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NDERRAVYTHGHHESVLRGHRQRTVANSAGYLSPHLRAGLSVLDIGCGPGTITVDLAARVAPATVTAVEP TDAALNLARAEVQRCDVSNVAFVTSDVHALDFPDDVFDVVHAHQVLQHVADPVQALREMKRVCAPGGLVA ARDADYAGFIWYPQLPALDHWLKLYQRAARANGGEPDAGRRLLSWARQAGFADITPTGSMWCYATDEMRA WWGGMWAERILRSDLSAQLLGSGMASAADLEAISQAWRDWAAAPDGWLGIPNGEILCRV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4799 | - | - | 100% (270) | hypothetical protein MMAR_4799 |
| M. marinum M | MMAR_4497 | - | 6e-09 | 33.96% (106) | methyltransferase |
| M. marinum M | MMAR_3349 | - | 6e-09 | 30.36% (112) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0862 | - | 1e-124 | 75.46% (269) | hypothetical protein Mb0862 |
| M. gilvum PYR-GCK | Mflv_2768 | - | 6e-09 | 31.78% (107) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv0839 | - | 1e-124 | 75.46% (269) | hypothetical protein Rv0839 |
| M. leprae Br4923 | MLBr_00551 | - | 5e-08 | 29.82% (114) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_4742c | - | 1e-11 | 27.87% (183) | hypothetical protein MAB_4742c |
| M. avium 104 | MAV_0854 | - | 1e-116 | 71.00% (269) | methyltransferase-UbiE family protein |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 2e-12 | 44.12% (102) | methyltransferase |
| M. thermoresistible (build 8) | TH_2028 | - | 4e-08 | 29.35% (201) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_0368 | - | 1e-157 | 97.78% (270) | hypothetical protein MUL_0368 |
| M. vanbaalenii PYR-1 | Mvan_4620 | - | 4e-11 | 35.92% (103) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4799|M.marinum_M ---------------------------------MNDERRAVYTHGHHESV
MUL_0368|M.ulcerans_Agy99 ---------------------------------MNDERRAVYTHGHHESV
Mb0862|M.bovis_AF2122/97 ---------------------------------MNDKRRAIYTHGYHESV
Rv0839|M.tuberculosis_H37Rv ---------------------------------MNDKRRAIYTHGYHESV
MAV_0854|M.avium_104 ---------------------------------MNDQHRATYTHGHHESV
Mflv_2768|M.gilvum_PYR-GCK -------MTTLAENSAPSSETTEEFAQRIVGALDAASLALLVSIGHQTHL
MAB_4742c|M.abscessus_ATCC_199 -------MTAPSANPVP--ETTEEFSERLTAAIDNAALVLLMSIGHQTGL
Mvan_4620|M.vanbaalenii_PYR-1 -------------------------------------MSFVVASEAYGRF
MSMEG_0098|M.smegmatis_MC2_155 MDTALRRAMDLLIDPPAEPDFSKGYLDLLGRGDSTAPKNTGLIQKAWASP
TH_2028|M.thermoresistible__bu --------MDAPRAAARRDVTELFARRATLRRSVRLLSEFRFEQSDPARF
MLBr_00551|M.leprae_Br4923 ---------------------MNLYTPIHEDQSLAAIHRAMWALGDYALM
MMAR_4799|M.marinum_M LR---------GHRQRTVANSAGYLSPHLRAGLSVLDIG-----------
MUL_0368|M.ulcerans_Agy99 LR---------GHRQRTVANSAGYLSPHLRAGLSVLDIG-----------
Mb0862|M.bovis_AF2122/97 LR---------SHRRRTAENSAGYLLPYLVPGLSVLDVG-----------
Rv0839|M.tuberculosis_H37Rv LR---------SHRRRTAENSAGYLLPYLVPGLSVLDVG-----------
MAV_0854|M.avium_104 LR---------SHRRRTAEDSAGYLLAHLTPGLSVLDVG-----------
Mflv_2768|M.gilvum_PYR-GCK FDTMANL---PPSTSTQIADAAGLNERYVREWLGGVAAGRIVDYDPAAQT
MAB_4742c|M.abscessus_ATCC_199 LDTLAAS---AGSTSEQLADAAGLEERYVREWLAGMTVAHVVDYEPVSAI
Mvan_4620|M.vanbaalenii_PYR-1 MG-----------RYAEPLAEAFVAFAGVGVGDKVLDVG-----------
MSMEG_0098|M.smegmatis_MC2_155 LGSKLYDRAQLLNRRLVASTRPPVEWLRIPPGGTVLDIG-----------
TH_2028|M.thermoresistible__bu YG------ALADDTAALVADLWRAATGSDPAGRTVLDVG-----------
MLBr_00551|M.leprae_Br4923 AE-----------EVMAPLGPILVTATGIRPGMQVLDVA-----------
: .
