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SALAGGVFAVTGSQDDDAELRQLVDDLGRRSYDAGLGRRGIPDQFDAELWRNLEDTGLTRLTSTPDMGAG PHELAIALYGVSRHAGAVPLAETDALAGWLGQQAGIELPNGPLTVAVADAETDGARVTGTATGVPWARAC AAALLAVTTPAGLRVGVIDVASGDLQEGHNLAGEPRDSVPFDVSADQLHAVDPALGAELTRRGAWSRCVQ TIGVLDAAAALSVEHTRQRVQFGRPLSAFQSVQQSLAGMAGEIERARAAAELAVAAASEHGFNSPHTDYA VTVAKVAVGRAVGPVTSVAHQLHGAIGVTSEHPLWLFTLRAQSWTADYGTTANYARRLGRLVLAAEDPWS LVTGDPPEVKTMVNKENW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2553 | - | - | 100% (369) | acyl-CoA dehydrogenase, C- |
| M. avium 104 | MAV_1813 | - | e-152 | 73.28% (363) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1631 | - | 4e-23 | 28.93% (356) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3535 | fadE27 | 1e-16 | 27.54% (334) | acyl-CoA dehydrogenase FADE27 |
| M. gilvum PYR-GCK | Mflv_5167 | - | 2e-49 | 38.46% (351) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3505 | fadE27 | 1e-16 | 27.54% (334) | acyl-CoA dehydrogenase FADE27 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-11 | 31.33% (150) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0594c | - | 1e-17 | 27.57% (301) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3512 | - | 3e-43 | 35.99% (314) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2878 | - | 1e-47 | 37.82% (312) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4629 | - | 1e-123 | 63.04% (349) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2756 | - | 5e-43 | 35.67% (314) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2875 | - | 3e-53 | 39.71% (345) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3535|M.bovis_AF2122/97 ----------MDFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKLEQRFD
Rv3505|M.tuberculosis_H37Rv ----------MDFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKLEQRFD
MAV_2553|M.avium_104 -MSALAGGVFAVTGSQDDDAELRQLVDDLGRRSYDAGLG--RRGIPDQFD
TH_4629|M.thermoresistible__bu --------VFATD-TADDYTDLRQLVDDIGRRSFDARIG--TRRVPDQFD
MMAR_3512|M.marinum_M ----------MSATVHTVDPALVDMMEAVFAQYRTSH----PPTEASRRD
MUL_2756|M.ulcerans_Agy99 ----------MSATVHTVDPALVNMMEAVFAQYRTSH----PPTEASRRD
MSMEG_2878|M.smegmatis_MC2_155 ---------------MTVDAELVAMMNAVFADHRTAH----GPTAG----
Mflv_5167|M.gilvum_PYR-GCK -----------MTGPTSVDPDLVEMLDAVFADHREQLG---AQRPAATWD
Mvan_2875|M.vanbaalenii_PYR-1 ------MTDVHADPGMAVDADLLEMMDAVLADYRQGH----PPAGVVRFD
MAB_0594c|M.abscessus_ATCC_199 ----------MKFDLDTQQRDFAASIDAALSVADVPAAARAWAAGNHGPG
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAA--DVDQRARFP
: :
Mb3535|M.bovis_AF2122/97 RELWRKLIDAGILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLES
Rv3505|M.tuberculosis_H37Rv RELWRKLIDAGILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLES
MAV_2553|M.avium_104 AELWRNLEDTGLTRLTSTPDMG---AGPHELAIALYGVSRHAGAVPLAET
TH_4629|M.thermoresistible__bu DELWGNLSDTGLTRLTSDPDLG---AGPNELAVVLSGIARYAGAVPLAET
MMAR_3512|M.marinum_M PALWQRLEQLGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLAEH
MUL_2756|M.ulcerans_Agy99 PALWQRLEQLGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLAEH
MSMEG_2878|M.smegmatis_MC2_155 PELWDQLRALGLARLTGAEESGGSGAGWHEAAELMAAAVRSGVRVGLPEH
Mflv_5167|M.gilvum_PYR-GCK AGLWDRLGQLGLTRLTGSEESGGSGAGWREGAELLRAAVQNGVQVPLAEH
Mvan_2875|M.vanbaalenii_PYR-1 AELWESLHQLGLVRLTGAPGSGGSGAGWAESAALISSATRHAVRVPLAEH
MAB_0594c|M.abscessus_ATCC_199 LAVWSTLAELGVTALAVSEKYDGIGAHPVDLVVALEGLGKWAVPGPVVES
MLBr_00737|M.leprae_Br4923 EEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPA
* *. . : :
Mb3535|M.bovis_AF2122/97 V-VLAAGALARFGSPELQQGWGVSAVSGDRILTVALDGEMGEGPVQAAGT
Rv3505|M.tuberculosis_H37Rv V-VLAAGALARFGSPELQQGWGVSAVSGDRILTVALDGEMGEGPVQAAGT
MAV_2553|M.avium_104 D-ALAGWLGQQAGIE-----------LPNGPLTVAVADAETDG-------
TH_4629|M.thermoresistible__bu D-ALAGWLGREAGLD-----------LPDGPLTVAIAEHSGDG-------
MMAR_3512|M.marinum_M D-LLACWLLDAHDMG-----------ADAAVRTVCLLDA-----------
MUL_2756|M.ulcerans_Agy99 D-LLACWLLDSHDMG-----------ADAAVRTVCLLDA-----------
MSMEG_2878|M.smegmatis_MC2_155 D-LLACWLLEVAGIA-----------VDDNTRTVALLDE-----------
Mflv_5167|M.gilvum_PYR-GCK D-LLACWLLESAGLP-----------VDDARRTVCVLD------------
Mvan_2875|M.vanbaalenii_PYR-1 D-LLACWLLEAAGLP-----------VDDAVRTVCVLDE-----------
MAB_0594c|M.abscessus_ATCC_199 V-AVAPVLLSSHEDG-----------AEPSTR------------------
MLBr_00737|M.leprae_Br4923 VNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRT
:.
