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TTEVASTTVTATDGVRLAVHTYTGIDPARPTVLAIHGYPDNHHVWDGVAAALRRRFNVVAYDVRGAGQSS TPPERSGYRLEQLVADVDAVIGRLGVDSVHLLAHDWGSIQGWAAVTDESVMGKIASFTSISGPHLNYAGR FLRSARTPGGVLDVVKQILASSYIWFFLAPGAPEWAIRSGATVKVFEAVERIGSTTAGAQRGAGYRSTDD YLNGLNLYRANMPGPILSPPARLPQTSVPVQVLVARRDYFVSPALQRFTGSIPDGSRVVPIDGGHWVVNS HPDVIARLTGDWVDLTTRPAGGHHTGQT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4120 | - | - | 100% (309) | hydrolase, alpha/beta fold family protein, putative |
| M. avium 104 | MAV_3670 | - | e-110 | 66.11% (301) | short chain dehydrogenase |
| M. avium 104 | MAV_2275 | - | 2e-32 | 32.65% (294) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 7e-36 | 35.48% (310) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2937 | - | 5e-29 | 30.51% (295) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 7e-36 | 35.48% (310) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 7e-34 | 33.44% (305) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4019c | - | 2e-38 | 34.91% (275) | short chain dehydrogenase |
| M. marinum M | MMAR_1932 | ephD_1 | 1e-110 | 66.10% (295) | short-chain dehydrogenase EphD_1 |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 6e-37 | 35.45% (299) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 8e-32 | 32.33% (300) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3574 | ephD | 2e-32 | 33.12% (308) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3576 | - | 4e-27 | 31.38% (290) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2237c|M.bovis_AF2122/97 ----MPATQ---QMSR-LVDSPDGVRIAVYHEG--NPDGPTVVLVHGFPD
Rv2214c|M.tuberculosis_H37Rv ----MPATQ---QMSR-LVDSPDGVRIAVYHEG--NPDGPTVVLVHGFPD
MUL_3574|M.ulcerans_Agy99 ----MPATK---QAPQQFVDSAGGVRIAVYEEG--NPDSPTVVLVHGFPD
MLBr_00862|M.leprae_Br4923 ----MPATQSIHKVPHQFVESPDGVRLAIYQSG--QPEGPAIVLVHGFPD
TH_4323|M.thermoresistible__bu ------------MATEHFIDSSGGVRIAAYEEG--NPDGPTVVLVHGWPD
Mflv_2937|M.gilvum_PYR-GCK ------------MSSQRFVVSRDGVRIAVYEEG--AADGPTVVLVHGHAD
Mvan_3576|M.vanbaalenii_PYR-1 ------------MSTQRFVESSDGVRIAVSEQG--NPDGPTLVLVHGLRD
MSMEG_4280|M.smegmatis_MC2_155 --------------MYTFVTSQDGTRIAVYQQG--DPERPTLVMAHGWPD
MAB_4019c|M.abscessus_ATCC_199 MTLTTERDGVTNGGMTEHVVRNGDIDVAYFMQG--NPEGETILLVHGWPD
MAV_4120|M.avium_104 ---------MTTEVASTTVTATDGVRLAVHTYTGIDPARPTVLAIHGYPD
MMAR_1932|M.marinum_M ----------MNTASRTGITASDGATLAVYHYTPLDPQRPTILAIHGWPD
: .. :* . ::: ** *
Mb2237c|M.bovis_AF2122/97 SHVLWDGVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAV
Rv2214c|M.tuberculosis_H37Rv SHVLWDGVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAV
