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MSDGMYLTQGLHRSLRATPDATMTICGERVRTFADVGDRVSRLAGGFRSLGASPGDRIAILSLNSDRYQE SLLATVWSGCVTNPVNIRWSAAEIAYALRDSDSRILLIDDAFLPMLPELRREFPGLGDVIHCGDGVAPPE CLAFEDLLGVSDPVTDAHRSGSDLAGVFYTGGTSGHPKGVMLTHDNLMTSAMGALASGFFLTSGGPLLHA APMFHLADLAIWLEQVIRGGTHVFIPSFKPEGVLDALQRHRVSDLLLVPTMVQMLVDHPALPVYDTSALQ MVMYGGSPIAAALLERASKRLPTASFVQAYGMTEVSPIATLLSPRDHDDPVLRRSGGVAAPHSEVRIVDE DDVEVPRGDVGEITVRGGHVMAGYWGRPEDTATALRGGWMHTGDAGYMDERGYVFVVDRIKDMIVSGGEN VYSVEVENALARHPAVAACAVIGVPDERWGERVHAVVVPSAEGGADARNLDPEELREFCRSLIGGYKVPR TVEVVAALPLSAAGKVLKRELRARYWEGSDRSVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3993 | - | - | 100% (524) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 6e-98 | 41.02% (512) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_4008 | - | 8e-88 | 37.96% (519) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0172 | fadD5 | 4e-83 | 38.24% (510) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4616 | - | 7e-93 | 39.84% (502) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 5e-83 | 38.24% (510) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 4e-50 | 30.53% (511) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 1e-176 | 58.38% (519) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_0409 | fadD5 | 1e-85 | 37.23% (513) | fatty-acid-CoA ligase FadD5 |
| M. avium 104 | MAV_3523 | - | 2e-83 | 37.76% (519) | acyl-CoA synthase |
| M. smegmatis MC2 155 | MSMEG_4065 | - | 1e-178 | 59.39% (522) | feruloyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2878 | - | 9e-86 | 39.16% (521) | PUTATIVE AMP-binding enzyme, putative |
| M. ulcerans Agy99 | MUL_0650 | fadD8 | 1e-73 | 35.55% (512) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4559|M.abscessus_ATCC_1997 ---------------------------------------------MQFTQ
MSMEG_4065|M.smegmatis_MC2_155 -------------------------------------------MTMYLTQ
Mvan_3993|M.vanbaalenii_PYR-1 -----------------------------------------MSDGMYLTQ
Mb0172|M.bovis_AF2122/97 -------------------MTAQLASHLTRALTLAQQQPYLARRQ-NWVN
Rv0166|M.tuberculosis_H37Rv -------------------MTAQLASHLTRALTLAQQQPYLARRQ-NWVN
MMAR_0409|M.marinum_M -------------------MTAELASHLPQAA-HALEQPYLARRQ-NWVN
TH_2878|M.thermoresistible__bu -----------------------------------LQQPYLARRQ-NWVN
Mflv_4616|M.gilvum_PYR-GCK ----------------------------------------MDRGIGQWVT
MAV_3523|M.avium_104 --------------------------------------MPAAETRETLAG
MUL_0650|M.ulcerans_Agy99 ------------------------------------MSDDLLRNPTHNGH
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
MAB_4559|M.abscessus_ATCC_1997 WLHRALQQYPDRLITIDQGREHTVEQFADRVARLSAGLRANGVRPGDRVG
