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TDVHADPGMAVDADLLEMMDAVLADYRQGHPPAGVVRFDAELWESLHQLGLVRLTGAPGSGGSGAGWAES AALISSATRHAVRVPLAEHDLLACWLLEAAGLPVDDAVRTVCVLDEAGTATAVPWAAYAGRVVAIWSDGD SHRVADIDRGSLHIAPGTNMIGEPRDTVTADISALAPHSTAIDADLVEQLRLKCALVRAIQVCSALDTIL VLAVEHTTSRVQFGRSLSKFQAVQHMIADMAGEAALASASTEAALAAAIASGWAADNLGFLVAVARSCTG HAASVVVRNAHQALGAIGTTIEHRLHEYTRAALTWRSEYGSVQHWDEVVTRNALDAGTRGLWGLITG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2875 | - | - | 100% (348) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3918 | - | e-113 | 62.69% (335) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4312 | - | 5e-15 | 24.76% (315) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1968c | fadE18 | 9e-14 | 27.94% (315) | acyl-CoA dehydrogenase FADE18 |
| M. gilvum PYR-GCK | Mflv_5167 | - | 1e-112 | 60.29% (340) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1933c | fadE18 | 9e-14 | 27.94% (315) | acyl-CoA dehydrogenase FADE18 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-09 | 29.05% (179) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0580 | - | 3e-14 | 27.61% (297) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3512 | - | 1e-116 | 63.20% (337) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_2553 | - | 2e-53 | 39.71% (345) | acyl-CoA dehydrogenase, C- |
| M. smegmatis MC2 155 | MSMEG_2878 | - | 1e-116 | 62.83% (339) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4629 | - | 3e-52 | 40.63% (315) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2756 | - | 1e-115 | 62.91% (337) | acyl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3512|M.marinum_M ----------MSATVHTVDPALVDMMEAVFAQYRTSH--PPTEASRRDPA
MUL_2756|M.ulcerans_Agy99 ----------MSATVHTVDPALVNMMEAVFAQYRTSH--PPTEASRRDPA
MSMEG_2878|M.smegmatis_MC2_155 ---------------MTVDAELVAMMNAVFADHRTAH--GPTAG----PE
Mflv_5167|M.gilvum_PYR-GCK -----------MTGPTSVDPDLVEMLDAVFADHREQLG-AQRPAATWDAG
Mvan_2875|M.vanbaalenii_PYR-1 ------MTDVHADPGMAVDADLLEMMDAVLADYRQGH--PPAGVVRFDAE
MAV_2553|M.avium_104 -MSALAGGVFAVTGSQDDDAELRQLVDDLGRRSYDAGLGRRGIPDQFDAE
TH_4629|M.thermoresistible__bu --------VFATD-TADDYTDLRQLVDDIGRRSFDARIGTRRVPDQFDDE
Mb1968c|M.bovis_AF2122/97 ----------MDFRYSTEQDDFRASLRGFLGRGAPVR--EMAAADGSDRR
Rv1933c|M.tuberculosis_H37Rv ----------MDFRYSTEQDDFRASLRGFLGRGAPVR--EMAAADGSDRR
MAB_0580|M.abscessus_ATCC_1997 ------MSVPSGLRASGSSEVQEAARDAVRQWARSAAVIESVRKMESEPD
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
.
MMAR_3512|M.marinum_M LWQRLE----QLGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLA
MUL_2756|M.ulcerans_Agy99 LWQRLE----QLGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLA
MSMEG_2878|M.smegmatis_MC2_155 LWDQLR----ALGLARLTGAEESGGSGAGWHEAAELMAAAVRSGVRVGLP
Mflv_5167|M.gilvum_PYR-GCK LWDRLG----QLGLTRLTGSEESGGSGAGWREGAELLRAAVQNGVQVPLA
Mvan_2875|M.vanbaalenii_PYR-1 LWESLH----QLGLVRLTGAPGSGGSGAGWAESAALISSATRHAVRVPLA
MAV_2553|M.avium_104 LWRNLE----DTGLTRLTSTPDMG---AGPHELAIALYGVSRHAGAVPLA
TH_4629|M.thermoresistible__bu LWGNLS----DTGLTRLTSDPDLG---AGPNELAVVLSGIARYAGAVPLA
Mb1968c|M.bovis_AF2122/97 LWQRLCT---ELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIPFA
Rv1933c|M.tuberculosis_H37Rv LWQRLCT---ELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIPFA
MAB_0580|M.abscessus_ATCC_1997 GWGPAYVGLAELGIFGVAVPEAAGGSGAGFDDMIAMVDEAAASLVPGPVA
MLBr_00737|M.leprae_Br4923 ALAALN----ASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLI
: : * * . .
