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NDERRAVYTHGHHESVLRGHRQRTVANSAGYLSPHLRAGLSVLDIGCGPGTITVDLAARVAPGTVTAVEP TDAALNLGRAEAQRCDVSNVAFVTSDVHALDFPDDVFDVVHAHQVLQHVADPVQALREMKRVGAPGGLVA ARDADYAGFIWYPQLPALDHWLQLYQRAARANGGEPDAGRRLLSWARQAGFADITPTGSMWCYATDEMRA WWGGMWADRILRSDLSAQLLGSGMASAADLEAISQAWRDWAAAPDGWLGIPNGEILCRV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0368 | - | - | 100% (270) | hypothetical protein MUL_0368 |
| M. ulcerans Agy99 | MUL_1293 | - | 1e-09 | 32.14% (112) | transcriptional regulatory protein |
| M. ulcerans Agy99 | MUL_4668 | - | 4e-09 | 31.82% (110) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0862 | - | 1e-124 | 75.84% (269) | hypothetical protein Mb0862 |
| M. gilvum PYR-GCK | Mflv_2768 | - | 3e-09 | 31.13% (106) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv0839 | - | 1e-124 | 75.84% (269) | hypothetical protein Rv0839 |
| M. leprae Br4923 | MLBr_01723 | - | 5e-08 | 27.94% (136) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_4742c | - | 8e-11 | 27.32% (183) | hypothetical protein MAB_4742c |
| M. marinum M | MMAR_4799 | - | 1e-157 | 97.78% (270) | hypothetical protein MMAR_4799 |
| M. avium 104 | MAV_0854 | - | 1e-116 | 71.38% (269) | methyltransferase-UbiE family protein |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 3e-12 | 44.23% (104) | methyltransferase |
| M. thermoresistible (build 8) | TH_2189 | - | 2e-08 | 26.81% (138) | CONSERVED HYPOTHETICAL PROTEIN |
| M. vanbaalenii PYR-1 | Mvan_0109 | - | 4e-10 | 38.46% (104) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0368|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4799|M.marinum_M --------------------------------------------------
Mb0862|M.bovis_AF2122/97 --------------------------------------------------
Rv0839|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
TH_2189|M.thermoresistible__bu VIRRLMATALTALTTAVLAGCGDAGSWVEAKPAEGWSAQYGDAANSSYTS
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2768|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4742c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_0368|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4799|M.marinum_M --------------------------------------------------
Mb0862|M.bovis_AF2122/97 --------------------------------------------------
Rv0839|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
TH_2189|M.thermoresistible__bu AAGAEALTLEWSRSVKGELAAQVAVGASGYLAVNAQTPAGCSLMVWEYAN
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2768|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4742c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_0368|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4799|M.marinum_M --------------------------------------------------