MSMEG_4065|M.smegmatis_MC2_155 GLHRAVQQTPGATMTVFGERRRTFLEVADRVARLAGALRALGVRAGDRVA
Mvan_3993|M.vanbaalenii_PYR-1 GLHRSLRATPDATMTICGERVRTFADVGDRVSRLAGGFRSLGASPGDRIA
Mb0172|M.bovis_AF2122/97 QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
Rv0166|M.tuberculosis_H37Rv QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
MMAR_0409|M.marinum_M QLERHAMMQPRATAIRYLGHTVTWADLRYRVAALAGSLSRRGVGFGDRVM
TH_2878|M.thermoresistible__bu HLARHALMQPDATALRFMGQTTTWADLHHRVNRLAGALRRRGVEFGDRVL
Mflv_4616|M.gilvum_PYR-GCK ---KRAFLNGQRTALVQGDTSFTYSDFDRRTNQVASSLLRLGVRKGDRVA
MAV_3523|M.avium_104 IVERHAQRRPDAIAIRYGERQWSWAEWSSRIRRAAGALRGDGIERGQCVA
MUL_0650|M.ulcerans_Agy99 LLVGALERHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTGVTVG
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
: : .: * * :
MAB_4559|M.abscessus_ATCC_1997 MLSLNSDRYIEYLTAVPWLGAALNAVNIRWSLAEIGYSLRESGTRVLLVD
MSMEG_4065|M.smegmatis_MC2_155 MLAQNSDRYHEYLLAVPWANGVLNPVNIRWTPAEIAYSLEDSGTKVMFVD
Mvan_3993|M.vanbaalenii_PYR-1 ILSLNSDRYQESLLATVWSGCVTNPVNIRWSAAEIAYALRDSDSRILLID
Mb0172|M.bovis_AF2122/97 ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLTE
Rv0166|M.tuberculosis_H37Rv ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLTE
MMAR_0409|M.marinum_M ILMLNRTEFVESVLAANMLGAIAVPLNFRLTPSEIAFLVEDCAPRLVITE
TH_2878|M.thermoresistible__bu ILMLNRTEFIETMLAANRLGAIAVPVNFRMTPPEIAFLAKDCEAKVIATE
Mflv_4616|M.gilvum_PYR-GCK ILLVNSVEFLEVLLGCAKIGAITIPINVRLAGPEIGYILADSGADVFVFH
MAV_3523|M.avium_104 FLDKNHPACLEVLIGGASVGAVTTVVNWRVIGDELVHVLADSGARVLVVG
MUL_0650|M.ulcerans_Agy99 LLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASALIID
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
:* * . . :: : . .
MAB_4559|M.abscessus_ATCC_1997 D-TFKAAAA-PLRAACACLETVIYCG--AGPAPQDMIGYEDLLASHEP--
MSMEG_4065|M.smegmatis_MC2_155 D-SFARMLP-AIKDAWAELSTVIYAG--EASPPAGTLAYEELIDKSDP--
Mvan_3993|M.vanbaalenii_PYR-1 D-AFLPMLP-ELRREFPGLGDVIHCG--DGVAPPECLAFEDLLGVSDP--
Mb0172|M.bovis_AF2122/97 A-ALAPVAI-GVRNIQPLLSVIVVAG---GSSQDSVFGYEDLLNEAGDV-
Rv0166|M.tuberculosis_H37Rv A-ALAPVAI-GVRNIQPLLSVIVVAG---GSSQDSVFGYEDLLNEAGDV-
MMAR_0409|M.marinum_M E-VLAQVAV-GVREIAPALSTIVVAG---GASDPTVVGYDELISETGDP-
TH_2878|M.thermoresistible__bu P-VLAGVAT-AVRDLAPSLSSVIVAGAADGSDTPDVLDYEALIAEPGED-
Mflv_4616|M.gilvum_PYR-GCK A-PLAAAAVSALTEPGVRVRHTLRAG---GAPADGEIPYTDLLSDGAPA-
MAV_3523|M.avium_104 A-ELRPAAEAAARRVPSLERIIEVGD-----------EYESLLAAAEPA-
MUL_0650|M.ulcerans_Agy99 PNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDRAVDLSAEAAKYQPKP
MLBr_02546|M.leprae_Br4923 D-----EYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSS
.
