For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VAVVALAGVGLMIFPVLKLHEKWLGVGRYTVTVQLPEAAGLYERANVTYRGYNVGQVQSVQLTDTGVEAK VLLNSDTKIPSEVNAEVHSVSAIGEQYIDLLPRSADAPPLKNGDVIARDRTTVPPNISSLLDATNKGLQA IPRDNLKTVVDEAYIAFGGLGPELARFVQGATALAIDARANINELTTIVDDSKPILDSQIDTSESIQAWA ANLATVTEQLRSEDQNLAKVLQDASPAVDEARALFDQLQPTLPIVLANLVSVTEVLAVYRGNLEQLLVLL PHGAAAIQAVGVANRNTKQDYNGGYLSFNLNLNLPPACTTGFLPPAQRRSAALEDYPPPPDGDLYCRVPQ DAPFNVRGARNTPCVEKPGKRAPTAAICESDENYMPLNDGYNWKGDPNATLSGQDVPAPRDPSAPGAGPP PAAPAPPPPPIAVAEYDPSSGSYVGPDGRMYTQKDLAIGGEPKVWQDLLVPPAGN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1807 | - | - | 100% (475) | virulence factor mce family protein |
| M. avium 104 | MAV_2537 | - | e-176 | 62.32% (475) | virulence factor mce family protein |
| M. avium 104 | MAV_2069 | - | e-145 | 54.11% (475) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 1e-88 | 38.45% (515) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_2106 | - | 1e-170 | 60.84% (475) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1971 | mce3F | 1e-136 | 58.44% (409) | MCE-family protein MCE3F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 3e-82 | 35.66% (516) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 3e-79 | 36.18% (503) | MCE-family protein |
| M. marinum M | MMAR_4056 | mce3F_1 | 1e-169 | 61.81% (474) | MCE-family protein Mce3F_1 |
| M. smegmatis MC2 155 | MSMEG_0351 | - | 1e-154 | 55.90% (483) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3681 | - | 1e-165 | 60.08% (476) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3923 | mce3F_1 | 1e-169 | 61.81% (474) | MCE-family protein Mce3F_1 |
| M. vanbaalenii PYR-1 | Mvan_4599 | - | 1e-169 | 61.07% (488) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4056|M.marinum_M -MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVPA-MVGIGQYRVTVELP
MUL_3923|M.ulcerans_Agy99 -MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVPA-MVGIGQYRVTVELP
Mvan_4599|M.vanbaalenii_PYR-1 -MRLTRQILIQMAIFAVIATTALVIMVFAYMRLPA-FLGIGQYRVTLELP
Mflv_2106|M.gilvum_PYR-GCK -MRVTRQMLIQLLIFSLLAVTALGIMVFGYMRLPE-MIGIGQYKVTLELP
MAV_1807|M.avium_104 --------------MAVVALAGVGLMIFPVLKLHEKWLGVGRYTVTVQLP
Rv1971|M.tuberculosis_H37Rv MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTVTMELV
MSMEG_0351|M.smegmatis_MC2_155 MIH--RRTKIQLAIFCVIAVVFGTVMIFGYMRLPAHLFGIGLYTVNLDLD
TH_3681|M.thermoresistible__bu -MNLTRRILLQLAVFVGVAVIAGSVMIVGVIKLPALALGVGRYTVTVELP