MMAR_4799|M.marinum_M -CGPGTITVDLAARVAPATVTA-VEPTDAALNLARAEVQRCD-----VSN
MUL_0368|M.ulcerans_Agy99 -CGPGTITVDLAARVAPGTVTA-VEPTDAALNLGRAEAQRCD-----VSN
Mb0862|M.bovis_AF2122/97 -CGPGTITVDLAARVVPGSVTG-VEPTDDALSLARAEAQLHR-----LSN
Rv0839|M.tuberculosis_H37Rv -CGPGTITVDLAARVVPGSVTG-VEPTDDALSLARAEAQLHR-----LSN
MAV_0854|M.avium_104 -CGPGTITADLAARVAPGQVTA-VDQAADVLEVARAEAEQRN-----LSN
Mflv_2768|M.gilvum_PYR-GCK FSLPAHRAAVLTRTAGPDNLAR-VTQFIPLLSEVEQKVIACFRDGGGLSY
MAB_4742c|M.abscessus_ATCC_199 YTLPSHRAATLTREAGLNNLAR-LAQYLPLLSEVEQKILGCFRRGGGLQY
Mvan_4620|M.vanbaalenii_PYR-1 -CGPGALTARLRSVG--ADIAA-IDPSPPFIDAIRRS----------FPD
MSMEG_0098|M.smegmatis_MC2_155 -CGPGNITAQLARAAGLDGLALGVDISEPMLARAVAAEAG--------RQ
TH_2028|M.thermoresistible__bu -GGPGYFAAAFARAG-MRYIGVEPDPREIHAGPAVECPEDDP------AA
MLBr_00551|M.leprae_Br4923 -AGSGNISLPAAKTG--ATIVS-TDLTPELLQRSQARATELG------LT
.. : :
MMAR_4799|M.marinum_M VAFVTSDVHALDFPDDVFDVVHAHQVLQHVADPVQALREMKRVCAPGG--
MUL_0368|M.ulcerans_Agy99 VAFVTSDVHALDFPDDVFDVVHAHQVLQHVADPVQALREMKRVGAPGG--
Mb0862|M.bovis_AF2122/97 ISFTTSDVHKLDFPDDAFDVVHAHQVLQHVADPVRALQEMRRVCTPGG--
Rv0839|M.tuberculosis_H37Rv ISFTTSDVHKLDFPDDAFDVVHAHQVLQHVADPVRALQEMRRVCTPGG--
MAV_0854|M.avium_104 VSFGTADVHRLDFADDTFDVVHAHQVLQHLSDPVAALREMRRVCRPGG--
Mflv_2768|M.gilvum_PYR-GCK AEYPRFHTLMAEQSGEVFDAALVDGILPMAEGLTDRLRQGVDVADFGCGS
MAB_4742c|M.abscessus_ATCC_199 QDYPRFHAVMGERSREVFDKALIRTVLPLVEGLPEGLEGGLDVADFGCGS
Mvan_4620|M.vanbaalenii_PYR-1 VDVRQGPAEELPYDSAAFDAALAQLVVHFMTDPVAGLRQMSRVTRPGG--
MSMEG_0098|M.smegmatis_MC2_155 VGFVRADAQQLPFRDEVFDAATSLAVFQLIPDPVAAVSEIVRVLKPGG--
TH_2028|M.thermoresistible__bu GTFVRASGMALPFADASVDICLSSNVAEHVPQPWLLGREMLRVTRPGG--
MLBr_00551|M.leprae_Br4923 LEYREADAQALPFGDGEFDVVMSAIGVMFAPDHRRAASELVRVCRPNG--
.* * .
MMAR_4799|M.marinum_M -------LVAARDADYAGFIWYPQ--LPALDHWLKLYQRAARANGGEPDA
MUL_0368|M.ulcerans_Agy99 -------LVAARDADYAGFIWYPQ--LPALDHWLQLYQRAARANGGEPDA
Mb0862|M.bovis_AF2122/97 -------IVAARDADYSGFIWFPK--LPALDRWLDLYERAARANGGEPDA
Rv0839|M.tuberculosis_H37Rv -------IVAARDADYSGFIWFPK--LPALDRWLDLYERAARANGGEPDA
MAV_0854|M.avium_104 -------IVAVRDADYAGFIWYPE--LPALDLWRDLYRRVARANRGEPDA
Mflv_2768|M.gilvum_PYR-GCK GHAVNVMAKAFPASRFTGIDFSEEGLAAGRDEARRLGLTNASFNATDVAT
MAB_4742c|M.abscessus_ATCC_199 GYAINLMAQAFPASRFTGVDFSDEAIATAAADAERLGLRNASFLSADVAT
Mvan_4620|M.vanbaalenii_PYR-1 --------------VVAACVWDGP-TGALAPFWDAVHVVDPEAEDEALLS
MSMEG_0098|M.smegmatis_MC2_155 ----------------------------------RVAIMVPTAGAVKPVT
TH_2028|M.thermoresistible__bu ------------LAVLSYTVWLGPFGGHETGLWHYLGGRRAADRYARRHG
MLBr_00551|M.leprae_Br4923 ---------TIGVISWTQEGFFGRMLATIRPYRPSLSAALPPAALWGREA
: .
