MAB_4559|M.abscessus_ATCC_1997 RSFEFVDELPLSGAGKILKRVLRQKY-----WESRDAGVS----------
MSMEG_4065|M.smegmatis_MC2_155 RSIEFVNALPLSGAGKVLKRELRERH-----LGARERDRGSLP-------
Mvan_3993|M.vanbaalenii_PYR-1 RTVEVVAALPLSAAGKVLKRELRARY-----WEGSDRSVG----------
Mb0172|M.bovis_AF2122/97 KALEIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQK
Rv0166|M.tuberculosis_H37Rv KALEIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQK
MMAR_0409|M.marinum_M KALEIVDALPRNPSGKVLKTELRLRYGVGVYSESRSVSRSFEFREGS---
Mflv_0027|M.gilvum_PYR-GCK KSVDFVDALPRNPSGKLLKRQLREPY-----WTDEDRHIG----------
MUL_0650|M.ulcerans_Agy99 KQVVVVDSLPLTGLGKPDKKAVRARF-----WEGAGRAVG----------
MLBr_02546|M.leprae_Br4923 REVIFLEELPRNPTGKVLKRELRDFEVH----------------------
MAV_1867|M.avium_104 -
TH_2634|M.thermoresistible__bu -
MAB_4559|M.abscessus_ATCC_1997 -
MSMEG_4065|M.smegmatis_MC2_155 -
Mvan_3993|M.vanbaalenii_PYR-1 -
Mb0172|M.bovis_AF2122/97 L
Rv0166|M.tuberculosis_H37Rv L
MMAR_0409|M.marinum_M -
Mflv_0027|M.gilvum_PYR-GCK -
MUL_0650|M.ulcerans_Agy99 -
MLBr_02546|M.leprae_Br4923 -