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SPMRGPGGTRPFRTAAGDVVPESVAEVGYCRLGGVDQWVLIRGRNLANPPLIHLHGGPGFSETRLLRHFN ADLEDRFTVVYWDQRGAGKSFRRGMPRSSMTVEQFLTDLDDLVDMVCARVGREQVVLHGHSWGSLLGVLY ADRHPERVAAYLGTAQIGDAAAAESASYACALAAAEHSGNRRALKALRAIGPPPYPASSVFSERTWLQRL DGQLSPSALWKLRGAVFGGRPESSPLDLINQIRGFRFTMDAMSREASALNLLSAVPALRMPVVFFVGCRD HWVPPATTVAYYDALTAPSKQLLWFDDSGHEPFVDEPATFNRAVVDTVGALITP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1084 | - | - | 100% (335) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_3415 | - | 8e-08 | 32.21% (149) | transcriptional regulator, CadC |
| M. vanbaalenii PYR-1 | Mvan_4733 | - | 6e-06 | 27.78% (144) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0863c | pip | 6e-08 | 23.43% (286) | proline iminopeptidase |
| M. gilvum PYR-GCK | Mflv_4933 | - | 3e-06 | 24.18% (273) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0840c | pip | 6e-08 | 23.43% (286) | proline iminopeptidase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3738c | - | 7e-07 | 27.13% (258) | putative hydrolase alpha/beta fold |
| M. marinum M | MMAR_1997 | - | 8e-09 | 25.55% (274) | hydrolase |
| M. avium 104 | MAV_0868 | - | 1e-09 | 23.97% (292) | proline imino-peptidase |
| M. smegmatis MC2 155 | MSMEG_1576 | - | 1e-08 | 25.84% (267) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_0684 | hpx | 8e-07 | 32.04% (103) | POSSIBLE NON-HEME HALOPEROXIDASE HPX |
| M. ulcerans Agy99 | MUL_3358 | - | 5e-09 | 25.55% (274) | hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1997|M.marinum_M ------------------------MTERKRNLRPVREVTAPSLQFRTIHG
MUL_3358|M.ulcerans_Agy99 ------------------------MTERKRNLRPVREVTAPSLQFRTIHG
Mflv_4933|M.gilvum_PYR-GCK -MSRGAGWLAGAAGVAAVGSAAGVSMARSLRRRVTDEDPHRDEDFELLDA
MSMEG_1576|M.smegmatis_MC2_155 -----------MAGLAAVGTVAGVSIARSLTLRVSKEDPYAGEDFELLDA
MAB_3738c|M.abscessus_ATCC_199 MSNKSNAWLAGVAGLGAVVAVAGVGTARSIGRRR-FDDPYRGENFDLLQT
Mb0863c|M.bovis_AF2122/97 -------------------------------MEGTIAVPGGRVWFQRIGG
Rv0840c|M.tuberculosis_H37Rv -------------------------------MEGTIAVPGGRVWFQRIGG
MAV_0868|M.avium_104 ----------------------------------MVAVPGGQVWFQRTGG
TH_0684|M.thermoresistible__bu ------------------------------------VEQMPPGRVVSVTA
Mvan_1084|M.vanbaalenii_PYR-1 ---------------MSPMRGPGGTRPFRTAAGDVVPESVAEVGYCRLGG
MMAR_1997|M.marinum_M YKR---------AFRIAGSGP-----AILLIHGIGDNSTTWTGIHAKLAQ
MUL_3358|M.ulcerans_Agy99 YKR---------AFRIAGSGP-----AILLIHGIGDNSTTWTGIHAKLAQ
Mflv_4933|M.gilvum_PYR-GCK DRSCVVTTSDGVPLAVREVGPEDAPLTVVFAHGFCLRMGSFHFQRVRLTE
MSMEG_1576|M.smegmatis_MC2_155 DRSSVITTDDGVPLAVREVGPKDAKLTVVFAHGFCLRMSAFHFQRARLAE
MAB_3738c|M.abscessus_ATCC_199 DRGSIVTTDDGVPLAVREVGPSNAPLTVVFVHGFCLQMASFHFQRRELAS
Mb0863c|M.bovis_AF2122/97 GPG--------RPLLVVHGGPG-------LPHNYLAPLRRLSDER-----
Rv0840c|M.tuberculosis_H37Rv GPG--------RPLLVVHGGPG-------LPHNYLAPLRRLSDER-----
MAV_0868|M.avium_104 GAG--------LPLLVIHGGPG-------LPHDYLRSLRRLATDR-----
TH_0684|M.thermoresistible__bu PDG--------VRLHAEVFGPADAP-PIVLAHGITCAIRVWAHQIAELAD
Mvan_1084|M.vanbaalenii_PYR-1 VDQ---------WVLIRGRNLANPPLIHLHGGPGFSETRLLRHFNADLED
. .
