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LNRRTWIQLSILALVTVVSCGAMAFNFMKLPATLFGIGEYRVTVDLPQSGGLYQTSVVTYRGTDVGQVKS VDVTATGVRAVLAMRSGIEVPFDVQASVHSRSAIGEQYIELTPRPGTGDHQSRTLRDGDVITAGRVEVPV DIGRLLDMTNRALQAIPRDNLRTVIDETNRAVGGLGPELSRIVDGSTALAVAGGHTVDPLATLIDQSPAV LNSQVQTSGAIATWAERTAALMAQFKAQDAAVRDLLAHGASGVEEGRALLDRVTPALPVLFANLVSLGDI AVVYRHDIEQLLVLLPQGIAAMAAIIVPSSNTKQEYRGAQLDFNLNLNLPPPCTTGYLPPAQRRSPASVD APDRPAADLYCRVPQDSEFNVRGVRNIPCESKPWKRAPTVELCESDEEYVPLNDGYNWKGDPNATTSGQG VPQYPPGQDPRLPPPRGTAPAPPPVAVAPYDPATGDYIGPDGRRYTESDLAHPRAKSWQSLLVPQP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2069 | - | - | 100% (486) | virulence factor mce family protein |
| M. avium 104 | MAV_2537 | - | e-153 | 53.48% (488) | virulence factor mce family protein |
| M. avium 104 | MAV_1807 | - | e-145 | 54.11% (475) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 9e-85 | 36.71% (523) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_2106 | - | 1e-155 | 55.24% (487) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1971 | mce3F | 1e-133 | 55.38% (437) | MCE-family protein MCE3F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 5e-80 | 34.67% (525) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 3e-81 | 35.91% (518) | MCE-family protein |
| M. marinum M | MMAR_2887 | mce3F | 1e-156 | 56.15% (488) | MCE-family protein Mce3F |
| M. smegmatis MC2 155 | MSMEG_0351 | - | 1e-147 | 54.86% (494) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3681 | - | 1e-153 | 56.26% (487) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_2865 | mce3F | 1e-156 | 56.15% (488) | MCE-family protein Mce3F |
| M. vanbaalenii PYR-1 | Mvan_3977 | - | 1e-157 | 57.00% (486) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2887|M.marinum_M -MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELT
MUL_2865|M.ulcerans_Agy99 -MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELT
Rv1971|M.tuberculosis_H37Rv MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTVTMELV
Mvan_3977|M.vanbaalenii_PYR-1 -MRLDRRMKIQLALFAVIALMAMGVMGVHFMKLPAKLFGVGRYTVTVQLP
MSMEG_0351|M.smegmatis_MC2_155 --MIHRRTKIQLAIFCVIAVVFGTVMIFGYMRLPAHLFGIGLYTVNLDLD
TH_3681|M.thermoresistible__bu -MNLTRRILLQLAVFVGVAVIAGSVMIVGVIKLPALALGVGRYTVTVELP
Mflv_2106|M.gilvum_PYR-GCK -MRVTRQMLIQLLIFSLLAVTALGIMVFGYMRLP-EMIGIGQYKVTLELP