MUL_3574|M.ulcerans_Agy99 SHVLWDGVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAV
MLBr_00862|M.leprae_Br4923 SHVLWDGVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAV
TH_4323|M.thermoresistible__bu SHVVWDSVAPLLADRFRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAV
Mflv_2937|M.gilvum_PYR-GCK THEAWDAVVALLAARFRIVRYDTRGAGRSAAPQRTSGFRLERYADDLAAV
Mvan_3576|M.vanbaalenii_PYR-1 THRVWDPVVALLADRFRIVAYDTRGAGNSGAPKQTSAYTVDRFADDFAAV
MSMEG_4280|M.smegmatis_MC2_155 SHVLWDGVVGELGDRYRIVRYDNRGAGASDVPKATSAYTMERFADDFSAV
MAB_4019c|M.abscessus_ATCC_199 SHHLWDGVAPLLRDRFRLVAIDNRGAGKSSNPKSFRDFRLTEMASDYVAV
MAV_4120|M.avium_104 NHHVWDGVAAALRRRFNVVAYDVRGAGQSSTPPERSGYRLEQLVADVDAV
MMAR_1932|M.marinum_M NHHLWDPVAELLGDRYNVVAYDVRGSGESSCPASRSGYRLEQLVSDTGAV
.* ** *. * *:.:: * ** * : * . . * **
Mb2237c|M.bovis_AF2122/97 IGELSPGEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLV
Rv2214c|M.tuberculosis_H37Rv IGELSPGEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLV
MUL_3574|M.ulcerans_Agy99 IEALSPGQPVHVLGHDWGSVAIWDYLTRSGAADRVASFTSVSGPSQDQLV
MLBr_00862|M.leprae_Br4923 IDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLV
TH_4323|M.thermoresistible__bu IDALAPGQRVHVLAHDWGSAGVWEYLARPEAEDRIASFTSVSGPSGDHLA
Mflv_2937|M.gilvum_PYR-GCK LDAVSAEAPVHVLAHDRGSAGVWRYLARPESRGRLASFTSVSGPAPEHVA
Mvan_3576|M.vanbaalenii_PYR-1 AAAVGGDTPVHVLAHGWGAAGVWQYLKRADAPERVASLTSVSGPSPEHVA
MSMEG_4280|M.smegmatis_MC2_155 IDAVSPDAPVHVLAHDWGSVGIWEYLSRQGSAARMVSFTSVSGPSTDHYG
MAB_4019c|M.abscessus_ATCC_199 ADAVSPDKPVHVLGHDWGSVAMWEAICDPELEHRFSSFTSVSGPSAHHMS
MAV_4120|M.avium_104 IGRLGVDS-VHLLAHDWGSIQGWAAVTDESVMGKIASFTSISGPHLNYAG
MMAR_1932|M.marinum_M IDSLGVDR-VHLLAHDWGSIQGWAAVTADSVMEKVASFTSISGPHLQYAG
:. **:*.*. *: * : :. *:**:*** .
Mb2237c|M.bovis_AF2122/97 NYVYGGLRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAA
Rv2214c|M.tuberculosis_H37Rv NYVYGGLRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAA
MUL_3574|M.ulcerans_Agy99 NYIFGGLRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRAS
MLBr_00862|M.leprae_Br4923 DYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSAT
TH_4323|M.thermoresistible__bu RYVLDGLAAPYRPRRFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSKAL
Mflv_2937|M.gilvum_PYR-GCK RYLRDTLARPQHPARFAGGLGHLAR--------------------LAAAA
Mvan_3576|M.vanbaalenii_PYR-1 GYVRAALTSPR---RFVRGAGQLVR--------------------LAAAA
MSMEG_4280|M.smegmatis_MC2_155 AYVRRGLARPYRPVQFARAVNLASRFSYWIPFSIPVLAPALMR---RGAA
MAB_4019c|M.abscessus_ATCC_199 KWVRSRFGNPT-PKNLALALGQIGSLLYMFGSMTPVIPNVLLKLTMNERR
MAV_4120|M.avium_104 RFLRS----ARTPGGVLDVVKQILASSYIWFFLAPGAPEWAIRSGATVKV
MMAR_1932|M.marinum_M AFLRS----GRTPRSVAQVARQLASSGYIGFFLCPVVPELFFRSGIGVKL
:: .
