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IRGVGRDWEIAEIELDPPRSGEVLVRMAVAGICHSDDHLFTGDVVPTPEVVAASGQPAPDWFPLLGGHEG AGVVAEVGPNVTSVRPGDHVALSFIPACGSCRFCVNGQSYICDVGASLFVREMPTDGTCRRHLGAENLLA YGQLGTFAEYAVLSERSVIKIDEAIPFHAASLVSCGVSTGWGSATVSAGTEPGDTVVVIGAGGVGMNALQ GARAVGAKYVVAVDPIAAKRDSAKIFGATHTAASARDAIPLVREITAGLMADRVVVCPGVVHVDSIPLAL ALLRKGGVCVLTGITPFTEPPVPLVLQEMTLSAKQLRGALYGGMNPRTSVPMLLSLYQAGDLKLDELVTR HYRLDEINEAFADLREGRNIRGVIDFAGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5214 | - | - | 100% (380) | alcohol dehydrogenase B |
| M. avium 104 | MAV_1614 | - | e-109 | 50.00% (378) | alcohol dehydrogenase B |
| M. avium 104 | MAV_0705 | - | 3e-95 | 47.15% (369) | alcohol dehydrogenase B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0784c | adhB | 1e-93 | 45.80% (369) | zinc-containing alcohol dehydrogenase NAD dependant ADHB |
| M. gilvum PYR-GCK | Mflv_1486 | - | 1e-100 | 48.11% (370) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0761c | adhB | 1e-93 | 45.80% (369) | zinc-containing alcohol dehydrogenase NAD dependent ADHB |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 4e-44 | 32.43% (367) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 2e-96 | 48.81% (377) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_3997 | adhB_1 | 1e-107 | 49.21% (378) | zinc-containing alcohol dehydrogenase NAD dependent AdhB_1 |
| M. smegmatis MC2 155 | MSMEG_5866 | - | 2e-94 | 46.88% (369) | alcohol dehydrogenase B |
| M. thermoresistible (build 8) | TH_4578 | - | 1e-141 | 62.24% (384) | PUTATIVE alcohol dehydrogenase B |
| M. ulcerans Agy99 | MUL_3861 | adhB_1 | 1e-105 | 48.41% (378) | zinc-containing alcohol dehydrogenase NAD dependent AdhB_1 |
| M. vanbaalenii PYR-1 | Mvan_5270 | - | 3e-99 | 47.30% (370) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5214|M.avium_104 --------MIRGVGRDWEIAEIELDPPRSGEVLVRMAVAGICHSDDHLFT
TH_4578|M.thermoresistible__bu --MRTKAAVLRGVGVDWEVTEIELDPPRAGEVLVKMAYAGICHSDEHFYT
Mb0784c|M.bovis_AF2122/97 --MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVT
Rv0761c|M.tuberculosis_H37Rv --MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVT
MSMEG_5866|M.smegmatis_MC2_155 --MKTKGALIWEFNQPWSIEEIEIGDPVKDEVKIQMEASGMCHSDHHLVT
Mflv_1486|M.gilvum_PYR-GCK --MKTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWQATGLCHSDEHIRT
Mvan_5270|M.vanbaalenii_PYR-1 --MKTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRT
MAB_2084|M.abscessus_ATCC_1997 --MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVT
MMAR_3997|M.marinum_M --MRSRAAILHDVGGPWSVEEFELDTPRTGEVLVEMSAAGLCHTDDHILK
MUL_3861|M.ulcerans_Agy99 --MRSRAAILHDVGEPWSVEEFELDAPRTAEVLVEMSAAGLCHTDDHILK
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
: : :. : * *. : *:*::*
