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MLGVLGTVILACVTVVAFQYNKLPFIKNTDDYAAYFSEAGGIKPGNAVRVSGMGVGRVSDLRLEGTKVRI GFTVRKGVVLGDRTEAAIKTETILGAKMLELTPRGDGRLSGVIPLERTTSPYDLPDALGDLTTTISGLDT TQLSAALTTLADTLKATPENLKPALQGVARFSDTLNSRDAQLRSLLGNANHVSAVLGRRSQQIAGLVANS NALLAALLDERDSLDALMNHLTAVSHQISGLVNDNRTQLKPALDKLNGVLEILDNRKEELQKTLPKFKRY AMSFGECLGSGPFFKAYVANLVPGQFGGPVLDADMYDRFLDPDQKLPSEVVDPPTGTPPVPPENAPVPLW SQPPSPPPSTPPVRTIPPPSPHEFDQP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2063 | - | - | 100% (377) | virulence factor Mce family protein |
| M. avium 104 | MAV_2534 | - | e-102 | 51.09% (368) | virulence factor Mce family protein |
| M. avium 104 | MAV_0659 | - | 4e-67 | 44.41% (331) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0177 | mce1C | 1e-66 | 36.79% (386) | MCE-family protein MCE1C |
| M. gilvum PYR-GCK | Mflv_0650 | - | 1e-104 | 48.51% (404) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 1e-102 | 48.26% (402) | MCE-family protein MCE3C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 3e-56 | 33.88% (369) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 7e-64 | 40.30% (330) | MCE-family protein |
| M. marinum M | MMAR_4053 | mce3C_1 | 1e-105 | 52.83% (371) | MCE-family protein, Mce3C_1 |
| M. smegmatis MC2 155 | MSMEG_0348 | - | 1e-102 | 46.97% (396) | mce-family protein mce3c |
| M. thermoresistible (build 8) | TH_3264 | - | 7e-98 | 50.54% (370) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 1e-102 | 52.83% (371) | MCE-family protein, Mce3C_1 |
| M. vanbaalenii PYR-1 | Mvan_0515 | - | 1e-104 | 48.51% (404) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4053|M.marinum_M ----MKSFAERNQIVVGAVGLAITIGIVVGSLQYDKLPFFQSGKQYSAYF
MUL_3920|M.ulcerans_Agy99 ----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSACF
Rv1968|M.tuberculosis_H37Rv ----MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAYF
MSMEG_0348|M.smegmatis_MC2_155 MRAEMKAFSERDPRTIGLVGIAITVVIALAALNFDKLPLLSSTKGYSAYF
Mflv_0650|M.gilvum_PYR-GCK ----MKTFSERNVIVIGAIGVLLTAAIVAGALNYNKLPFVSSGKSYSAYF
Mvan_0515|M.vanbaalenii_PYR-1 ----MKTFSERNVIVIGAIGVLLTAAIVAGALNYNKLPFVSSGKSYSAYF
TH_3264|M.thermoresistible__bu -------------VTVGAVGVLIVAMLVVGALQYDKLMFWTD-KSYTAYF
MAV_2063|M.avium_104 --------------MLGVLGTVILACVTVVAFQYNKLPFIKNTDDYAAYF
MAB_4151c|M.abscessus_ATCC_199 MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGYF
Mb0177|M.bovis_AF2122/97 ----MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPMLFAKPSYYGQF
MLBr_02591|M.leprae_Br4923 ----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQF
* . : : . : : : . *
MMAR_4053|M.marinum_M ADAGGLTTGVRVQVSGFRVGEVSSIELDGPRVLVKFTVDKHIRLGDHTEA
MUL_3920|M.ulcerans_Agy99 ADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTEA
Rv1968|M.tuberculosis_H37Rv ADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTEV
MSMEG_0348|M.smegmatis_MC2_155 ADAGGLNTGATVRVSGFAVGKVERIRLDGRKVLVDFTVDSAIHLGEQSEA
Mflv_0650|M.gilvum_PYR-GCK DEAGGLTTGAPVRVSGAPAGQVQSITLDGQWVLVTFTVADGIRLGDRTEA
Mvan_0515|M.vanbaalenii_PYR-1 DEAGGLTTGAPVRVSGAPAGQVQSITLDGQWVLVTFTVADGIRLGDRTEA
TH_3264|M.thermoresistible__bu TQAGGLRAGAMVQVSGLRSGRVTSVALEGSQVRVKFDVNRKVRLGDRSEA
MAV_2063|M.avium_104 SEAGGIKPGNAVRVSGMGVGRVSDLRLEGTKVRIGFTVRKGVVLGDRTEA
MAB_4151c|M.abscessus_ATCC_199 ADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSLA
Mb0177|M.bovis_AF2122/97 TDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIG-TNTIGTESRL
MLBr_02591|M.leprae_Br4923 TDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASRL
::**: * * ::* * * : : * : : * : :* :
MMAR_4053|M.marinum_M AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
MUL_3920|M.ulcerans_Agy99 AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
Rv1968|M.tuberculosis_H37Rv AIKTKGLLGSKFLDVTPRGDGRLDS--PIPIERTTSPYQLPDALGDLAAT
MSMEG_0348|M.smegmatis_MC2_155 AIKVKSLLGTKVIDVIPRGGGQLHE--PIPLERTTSPYQLPDALGDLATT
Mflv_0650|M.gilvum_PYR-GCK SIKTTSVLGNKVLDLTTRGAGTLAG--TIPVERTTSPYQLPDAIGDLTTT
Mvan_0515|M.vanbaalenii_PYR-1 SIKTTSVLGNKVLDLTTRGAGTLAG--TIPVERTTSPYQLPDAIGDLTTT
TH_3264|M.thermoresistible__bu AIKTKSLLGAKYLEITTRGDGVLGG--PIPADRTTPPYELPDALGDLATT
MAV_2063|M.avium_104 AIKTETILGAKMLELTPRGDGRLSG--VIPLERTTSPYDLPDALGDLTTT
MAB_4151c|M.abscessus_ATCC_199 AIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGAS
Mb0177|M.bovis_AF2122/97 AIRTDTILGRKVLEIEPRGAQALPPGGVLPVGQSTTPYQIYDAFFDVTKA
MLBr_02591|M.leprae_Br4923 GIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATKV
.*:. :** * :.: . * : :* :: .** .*: *
MMAR_4053|M.marinum_M ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
MUL_3920|M.ulcerans_Agy99 ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
Rv1968|M.tuberculosis_H37Rv ISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLRS
MSMEG_0348|M.smegmatis_MC2_155 VENLNTDDLSAALDTMAQTFAGTPPDVKIAVAGVARLSETINKRDTELRN
Mflv_0650|M.gilvum_PYR-GCK ISGLDTGQLSASLAVLSQTLQDTPDDLRFAVAGIARFSETLNQRDAQLRD
Mvan_0515|M.vanbaalenii_PYR-1 ISGLDTGQLSASLAVLSQTLQDTPDDLRFAVAGIARFSETLNQRDAQLRD
TH_3264|M.thermoresistible__bu ISGLDTIGVSDSLATLAETFSGTAPDVQQAVQGLSAFSETIDRRNRHLRE
MAV_2063|M.avium_104 ISGLDTTQLSAALTTLADTLKATPENLKPALQGVARFSDTLNSRDAQLRS
MAB_4151c|M.abscessus_ATCC_199 AGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALEQ
Mb0177|M.bovis_AF2122/97 ASGWDIETVKRSLNVLSETVDQTYPHLSAALDGVAKFSDTIGKRDEQITH
MLBr_02591|M.leprae_Br4923 ASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIKH
. . :. :* .::::. : .. *: *:: :: *:. *: :
MMAR_4053|M.marinum_M LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