Mb3535|M.bovis_AF2122/97 -----------GHGYRLTGTRTQVGYGPVADAFLVPAETDSGAAVFLVAA
Rv3505|M.tuberculosis_H37Rv -----------GHGYRLTGTRTQVGYGPVADAFLVPAETDSGAAVFLVAA
MAV_2553|M.avium_104 --------------ARVTGTATGVPWARACAAALLAVTT-PAGLRVGVID
TH_4629|M.thermoresistible__bu --------------P---VKAVDVPWARAAAAVLLAVRT-PDGARIGITS
MMAR_3512|M.marinum_M -----------------DGVATEVPWASHADRIVVIRQS-AGEYHLADVD
MUL_2756|M.ulcerans_Agy99 -----------------DGVATEVPWASRADRIVVIRQS-AGEYRLADVD
MSMEG_2878|M.smegmatis_MC2_155 -----------------SGTATAVPWASTAQRIVLVWRTQTGEHRVADVD
Mflv_5167|M.gilvum_PYR-GCK -----------------DGVAHGVPWASEADRIVVVWRT-NGTAQVADVA
Mvan_2875|M.vanbaalenii_PYR-1 -----------------AGTATAVPWAAYAGRVVAIWSD-GDSHRVADID
MAB_0594c|M.abscessus_ATCC_199 -------------------LASGELIATVAAPPIAPRALDADIAGLVLIA
MLBr_00737|M.leprae_Br4923 RAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKD
.
Mb3535|M.bovis_AF2122/97 GDPGVAVTALATTGLG--SVGHLELNGAKVDAARRVGGT----DVVVWLG
Rv3505|M.tuberculosis_H37Rv GDPGVAVTALATTGLG--SVGHLELNGAKVDAARRVGGT----DVAVWLG
MAV_2553|M.avium_104 VASGDLQEGHNLAGE---PRDSVPFDVSADQL--HAVDP----ALGAELT
TH_4629|M.thermoresistible__bu NPQ--VVDGHNAAGE---PRGRVTVDLGAVTL--ASVDD----AVLTELT
MMAR_3512|M.marinum_M AQTLTITPGANMIGE---PRNTVRADHLDLRG--VPTTG----AVVSTLK
MUL_2756|M.ulcerans_Agy99 AQTLTITPGANMIGE---PRNTVRADHLDLRG--VPTAG----AVVSTLK
MSMEG_2878|M.smegmatis_MC2_155 AAAVRITAGANMIGE---PRDTVSAD-VPADG--ATVSE----ATVTTLH
Mflv_5167|M.gilvum_PYR-GCK AGDLAVTSGANLAGE---PRDTVAADPAALTG--TTVPN----ALIDQLL
Mvan_2875|M.vanbaalenii_PYR-1 RGSLHIAPGTNMIGE---PRDTVTADISALAPHSTAIDA----DLVEQLR
MAB_0594c|M.abscessus_ATCC_199 DDIGIREAQAGAQHES--IDATRRVFDVQPKEAGISLDT----SRAIDFG
MLBr_00737|M.leprae_Br4923 DEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATL
Mb3535|M.bovis_AF2122/97 TLSTLSRTAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGY
Rv3505|M.tuberculosis_H37Rv TLSTLSRTAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGY
MAV_2553|M.avium_104 RRGAWSRCVQTIGVLDAAAALSVEHTRQRVQFGRPLSAFQSVQQSLAGMA
TH_4629|M.thermoresistible__bu LRGAWCRAVQIVGALDTAAAMTVRHTAEREQFGRSLSKFQAVQHALAGMA
MMAR_3512|M.marinum_M FKSALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFQAVQNLIADIA
MUL_2756|M.ulcerans_Agy99 FKSALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFHAVQNLIADIA
MSMEG_2878|M.smegmatis_MC2_155 LKAALVRAVQVCAAMDTILELAVEHSSSRIQFGRPLAKFQAIQHMISDIA
Mflv_5167|M.gilvum_PYR-GCK LRGALVRGLQVCAALDRIVALSIAHTTDRTQFGRPLAKFQSVQNLVSDSA
Mvan_2875|M.vanbaalenii_PYR-1 LKCALVRAIQVCSALDTILVLAVEHTTSRVQFGRSLSKFQAVQHMIADMA
MAB_0594c|M.abscessus_ATCC_199 ---VLAISAQLIGAGQALLDRAVAYAKQRSQFGRPIGSYQAVKHKLADVH
MLBr_00737|M.leprae_Br4923 DHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMA
. : : : * **...:. :::: ::.