Mb0862|M.bovis_AF2122/97 --------------------------------------------------
Rv0839|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
TH_2189|M.thermoresistible__bu SARQRWCTRLVQGGGRTSPLLDGFDNVYIGQPGAILSFPPTQWIRWRKPV
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2768|M.gilvum_PYR-GCK --------------------------------------------MTTLAE
MAB_4742c|M.abscessus_ATCC_199 --------------------------------------------MTAPSA
MUL_0368|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4799|M.marinum_M --------------------------------------------------
Mb0862|M.bovis_AF2122/97 --------------------------------------------------
Rv0839|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
TH_2189|M.thermoresistible__bu IGMPTTPRILAPGELLVVTHLGQVLLFDAHRGTVTGTPLDLVAGVDPTDS
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2768|M.gilvum_PYR-GCK NSAPSSETTEEFAQRIVGALDAASLALLVSIGHQTHLFDTMANLPPSTST
MAB_4742c|M.abscessus_ATCC_199 NPVP--ETTEEFSERLTAAIDNAALVLLMSIGHQTGLLDTLAASAGSTSE
MUL_0368|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4799|M.marinum_M --------------------------------------------------
Mb0862|M.bovis_AF2122/97 --------------------------------------------------
Rv0839|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 ------------------------------------------MTRSTEIS
TH_2189|M.thermoresistible__bu ERGLADCAGARXXXCWPPPRPPSTVTPRARDAARHPTARLPAMTETTEPG
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------MDTALRRAMDLL
Mvan_0109|M.vanbaalenii_PYR-1 -------------------------------------MTHTVLRMTERLL
Mflv_2768|M.gilvum_PYR-GCK QIADAAGLNERYVREWLGGVAAGRIVDYDPAAQTFSLPAHRAAVLTRTAG
MAB_4742c|M.abscessus_ATCC_199 QLADAAGLEERYVREWLAGMTVAHVVDYEPVSAIYTLPSHRAATLTREAG
MUL_0368|M.ulcerans_Agy99 -------------------------------------MNDERRAVYTHGH
MMAR_4799|M.marinum_M -------------------------------------MNDERRAVYTHGH
Mb0862|M.bovis_AF2122/97 -------------------------------------MNDKRRAIYTHGY
Rv0839|M.tuberculosis_H37Rv -------------------------------------MNDKRRAIYTHGY
MAV_0854|M.avium_104 -------------------------------------MNDQHRATYTHGH
MLBr_01723|M.leprae_Br4923 AN-------AVPNPHATAEQVAAARKDSKLAQVLYHDWEAENYDEKWSIS
TH_2189|M.thermoresistible__bu IGSEGAGDLPAPNPHATAEQVEAAMRDSKLAQILYHDWEAESYDDKWSIS
MSMEG_0098|M.smegmatis_MC2_155 ID-------PPAEPDFSKGYLDLLGRGDSTAPKNTGLIQKAWASPLGSKL
Mvan_0109|M.vanbaalenii_PYR-1 ID-------PPEHPDTSKGYLDLLG---DEPDSNRGAIQALWASRLGSMF
Mflv_2768|M.gilvum_PYR-GCK PD-------NLARVTQFIPLLSEVEQKVIACFRDGGGLSYAEYPRFHTLM
MAB_4742c|M.abscessus_ATCC_199 LN-------NLARLAQYLPLLSEVEQKILGCFRRGGGLQYQDYPRFHAVM