MUL_3920|M.ulcerans_Agy99 LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
Rv1968|M.tuberculosis_H37Rv LLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISAV
MSMEG_0348|M.smegmatis_MC2_155 LLANARKATAVLATRTDQVVGLVQDSNALLAELRTQSDALDRVSQDISRA
Mflv_0650|M.gilvum_PYR-GCK LLAHAAKATTVLGERSNDIVRLISDTNAVLAQLRTQSAALDEISTSISAV
Mvan_0515|M.vanbaalenii_PYR-1 LLAHAAKATTVLGERSNDIVRLISDTNAVLAQLRTQSAALDEISTSISAV
TH_3264|M.thermoresistible__bu LLADARKVSDVLGERSEQIVKLVRHSNALLIALQQQSVALDQISHHISLF
MAV_2063|M.avium_104 LLGNANHVSAVLGRRSQQIAGLVANSNALLAALLDERDSLDALMNHLTAV
MAB_4151c|M.abscessus_ATCC_199 LLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQGL
Mb0177|M.bovis_AF2122/97 LLAQANQVASILGDRSDQVDRLLVNAKTLIAAFNERGRAVDALLGNISAF
MLBr_02591|M.leprae_Br4923 LIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAAF
*: .* .: :*. * :: *: . : :: : . ::. : :
MMAR_4053|M.marinum_M GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
MUL_3920|M.ulcerans_Agy99 GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
Rv1968|M.tuberculosis_H37Rv AEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMSL
MSMEG_0348|M.smegmatis_MC2_155 ATQLRGFMADNRQQLRPMLDKLNGVLTIVDNRKDRLQEAVKLLNKYALSL
Mflv_0650|M.gilvum_PYR-GCK SRQLAGFIAENKTTLKPALEKLNGVLAILDNRKAQIQESIKGLAAYAMQF
Mvan_0515|M.vanbaalenii_PYR-1 SRQLAGFIAENKTTLKPALEKLNGVLAILDNRKAQIQESIKGLAAYAMQF
TH_3264|M.thermoresistible__bu ARQTSELVAENRAELRPALDKLNGVLTIVDNRRDRLQETLPLLNKYVMQL
MAV_2063|M.avium_104 SHQISGLVNDNRTQLKPALDKLNGVLEILDNRKEELQKTLPKFKRYAMSF
MAB_4151c|M.abscessus_ATCC_199 SQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTAL
Mb0177|M.bovis_AF2122/97 SAQVQNLINDN-PNLNHVLEQLRILTDLLVDRKEDLAETLTILGRFSASF
MLBr_02591|M.leprae_Br4923 AAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPSL
. * :: :* :. :::* : : ::: : ::: . : :
MMAR_4053|M.marinum_M GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLD-------------
MUL_3920|M.ulcerans_Agy99 GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLD-------------
Rv1968|M.tuberculosis_H37Rv GESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLD-------------
MSMEG_0348|M.smegmatis_MC2_155 GESVGSGPFFKAYIPNLIPGQFSQPFIDAAFSDLGLD-------------
Mflv_0650|M.gilvum_PYR-GCK GETIAAGPFFNAYLANLVPGQFIQPFVDAAFSDLGLD-------------
Mvan_0515|M.vanbaalenii_PYR-1 GETIAAGPFFNAYLANLVPGQFIQPFVDAAFSDLGLD-------------
TH_3264|M.thermoresistible__bu GESVASGPFFKAYIVNLLPGQFLQPFIDAAFSDLGLD-------------
MAV_2063|M.avium_104 GECLGSGPFFKAYVANLVPGQFGGPVLDADMYDRFLD-------------
MAB_4151c|M.abscessus_ATCC_199 GEVVSSGPGFHVNVYGFPP-----ATLTAVAFDTYFQ-------------
Mb0177|M.bovis_AF2122/97 GETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPEDFWRSAGLPAY
MLBr_02591|M.leprae_Br4923 NEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPEF
.* ..:** *:. : .: * . : * . :.