MAV_2069|M.avium_104 ---MNRRTWIQLSILALVTVVSCGAMAFNFMKLPATLFGIGEYRVTVDLP
MAB_4148c|M.abscessus_ATCC_199 ---MERLIKIQLAIFAAVTVISVALMAIFYLRVP-TALGIGKHDVKAQFV
Mb0180|M.bovis_AF2122/97 --MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIP-SLVGIGQYTLKADLP
MLBr_02594|M.leprae_Br4923 --MLTPLIRRQLVLFAILTVISLTVLGVYYLQIP-SLVGIGRYSLKAELS
: ** :: ::: ::* .*:* : :. ::
MMAR_2887|M.marinum_M KSGGLYSSGNVTYRGSEVGRVESVQLTDTG-VVAVLSLKSGIDIPSDLKA
MUL_2865|M.ulcerans_Agy99 KSGGLYTSGNVTYRGSEVGRVESVQLTDTG-VVAVLSLKSGIDIPSDLKA
Rv1971|M.tuberculosis_H37Rv EAGGLYRTGNVTYRGFEVGRVAAVRLTDTG-VQAVLALKSGIDIPSDLKA
Mvan_3977|M.vanbaalenii_PYR-1 QAGGLYSGGNVTYRGTEVGRVEAVRLTPGG-VDAVLSLKSGIDVPSDLRA
MSMEG_0351|M.smegmatis_MC2_155 RTGGLYPTGNVTYRGTEVGRVESVGLSENGGVRAVLKLKSGIDIPSDLRA
TH_3681|M.thermoresistible__bu EAAGLYEGGNVTYRGTTVGRIRDVRLTDTG-VEAVLSLDSGIDIPSNLRA
Mflv_2106|M.gilvum_PYR-GCK ETGGLYERSNVTYRGSQVGIVESVGLTDRG-VAAELSLNSDVSIPADLIA
MAV_2069|M.avium_104 QSGGLYQTSVVTYRGTDVGQVKSVDVTATG-VRAVLAMRSGIEVPFDVQA
MAB_4148c|M.abscessus_ATCC_199 ASGGLYQNANVTFRGVQIGRVTDVELTPEG-VTATMRLNDNVKVPGNVVA
Mb0180|M.bovis_AF2122/97 ASGGLYPTANVTYRGITIGKVTAVEPTDQG-ARVTMSIASNYKIPVDASA
MLBr_02594|M.leprae_Br4923 ATGGLYPTANVTYRGIAIGKVTDVEPTATG-AEATMSIDSRYKIPIDSAA
:.*** . **:** :* : * : * . . : : . .:* : *
MMAR_2887|M.marinum_M EVHSQTAIGETYVELLPRNAT----SPPLKDGDVIRLVNTSVPPDINTLL
MUL_2865|M.ulcerans_Agy99 EVHSQTAIGETYVELLPRNAT----SPPLKDGDVIRLVNTSVPPDINTLL
Rv1971|M.tuberculosis_H37Rv EVHSHTAIGETYVELLPRNAA----SPPLKNGDVIALADTSVPPDINDLL
Mvan_3977|M.vanbaalenii_PYR-1 EVHSQSAIGEQYVALLPRSGD----ARPLRDGDVITPADTSVPPNVNTLL
MSMEG_0351|M.smegmatis_MC2_155 EVHSQSAIGEQYVELLPRSAA----APPLQDGDVIAAKDVFIPPDINSLL
TH_3681|M.thermoresistible__bu EVHSQSAVGEQYVALLPRDGE----SPPLRDGDVVSRENVKVPPNINALV
Mflv_2106|M.gilvum_PYR-GCK SVRSQSAVGEQFVELVPQSGD----GPALRNGDVISRDRARVPADVNTVL
MAV_2069|M.avium_104 SVHSRSAIGEQYIELTPRPGTGDHQSRTLRDGDVITAGRVEVPVDIGRLL
MAB_4148c|M.abscessus_ATCC_199 AVKSVSAIGEQYVDLIPPPTG---AAGTLRSGDVIGADRTSIPTDVSTLL
Mb0180|M.bovis_AF2122/97 NVHSVSAVGEQYIDLVSTGAP----GKYFSSGQTITKG--TVPSEIGPAL
MLBr_02594|M.leprae_Br4923 NVHSVSAVGEQYLDLVSSGNP----GKYLAPGQTITKS--KIPIEIGPAL
*:* :*:** :: * . . : *:.: :* ::. :
MMAR_2887|M.marinum_M SAANTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKN
MUL_2865|M.ulcerans_Agy99 SAANTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKN
Rv1971|M.tuberculosis_H37Rv SAANTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKGSAELAIDARAN
Mvan_3977|M.vanbaalenii_PYR-1 ADANVGLQAIPRDNLQTVVEESYAAVGGLGPELSRIVDSSTKLAIEARRH
MSMEG_0351|M.smegmatis_MC2_155 DAANTGLQAIPQDNLKTAIDESYAAVGGLGPAISRLVRGSTALASDARKN
TH_3681|M.thermoresistible__bu AATNRGLQAIPRENLETVVDESYNAVGGLGPELARLVSGSASLAIEARKN
Mflv_2106|M.gilvum_PYR-GCK ELTNEGLRAIPQDNLRTVVDEAYEAVGGLGPELRRLVNGSSQLAIDARAN
MAV_2069|M.avium_104 DMTNRALQAIPRDNLRTVIDETNRAVGGLGPELSRIVDGSTALAVAGGHT
MAB_4148c|M.abscessus_ATCC_199 RQADGLVNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTN
Mb0180|M.bovis_AF2122/97 DNSNRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTN
MLBr_02594|M.leprae_Br4923 DSVNRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTN
: : ::. .: : *: *. * * : *:: .: :
MMAR_2887|M.marinum_M LDPLIALIDQTPPVLDSQTHSSDAIAGWASHLAAVTTELQTHDQAVAATI
MUL_2865|M.ulcerans_Agy99 LDPLIALIDQTPPVLDSQTHSSDAIAGWASHLAAVTTELQTHDQAVAATI
Rv1971|M.tuberculosis_H37Rv LDPLVALIDRAGPVLDSQTHTSDAIAAWAAQLAAVTGQLQTHDSAVGDLI
Mvan_3977|M.vanbaalenii_PYR-1 LDPLITLIDQSQPVLDSQTRTSEAIQAWAAQVATVTTQLQTQDQTLARVI
MSMEG_0351|M.smegmatis_MC2_155 LGSLTTLIDLWQPVAESQIGTADSIEAWAANLAAVTGQLKQHNADVVGLI
TH_3681|M.thermoresistible__bu LDSLTALIDQSQPVLDSQVDTSDSIARWARNLAALTAQLKIHDPAVRGLL
Mflv_2106|M.gilvum_PYR-GCK LDSLTTVIDESKPVLDSQIETSGSIRAWASNLADLTGQLQSQDAAVSGIL
MAV_2069|M.avium_104 VDPLATLIDQSPAVLNSQVQTSGAIATWAERTAALMAQFKAQDAAVRDLL
MAB_4148c|M.abscessus_ATCC_199 YDSTTKLIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFL
Mb0180|M.bovis_AF2122/97 IGDVNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSIL
MLBr_02594|M.leprae_Br4923 ITDVNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSIL
:*: .: ::* : * . : . : : :
MMAR_2887|M.marinum_M DNGGPALDEVNSLLERVQPTLPILLANLVSVGQVALAYQNDIEQLLVVFP
MUL_2865|M.ulcerans_Agy99 DNGGPALDEVNSLLERVQPTLPILLANLVSVGQVALAYQNDIEQLLVVFP
Rv1971|M.tuberculosis_H37Rv DRGGPALGETRQLLERLQPTVPILLANLVSVGQVALTYHNDIEQLLVVFP
Mvan_3977|M.vanbaalenii_PYR-1 DDGGESADAVRQLVDRVKPTLPIVLANLVSVGQVAVTYHDNIEQLLVLFP
MSMEG_0351|M.smegmatis_MC2_155 EQGAPAAEEARRLFERVQPTLPILLANLVSINEVAVTYQPGIEQILVLLP
TH_3681|M.thermoresistible__bu DNGAGAGEQGRLLFERLKPTLPVLMANLVSVGEVAVTYNAGIEQLLVLLP