MAB_4148c|M.abscessus_ATCC_199 ---MERLIKIQLAIFAAVTVISVALMAIFYLRVPT-ALGIGKHDVKAQFV
Mb0180|M.bovis_AF2122/97 --MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPS-LVGIGQYTLKADLP
MLBr_02594|M.leprae_Br4923 --MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPS-LVGIGRYSLKAELS
: :: : ::: .*:* : :. ::
MMAR_4056|M.marinum_M EAGGLYPRSNVTYRGVEVGTVKSVHLTNTG-VAAVLSLNSDVKIPADVEA
MUL_3923|M.ulcerans_Agy99 EAGGLYPRSNVTYRGVEVGTVKSVHLTNTG-VAAVLSLNSDVKIPADVEA
Mvan_4599|M.vanbaalenii_PYR-1 ETGGLYPRGNVTYRGVEVGEVKSVQLTDTG-VEAVLSLNDNVEIPANLEA
Mflv_2106|M.gilvum_PYR-GCK ETGGLYERSNVTYRGSQVGIVESVGLTDRG-VAAELSLNSDVSIPADLIA
MAV_1807|M.avium_104 EAAGLYERANVTYRGYNVGQVQSVQLTDTG-VEAKVLLNSDTKIPSEVNA
Rv1971|M.tuberculosis_H37Rv EAGGLYRTGNVTYRGFEVGRVAAVRLTDTG-VQAVLALKSGIDIPSDLKA
MSMEG_0351|M.smegmatis_MC2_155 RTGGLYPTGNVTYRGTEVGRVESVGLSENGGVRAVLKLKSGIDIPSDLRA
TH_3681|M.thermoresistible__bu EAAGLYEGGNVTYRGTTVGRIRDVRLTDTG-VEAVLSLDSGIDIPSNLRA
MAB_4148c|M.abscessus_ATCC_199 ASGGLYQNANVTFRGVQIGRVTDVELTPEG-VTATMRLNDNVKVPGNVVA
Mb0180|M.bovis_AF2122/97 ASGGLYPTANVTYRGITIGKVTAVEPTDQG-ARVTMSIASNYKIPVDASA
MLBr_02594|M.leprae_Br4923 ATGGLYPTANVTYRGIAIGKVTDVEPTATG-AEATMSIDSRYKIPIDSAA
:.*** .***:** :* : * : * . . : : . .:* : *
MMAR_4056|M.marinum_M EVHSVSSVGEQYVQLLPR-SGQGPSLKDGDVIPSSRTRVPTDINTILDET
MUL_3923|M.ulcerans_Agy99 EVHSVSSVGEQYVQLLPR-SGQGPSLKDGDVIPSSRTRVPTDINTILDET
Mvan_4599|M.vanbaalenii_PYR-1 EVHSVSSVGEQFVQLLPR-SADGPVLKDGDVIPINRTTVPTDINGVLDAT
Mflv_2106|M.gilvum_PYR-GCK SVRSQSAVGEQFVELVPQ-SGDGPALRNGDVISRDRARVPADVNTVLELT
MAV_1807|M.avium_104 EVHSVSAIGEQYIDLLPR-SADAPPLKNGDVIARDRTTVPPNISSLLDAT
Rv1971|M.tuberculosis_H37Rv EVHSHTAIGETYVELLPR-NAASPPLKNGDVIALADTSVPPDINDLLSAA
MSMEG_0351|M.smegmatis_MC2_155 EVHSQSAIGEQYVELLPR-SAAAPPLQDGDVIAAKDVFIPPDINSLLDAA
TH_3681|M.thermoresistible__bu EVHSQSAVGEQYVALLPR-DGESPPLRDGDVVSRENVKVPPNINALVAAT
MAB_4148c|M.abscessus_ATCC_199 AVKSVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQA
Mb0180|M.bovis_AF2122/97 NVHSVSAVGEQYIDLVST-GAPGKYFSSGQTITKG--TVPSEIGPALDNS
MLBr_02594|M.leprae_Br4923 NVHSVSAVGEQYLDLVSS-GNPGKYLAPGQTITKS--KIPIEIGPALDSV
*:* :::** :: *:. . : *:.: :* ::. :
MMAR_4056|M.marinum_M NRGLQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDE
MUL_3923|M.ulcerans_Agy99 NRGLQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDE
Mvan_4599|M.vanbaalenii_PYR-1 NAGLEAIPQENLQTVIDEAYTAVGGLGPELRRLVTGSTALAIDARKNLES
Mflv_2106|M.gilvum_PYR-GCK NEGLRAIPQDNLRTVVDEAYEAVGGLGPELRRLVNGSSQLAIDARANLDS