MAV_5214|M.avium_104 GDVVPTP---EVVAASGQPAPDWFPLLGGHEGAGVVAEVGPNVTSVRPGD
TH_4578|M.thermoresistible__bu GDSVPSKEMEEMMRASGVPVPEWFPMLGGHEGAGVVEDVGPEVRTLKPGD
Mb0784c|M.bovis_AF2122/97 GD-IPMAG---------------FPVLGGHEGAGIVTEVGPGVDDFAPGD
Rv0761c|M.tuberculosis_H37Rv GD-IPMAG---------------FPVLGGHEGAGIVTEVGPGVDDFAPGD
MSMEG_5866|M.smegmatis_MC2_155 GG-IPMGG---------------FPVLGGHEGAGIVTEVGPGVEGIEPGD
Mflv_1486|M.gilvum_PYR-GCK GD-LPAP----------------LPLIGGHEGAGIVREVGAGVVGLAPGD
Mvan_5270|M.vanbaalenii_PYR-1 GD-LPAP----------------LPLIGGHEGAGIVREVGPGVVGLAPGD
MAB_2084|M.abscessus_ATCC_1997 GD-LPIP----------------LPVVGGHEGAGTVVECGEGVEDLSEGD
MMAR_3997|M.marinum_M GD-MSAPN----EVLRSRGLPTMFPTIGGHEGSGIVREIGPGVTDFAPGD
MUL_3861|M.ulcerans_Agy99 GD-MSAPN----EVLRSRGLPTMFPTIGGHEGSGIVREIGPGVTDFVPGD
MLBr_01784|M.leprae_Br4923 GG-INDR----------------YPFLLGHEAAGTVEVVGPGVTAVEPGD
*. : * : ***.:* * * * . **
MAV_5214|M.avium_104 HVALSFIPACGSCRFCVNGQSYICDVGASLFVREMPTDGTCRRHL----G
TH_4578|M.thermoresistible__bu HVAVSFLPACGSCRWCASGHTYLCDVGADLYSKRMTTDGTARRHLPDPDG
Mb0784c|M.bovis_AF2122/97 HVVLAFIPSCGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQAR----
Rv0761c|M.tuberculosis_H37Rv HVVLAFIPSCGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQAR----
MSMEG_5866|M.smegmatis_MC2_155 HVVLSFIPSCGSCPSCQAGLRNLCDLGAGLLGGVAVADGTHRIHAN----
Mflv_1486|M.gilvum_PYR-GCK HVVASFLPACGRCRFCSTGHQNLCDLGAMIMAGTQL-DGTYRRHIN----
Mvan_5270|M.vanbaalenii_PYR-1 HVVASFLPACGRCRFCSTGHQNLCDLGAMIMAGTQL-DGTYRRHVR----
MAB_2084|M.abscessus_ATCC_1997 SVILTFLPSCGRCSYCARGMGNLCELGAALMMGPQI-DGTYRFHAR----
MMAR_3997|M.marinum_M HVVMSFIAVCGQCRWCASGMEYLCDAGIGTLTPGMPTDGTFRHHTAD---
MUL_3861|M.ulcerans_Agy99 HVVMSFVAVCGQCRWCASGMEYLCDAGIGTLTPGMPTDGTFRHHTAD---
MLBr_01784|M.leprae_Br4923 FVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALG---
* : . ** * * * * **:
MAV_5214|M.avium_104 AENLLAYGQLGTFAEYAVLSERSVIKIDEAIPFHAASLVSCGVSTGWGSA
TH_4578|M.thermoresistible__bu DRDLMAMMQVGTFAEYVVASERSLVKVHDWIPLAAASLVSCGVTTGFGSG
Mb0784c|M.bovis_AF2122/97 GQNVYPMTLLGTFSPYMVVHRSSVVKIDPSVPFEVACLVGCGVTTGYGSA
Rv0761c|M.tuberculosis_H37Rv GQNVYPMTLLGTFSPYMVVHRSSVVKIDPSVPFEVACLVGCGVTTGYGSA
MSMEG_5866|M.smegmatis_MC2_155 GKPVFPMTLLGTFSPYMVVHKSSVVKIDKSIPFEVACLVGCGVTTGYGSA
Mflv_1486|M.gilvum_PYR-GCK GQDVGVMALVGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSA
Mvan_5270|M.vanbaalenii_PYR-1 GQDVGVMALVGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSA
MAB_2084|M.abscessus_ATCC_1997 GEDVGQMCLLGTFSEYTVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSA
MMAR_3997|M.marinum_M GTPLGHLAKVGAFAEHTVVSRDSLVKIDPDLPLAPSALLSCAIPTGYGSA
MUL_3861|M.ulcerans_Agy99 GTPLGHLAKVGAFAEHTVVSRDSLVKIDPDLPLAPSALLSCAIPTGYGSA
MLBr_01784|M.leprae_Br4923 ---------IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAA
:*:*: . *:. : *:.*.: :* *:.