MMAR_4053|M.marinum_M --------------PNVLLPSQRTDPPIGQPGTPP---------------
MUL_3920|M.ulcerans_Agy99 --------------PNVLLPSQRTDPPIGQPGTPP---------------
Rv1968|M.tuberculosis_H37Rv --------------PATLLPSQLTDPPTGQPGTPP---------------
MSMEG_0348|M.smegmatis_MC2_155 --------------PATLLPSQLVDPPVGQPGTPA---------------
Mflv_0650|M.gilvum_PYR-GCK --------------PNVLLPSERTDPQVGQPGTPA---------------
Mvan_0515|M.vanbaalenii_PYR-1 --------------PNVLLPSERTDPQVGQPGTPA---------------
TH_3264|M.thermoresistible__bu --------------PNVLSPSERTDPLTGQAATPA---------------
MAV_2063|M.avium_104 --------------PDQKLPSEVVDPPTGTPPVPP---------------
MAB_4151c|M.abscessus_ATCC_199 --------------PGK-LPASLSDYLNGLIGERQ---------------
Mb0177|M.bovis_AF2122/97 RWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCSYTPPADG---
MLBr_02591|M.leprae_Br4923 RFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGNN
* *
MMAR_4053|M.marinum_M --------------LPLPFPRTGQGGEPHLKLPDAITGNPDDPRYPYREP
MUL_3920|M.ulcerans_Agy99 --------------LPLPFPRTGQGGEPHRKLPDAITGNPDDPRYPYREP
Rv1968|M.tuberculosis_H37Rv --------------LPMPYPRTGQGGEPRLTLPDAITGNPGDPRYPYRPE
MSMEG_0348|M.smegmatis_MC2_155 --------------LPVPYPRTGQGGEPRLNLPDAITGNPGDPRYPYREP
Mflv_0650|M.gilvum_PYR-GCK --------------LPIPYPRTGQGGDPKLTLPDAITGNPGDPRYPYRES
Mvan_0515|M.vanbaalenii_PYR-1 --------------LPIPYPRTGQGGDPKLTLPDAITGNPGDPRYPYRES
TH_3264|M.thermoresistible__bu --------------LPVPYPRTGQGGEPHLTLPDAITGKPGDPRYPYREP
MAV_2063|M.avium_104 --------------ENAPVPLWSQ--------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------IMRPKSP-----------------------------
Mb0177|M.bovis_AF2122/97 -------LPRPWDPLPCANLTQGPFGGPDFPAPLDVATSPPNPDGPPPAP
MLBr_02591|M.leprae_Br4923 TIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLLP
.
MMAR_4053|M.marinum_M LPAPP--PGGPPPGPPAPAPPELASIPQPTPSSVLVPAPGEVS---APQT
MUL_3920|M.ulcerans_Agy99 LPAPP--PGGPPPGPPAPAPPELASIPQPTPSSVLVPAPGEVS---APQT
Rv1968|M.tuberculosis_H37Rv PPAPP--PGGPPPGPPAQ-------------------QPGDQP-------
MSMEG_0348|M.smegmatis_MC2_155 PPAPA--PGGPPPGPPAPPVPGLESTPSPTPSPVYVPAPGEPT---TPIP
Mflv_0650|M.gilvum_PYR-GCK VPAPP--PGGPPPGPPAPPPPDQQAPQPPTPSPVVVPAPDEVAPGPTDSS
Mvan_0515|M.vanbaalenii_PYR-1 VPAPP--PGGPPPGPPAPPPPDQQAPQPPTPSPVVVPAPDEVAPGPTDSS
TH_3264|M.thermoresistible__bu LPAPP--PGGPPPGPPAEAPPN-EASDQPSPQPTLVLAPGEPGAPAPSVP
MAV_2063|M.avium_104 PPSPP--PSTPPVRTIPP------------------PSPHEFDQP-----
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0177|M.bovis_AF2122/97 GLPIAGRPGEVPPNVPGTPVPIPQEAPPGARTLPLGPAPGPAPPPAAPGP
MLBr_02591|M.leprae_Br4923 GIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPA---AP---AQDS
MMAR_4053|M.marinum_M AGAGR--------------------------
MUL_3920|M.ulcerans_Agy99 AGAGR--------------------------
Rv1968|M.tuberculosis_H37Rv -------------------------------
MSMEG_0348|M.smegmatis_MC2_155 AGEGR--------------------------
Mflv_0650|M.gilvum_PYR-GCK IPQGRR-------------------------
Mvan_0515|M.vanbaalenii_PYR-1 IPQGRR-------------------------
TH_3264|M.thermoresistible__bu PPPPEAVP-----------------------
MAV_2063|M.avium_104 -------------------------------
MAB_4151c|M.abscessus_ATCC_199 -------------------------------
Mb0177|M.bovis_AF2122/97 PAPPGPGPQLPAPFINPGGTGGSGVTGGSEN
MLBr_02591|M.leprae_Br4923 SAPHEPREQLSAPLINPGGTGGSGGAGGSRN