Mflv_2106|M.gilvum_PYR-GCK SNGPGAAEETRALFDRIKPTLPIVLANLISVGEVAVAYQPNLEQLLVLLP
MAV_2069|M.avium_104 AHGASGVEEGRALLDRVTPALPVLFANLVSLGDIAVVYRHDIEQLLVLLP
MAB_4148c|M.abscessus_ATCC_199 KVAPGASEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILP
Mb0180|M.bovis_AF2122/97 SQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLP
MLBr_02594|M.leprae_Br4923 SQAAPTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLP
. :. : :.* *.: : : *. .:** **.:*
MMAR_2887|M.marinum_M MAISAEQAGILANVNTK-QAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRV
MUL_2865|M.ulcerans_Agy99 MAISAEQAGILANVNTK-QAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRV
Rv1971|M.tuberculosis_H37Rv MAIAAEQAGILANLNTK-QAYRGQYLSFNLNLNLPPPCTTGFLPAQQRRI
Mvan_3977|M.vanbaalenii_PYR-1 AVVSAEQAGLVANLHTK-QDYKGQYLSFNLNINLPPPCTTGFLPAQQQRS
MSMEG_0351|M.smegmatis_MC2_155 QGIAQLQGPNLANRDNKDTAHKGMFLAFNTNINLPPPCTTGFLPAQQRRP
TH_3681|M.thermoresistible__bu PSVAALQAAGVANFNTK-QDYKGAYLNFNLNVNLPPPCVTGYFPTQQRRS
Mflv_2106|M.gilvum_PYR-GCK QGTAVTQAVGVAKNGTK-QDYMGDYLVFNLNLNVPPPCTTGFLPAQQQRA
MAV_2069|M.avium_104 QGIAAMAAIIVPSSNTK-QEYRGAQLDFNLNLNLPPPCTTGYLPPAQRRS
MAB_4148c|M.abscessus_ATCC_199 ALFSALLTVAGGAPMDE-----GAKLDFRLNLGDPPPCLTGFVPPPLMRT
Mb0180|M.bovis_AF2122/97 QGAAIAQTVLTPTPGAA-------QLPLAPAINYPPPCLTGFLPASEWRS
MLBr_02594|M.leprae_Br4923 QGASIAQTASATFPNMA-------ALDLALSINQPPPCLTGFIPAAEWRS
: * : :. **** **:.*. *
MMAR_2887|M.marinum_M PIFEDYPNRPAGDLYCRVPQDS-PLNVRGARNIPCETVPGKRAPTVKLCE
MUL_2865|M.ulcerans_Agy99 PTFEDYPNRPAGDLYCRVPQDS-PLNVRGARNIPCETVPGKRAPTVNLCE
Rv1971|M.tuberculosis_H37Rv PTFEDYPDRPAGDLYCRVPQDS-PFNVRGARNIPCETVPGKRAPTVKLCE
Mvan_3977|M.vanbaalenii_PYR-1 PVFEDAPERPPGDLYCRVPQDS-PLNVRGAHNIPCATRPGKRAPTVAICE
MSMEG_0351|M.smegmatis_MC2_155 PSFEDYPERPAGDLYCRTPQDS-PFNARGARNIPCETVPGKRAPTVKLCE
TH_3681|M.thermoresistible__bu PALVDSPDLPPGDVYCRVPQDSTVLAVRGARNIPCLNKPGKRAPTAQLCE
Mflv_2106|M.gilvum_PYR-GCK PTFEDAPDRPRGDLYCRVPQDS-AFNVRGARNIPCATVPGKRAPSAAMCE
MAV_2069|M.avium_104 PASVDAPDRPAADLYCRVPQDS-EFNVRGVRNIPCESKPWKRAPTVELCE
MAB_4148c|M.abscessus_ATCC_199 PADETLRELPR-DMYCKTAQND-PSAVRGARNYPCQEFPGKRAPTIQLCR
Mb0180|M.bovis_AF2122/97 PADTSPRPLPS-GTYCKIPQDAQLQ-VRGARNIPCVDVPGKRAATPKECR
MLBr_02594|M.leprae_Br4923 PADTSLQPLPV-GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECR
* * . **: . : .** :* ** * ***.: *.
