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MDFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKLEQRFDRELWRKLIDAGILSSAAPESLGGDGFGVLE QVAVLVALGHQLAAVPYLESVVLAAGALARFGSPELQQGWGVSAVSGDRILTVALDGEMGEGPVQAAGTG HGYRLTGTRTQVGYGPVADAFLVPAETDSGAAVFLVAAGDPGVAVTALATTGLGSVGHLELNGAKVDAAR RVGGTDVAVWLGTLSTLSRTAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRL TLTQAAWRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKQT EFALGGATGQLRRIGRELAETPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3505 | fadE27 | - | 100% (373) | PROBABLE ACYL-CoA DEHYDROGENASE FADE27 |
| M. tuberculosis H37Rv | Rv3544c | fadE28 | 7e-36 | 30.09% (349) | acyl-CoA dehydrogenase FADE28 |
| M. tuberculosis H37Rv | Rv1933c | fadE18 | 4e-29 | 31.95% (338) | acyl-CoA dehydrogenase FADE18 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3535 | fadE27 | 0.0 | 99.73% (373) | acyl-CoA dehydrogenase FADE27 |
| M. gilvum PYR-GCK | Mflv_1550 | - | 1e-152 | 72.68% (377) | acyl-CoA dehydrogenase domain-containing protein |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-15 | 26.68% (386) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4159 | - | 1e-133 | 64.88% (373) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4993 | fadE27 | 1e-178 | 83.91% (373) | acyl-CoA dehydrogenase FadE27 |
| M. avium 104 | MAV_0651 | - | 1e-179 | 84.18% (373) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5907 | - | 1e-152 | 72.85% (372) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3575 | - | 6e-94 | 68.85% (260) | PUTATIVE acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4068 | fadE27 | 1e-176 | 83.65% (373) | acyl-CoA dehydrogenase FadE27 |
| M. vanbaalenii PYR-1 | Mvan_5207 | - | 1e-152 | 72.41% (377) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3505|M.tuberculosis_H37Rv ----------MDFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKL----E
Mb3535|M.bovis_AF2122/97 ----------MDFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKL----E
MMAR_4993|M.marinum_M ----------MDFSTTEAAQDLGGLVDTIVDAVCTPEHQRQLDRL----E
MUL_4068|M.ulcerans_Agy99 ----------MDFSTTEAAQDLGGLVATIVDAVCTPEHQRQLDGL----E
MAV_0651|M.avium_104 ----------MDFTTTEAAHDLGNLVDTIVDSVCTPEHQRELDGL----D
Mflv_1550|M.gilvum_PYR-GCK ----------MDFTTTEASEDLGGLVRTITESVCTPEHQRELDGLGPDAG
Mvan_5207|M.vanbaalenii_PYR-1 ----------MDFKTTEASEDLGGLVRTITESVCTPEHQRELDGLRPEAG
MSMEG_5907|M.smegmatis_MC2_155 ----------MDFTTTEAAADLGGLVRTITESVCTPEHQRELDGLP----
MAB_4159|M.abscessus_ATCC_1997 ----------MDFSLTEAQTDLAGLTRTIASTISTPERQKELDKQ----D
TH_3575|M.thermoresistible__bu ----------MDFTSTEAAEELGGLVRTITESVCTHEHQRELDKL----E
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAP-HAADVDQR-----
*. .* :* ::.. : : ::*
Rv3505|M.tuberculosis_H37Rv QRFDRELWRKLIDAGILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVP
Mb3535|M.bovis_AF2122/97 QRFDRELWRKLIDAGILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVP
MMAR_4993|M.marinum_M QRFDRELWRKLIDSDILSSAAATQVGGDGFGVLEQVAILVALGHQLAAVP
MUL_4068|M.ulcerans_Agy99 QRFDRELWRKLIDSDILSSAAATQVGGDGFGVLEQVAILVALGHQLAAVP
MAV_0651|M.avium_104 QRFDRDLWAKLIDAGILSSASATSLGGDGFGALEQIAILVALGHQLAAVP
Mflv_1550|M.gilvum_PYR-GCK GRFDKTLWSKLIDADVLSTTAPESLGGGGFGVLEEVAVLVALGRQLAAVP
Mvan_5207|M.vanbaalenii_PYR-1 GRFDRDLWGKLIDADILSTTSPESLGGGGFGVLEEVAVLVALGRQLAAVP
MSMEG_5907|M.smegmatis_MC2_155 ERFDRDLWAKLVEADILSAAAPESVGGGGFGVLEQTSVLTALGRQLAAVP
MAB_4159|M.abscessus_ATCC_1997 SRFDRQLWTKLAEADILSTAAPESVGGAGFGVLEQSSILVELGRELAAVP
TH_3575|M.thermoresistible__bu QRFDTELWAKLIDADVLSTAAPESIGGGGFGVLEQVAVLVALGRQLGAVP
MLBr_00737|M.leprae_Br4923 ARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASAS
** * :.. : . . ** * . : :: :.: .:..
Rv3505|M.tuberculosis_H37Rv YLESV-VLAAGALARFGSPELQQGWGVSAVSGDRILTVALD-----GEMG
Mb3535|M.bovis_AF2122/97 YLESV-VLAAGALARFGSPELQQGWGVSAVSGDRILTVALD-----GEMG
MMAR_4993|M.marinum_M YLESV-VLAAGALARFGSEELQQSWGAAAVGGEKILAVALD-----AEMG
MUL_4068|M.ulcerans_Agy99 YLESV-VLAAGALARFGSEELQQSWGAAAVGGEKILAVALD-----AEMG
MAV_0651|M.avium_104 YLESV-VLGAGALARFGTEELQQGWGVPAVSGEKTLTVALD-----PEMG
Mflv_1550|M.gilvum_PYR-GCK YLESV-VLGAGALARFGDDGLQQQWAAPAVTGDKVLTVALD-----GEMG
Mvan_5207|M.vanbaalenii_PYR-1 YLESV-MLAAGALATFGSASLQQDWAAQAIKGEKVLAVAFD-----GEMG
MSMEG_5907|M.smegmatis_MC2_155 YLESV-VAAAGAIAEFGSDAQRAEWGAPAVAGSKILTVALD-----GEMG
MAB_4159|M.abscessus_ATCC_1997 YLESV-VLAAGALAAFGSEAMRNDWAAPAVAGKKVLTIALE-----GEPG
TH_3575|M.thermoresistible__bu YLESV-VLGAGALAEFGSDAQREQWAAPAVGGQRILTAALE-----GETG
MLBr_00737|M.leprae_Br4923 LIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAA
: :* .: .: * : : *:. : .