MMAR_3512|M.marinum_M EHD--LLACWLLDA----------HDMGADAAVRTVCLLDA---------
MUL_2756|M.ulcerans_Agy99 EHD--LLACWLLDS----------HDMGADAAVRTVCLLDA---------
MSMEG_2878|M.smegmatis_MC2_155 EHD--LLACWLLEV----------AGIAVDDNTRTVALLDE---------
Mflv_5167|M.gilvum_PYR-GCK EHD--LLACWLLES----------AGLPVDDARRTVCVLD----------
Mvan_2875|M.vanbaalenii_PYR-1 EHD--LLACWLLEA----------AGLPVDDAVRTVCVLDE---------
MAV_2553|M.avium_104 ETD--ALAGWLGQQ----------AGIELPNGPLTVAVADAETDGAR---
TH_4629|M.thermoresistible__bu ETD--ALAGWLGRE----------AGLDLPDGPLTVAIAEHSGDGP----
Mb1968c|M.bovis_AF2122/97 ATV--FAIEAILRMGDDEQRKRLLAGLLTGARIGTIAVSGHDVASATTVR
Rv1933c|M.tuberculosis_H37Rv ATV--FAIEAILRMGDDEQRKRLLAGLLTGARIGTIAVSGHDVASATTVR
MAB_0580|M.abscessus_ATCC_1997 TSA--LVAVVLAADG----HEELVPPLAAGERTAGLALTGN---------
MLBr_00737|M.leprae_Br4923 PAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASM
: : .:
MMAR_3512|M.marinum_M -------------DGVATEVPWASHADRIVVIRQS--AGEYH-----LAD
MUL_2756|M.ulcerans_Agy99 -------------DGVATEVPWASRADRIVVIRQS--AGEYR-----LAD
MSMEG_2878|M.smegmatis_MC2_155 -------------SGTATAVPWASTAQRIVLVWRTQ-TGEHR-----VAD
Mflv_5167|M.gilvum_PYR-GCK -------------DGVAHGVPWASEADRIVVVWRT--NGTAQ-----VAD
Mvan_2875|M.vanbaalenii_PYR-1 -------------AGTATAVPWAAYAGRVVAIWSD--GDSHR-----VAD
MAV_2553|M.avium_104 ------------VTGTATGVPWARACAAALLAVTT--PAGLR-----VGV
TH_4629|M.thermoresistible__bu --------------VKAVDVPWARAAAAVLLAVRT--PDGAR-----IGI
Mb1968c|M.bovis_AF2122/97 AVRRDG---RPALTGECTPVLHGHVADLFVVPAVADGSIVLH-----VVA
Rv1933c|M.tuberculosis_H37Rv AVRRDG---RPALTGECTPVLHGHVADLFVVPAVADGSIVLH-----VVA
MAB_0580|M.abscessus_ATCC_1997 ---------LAIADGLASGVLPAVLGGTADGVLLAPVPDGWV-----LVD
MLBr_00737|M.leprae_Br4923 RTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVH
: . :
MMAR_3512|M.marinum_M VDAQTLTITPGANMIGE---PRNTVRADHLDLRG------VPTTGAVVST
MUL_2756|M.ulcerans_Agy99 VDAQTLTITPGANMIGE---PRNTVRADHLDLRG------VPTAGAVVST
MSMEG_2878|M.smegmatis_MC2_155 VDAAAVRITAGANMIGE---PRDTVSAD-VPADG------ATVSEATVTT
Mflv_5167|M.gilvum_PYR-GCK VAAGDLAVTSGANLAGE---PRDTVAADPAALTG------TTVPNALIDQ
Mvan_2875|M.vanbaalenii_PYR-1 IDRGSLHIAPGTNMIGE---PRDTVTADISALAPH----STAIDADLVEQ
MAV_2553|M.avium_104 IDVASGDLQEGHNLAGE---PRDSVPFDVSADQL------HAVDPALGAE
TH_4629|M.thermoresistible__bu TSNPQ--VVDGHNAAGE---PRGRVTVDLGAVTL------ASVDDAVLTE
Mb1968c|M.bovis_AF2122/97 ADAPGVTVTPLPSFDITR--PVATLRLAGSPAEP-----LTAGTPDDMER
Rv1933c|M.tuberculosis_H37Rv ADAPGVTVTPLPSFDITR--PVATLRLAGSPAEP-----LTAGTPDDMER
MAB_0580|M.abscessus_ATCC_1997 CAEAGVAVEAKKATDFSR--PWVTVTLHGAAVRP---------VGLPAAV