Mb2237c|M.bovis_AF2122/97 VR--RNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAI
Rv2214c|M.tuberculosis_H37Rv VR--RNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAI
MUL_3574|M.ulcerans_Agy99 VR--RNMVDNLPLDQIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGV
MLBr_00862|M.leprae_Br4923 IR--RTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGV
TH_4323|M.thermoresistible__bu RRS-LRLRDGVPADRLHHSDTFAADAARSIKVYGANFLRTLRHARTDH--
Mflv_2937|M.gilvum_PYR-GCK PR------------------------AVTDKTLRANLFPVS----SGGDA
Mvan_3576|M.vanbaalenii_PYR-1 PR------------------------AATAKPYRANLRPAA----PAG--
MSMEG_4280|M.smegmatis_MC2_155 RR----LQAIDTPGPKFQSENLDIDAANSLKIYRANAIRSFTHVRRDH--
MAB_4019c|M.abscessus_ATCC_199 WRTGLSLAEGAPVEDIHLGSTFMSDITRTLRVYRANALPAMLHPQDRH--
MAV_4120|M.avium_104 FEAVERIGSTTAGAQRGAGYRSTDDYLNGLNLYRANMPGPILSPPARLP-
MMAR_1932|M.marinum_M VGAFERIGQSSTRSQRGQTPRSIGDYVNALNLYRANMPAGFVTDGSSLP-
. **
Mb2237c|M.bovis_AF2122/97 PIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQ
Rv2214c|M.tuberculosis_H37Rv PIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQ
MUL_3574|M.ulcerans_Agy99 PVIDVPVQLIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQ
MLBr_00862|M.leprae_Br4923 PVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQ
TH_4323|M.thermoresistible__bu -FVRVPVQLIVNTRDPYVRPHVYDETDRWVSRLWRRDIKAGHWSPMSHPQ
Mflv_2937|M.gilvum_PYR-GCK HDVDIPVQLIVGSADPYPDPHLFEDRAGRPARLWRRDVKAGHVTPTSHPG
Mvan_3576|M.vanbaalenii_PYR-1 VPVDVPVQLIVPDHDPHVGPHVYDGMSASVSRLWRRDIKTGDLSPGSHPQ
MSMEG_4280|M.smegmatis_MC2_155 -YVQVPVQLICNRKDPVVRGEGYRDESKWVPLLWRRDLDAGHWAPFSHPR
MAB_4019c|M.abscessus_ATCC_199 --TRVPVQVIVGTRDPAVRQSNYDDELKWNQQTWRRVLDGGHWLPFSHPQ
MAV_4120|M.avium_104 -QTSVPVQVLVARRDYFVSPALQRFTGSIPDGSRVVPIDGGHWVVNSHPD
MMAR_1932|M.marinum_M -QTSVPVQVLVPRKDMFVTPALQRFTGAIPGGGRVVPIEGGHWVVTSRPD
:***:: * :. *. *:*
Mb2237c|M.bovis_AF2122/97 VMAAAVHDFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGR
Rv2214c|M.tuberculosis_H37Rv VMAAAVHDFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGR
MUL_3574|M.ulcerans_Agy99 VMAAAVHDFADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGR
MLBr_00862|M.leprae_Br4923 VMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGR
TH_4323|M.thermoresistible__bu VLATAVTELADHLAGAPAGRALLRAQVGRPREYFGDMLVAITGAGGGIGR
Mflv_2937|M.gilvum_PYR-GCK ILARALTQLVDHLDGAPAARELLRAQVGRPRKAFGDTLVAVTGAASGIGR
Mvan_3576|M.vanbaalenii_PYR-1 VLARAVDQLVDHLGGAPAPRELLRAQVGRARKVFGDTLVSVTGAASGIGR
MSMEG_4280|M.smegmatis_MC2_155 AIAQAVGEFVDHMEGAPPARALRRAEVARPRKAFSDMLVSVTGAASGIGR
MAB_4019c|M.abscessus_ATCC_199 VLAAATAELIDAVSGNQPGRGLRRAEMGKSRRPFEDQLVVITGGGSGIGR
MAV_4120|M.avium_104 VIARLTGDWVD-----------LTTRPAGGH--HTGQT------------
MMAR_1932|M.marinum_M VVARLTADWVDRVVAGTGDAAATVVRAGPGE--VRGQLALVTGAGAGIGR
:* : * .. . . .