Rv3505|M.tuberculosis_H37Rv EGPVQAAGTGH-GYRLTGTRTQVGYGPVADAFLVPAETDS-----GAAVF
Mb3535|M.bovis_AF2122/97 EGPVQAAGTGH-GYRLTGTRTQVGYGPVADAFLVPAETDS-----GAAVF
MMAR_4993|M.marinum_M EGPVQAARSGA-GFRLTGTRTQVGYGPVADAFLVPAETDS-----GTVVF
MUL_4068|M.ulcerans_Agy99 EGPVQAARSGA-GFRLTGTRTQVGYGPVADAFLVPAETDS-----GTVVF
MAV_0651|M.avium_104 EGPVQAVSAGA-GYRLTGTRTQVGFGPVADAFLVPAETDS-----GTAVF
Mflv_1550|M.gilvum_PYR-GCK EGPVRATTTAD-GVTLTGTRTQVPFAVGADAFLVPAETDS-----GVAVF
Mvan_5207|M.vanbaalenii_PYR-1 EGPVLAQGSGD-GYTLTGSRTQVAFGVNADAFLVPAETDS-----GTAVF
MSMEG_5907|M.smegmatis_MC2_155 QGPVQAQADGD-DHRLTGSRTLVSYGPVADAYLVPAETGS-----GVSVF
MAB_4159|M.abscessus_ATCC_1997 EGPVAARTEGT-GYVLTGNRVLVPFGVEADAYLVPAETET-----GTAVF
TH_3575|M.thermoresistible__bu EGPVRAEVNADSGHTLTGTRTLVRFGPVADGFLVPAETDS-----GTRVF
MLBr_00737|M.leprae_Br4923 SMRTRAKADGD-DWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAF
. . * . . *.* : : . : : * * * . * .*
Rv3505|M.tuberculosis_H37Rv LVAAGDPGVAVTALATTG--LGS-VGHLELNGAKVDAARRVGGTD-VAVW
Mb3535|M.bovis_AF2122/97 LVAAGDPGVAVTALATTG--LGS-VGHLELNGAKVDAARRVGGTD-VVVW
MMAR_4993|M.marinum_M LVAADDPGVSVTALQTTG--LGS-VGHLALDGTEVDAARGIGGSD-VTAW
MUL_4068|M.ulcerans_Agy99 LVAADDPGVSVTALQTTG--LGS-VGHLALDGTEVDAARGIGGSD-VTAW
MAV_0651|M.avium_104 LVAADDPGVTVTALETTG--LGS-VGHLALDGTQVDGTRQVGGAE-VAAW
Mflv_1550|M.gilvum_PYR-GCK LVAAADAGVTVTPLDTTG--HGS-VAALDLQGVGITGDRRVGGSE-VLDW
Mvan_5207|M.vanbaalenii_PYR-1 LVGSADDGVAVTALDTTG--HGS-VAGLQLQGVAIGSDRRVGGPE-VLDW
MSMEG_5907|M.smegmatis_MC2_155 IVAADDAGVTETSLNTTG--KGS-VAHLDLQDVAVGADRVLGGTQ-VAEW
MAB_4159|M.abscessus_ATCC_1997 LVSADDAGVTQQALHTTG--KDS-SAELILSEVPVPAERKVGGAE-VVEW
TH_3575|M.thermoresistible__bu LVAADDPGVTVTALNTTG--RGS-VGRLELAGTVLPPDRTVGADEAALRW
MLBr_00737|M.leprae_Br4923 IVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPG--TGF
:* * *.: . .. .* * : : * :* :
Rv3505|M.tuberculosis_H37Rv LGTLSTLSRT-----AFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVG
Mb3535|M.bovis_AF2122/97 LGTLSTLSRT-----AFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVG
MMAR_4993|M.marinum_M LRTINTLGRS-----AFQLGVLERGLRMTAEYARTREQFDRPIGSFQAVG
MUL_4068|M.ulcerans_Agy99 LRTINTLGRS-----AFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVG
MAV_0651|M.avium_104 LGTLGTLGRA-----AFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVS
Mflv_1550|M.gilvum_PYR-GCK LVTRNALARS-----AYQLGVVERALELTAQYAREREQFDRPIGSFQAVS
Mvan_5207|M.vanbaalenii_PYR-1 LVTRHALGRS-----AYQLGVLERALELTASYAREREQFDRPIGSFQAVS
MSMEG_5907|M.smegmatis_MC2_155 LTTRVTLGRT-----AYQLGVLERALELTASYAREREQFDRPIGSFQAVS