MMAR_1997|M.marinum_M RF----TVIAPDLLGHGRS-DKPR--ADYSIAAYANGMRDLLSVLDIER-
MUL_3358|M.ulcerans_Agy99 RF----TVIAPDLLGHGRS-DKPR--ADYSIAAYANGMRDLLSVLDIER-
Mflv_4933|M.gilvum_PYR-GCK HWGAQVRMVFFDQRGHGQSGDAPP--ETYTVEQLGRDLEAVLAVMAPKGP
MSMEG_1576|M.smegmatis_MC2_155 QWGDQVRMVFYDQRGHGRSGEAPP--DTYTVEQLGRDLESVLAVTAPRGP
MAB_3738c|M.abscessus_ATCC_199 RWGDNVRMVFYDQRGHGRSGLPAP--ASCTVGQLGDDLESVLRVLVPRGN
Mb0863c|M.bovis_AF2122/97 ------EVIFWDQLGCGNSACPSDV-DLWTMNRSVAEMATVAEALALTR-
Rv0840c|M.tuberculosis_H37Rv ------EVIFWDQLGCGNSACPSDV-DLWTMNRSVAEMATVAEALALTR-
MAV_0868|M.avium_104 ------EVIFWDQLGCGNSKCPPNP-GLWTMERSVAEVDAVVRALRLDR-
TH_0684|M.thermoresistible__bu DY----RVIAFDHRGHGRSSVPRRR-WQYSLDHLASDLDAVLDATLDPGE
Mvan_1084|M.vanbaalenii_PYR-1 RF----TVVYWDQRGAGKSFRRGMPRSSMTVEQFLTDLDDLVDMVCARVG
:: * * *.* :: : :
MMAR_1997|M.marinum_M ---VTIIGHSLGGGVAMQFAY-QFPQLVDRLILVGAGGVTKDVNVVFRLA
MUL_3358|M.ulcerans_Agy99 ---VTIIGHSLGGGVAMQFAY-QFPQLVDRLILVGAGGVTKDVNVVFRLA
Mflv_4933|M.gilvum_PYR-GCK ---VVLVGHSMGGMAVLSHAR-QYPQRYPTRVVGAALISSAAEGVARSPV
MSMEG_1576|M.smegmatis_MC2_155 ---VVLVGHSMGGMTVLSHAR-QFPQRYPARIVGAALISSAAEGVDRSPL
MAB_3738c|M.abscessus_ATCC_199 ---AVLVGHSMGGMTVLAHAR-RHPEQYGRRIVGVGLIASAAEGLSHTAI
Mb0863c|M.bovis_AF2122/97 ---FHIFSHSWGGMLAQQYVLDKAPD-AVSLTIANSTASIPEFSASLVSL
Rv0840c|M.tuberculosis_H37Rv ---FHIFSHSWGGMLAQQYVLDKAPD-AVSLTIANSTASIPEFSASLVSL
MAV_0868|M.avium_104 ---FHLFGNSWGGMLAQQYVLDAAPAGAASLTISNSIASIPQFGKMVARL
TH_0684|M.thermoresistible__bu R--AVIAGHSMGGIAISSWAE-RYPERVSERAAAVALINTTTGDLLHNVQ
Mvan_1084|M.vanbaalenii_PYR-1 REQVVLHGHSWGSLLGVLYAD-RHPERVAAYLGTAQIGDAAAAES--ASY
: .:* *. . *
MMAR_1997|M.marinum_M SLPMGAEALALLRLP-MVLPTVQLAGKVLGMALGSTALGQDLPNVLRILD
MUL_3358|M.ulcerans_Agy99 SLPMGAEALALLRLP-MVLPTVQLAGKVLGMALGSTALGQDLPNVLRILD
Mflv_4933|M.gilvum_PYR-GCK GEILKNPALEAVRFTARYAPKLVHRGRGAARSVIGPILRAASYGDEKISP
MSMEG_1576|M.smegmatis_MC2_155 GEILRNPALEAVRFSARYAPKLVHRTRGAARSLIAPILQAGSFGDEQVSP
MAB_3738c|M.abscessus_ATCC_199 GEGLRNPALRVLRTAVHYAPGPAHHGRGAIKSLVGPVLQAASYGGHRVSP
Mb0863c|M.bovis_AF2122/97 KSCLDVATRSAIDRHEAAGTTHSAEYQAAIRTWNETYLCRTRPWPRELTE
Rv0840c|M.tuberculosis_H37Rv KSCLDVATRSAIDRHEAAGTTHSAEYQAAIRTWNETYLCRTRPWPRELTE
MAV_0868|M.avium_104 KSELDPATQAAIDRHEAAGTTHDPEYQAAIRTWNETYLCRVRPWPRDLED
TH_0684|M.thermoresistible__bu LLPVPDRFAAVRVRTASAVIKTVAGMPARLAAVPSRYVVSMMAVGRDADP
Mvan_1084|M.vanbaalenii_PYR-1 ACALAAAEHSGNRRALKALRAIGPPPYPASSVFSERTWLQRLDG-QLSPS
:
MMAR_1997|M.marinum_M DLPEPTASSAFTRTLRAVVDWRGQIV----TMLDRCYLT-----------
MUL_3358|M.ulcerans_Agy99 DLPEPTASSAFTRTLRAVVDWRGQIV----TMLDRCYLT-----------
Mflv_4933|M.gilvum_PYR-GCK SVVAFSERMMHDTPIATLVEFLHALE----VHDETAGLETL---------