MLBr_00737|M.leprae_Br4923 KDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALA
: * :
MMAR_3512|M.marinum_M LKFKSALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFQAVQNLIAD
MUL_2756|M.ulcerans_Agy99 LKFKSALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFHAVQNLIAD
MSMEG_2878|M.smegmatis_MC2_155 LHLKAALVRAVQVCAAMDTILELAVEHSSSRIQFGRPLAKFQAIQHMISD
Mflv_5167|M.gilvum_PYR-GCK LLLRGALVRGLQVCAALDRIVALSIAHTTDRTQFGRPLAKFQSVQNLVSD
Mvan_2875|M.vanbaalenii_PYR-1 LRLKCALVRAIQVCSALDTILVLAVEHTTSRVQFGRSLSKFQAVQHMIAD
MAV_2553|M.avium_104 LTRRGAWSRCVQTIGVLDAAAALSVEHTRQRVQFGRPLSAFQSVQQSLAG
TH_4629|M.thermoresistible__bu LTLRGAWCRAVQIVGALDTAAAMTVRHTAEREQFGRSLSKFQAVQHALAG
Mb1968c|M.bovis_AF2122/97 VLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHACAD
Rv1933c|M.tuberculosis_H37Rv VLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHACAD
MAB_0580|M.abscessus_ATCC_1997 IADLSVVTLSAEAVGVARWALQTAVEYAKVREQFGKQIGSFQAIKHMCAE
MLBr_00737|M.leprae_Br4923 TLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLAD
: . :: : * **.. :. *:::: :
MMAR_3512|M.marinum_M IAAETALARAATEAALTKAVTSQWS---AQNLDFLVAVARSCVGHAVSVV
MUL_2756|M.ulcerans_Agy99 IAAETALARAATEAALTKAVTSQWS---AQNLDFLVAVARSCVGHVVSVV
MSMEG_2878|M.smegmatis_MC2_155 IAAEATLARTATEAALTAAVDTTWS---APHLEFLVAVARSCCGHAASVV
Mflv_5167|M.gilvum_PYR-GCK SAAEAALARAATEAALTEAVRTGWS---GTNLEFLVAVARSCTGHATSVV
Mvan_2875|M.vanbaalenii_PYR-1 MAGEAALASASTEAALAAAIASGWA---ADNLGFLVAVARSCTGHAASVV
MAV_2553|M.avium_104 MAGEIERARAAAELAVAAASEHGFN---SPHTDYAVTVAKVAVGRAVGPV
TH_4629|M.thermoresistible__bu MAGEIERARAAASLAVAAAADYGFA---APRTEFAITAARVTAGRAVTAV
Mb1968c|M.bovis_AF2122/97 MMIEIDATRATVMFAAMSAAN-------GDELQTVAPLAKAQTAETFVLC
Rv1933c|M.tuberculosis_H37Rv MMIEIDATRATVMFAAMSAAN-------GDELQTVAPLAKAQTAETFVLC
MAB_0580|M.abscessus_ATCC_1997 MLCRVEQADVAVWDAAGCAQDVLANKGDSQQLSLAAAVAAAVAVDAAVAN
MLBr_00737|M.leprae_Br4923 MAMKVEAARLIVYAAAARAERG------EPDLGFISAASKCFASDIAMEV
. : . * * . :
MMAR_3512|M.marinum_M VRNAHQVHGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVTKAALHA
MUL_2756|M.ulcerans_Agy99 VRNAHQVHGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVTKAALHA
MSMEG_2878|M.smegmatis_MC2_155 VRNAHQVFGAIGTTAEHRLHEYTRAALAWRGEFGSVRSWDERVTTAALQA
Mflv_5167|M.gilvum_PYR-GCK VRNAHQVHGAIGTTREHRLHEFTQPALAWRSEFGSVHYWDELLTTAALAA
Mvan_2875|M.vanbaalenii_PYR-1 VRNAHQALGAIGTTIEHRLHEYTRAALTWRSEYGSVQHWDEVVTRNALDA
MAV_2553|M.avium_104 TSVAHQLHGAIGVTSEHPLWLFTLRAQSWTADYGTTANYARRLGRLVLAA
TH_4629|M.thermoresistible__bu TTSAHQLHGAIGVTAEHPLWSVTLRAQAWADEFGTTAGYARRLGRLALES