Mb2237c|M.bovis_AF2122/97 ETALAFAREG-AEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEA
Rv2214c|M.tuberculosis_H37Rv ETALAFAREG-AEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEA
MUL_3574|M.ulcerans_Agy99 ETALAFAREG-AEVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEA
MLBr_00862|M.leprae_Br4923 ETALALARRG-AEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAA
TH_4323|M.thermoresistible__bu ETALAFAREG-AEVIVSDIDEATAKDTAAEIAARGGVAHAYQLDVSDAAA
Mflv_2937|M.gilvum_PYR-GCK ATALAFAHHG-ADVVISDVNAAGLDETARLVTSAGVHAYPYTVDVADAAA
Mvan_3576|M.vanbaalenii_PYR-1 ETALAFARAG-ADVVISDVDEAGLEQTARLVTAAGAAAHSYTVDVADAAA
MSMEG_4280|M.smegmatis_MC2_155 ATALEFARLG-AEIVVSDIDEAGAKATATAIDEAGGVAHAYGLDVADPDA
MAB_4019c|M.abscessus_ATCC_199 ETALEFARQG-AEVVLSDVNLDGANETVSLIEQSGGVAHAYRLNVADEEA
MAV_4120|M.avium_104 --------------------------------------------------
MMAR_1932|M.marinum_M ATAVELARQGARMVIIADRDLAAANESATQVRAAGAAAAVYQVDVSDETA
Mb2237c|M.bovis_AF2122/97 VEAFAERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVV
Rv2214c|M.tuberculosis_H37Rv VEAFAERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVV
MUL_3574|M.ulcerans_Agy99 VEAFADQVSATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLGGVV
MLBr_00862|M.leprae_Br4923 VEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVV
TH_4323|M.thermoresistible__bu VDRFADEVCARHGVPDIVVNNAGIGHAGRFLDTPRDQWDRVLEVNLGGVV
Mflv_2937|M.gilvum_PYR-GCK VEAFAEQVCAEHGVPDVVVNNAGVGHAGFFLDTPAEEFDRVLDINFGGVV
Mvan_3576|M.vanbaalenii_PYR-1 VEAMAELVCAAHGVPDIVVNNAGVGHAGFFLDTPAEEFDRVLGINFGGVV
MSMEG_4280|M.smegmatis_MC2_155 VQRFVDDVCATHGVPDIVVNNAGIGHAGNFLDTPADQYERVLEVNFGGVV
MAB_4019c|M.abscessus_ATCC_199 VNAHAEEVVKRHGVPDVLVNNAGVGAAGGFLDTPSEEFRRVIETNLFGVV
MAV_4120|M.avium_104 --------------------------------------------------
MMAR_1932|M.marinum_M MNDLAAQVLDEHGVVDILVNNAGIGMAGRFLETTPQHWDAILGINVGGVI
Mb2237c|M.bovis_AF2122/97 NGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDC
Rv2214c|M.tuberculosis_H37Rv NGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDC
MUL_3574|M.ulcerans_Agy99 NGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDC
MLBr_00862|M.leprae_Br4923 NCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDC
TH_4323|M.thermoresistible__bu NGCRAFAPRLVERGTGGHIVNIASMASYAPLQSLNAYCTSKAAVYMFSDC
Mflv_2937|M.gilvum_PYR-GCK NGCRSFGKRLADRGVGGHIVNVASMASYTPVNVMNAYCTSKAAVFMFSDC
Mvan_3576|M.vanbaalenii_PYR-1 NGCRSWGRRLVDRGTGGHIVNVASMASYTPVNVMNAYCTSKAAVFMFSDC
MSMEG_4280|M.smegmatis_MC2_155 NCCRAFGRRLVEQGTGGHIVNVASMAAYSPAGSMNAYATSKAAVFMFSDC