MSMEG_1576|M.smegmatis_MC2_155 SVAAFAADMMHGTPIPTLVEFLHALE----VHDETAALDVL---------
MAB_3738c|M.abscessus_ATCC_199 TLVKFSERMIHQTPVTTIVDFLRALE----QHDETAALPTI---------
Mb0863c|M.bovis_AF2122/97 AFANMGTEIFETMFGPSDFRIVGNVR----DWDVVDRLA-D---------
Rv0840c|M.tuberculosis_H37Rv AFANMGTEIFETMFGPSDFRIVGNVR----DWDVVDRLA-D---------
MAV_0868|M.avium_104 AFRKMSAEVFETMFGASDFHIVGTVR----DWDVFDRLG-E---------
TH_0684|M.thermoresistible__bu AITNFVHELFTETPPAARDGWARTLV----DAMGPRHIGLHN--------
Mvan_1084|M.vanbaalenii_PYR-1 ALWKLRGAVFGGRPESSPLDLINQIRGFRFTMDAMSREASALNLLSAVPA
. : :
MMAR_1997|M.marinum_M QAIPVQIIWGSRDAVVPVRHAEMAHAAMPGS---KLEVFEGSGHFPFHDD
MUL_3358|M.ulcerans_Agy99 QAIPVQIIWGSRDAVVPVRHAEMAHAAMPGS---KLEVFEGSGHFPFHDD
Mflv_4933|M.gilvum_PYR-GCK RRVPTLVACGDRDLLTPKEYSQEMADVLAKS---ELVIVPGAGHLVQLEC
MSMEG_1576|M.smegmatis_MC2_155 AGVPTLIACGDRDLLTPVEYSREMAERLPKS---ELVVVGGAGHLVQLEE
MAB_3738c|M.abscessus_ATCC_199 APLPSLVICGDTDMLTPHTQSESMAARLAASGHNELILVRESGHLVQLEH
Mb0863c|M.bovis_AF2122/97 IAVPTLLVVGRFDECSP-EHMREMQGRIAGS---RLEFFESSSHMPFIEE
Rv0840c|M.tuberculosis_H37Rv IAVPTLLVVGRFDECSP-EHMREMQGRIAGS---RLEFFESSSHMPFIEE
MAV_0868|M.avium_104 IAVPTLVLAGRYDECVP-EHMWEMHRRIPGS---RFELFESSAHMPFIEE
TH_0684|M.thermoresistible__bu LTVPTLVIGSDRDRLLPLVSSRRIAEAAPNLF--DFVELPG-GHCAILEC
Mvan_1084|M.vanbaalenii_PYR-1 LRMPVVFFVGCRDHWVPPATTVAYYDALTAPS-KQLLWFDDSGHEPFVDE
:* . . * * . : . .* :
MMAR_1997|M.marinum_M PARFIDIVLRFIDSTQPPEYDQAALRELLRTGGGERTVSGPADTRVAVLS
MUL_3358|M.ulcerans_Agy99 PARFIDIVLRFIDSTQPPEYDQAALRELLRTGGGERTVSDPADTRVAVLS
Mflv_4933|M.gilvum_PYR-GCK PEVINDALVRLVERATPSKLTALTRRVTQRVRSDD---------------
MSMEG_1576|M.smegmatis_MC2_155 PEVINDALIRLVERATPSKLVALARRVRNRVRPHG---------------
MAB_3738c|M.abscessus_ATCC_199 PEIVNDGIDRLVRRSTPPLFAAIKQRLRDRTGL-----------------
Mb0863c|M.bovis_AF2122/97 PARFDRVMREFLRLHDI---------------------------------
Rv0840c|M.tuberculosis_H37Rv PARFDRVMREFLRLHDI---------------------------------
MAV_0868|M.avium_104 PEKFDAVMRDFLRLHD----------------------------------
TH_0684|M.thermoresistible__bu PDRVNDHLRALAAAAADARRATS---------------------------
Mvan_1084|M.vanbaalenii_PYR-1 PATFNRAVVDTVGALITP--------------------------------
* . :
MMAR_1997|M.marinum_M AMGSDERSAT
MUL_3358|M.ulcerans_Agy99 AMGSDERSAT
Mflv_4933|M.gilvum_PYR-GCK ----------
MSMEG_1576|M.smegmatis_MC2_155 ----------
MAB_3738c|M.abscessus_ATCC_199 ----------
Mb0863c|M.bovis_AF2122/97 ----------
Rv0840c|M.tuberculosis_H37Rv ----------
MAV_0868|M.avium_104 ----------
TH_0684|M.thermoresistible__bu ----------
Mvan_1084|M.vanbaalenii_PYR-1 ----------