MAV_5214|M.avium_104 TVSAGTEPGDTVVVIGAGGVGMNALQGARAVGAKYVVAVDPIAAKRDSAK
TH_4578|M.thermoresistible__bu SVAAGTQPGDTVVVVGVGGIGMNAVQGARTAGAKHIVAVDPVEFKREIAP
Mb0784c|M.bovis_AF2122/97 VRTADVRPGDDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQAL
Rv0761c|M.tuberculosis_H37Rv VRTADVRPGDDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQAL
MSMEG_5866|M.smegmatis_MC2_155 VRSGDIRPGDDVAIFGIGGVGMGALQGAVNAGARYIFAIDPVEWKRDQAL
Mflv_1486|M.gilvum_PYR-GCK VNTADVSPGDTVVIIGLGGIGSGAIQGARLAGAEKIVVVEPVETKRDLAF
Mvan_5270|M.vanbaalenii_PYR-1 VNTADVSPGDTVVIIGLGGIGSGAIQGARLAGAEKIVVIEPVESKRELAF
MAB_2084|M.abscessus_ATCC_1997 VRTGEVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQAS
MMAR_3997|M.marinum_M ANRAGVRGGDTVVVLGAGGIGTGAIQGARINGAAQIVAVDPVEFKQKSAH
MUL_3861|M.ulcerans_Agy99 ANRAGVRGGDTVVVLGAGGIGTGAIQGARINGAAQIVAIDPVEFKQKSAY
MLBr_01784|M.leprae_Br4923 INTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWAR
. .* *.:.* **:* *:.** ** :..:: * . *
MAV_5214|M.avium_104 IFGATHTAASAR-DAIPLVREITAGLMADRVVVCPGVVHVDSIPLALALL
TH_4578|M.thermoresistible__bu TFGATHAVADIG-AALDLVKDITWGVMADRVVLTPGVVPPDMVMAAMMLL
Mb0784c|M.bovis_AF2122/97 KFGATHVYPDIN-AALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTIT
Rv0761c|M.tuberculosis_H37Rv KFGATHVYPDIN-AALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTIT
MSMEG_5866|M.smegmatis_MC2_155 KFGATHVYPDVF-SAMAGIAEVTAGGMAKKVIVTVGELHGEDIDNYLNVT
Mflv_1486|M.gilvum_PYR-GCK RFGATHFVTSME-EATALVAELTRGVMADSAILTVGLLAGSMLEEAANII
Mvan_5270|M.vanbaalenii_PYR-1 RFGATHFVTSME-EATALVADLTRGVMADSAILTVGLLEGSMLEEAANII
MAB_2084|M.abscessus_ATCC_1997 GFGATHTAASMD-EAWSLVSDMTRGKLADVCILTTDVAEGSYTAEALALV
MMAR_3997|M.marinum_M LFGATHGAGSIS-EAMALVRELTHGVMADSVLVSPSLITADDVRDALRLT
MUL_3861|M.ulcerans_Agy99 LFGATHGAGSIS-QAMALVRELTHGVMADSVLVSPSLITADDVRDALRLT
MLBr_01784|M.leprae_Br4923 TFGATHTVNALELEVVKTIQDLTSGFGVDVVIDTVGRPE--TWKQAFYAR
***** . : ::* * .. : .
MAV_5214|M.avium_104 RKGGVCVLTGITPFTEPPVPLVLQEMTLSAKQLRGALYGGMNPRTSVPML
TH_4578|M.thermoresistible__bu RKGGTCVLTGMAKVSDLNVPLSLPDMVSSCKTLKGVLYGEMNPRDAMPKL
Mb0784c|M.bovis_AF2122/97 AKGGTCVLTAIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNPHYDIPKL
Rv0761c|M.tuberculosis_H37Rv AKGGTCVLTAIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNPHYDIPKL
MSMEG_5866|M.smegmatis_MC2_155 SKGGTCVVTAVGSMLDTNANINLAMLTLLQKNLQGTIFGGGNPHHDIPQL
Mflv_1486|M.gilvum_PYR-GCK RKGGAVVMTALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRL
Mvan_5270|M.vanbaalenii_PYR-1 RKGGAVVMTALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRL
MAB_2084|M.abscessus_ATCC_1997 GKRGRVVVTAIGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRL
MMAR_3997|M.marinum_M RKGGTCVLAGMTSQLTRSVNIDLQEFILMNKTLAGTIFGSCNPRADIARL
MUL_3861|M.ulcerans_Agy99 CKGGTCVLAGMTSQLTRSVNIDLQEFILMNKTLAGTIFGSCNPRADIARL
MLBr_01784|M.leprae_Br4923 DLAGTVVLVGVPTP-DMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTL
* *:..: : : : . :* . .. *
MAV_5214|M.avium_104 LSLYQAGDLKLDELVTRHYRLDEINEAFADLREGRNIRGVIDFAGR--
TH_4578|M.thermoresistible__bu LSMYEAGTLKLDELITNRYKLDDINEAMRDLRAGKNIRGVIAFD----
Mb0784c|M.bovis_AF2122/97 LSMYKAGKLNLDDMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR
Rv0761c|M.tuberculosis_H37Rv LSMYKAGKLNLDDMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR
MSMEG_5866|M.smegmatis_MC2_155 LSMYKAGKLNLDDMVTRQYRLEQINDGYQDMLEGRNIRGVIRYTDADR
Mflv_1486|M.gilvum_PYR-GCK LSLYREGKLLLDETVTHEYKLAEVNEGYEDMREGRNIRGVILHDH---
Mvan_5270|M.vanbaalenii_PYR-1 LSLYREGKLLLDETVTHEYKLAEVNEGYEDMRAGRNIRGVILHDH---
MAB_2084|M.abscessus_ATCC_1997 VELYSAGLLKLDELVTREYSLDQINEGYQDMRSGRNIRGLVRF-----
MMAR_3997|M.marinum_M AGLYQSGQLQLDDMITRRYRLDDINAAYTDLLNGDIVRGIIDFTI---
MUL_3861|M.ulcerans_Agy99 AGLYQSGQLQLDEMITRRYRLDDINAAYTDLLNGDIVRGIIDFTI---
MLBr_01784|M.leprae_Br4923 VDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML-----
:* * * *.. :: * ::: . .: * :*.::