MAB_4019c|M.abscessus_ATCC_199 NGSRAFGAKMAERGLGGHIVNLSSMAAYSPQKAFTAYSTSKSAVFMFSDC
MAV_4120|M.avium_104 --------------------------------------------------
MMAR_1932|M.marinum_M SGSRAFGAQMVERGQGGTIINIASAAAYLPSKSMVAYSTTKAAVLGFSEA
Mb2237c|M.bovis_AF2122/97 LRAELDAAGVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQIDK
Rv2214c|M.tuberculosis_H37Rv LRAELDAAGVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQIDK
MUL_3574|M.ulcerans_Agy99 LRAELDAADVGLTTICPGVINTNIVNTTRFDAPPGKGGDQLDGRRGQIDK
MLBr_00862|M.leprae_Br4923 LRAELDAVGVGLTTICPGVIDTNIIQSTRIDTP-TAKQERVRDRRGQLDM
TH_4323|M.thermoresistible__bu LRAELDSAGIMLTTICPSTVNTNIIGSTRFNAP-DGLDDVVDTRREQLQK
Mflv_2937|M.gilvum_PYR-GCK LRAELDSFGIGLTTICPGFISTNIVDTTRFSLA-QGRDDDVDVLRGRAQK
Mvan_3576|M.vanbaalenii_PYR-1 LRAELDSAGIGVTTICPGVIGTNIVDTTRFSLP-EARRDDAESIRRRARQ
MSMEG_4280|M.smegmatis_MC2_155 LRAELAHAGIGVTTLCPGMIDTGIVDTTRFDVP-AHKAGQVEARRAQVKK
MAB_4019c|M.abscessus_ATCC_199 LRADLAAHNIGVTTICPGVVHTNIVATTKISGV---SADEEARMQQAGDR
MAV_4120|M.avium_104 --------------------------------------------------
MMAR_1932|M.marinum_M LRADLADEGISVTAVCPGFVNTNIAKSTVYAGM---STEQQERARQKADA
Mb2237c|M.bovis_AF2122/97 MFALRSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRST
Rv2214c|M.tuberculosis_H37Rv MFALRSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRST
MUL_3574|M.ulcerans_Agy99 MFALRSYGPDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRST
MLBr_00862|M.leprae_Br4923 MFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRST
TH_4323|M.thermoresistible__bu LFALRRFGPDKAAKAIVSAVKQNKPIRPVMPEAYFVYGVSRVLPQALRST
Mflv_2937|M.gilvum_PYR-GCK GFSARKYGPEKVADAIVDAVRTNKAIRPVAPEARFVYGVAHALPQVLRST
Mvan_3576|M.vanbaalenii_PYR-1 GFAVRRVGPDKVAKAIVAAVQKNKPVRPVTTEAYLVYGVAHALPQAMRSA
MSMEG_4280|M.smegmatis_MC2_155 TFQARRYGPEKVAKAVTSAVSRNQALRPVTPEAYVAYGVSRLFPAALRRA
MAB_4019c|M.abscessus_ATCC_199 AYAMRRYGPEKVARQIVGAVRKNKQVVPVTPEARLQYLNNRLAPGLTRYF
MAV_4120|M.avium_104 --------------------------------------------------
MMAR_1932|M.marinum_M AYRRRNFTPEATARAIVKAIRSGPAVLPVAAESKVGYAMRRISPSMIRMF
Mb2237c|M.bovis_AF2122/97 ARLRVI-----------
Rv2214c|M.tuberculosis_H37Rv ARLRVI-----------
MUL_3574|M.ulcerans_Agy99 ARMRVI-----------
MLBr_00862|M.leprae_Br4923 ARIRVI-----------
TH_4323|M.thermoresistible__bu ARGRVL-----------
Mflv_2937|M.gilvum_PYR-GCK ARGGNFV----------
Mvan_3576|M.vanbaalenii_PYR-1 ARGGNIM----------
MSMEG_4280|M.smegmatis_MC2_155 ARSQVL-----------
MAB_4019c|M.abscessus_ATCC_199 ATKAGMTDLIKLVPNKK
MAV_4120|M.avium_104 -----------------
MMAR_1932|M.marinum_M ARLDIRQR---------