MAB_4559|M.abscessus_ATCC_1997 IDDTRTGGDSLLGVFYTGGTTGNPKGVMLSHNNVLASAMGSLSTGNFLTR
MSMEG_4065|M.smegmatis_MC2_155 VDDARRGGDELAGLFYTGGTTGFPKGVMLSHANLLTSTYGLLTPGFAFRP
Mvan_3993|M.vanbaalenii_PYR-1 VTDAHRSGSDLAGVFYTGGTSGHPKGVMLTHDNLMTSAMGALASGFFLTS
Mb0172|M.bovis_AF2122/97 HEPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSGANIN
Rv0166|M.tuberculosis_H37Rv HEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGANIN
MMAR_0409|M.marinum_M PEPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLTGQVMTALYTGGANIN
TH_2878|M.thermoresistible__bu PPPVDIPDDSPALIMYTSGTTGNPKGAVLTHSNLTGQAMTNLFTIGVDLA
Mflv_4616|M.gilvum_PYR-GCK PLDSDVEGRDPAFIMYTSGTTGRPKGAILTHDNLRWNAINVLGAEQGLTG
MAV_3523|M.avium_104 PSDAGVDTDETALVIYSSGTTGRPKGVLLSQRALVNHAAN-LAPAFPFGD
MUL_0650|M.ulcerans_Agy99 LVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNITAMTSIQLAEWEWP-E
MLBr_02546|M.leprae_Br4923 SAPAPKVRKRASIIILTSGTTGTPKGANRNTP-ASLAPLGGILSKVPFRA
: :.**:* ***. . :
MAB_4559|M.abscessus_ATCC_1997 GGRLLHSAPMFHMADFS-AVLAGNLSGSTHVIVPS--FSPQGVLDAIVAH
MSMEG_4065|M.smegmatis_MC2_155 GGICLHAAPMFHLADLM-SWSAGLLQGGRHVFIPS--FEPVTVMQAIAQH
Mvan_3993|M.vanbaalenii_PYR-1 GGPLLHAAPMFHLADLA-IWLEQVIRGGTHVFIPS--FKPEGVLDALQRH
Mb0172|M.bovis_AF2122/97 SDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAE
Rv0166|M.tuberculosis_H37Rv SDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAE
MMAR_0409|M.marinum_M SDVGFIGVPFFHIAGIG-NMLSGMLLGVPTVIYPLGAFNPGQLLDVLEAE
TH_2878|M.thermoresistible__bu NDVGFIGVPLFHIAGIAGNVLSGLTLGLPTVLYPLGAFDPGGLLDVLEAE
Mflv_4616|M.gilvum_PYR-GCK SDVTVAVAPMFHIGGLGVHTLPLLYVGGTSVILPS--FDPVGTLKAMAES
MAV_3523|M.avium_104 GDANLVAMPLFHVGGIG-YALFGIRAGAPTIMTREP--DAAALIGAVRAG
MUL_0650|M.ulcerans_Agy99 HPRFLMCTPLSHAGAAF--FTPTLVKGGEMIVLAK--FDPGEVLRVIEEQ
MLBr_02546|M.leprae_Br4923 HEVTLLPAPMFHALGYL-HATLAMFLGSTLVLRRR--FKPATVLEDIEKH
. *: * * :. .. : :
MAB_4559|M.abscessus_ATCC_1997 DVQDMLLVPTMIQMLVDHPG--AAQLDLSGIRSITYGASVISEAVLQRAT
MSMEG_4065|M.smegmatis_MC2_155 QVTDALLVPTMIQKLIDHPD--INRYDLTSFRALFYAASAIPQALLERAM
Mvan_3993|M.vanbaalenii_PYR-1 RVSDLLLVPTMVQMLVDHPA--LPVYDTSALQMVMYGGSPIAAALLERAS
Mb0172|M.bovis_AF2122/97 KVTGIFLVPAQWQAVCTEQQ--ARPRDLR-LRVLSWGAAPAPDALLRQMS
Rv0166|M.tuberculosis_H37Rv KVTGIFLVPAQWQAVCTEQQ--ARPRDLR-LRVLSWGAAPAPDALLRQMS
MMAR_0409|M.marinum_M RVSGIFLVPAQWQAVCAEQQ--ARPRELS-LRVMSWGAAPAPDALLRQMS
TH_2878|M.thermoresistible__bu KVTGIFLVPAQWQAVCAEQR--ARPRDLR-LRALSWGAAPASDTLLQEMT