MMAR_2887|M.marinum_M SDEQYVPLNDGYNWKG----------DPNSTLSGQDI-----PQLPPG--
MUL_2865|M.ulcerans_Agy99 SNEQYVPLNDGYNWKG----------DPNSTLSGQDI-----PQLPPG--
Rv1971|M.tuberculosis_H37Rv SDAPYLPLNDGYNWKG----------DPNATVPG----------------
Mvan_3977|M.vanbaalenii_PYR-1 SDEIYVPLNDGFNWKG----------DPNATSSGQPV-----PQLPP---
MSMEG_0351|M.smegmatis_MC2_155 SDENFVPLNDGYNWKG----------DPNATLSGQSI-----PDLGPGQG
TH_3681|M.thermoresistible__bu SDEEYTPLNDGMNWKG----------DPNATLSGQDI-----PEVRRG--
Mflv_2106|M.gilvum_PYR-GCK SGEVYVPLNEGYIWKG----------DPNATLSGQAV-----PQLRPG--
MAV_2069|M.avium_104 SDEEYVPLNDGYNWKG----------DPNATTSGQGV-----PQYPPGQ-
MAB_4148c|M.abscessus_ATCC_199 DPRGYVPIGS-NPWRGPPAPYDTPVEDPRNILPPNKF-----PNIPPGAE
Mb0180|M.bovis_AF2122/97 SKDPYVPLGT-NPWFG----------DPNQILTCPAPGARCDQPVKPGLV
MLBr_02594|M.leprae_Br4923 DSKPYVPLGT-NPWFG----------DPNQLLTCPAPGARCDQPVKPGLV
. : *:. * * **. .
MMAR_2887|M.marinum_M --------PSPPAAAGPGEAPPPP--------------------------
MUL_2865|M.ulcerans_Agy99 --------PPPPAAAGPGEAPPPP--------------------------
Rv1971|M.tuberculosis_H37Rv --------------LGSGQDIP----------------------------
Mvan_3977|M.vanbaalenii_PYR-1 --------------AAGPQAAPPA--------------------------
MSMEG_0351|M.smegmatis_MC2_155 ESA---PETSPAPPAPPVEGDPVP--------------------------
TH_3681|M.thermoresistible__bu --------PGAAQVSTSGPVAPPS--------------------------
Mflv_2106|M.gilvum_PYR-GCK --------QQPAQASPPPGPAPPP--------------------------
MAV_2069|M.avium_104 --------DPRLPPPRGTAPAPPP--------------------------
MAB_4148c|M.abscessus_ATCC_199 PDP---GTPTLPPPSPPAPEVPPAGGDVM----------------PVSAQ
Mb0180|M.bovis_AF2122/97 IPAPSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYT
MLBr_02594|M.leprae_Br4923 IPAPTVDNGLNPAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYT
*
MMAR_2887|M.marinum_M ---IAAAEYDPTTGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPVP
MUL_2865|M.ulcerans_Agy99 ---IAAAEYDPATGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPLP
Rv1971|M.tuberculosis_H37Rv ------------------------------------QTWQTMLLPPGS-
Mvan_3977|M.vanbaalenii_PYR-1 ---LAAAEYDPATGSYIGPDGRSYTQADLAQGAPAGQTWQTMLLPPGS-
MSMEG_0351|M.smegmatis_MC2_155 ---MAIARYDPATGTYLGPDGQVYTQADLADNGSKEQTWQSMLTPHGMN
TH_3681|M.thermoresistible__bu ---IAVTEYDPATGTYVGPDGRLYTQSNLVRSAFEVKTWESLMLPPGG-
Mflv_2106|M.gilvum_PYR-GCK ---MAAAEYDPANGTYVGPDGRVYTQSNLAEGATEEQTWQTMLLPPKGN
MAV_2069|M.avium_104 ---VAVAPYDPATGDYIGPDGRRYTESDLAHP--RAKSWQSLLVPQP--
MAB_4148c|M.abscessus_ATCC_199 SGPMAARAYDPKNGVFLDANNQPSVYAPALDRGTEAETWADLMLGPKPV
Mb0180|M.bovis_AF2122/97 PTSGPSAVYSPASGELVGPDGVKYAVANSSTTG--DDGWKEMLAPAS--
MLBr_02594|M.leprae_Br4923 PSGPPSAVYSPQSGELVGPDGVAYAVENSTKTG--DDGWKEMLAPAG--
. * ::