.
MUL_0368|M.ulcerans_Agy99 HESVLRGHRQRTVANSAGYLS---PHLRAGLSVLDIGCGPGTITVDLAAR
MMAR_4799|M.marinum_M HESVLRGHRQRTVANSAGYLS---PHLRAGLSVLDIGCGPGTITVDLAAR
Mb0862|M.bovis_AF2122/97 HESVLRSHRRRTAENSAGYLL---PYLVPGLSVLDVGCGPGTITVDLAAR
Rv0839|M.tuberculosis_H37Rv HESVLRSHRRRTAENSAGYLL---PYLVPGLSVLDVGCGPGTITVDLAAR
MAV_0854|M.avium_104 HESVLRSHRRRTAEDSAGYLL---AHLTPGLSVLDVGCGPGTITADLAAR
MLBr_01723|M.leprae_Br4923 YDQRCVDYVRHCFDAIVPDEL---FTELPYDCALELGCGTGFFLLNLIQS
TH_2189|M.thermoresistible__bu YDQRCVDYARGRFDAIVPDHV---QRELPYDNALELGCGTGFFLLNLIQS
MSMEG_0098|M.smegmatis_MC2_155 YDRAQLLNRRLVASTRPPVEW---LRIPPGGTVLDIGCGPGNITAQLAR-
Mvan_0109|M.vanbaalenii_PYR-1 YDNAQTLARRLMTAWQQPTEW---LNVPVGGTALDVGSGPGNVTGALGR-
Mflv_2768|M.gilvum_PYR-GCK AEQSGEVFDAALVDGILPMAEGLTDRLRQGVDVADFGCGSGHAVNVMAKA
MAB_4742c|M.abscessus_ATCC_199 GERSREVFDKALIRTVLPLVEGLPEGLEGGLDVADFGCGSGYAINLMAQA
: . :.*.*.* :
MUL_0368|M.ulcerans_Agy99 VAPGTVTAVEPTDAALNLGRAEAQRCDVSNVAFVTSDVHALDFPDDVFDV
MMAR_4799|M.marinum_M VAPATVTAVEPTDAALNLARAEVQRCDVSNVAFVTSDVHALDFPDDVFDV
Mb0862|M.bovis_AF2122/97 VVPGSVTGVEPTDDALSLARAEAQLHRLSNISFTTSDVHKLDFPDDAFDV
Rv0839|M.tuberculosis_H37Rv VVPGSVTGVEPTDDALSLARAEAQLHRLSNISFTTSDVHKLDFPDDAFDV
MAV_0854|M.avium_104 VAPGQVTAVDQAADVLEVARAEAEQRNLSNVSFGTADVHRLDFADDTFDV
MLBr_01723|M.leprae_Br4923 GVARRGSVTDLSPGMVKIATRNGQSLGLD-INGRVADAEGIPYDDNTFDL
TH_2189|M.thermoresistible__bu GVARRGSVTDLSPGMVRVATRNGRSLGLD-VDGRVADAEGIPYDDNTFDL
MSMEG_0098|M.smegmatis_MC2_155 AAGLDGLALGVDISEPMLARAVAAEAGRQ-VGFVRADAQQLPFRDEVFDA
Mvan_0109|M.vanbaalenii_PYR-1 AVGPGGLALGVDISEPMLARAVRAEAGPN-VGFIRADAQHLPFRDESFDA
Mflv_2768|M.gilvum_PYR-GCK FPASRFTGIDFSEEGLAAGRDEARRLGLTNASFNATDVATYDAA-ESFDV
MAB_4742c|M.abscessus_ATCC_199 FPASRFTGVDFSDEAIATAAADAERLGLRNASFLSADVATLNAP-ATYDL
. :*. :*
MUL_0368|M.ulcerans_Agy99 VHAHQVLQHVADPVQALREMKRVGAPGGLVAARDADYAGFIWYPQLPALD
MMAR_4799|M.marinum_M VHAHQVLQHVADPVQALREMKRVCAPGGLVAARDADYAGFIWYPQLPALD
Mb0862|M.bovis_AF2122/97 VHAHQVLQHVADPVRALQEMRRVCTPGGIVAARDADYSGFIWFPKLPALD
Rv0839|M.tuberculosis_H37Rv VHAHQVLQHVADPVRALQEMRRVCTPGGIVAARDADYSGFIWFPKLPALD
MAV_0854|M.avium_104 VHAHQVLQHLSDPVAALREMRRVCRPGGIVAVRDADYAGFIWYPELPALD
MLBr_01723|M.leprae_Br4923 VVGHAVLHHIPDVELSLREVLRVLKPGGRFVFAGEPTDVGNRYARVFADL
TH_2189|M.thermoresistible__bu VVGHAVLHHIPDVELSLREVVRVLRPGGRFVFAGEPTTVGNSYARALSTL
MSMEG_0098|M.smegmatis_MC2_155 ATSLAVFQLIPDPVAAVSEIVRVLKPGGRVAIMVPTAG-AVKPVTFLARG
Mvan_0109|M.vanbaalenii_PYR-1 VVSIAMLQLIPDPAVALAEMVRVLRPGRRMAVMVPTAGPAAGLLRYLPNA
Mflv_2768|M.gilvum_PYR-GCK ITAFDAIHDQAHPARVLANIHAALRPGGTFLMVDIKSSSRLENNIGVPFA
MAB_4742c|M.abscessus_ATCC_199 ITAFDTIHDQAHPAAVLANIHRALRPGGVLLMADIKASSRLEDNIGVAMS
. :: .. : :: . ** . .