Mb1968c|M.bovis_AF2122/97 AGSALQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLV
Rv1933c|M.tuberculosis_H37Rv AGSALQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLV
MAB_0580|M.abscessus_ATCC_1997 TKDCIQILGGIGFTWEHDAHLYLRRAYALQSFVGKPAVWRRKAAALTIGG
MLBr_00737|M.leprae_Br4923 TTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-
. . * *. . * :. * *.
MMAR_3512|M.marinum_M GGSGLWGLITG---------------------------------------
MUL_2756|M.ulcerans_Agy99 GGSGLWGLITG---------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 GGAGLWELITS---------------------------------------
Mflv_5167|M.gilvum_PYR-GCK GRDGLWPLITA---------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 GTRGLWGLITG---------------------------------------
MAV_2553|M.avium_104 EDP--WSLVTGDPPEVKTMVNKENW-------------------------
TH_4629|M.thermoresistible__bu ANP--WDLVIGNV-------------------------------------
Mb1968c|M.bovis_AF2122/97 KA------------------------------------------------
Rv1933c|M.tuberculosis_H37Rv KA------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 IRRSLTIDLGEVESQRAEVAGQVAEIASAPKAEHQVRLAEAGFLAPHWPA
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
Rv1933c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 PYGLGAGAAQQLLIDQELHAAGVNRPDLVIGWWAAPTILEHGTPEQIAQF
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
Rv1933c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 VAPTLRGEIEWCQLFSEPGAGSDLAALRTKATRVDGGWKLDGQKVWNSKA
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
Rv1933c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 QIADWAICLARTNPDVPKHKGITYFLLDMKTPGITVRPLREITGEEMFNE
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
Rv1933c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 VFLDGVIVPDENVVGSVDDGWRLARTTLANERVAMAGGGTLDEAMESLLA
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
Rv1933c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 LIGDTELDAAQLDTLGAFVCSAQTGALLDLRTALRAIGGQDPGAASSVRK
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
Rv1933c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 LVGVRHRQGLSEHILDYVDTHGAVESREMWLFMRDRCLSIAGGTTQILLS
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M -----------
MUL_2756|M.ulcerans_Agy99 -----------
MSMEG_2878|M.smegmatis_MC2_155 -----------
Mflv_5167|M.gilvum_PYR-GCK -----------
Mvan_2875|M.vanbaalenii_PYR-1 -----------
MAV_2553|M.avium_104 -----------
TH_4629|M.thermoresistible__bu -----------
Mb1968c|M.bovis_AF2122/97 -----------
Rv1933c|M.tuberculosis_H37Rv -----------
MAB_0580|M.abscessus_ATCC_1997 VAGERLLGLPR
MLBr_00737|M.leprae_Br4923 -----------