MAB_4159|M.abscessus_ATCC_1997 LRLRESLGHS-----AYQLGVLERALELTADYARTREQFGKPIGGFQAVA
TH_3575|M.thermoresistible__bu IKIRNILGHS-----AFQLGVLERALEMTAAYAREREQFDRPLX---XXA
MLBr_00737|M.leprae_Br4923 KTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQ
* :: * :*: : .* : *:: *:**...:
Rv3505|M.tuberculosis_H37Rv QRLADGYIDVKGLRLTLTQAAWRVAEDSLASRECPQPADIDVATAGFWAA
Mb3535|M.bovis_AF2122/97 QRLADGYIDVKGLRLTLTQAAWRVAEDSLASRECPQPADIDVATAGFWAA
MMAR_4993|M.marinum_M QRLADGYIDVKGLRLTLTQAAWRVSED--------LPAEIDVASAGFWAA
MUL_4068|M.ulcerans_Agy99 QRLADGYIDVKGLRLTLTQAAWRVSED--------LPAEIDVASAGFCAA
MAV_0651|M.avium_104 QRLADGYIDVKGLRLTLTQAAWRVSED--------LPAEVDVATAAFWAA
Mflv_1550|M.gilvum_PYR-GCK SRLADGYIDIKGLRLTVTQAAWRVSED--------LPADVDVASAAFWAA
Mvan_5207|M.vanbaalenii_PYR-1 SRLADGYIDIKGLRLTLTQAAWRLSED--------LPADLDVASAAFWAA
MSMEG_5907|M.smegmatis_MC2_155 SRLADGYIDVKGLRLTLTQAAWRLSED--------LPADVDVASAAFWAA
MAB_4159|M.abscessus_ATCC_1997 QRLADGYIDVKGLCLTLWQAAWRVSED--------LPSDVDVATAKFWAA
TH_3575|M.thermoresistible__bu GGCAGGGVPAG------------------------RPGHRGAAVGGGRAG
MLBr_00737|M.leprae_Br4923 FMLADMAMKVEAARLIVYAAAARAERGE-------PDLGFISAASKCFAS
*. : * . *.
Rv3505|M.tuberculosis_H37Rv EAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKQTEFALGGATGQLRRIG
Mb3535|M.bovis_AF2122/97 EAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKQTEFALGGATGQLRRIG
MMAR_4993|M.marinum_M EAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKEAEFALGGATTALRQIG
MUL_4068|M.ulcerans_Agy99 EAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKEAEFALGGATTALRQIG
MAV_0651|M.avium_104 DAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKQAEFALGGATGQLRRIG
Mflv_1550|M.gilvum_PYR-GCK EAGHRVAHTAVHVHGGVGIDIDHPVHRYFLAAKQTEFAVGGATGQLLRIG
Mvan_5207|M.vanbaalenii_PYR-1 EAGHRVAHTTVHVHGGVGIDIDHPVHRYFLAAKQTEFAVGGATGQLLRIG
MSMEG_5907|M.smegmatis_MC2_155 EAGHRVAHTAVHVHGGVGIDMDHPVHRYFLAAKQSEFALGSATGQLLRIG
MAB_4159|M.abscessus_ATCC_1997 DAGHRVAHTAVHVHGGVGIDEDHPVHRYFLAAKRGEFASGSATEQLRRIG
TH_3575|M.thermoresistible__bu PSG-RTAHPGRPGH----------LRRRARDGVQDAAGRCADGGGARRW-
MLBr_00737|M.leprae_Br4923 DIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMS
. ..: . :.* .
Rv3505|M.tuberculosis_H37Rv RELAETPA
Mb3535|M.bovis_AF2122/97 RELAETPA
MMAR_4993|M.marinum_M RELAETPA
MUL_4068|M.ulcerans_Agy99 RELAETPA
MAV_0651|M.avium_104 RELAETPA
Mflv_1550|M.gilvum_PYR-GCK RELADTPA
Mvan_5207|M.vanbaalenii_PYR-1 RELADTPA
MSMEG_5907|M.smegmatis_MC2_155 RELADTPV
MAB_4159|M.abscessus_ATCC_1997 RELADTPA
TH_3575|M.thermoresistible__bu --------
MLBr_00737|M.leprae_Br4923 RALLR---