Mb3535|M.bovis_AF2122/97 IDVKGLRLTLTQAAWRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVA
Rv3505|M.tuberculosis_H37Rv IDVKGLRLTLTQAAWRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVA
MAV_2553|M.avium_104 GEIERARAAAELAVAAASEHGFNS----PHTDYAVTVAKVAVGRAVGPVT
TH_4629|M.thermoresistible__bu GEIERARAAASLAVAAAADYGFAA----PRTEFAITAARVTAGRAVTAVT
MMAR_3512|M.marinum_M AETALARAATEAALTKAVTSQWSA----QNLDFLVAVARSCVGHAVSVVV
MUL_2756|M.ulcerans_Agy99 AETALARAATEAALTKAVTSQWSA----QNLDFLVAVARSCVGHVVSVVV
MSMEG_2878|M.smegmatis_MC2_155 AEATLARTATEAALTAAVDTTWSA----PHLEFLVAVARSCCGHAASVVV
Mflv_5167|M.gilvum_PYR-GCK AEAALARAATEAALTEAVRTGWSG----TNLEFLVAVARSCTGHATSVVV
Mvan_2875|M.vanbaalenii_PYR-1 GEAALASASTEAALAAAIASGWAA----DNLGFLVAVARSCTGHAASVVV
MAB_0594c|M.abscessus_ATCC_199 IALELARPLVYGAALSLADQSPTA-------ARDASAAKVAAAKAAYLAA
MLBr_00737|M.leprae_Br4923 MKVEAARLIVYAAAARAERGEPDLG-------FISAASKCFASDIAMEVT
* :.: . ..
Mb3535|M.bovis_AF2122/97 HTIVHVHGGVGVDTDHPVHRYFLAAKQTEFALGGATGQLRRIGRELAETP
Rv3505|M.tuberculosis_H37Rv HTIVHVHGGVGVDTDHPVHRYFLAAKQTEFALGGATGQLRRIGRELAETP
MAV_2553|M.avium_104 SVAHQLHGAIGVTSEHPLWLFTLRAQSWTADYGTTANYARRLGRLVLAAE
TH_4629|M.thermoresistible__bu TSAHQLHGAIGVTAEHPLWSVTLRAQAWADEFGTTAGYARRLGRLALESA
MMAR_3512|M.marinum_M RNAHQVHGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVTKAALHAG
MUL_2756|M.ulcerans_Agy99 RNAHQVHGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVTKAALHAG
MSMEG_2878|M.smegmatis_MC2_155 RNAHQVFGAIGTTAEHRLHEYTRAALAWRGEFGSVRSWDERVTTAALQAG
Mflv_5167|M.gilvum_PYR-GCK RNAHQVHGAIGTTREHRLHEFTQPALAWRSEFGSVHYWDELLTTAALAAG
Mvan_2875|M.vanbaalenii_PYR-1 RNAHQALGAIGTTIEHRLHEYTRAALTWRSEYGSVQHWDEVVTRNALDAG
MAB_0594c|M.abscessus_ATCC_199 RSALQTHGAIGFTAEYDLSLWILKVRALTSAWGTSEWHRARVLEAL----
MLBr_00737|M.leprae_Br4923 TDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR--
: *. * :. : . * :
Mb3535|M.bovis_AF2122/97 A-----------------------
Rv3505|M.tuberculosis_H37Rv A-----------------------
MAV_2553|M.avium_104 DP--WSLVTGDPPEVKTMVNKENW
TH_4629|M.thermoresistible__bu NP--WDLVIGNV------------
MMAR_3512|M.marinum_M GSGLWGLITG--------------
MUL_2756|M.ulcerans_Agy99 GSGLWGLITG--------------
MSMEG_2878|M.smegmatis_MC2_155 GAGLWELITS--------------
Mflv_5167|M.gilvum_PYR-GCK RDGLWPLITA--------------
Mvan_2875|M.vanbaalenii_PYR-1 TRGLWGLITG--------------
MAB_0594c|M.abscessus_ATCC_199 ------------------------
MLBr_00737|M.leprae_Br4923 ------------------------