MAV_1807|M.avium_104 NKGLQAIPRDNLKTVVDEAYIAFGGLGPELARFVQGATALAIDARANINE
Rv1971|M.tuberculosis_H37Rv NTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKGSAELAIDARANLDP
MSMEG_0351|M.smegmatis_MC2_155 NTGLQAIPQDNLKTAIDESYAAVGGLGPAISRLVRGSTALASDARKNLGS
TH_3681|M.thermoresistible__bu NRGLQAIPRENLETVVDESYNAVGGLGPELARLVSGSASLAIEARKNLDS
MAB_4148c|M.abscessus_ATCC_199 DGLVNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDS
Mb0180|M.bovis_AF2122/97 NRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGD
MLBr_02594|M.leprae_Br4923 NRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITD
: : ::. .: : *: *. * * : *:: .: : . *
MMAR_4056|M.marinum_M LTLLIDQSKPVLDTQTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQG
MUL_3923|M.ulcerans_Agy99 LTLLIDQSKPVLDTQTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQG
Mvan_4599|M.vanbaalenii_PYR-1 LTTLIDQSKPVLDSQTETGDSIQAWAANLASISGQLQSQDPAVAGILDKG
Mflv_2106|M.gilvum_PYR-GCK LTTVIDESKPVLDSQIETSGSIRAWASNLADLTGQLQSQDAAVSGILSNG
MAV_1807|M.avium_104 LTTIVDDSKPILDSQIDTSESIQAWAANLATVTEQLRSEDQNLAKVLQDA
Rv1971|M.tuberculosis_H37Rv LVALIDRAGPVLDSQTHTSDAIAAWAAQLAAVTGQLQTHDSAVGDLIDRG
MSMEG_0351|M.smegmatis_MC2_155 LTTLIDLWQPVAESQIGTADSIEAWAANLAAVTGQLKQHNADVVGLIEQG
TH_3681|M.thermoresistible__bu LTALIDQSQPVLDSQVDTSDSIARWARNLAALTAQLKIHDPAVRGLLDNG
MAB_4148c|M.abscessus_ATCC_199 TTKLIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVA
Mb0180|M.bovis_AF2122/97 VNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQA
MLBr_02594|M.leprae_Br4923 VNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQA
::: *: ::* : * . .* :: : : : .:. .
MMAR_4056|M.marinum_M PGAADEVRALFNRLRPTLPIVLANLVSVGEVAVAYHPSLEQLLVLFPQGT
MUL_3923|M.ulcerans_Agy99 PGAADEVRALFNRLRPTLPIVLANLVSVGEVAVAYHPSLEQLLVLFPQGT
Mvan_4599|M.vanbaalenii_PYR-1 PGGAEEVRALFDRLQPTLPIVLANLVSIGEVAVTYQPSLEQLLVLLPQGT
Mflv_2106|M.gilvum_PYR-GCK PGAAEETRALFDRIKPTLPIVLANLISVGEVAVAYQPNLEQLLVLLPQGT
MAV_1807|M.avium_104 SPAVDEARALFDQLQPTLPIVLANLVSVTEVLAVYRGNLEQLLVLLPHGA
Rv1971|M.tuberculosis_H37Rv GPALGETRQLLERLQPTVPILLANLVSVGQVALTYHNDIEQLLVVFPMAI
MSMEG_0351|M.smegmatis_MC2_155 APAAEEARRLFERVQPTLPILLANLVSINEVAVTYQPGIEQILVLLPQGI
TH_3681|M.thermoresistible__bu AGAGEQGRLLFERLKPTLPVLMANLVSVGEVAVTYNAGIEQLLVLLPPSV
MAB_4148c|M.abscessus_ATCC_199 PGASEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALF
Mb0180|M.bovis_AF2122/97 APTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGA
MLBr_02594|M.leprae_Br4923 APTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGA
: :: :: :.* *.: : : *. .:** **.:*
MMAR_4056|M.marinum_M AVTQAVGVAKRNTI-QDYKGDYLVFNLNLN--------------LPPPCT
MUL_3923|M.ulcerans_Agy99 AVTQAVGVAKRNTI-QDYKGDYLVFNLNLN--------------LPPPCT
Mvan_4599|M.vanbaalenii_PYR-1 AVTQAVGVHKRNTK-QDYMGDALVFNLNLAIPLLPAPIPLPPQQLPPPCT
Mflv_2106|M.gilvum_PYR-GCK AVTQAVGVAKNGTK-QDYMGDYLVFNLNLN--------------VPPPCT
MAV_1807|M.avium_104 AAIQAVGVANRNTK-QDYNGGYLSFNLNLN--------------LPPACT
Rv1971|M.tuberculosis_H37Rv AAEQAGILANLNTK-QAYRGQYLSFNLNLN--------------LPPPCT
MSMEG_0351|M.smegmatis_MC2_155 AQLQGPNLANRDNKDTAHKGMFLAFNTNIN--------------LPPPCT
TH_3681|M.thermoresistible__bu AALQAAGVANFNTK-QDYKGAYLNFNLNVN--------------LPPPCV
MAB_4148c|M.abscessus_ATCC_199 SALLTVAGGAPMDE-----GAKLDFRLNLG--------------DPPPCL
Mb0180|M.bovis_AF2122/97 AIAQTVLTPTPGAA-------QLPLAPAIN--------------YPPPCL
MLBr_02594|M.leprae_Br4923 SIAQTASATFPNMA-------ALDLALSIN--------------QPPPCL
: * : : **.*
MMAR_4056|M.marinum_M TGFLPAQQQRVPTFEDYPNRAPGDLYCRVPQDA-PFNVRGARNLPCVTVP
MUL_3923|M.ulcerans_Agy99 TGFLPAQQQRVPTFEDYPNRAPGDLYCRVPQDA-PFNVRGARNLPCVTVP
Mvan_4599|M.vanbaalenii_PYR-1 TGFLPAQQRRVPTFEDYPDRPVGNLYCRVPQDA-PFNVRGARNLPCISVP
Mflv_2106|M.gilvum_PYR-GCK TGFLPAQQQRAPTFEDAPDRPRGDLYCRVPQDS-AFNVRGARNIPCATVP
MAV_1807|M.avium_104 TGFLPPAQRRSAALEDYPPPPDGDLYCRVPQDA-PFNVRGARNTPCVEKP
Rv1971|M.tuberculosis_H37Rv TGFLPAQQRRIPTFEDYPDRPAGDLYCRVPQDS-PFNVRGARNIPCETVP
MSMEG_0351|M.smegmatis_MC2_155 TGFLPAQQRRPPSFEDYPERPAGDLYCRTPQDS-PFNARGARNIPCETVP
TH_3681|M.thermoresistible__bu TGYFPTQQRRSPALVDSPDLPPGDVYCRVPQDSTVLAVRGARNIPCLNKP
MAB_4148c|M.abscessus_ATCC_199 TGFVPPPLMRTPADETLRELPR-DMYCKTAQND-PSAVRGARNYPCQEFP
Mb0180|M.bovis_AF2122/97 TGFLPASEWRSPADTSPRPLPS-GTYCKIPQDAQLQ-VRGARNIPCVDVP
MLBr_02594|M.leprae_Br4923 TGFIPAAEWRSPADTSLQPLPV-GTYCKIPMDTPANSVRGSRNIPCVDVP
**:.*. * .: . . **: . : .**:** ** *
MMAR_4056|M.marinum_M GKRAPTAKLCESNEVYVPLNDGYNWKG----------DPNSTLSGQP---
MUL_3923|M.ulcerans_Agy99 GKRAPTAKLCESNEVYVPLNDGYNWKG----------DPNSTLSGQP---
Mvan_4599|M.vanbaalenii_PYR-1 GKRAPTWQDCESNEVYVPLNDGYNWKG----------DPNATLSGEP---
Mflv_2106|M.gilvum_PYR-GCK GKRAPSAAMCESGEVYVPLNEGYIWKG----------DPNATLSGQA---
MAV_1807|M.avium_104 GKRAPTAAICESDENYMPLNDGYNWKG----------DPNATLSGQD---
Rv1971|M.tuberculosis_H37Rv GKRAPTVKLCESDAPYLPLNDGYNWKG----------DPNATVPG-----
MSMEG_0351|M.smegmatis_MC2_155 GKRAPTVKLCESDENFVPLNDGYNWKG----------DPNATLSGQS---
TH_3681|M.thermoresistible__bu GKRAPTAQLCESDEEYTPLNDGMNWKG----------DPNATLSGQD---