Mflv_4616|M.gilvum_PYR-GCK RATVQFMVPAMWSALTQVPD--FDSYDLSALRLAMGGGAPMPLTVIDFMH
MAV_3523|M.avium_104 -ATHAFFVPPVIARFLDAGE--AARASIAGLRYIVYGAAPMPLPLLHRAL
MUL_0650|M.ulcerans_Agy99 RITATMLVPSMLYALMDHPD--PHTRDLSSLETVYYGASAINPVRLAEAI
MLBr_02546|M.leprae_Br4923 QATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRAL
..** . . :. ..:
MAB_4559|M.abscessus_ATCC_1997 RVFPNARFTQAYGMTEVSPVATLLLPDDHDDPALLR---SAGRAAPHCEV
MSMEG_4065|M.smegmatis_MC2_155 KVFPNAEFVQGYGMTELSPLATLLSPDDHQKPRLLR---SAGRAAPSAEV
Mvan_3993|M.vanbaalenii_PYR-1 KRLPTASFVQAYGMTEVSPIATLLSPRDHDDPVLRR---SGGVAAPHSEV
Mb0172|M.bovis_AF2122/97 ATFPETQILAAFGQTEMSPVTCMLLGEDAIAKRG-----SVGRVIPTVAA
Rv0166|M.tuberculosis_H37Rv ATFPETQILAAFGQTEMSPVTCMLLGEDAIAKRG-----SVGRVIPTVAA
MMAR_0409|M.marinum_M EVFPGTQIMAAFGQTEMSPVTCMLLGEDAIRKRG-----SVGKVIPTVSA
TH_2878|M.thermoresistible__bu EVFPGTKIFAAFGQTEMSPVTCMLLAEDAVRKLG-----SVGKVIPTVAA
Mflv_4616|M.gilvum_PYR-GCK QR--GVPFTEGFGMTETAPMVSVLDAANITTRAG-----SIGRVAMHVDA
MAV_3523|M.avium_104 STWPGTKFVQVYGQTELCGAVTALSDDDHRDAARPQLQLSAGKAVQGCEI
MUL_0650|M.ulcerans_Agy99 DR-FGPIFAQYYGQSEAPMVITYLPKADHDEKRLT----SCGRPTLFARV
MLBr_02546|M.leprae_Br4923 EELGPVIYN-MYGSTEIAFATIAGPKDLQINSAT------VGPVVKGVKV
:* :* *
MAB_4559|M.abscessus_ATCC_1997 RIVDPD-DNEVPRGEIGEVIVKGDNVMLGYWELPEESAAAIRD-GWMHTG
MSMEG_4065|M.smegmatis_MC2_155 RIVDPD-GNEVPRRTVGEVAVRGGNVMLGYWNKPQETAAAIRD-GWMHTG
Mvan_3993|M.vanbaalenii_PYR-1 RIVDED-DVEVPRGDVGEITVRGGHVMAGYWGRPEDTATALRG-GWMHTG
Mb0172|M.bovis_AF2122/97 RVVDQN-MNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAG-GWFHSG
Rv0166|M.tuberculosis_H37Rv RVVDQN-MNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAG-GWFHSG
MMAR_0409|M.marinum_M RVVDDE-MNDVPIGQVGEIVYRAPTLMSGYWNNPDATAEAFAG-GWFHSG
TH_2878|M.thermoresistible__bu RIVDDT-MNDVPVGEVGEIVYRAPTLMAGYWNNPQATAEAFAG-GWFHSG
Mflv_4616|M.gilvum_PYR-GCK RIVDAD-DRDVPADTVGELLVRGPNVFVGYWMKPATTAEAFRG-GWFHTG
MAV_3523|M.avium_104 RIVDPNNCAELPAGRSGEVWVRSNQNMSGYLNRAEATAETITADGWVRTG
MUL_0650|M.ulcerans_Agy99 ALLGED-GKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFRD-GWLHTG
MLBr_02546|M.leprae_Br4923 KILDDS-GKEVPRGQVGRIFVGNAFPFEGYTG---GGGKQIID-GLLSSG
::. :* *.: * . : * . :*
MAB_4559|M.abscessus_ATCC_1997 DAGRMDDRGYVYIVDRIKDMVVTGGENVYSAEVENALAKHPAVAACAVIG
MSMEG_4065|M.smegmatis_MC2_155 DAAYMDDDGYIYVVDRIKDMIITGGENVYSAEVENAVVQHPSVAACAVIG
Mvan_3993|M.vanbaalenii_PYR-1 DAGYMDERGYVFVVDRIKDMIVSGGENVYSVEVENALARHPAVAACAVIG
Mb0172|M.bovis_AF2122/97 DLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIG
Rv0166|M.tuberculosis_H37Rv DLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIG
MMAR_0409|M.marinum_M DLVRMDEDGYVWVVDRKKDMIISGGENVYCAEVENVLASHPSIVEVAVIG
TH_2878|M.thermoresistible__bu DLVRQDEEGYIWVVDRKKDMIISGGENIYCAEVENVLAAHPAVAEVAVVG
Mflv_4616|M.gilvum_PYR-GCK DLGRIDADGYITLVDRKKDMIISGGENVYPIEVEQVLFRHPGVLDAAVVG
MAV_3523|M.avium_104 DVGRLDADGYVYIEDRLKDMIITGGENVYGPEVESVLIEHPAVVDAAVIG
MUL_0650|M.ulcerans_Agy99 DMAREDEDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVG
MLBr_02546|M.leprae_Br4923 DVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIG
* * . : .* .:*:::** *:: *:*. : *. : .:*
MAB_4559|M.abscessus_ATCC_1997 IPDEQWGERVHAVVVKQAQSECCDG-------DLQEHCREHIANYKVPRS
MSMEG_4065|M.smegmatis_MC2_155 VPDADWGERVHAVVVLQPGAELAAC-------QIREHAKRLIAGYKCPRS
Mvan_3993|M.vanbaalenii_PYR-1 VPDERWGERVHAVVVPSAEGGADARNLD--PEELREFCRSLIGGYKVPRT
Mb0172|M.bovis_AF2122/97 RADEKWGEVPIAVAAVT-NDDLR-------IEDLGEFLTDRLARYKHPKA
Rv0166|M.tuberculosis_H37Rv RADEKWGEVPIAVAAVT-NDDLR-------IEDLGEFLTDRLARYKHPKA
MMAR_0409|M.marinum_M RADEKWGEVPIAVAAVT-KDHLR-------IEDLDEYLTERLARYKHPKA
TH_2878|M.thermoresistible__bu RPHEKWGEVPVAVVALNPDAELT-------MAELEEFLADRLARYKHPKV
Mflv_4616|M.gilvum_PYR-GCK GPDDKWGERVVAVVVADPAAEQEPS-----ADELIAWCRERLAHFKCPRE
MAV_3523|M.avium_104 VPDDFWGESVKAIVVADGDVDAA---------DVIEFCRRHLAGFKCPRT
MUL_0650|M.ulcerans_Agy99 APDEKWGEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKGSVQSPKQ
MLBr_02546|M.leprae_Br4923 VDDKEWGARLRAFVVKKQDATIDED-------AIKAYVRDHLARYKVPRE
. ** *... : . : *:
MAB_4559|M.abscessus_ATCC_1997 FEFVDELPLSGAGKILKRVLRQKYWESRDAGVS----------------
MSMEG_4065|M.smegmatis_MC2_155 IEFVNALPLSGAGKVLKRELRERHLGARERDRGSLP-------------
Mvan_3993|M.vanbaalenii_PYR-1 VEVVAALPLSAAGKVLKRELRARYWEGSDRSVG----------------
Mb0172|M.bovis_AF2122/97 LEIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
Rv0166|M.tuberculosis_H37Rv LEIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
MMAR_0409|M.marinum_M LEIVDALPRNPSGKVLKTELRLRYGVGVYSESRSVSRSFEFREGS----
TH_2878|M.thermoresistible__bu LEIVDALPRNPAGKVLKTELRARFAAGPSAEKEQSSSGATTSAGSS---
Mflv_4616|M.gilvum_PYR-GCK VHLLPELPRNATGKLLKTELRKRFTG--------VEGGVVQR-------
MAV_3523|M.avium_104 VDFVAELPRNASGKILKTQLREPFWRDRDRRV-----------------
MUL_0650|M.ulcerans_Agy99 VVVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG----------------
MLBr_02546|M.leprae_Br4923 VIFLEELPRNPTGKVLKRELRDFEVH-----------------------
. .: ** . ** * :*