MUL_0368|M.ulcerans_Agy99 HWLQLYQRAARANGGEPDAGRRLLSWARQAGFADITPTGSMWCYATDEMR
MMAR_4799|M.marinum_M HWLKLYQRAARANGGEPDAGRRLLSWARQAGFADITPTGSMWCYATDEMR
Mb0862|M.bovis_AF2122/97 RWLDLYERAARANGGEPDAGRRLLSWARAAGFDDVTPTASVWCFATASAR
Rv0839|M.tuberculosis_H37Rv RWLDLYERAARANGGEPDAGRRLLSWARAAGFDDVTPTASVWCFATASAR
MAV_0854|M.avium_104 LWRDLYRRVARANRGEPDAGRRLLSWARQAGFDDITPTGSLWCYATPETR
MLBr_01723|M.leprae_Br4923 TWKVTIRVVQLP--GLSAWRRTQVEIDENSRAAALEWVVDLHTFEPKVLE
TH_2189|M.thermoresistible__bu TWHVATTVTRLP--GLQGWRRPQAELDESSRAAALEAVVDLHTFEPSDLE
MSMEG_0098|M.smegmatis_MC2_155 ---------------------------------------GARIFGDDELG
Mvan_0109|M.vanbaalenii_PYR-1 ---------------------------------------GAHAFGDDELG
Mflv_2768|M.gilvum_PYR-GCK P----------------------------------------YLYTVSAMH
MAB_4742c|M.abscessus_ATCC_199 T----------------------------------------YRYTVSLTH
:
MUL_0368|M.ulcerans_Agy99 AWWGGMWADRILRSDLSAQLLGSGMASAADLEAISQAWRDWAAAPDGWLG
MMAR_4799|M.marinum_M AWWGGMWAERILRSDLSAQLLGSGMASAADLEAISQAWRDWAAAPDGWLG
Mb0862|M.bovis_AF2122/97 EWWGLVWADRILQSDLAHQLVDSGLATAAQLEEISTAWREWAAAPDGWLA
Rv0839|M.tuberculosis_H37Rv EWWGLVWADRILQSDLAHQLVDSGLATAAQLEEISTAWREWAAAPDGWLA
MAV_0854|M.avium_104 DWWGGMWADRILHSTVARDLVSLGLAAREQLEEISAAWREWAAAPDGWIA
MLBr_01723|M.leprae_Br4923 TMATNAGAVQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWARFAFTS
TH_2189|M.thermoresistible__bu RMARNAGAVEVATASEEFTAAMLGWPVRTFEAAVPPGKLGWNWAKFAFGS
MSMEG_0098|M.smegmatis_MC2_155 DIFENVGLVGVRVKTHGFIQWVRGTKL-----------------------
Mvan_0109|M.vanbaalenii_PYR-1 DTFESLGLAGVRINTVGTIQWVRGRKS-----------------------
Mflv_2768|M.gilvum_PYR-GCK CMSVSLGLDGDGLGTCWGREVATTMLADAGFGDVQVREIESDPINYYYIA
MAB_4742c|M.abscessus_ATCC_199 CMPVSLGLEGAGLGTMWGRQLAESMLAEAGFSDVTVREIEQDTSNYFYIA
MUL_0368|M.ulcerans_Agy99 IPNGEILCRV----------------------
MMAR_4799|M.marinum_M IPNGEILCRV----------------------
Mb0862|M.bovis_AF2122/97 IPHGEILCRA----------------------
Rv0839|M.tuberculosis_H37Rv IPHGEILCRA----------------------
MAV_0854|M.avium_104 IPHGEIICRA----------------------
MLBr_01723|M.leprae_Br4923 WKTLSWVDANVWRRVIPKSWFYNIIITGVKPS
TH_2189|M.thermoresistible__bu WTALSWVDANVWRRVMPKGWFYNVMVTGVKPS
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------
Mflv_2768|M.gilvum_PYR-GCK RK------------------------------
MAB_4742c|M.abscessus_ATCC_199 RR------------------------------