MAB_4148c|M.abscessus_ATCC_199 GKRAPTIQLCRDPRGYVPIGS-NPWRGPPAPYDTPVEDPRNILPPNK---
Mb0180|M.bovis_AF2122/97 GKRAATPKECRSKDPYVPLGT-NPWFG----------DPNQILTCPAPGA
MLBr_02594|M.leprae_Br4923 GKRAASPRECRDSKPYVPLGT-NPWFG----------DPNQLLTCPAPGA
****.: *.. : *:. * * **. :.
MMAR_4056|M.marinum_M -------------IPQLPPEPPLEQSAPPGP--APPAP------------
MUL_3923|M.ulcerans_Agy99 -------------IPQLPPEPPLEQSAPPGP--APPAP------------
Mvan_4599|M.vanbaalenii_PYR-1 -------------IPDVPPDVPVAVTPPPPG--TPPLP------------
Mflv_2106|M.gilvum_PYR-GCK -------------VPQLRPGQQPAQASPPPG--PAPPP------------
MAV_1807|M.avium_104 -------------VPAPRDPSAPGAGPPPAAPAPPPPP------------
Rv1971|M.tuberculosis_H37Rv ----------------LGSGQ-----------------------------
MSMEG_0351|M.smegmatis_MC2_155 -------------IPDLGPGQGESAPETSPAPPAPPVEGDP---------
TH_3681|M.thermoresistible__bu -------------IPEVRRGPGAAQVSTSGPVAPP---------------
MAB_4148c|M.abscessus_ATCC_199 -------------FPNIPPGAEPDPGTPTLPPPSPPAPEVPPAGGDVMPV
Mb0180|M.bovis_AF2122/97 RCDQPVKPGLVIPAPSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQC
MLBr_02594|M.leprae_Br4923 RCDQPVKPGLVIPAPTVDNGLNPAPADRLPGTPPPVSDPLSQPRSGSVQC
MMAR_4056|M.marinum_M --------------IAAAEYDPATGTYMGPDGHLYTQANLGQTVPEEQTW
MUL_3923|M.ulcerans_Agy99 --------------IAAAEYDPATGTYMGPDGHLYTQANLGQTVPEEQTW
Mvan_4599|M.vanbaalenii_PYR-1 --------------VAAAEYDPASGEYVGPDGKVYTQSNLADGASGERPW
Mflv_2106|M.gilvum_PYR-GCK --------------MAAAEYDPANGTYVGPDGRVYTQSNLAEGATEEQTW
MAV_1807|M.avium_104 --------------IAVAEYDPSSGSYVGPDGRMYTQKDLAIGG-EPKVW
Rv1971|M.tuberculosis_H37Rv --------------------------------------DIP------QTW
MSMEG_0351|M.smegmatis_MC2_155 ------------VPMAIARYDPATGTYLGPDGQVYTQADLADNGSKEQTW
TH_3681|M.thermoresistible__bu -------------SIAVTEYDPATGTYVGPDGRLYTQSNLVRSAFEVKTW
MAB_4148c|M.abscessus_ATCC_199 SAQS--------GPMAARAYDPKNGVFLDANNQPSVYAPALDRGTEAETW
Mb0180|M.bovis_AF2122/97 NGQQPNPCVYTPTSGPSAVYSPASGELVGPDGVKYAVANSSTTG--DDGW
MLBr_02594|M.leprae_Br4923 NGQQPNTCVYTPSGPPSAVYSPQSGELVGPDGVAYAVENSTKTG--DDGW
*
MMAR_4056|M.marinum_M QTMLLPPKK-
MUL_3923|M.ulcerans_Agy99 QTMLLPPKK-
Mvan_4599|M.vanbaalenii_PYR-1 QSMLVPPGG-
Mflv_2106|M.gilvum_PYR-GCK QTMLLPPKGN
MAV_1807|M.avium_104 QDLLVPPAGN
Rv1971|M.tuberculosis_H37Rv QTMLLPPGS-
MSMEG_0351|M.smegmatis_MC2_155 QSMLTPHGMN
TH_3681|M.thermoresistible__bu ESLMLPPGG-
MAB_4148c|M.abscessus_ATCC_199 ADLMLGPKPV
Mb0180|M.bovis_AF2122/97 KEMLAPAS--
MLBr_02594|M.leprae_Br4923 KEMLAPAG--
::