MMAR_4799|M.marinum_M GRRLLSWARQAGFADITPTGS---MWCYATDEMRAWWGGMWAERILRSDL
MUL_0368|M.ulcerans_Agy99 GRRLLSWARQAGFADITPTGS---MWCYATDEMRAWWGGMWADRILRSDL
Mb0862|M.bovis_AF2122/97 GRRLLSWARAAGFDDVTPTAS---VWCFATASAREWWGLVWADRILQSDL
Rv0839|M.tuberculosis_H37Rv GRRLLSWARAAGFDDVTPTAS---VWCFATASAREWWGLVWADRILQSDL
MAV_0854|M.avium_104 GRRLLSWARQAGFDDITPTGS---LWCYATPETRDWWGGMWADRILHSTV
Mflv_2768|M.gilvum_PYR-GCK YDAAESFDVITAFDAIHDQAHPARVLANIHAALRPGGTFLMVDIKSSSRL
MAB_4742c|M.abscessus_ATCC_199 LNAPATYDLITAFDTIHDQAHPAAVLANIHRALRPGGVLLMADIKASSRL
Mvan_4620|M.vanbaalenii_PYR-1 GARSGHLTELFEAAGLRDVVEDSIAVDVVHPTFEQWWEPYTYGVGPAGDY
MSMEG_0098|M.smegmatis_MC2_155 FLARG-GARIFGDDELGDIFEN----------------------------
TH_2028|M.thermoresistible__bu HRPKNDYGSSLFAVSAADGLR--------------WAAATGALLAAFPRY
MLBr_00551|M.leprae_Br4923 YIRGLLDDTVTNVKTERRQLEVK-RFNSAEGVHNYFKNHYGPTIEAYTNI
MMAR_4799|M.marinum_M SAQL------------------LGSGMASAADLEAISQAWRDWAAAPDGW
MUL_0368|M.ulcerans_Agy99 SAQL------------------LGSGMASAADLEAISQAWRDWAAAPDGW
Mb0862|M.bovis_AF2122/97 AHQL------------------VDSGLATAAQLEEISTAWREWAAAPDGW
Rv0839|M.tuberculosis_H37Rv AHQL------------------VDSGLATAAQLEEISTAWREWAAAPDGW
MAV_0854|M.avium_104 ARDL------------------VSLGLAAREQLEEISAAWREWAAAPDGW
Mflv_2768|M.gilvum_PYR-GCK ENNIGVPFAPYLYTVSAMHCMSVSLGLDGDGLGTCWGREVATTMLADAGF
MAB_4742c|M.abscessus_ATCC_199 EDNIGVAMSTYRYTVSLTHCMPVSLGLEGAGLGTMWGRQLAESMLAEAGF
Mvan_4620|M.vanbaalenii_PYR-1 VQQLD------------------DEGRARLESAARERLGKGPFTVTAVAW
MSMEG_0098|M.smegmatis_MC2_155 ------------------------VGLVG-------------VRVKTHGF
TH_2028|M.thermoresistible__bu HPKWG-------------------WWLTRAPVVREFLVSNLVLVLSPPEI
MLBr_00551|M.leprae_Br4923 GDNS---------------------VLAAELDAQLTELAQKYLTNSTMGW
MMAR_4799|M.marinum_M LGIPNGEILCRV---------
MUL_0368|M.ulcerans_Agy99 LGIPNGEILCRV---------
Mb0862|M.bovis_AF2122/97 LAIPHGEILCRA---------
Rv0839|M.tuberculosis_H37Rv LAIPHGEILCRA---------
MAV_0854|M.avium_104 IAIPHGEIICRA---------
Mflv_2768|M.gilvum_PYR-GCK GDVQVREIESDPINYYYIARK
MAB_4742c|M.abscessus_ATCC_199 SDVTVREIEQDTSNYFYIARR
Mvan_4620|M.vanbaalenii_PYR-1 AARGTA---------------
MSMEG_0098|M.smegmatis_MC2_155 IQWVRGTKL------------
TH_2028|M.thermoresistible__bu VN-------------------
MLBr_00551|M.leprae_Br4923 EYLLLTAQKH-----------