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MAALQDKVALVTGASSGLGAETAKLFSSRGATVFGIGRDTARLAEVFAGIERGGFASVDIASPQACTEAV AQCVRDFGGLDVLVNVAGIHRMRRTESMTDEDWEHDLAVNLNGPFFLCRAALPQLLERGGNIVNVSSIAG VEGQAYSAGYCAAKHGLIGLTRALAVEYTADRLRVNAVCPGGMLTPQIERFSAPDDPNYDLILRTAAPRG MMRPLDVANVIAFLASDAAAAVHGAVYRVDNGKGAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0087 | - | - | 100% (246) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. avium 104 | MAV_3034 | - | 3e-32 | 37.30% (252) | oxidoreductase |
| M. avium 104 | MAV_3019 | - | 1e-31 | 34.85% (264) | carveol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 2e-31 | 36.78% (242) | 20-beta-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2757 | - | 2e-99 | 70.73% (246) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 2e-31 | 36.78% (242) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 9e-25 | 34.17% (240) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0072c | - | 4e-30 | 34.33% (268) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_4967 | - | 5e-33 | 34.98% (263) | short-chain type dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_4358 | - | 6e-95 | 70.33% (246) | D-beta-hydroxybutyrate dehydrogenase |
| M. thermoresistible (build 8) | TH_3018 | - | 2e-30 | 34.30% (277) | PUTATIVE carveol dehydrogenase |
| M. ulcerans Agy99 | MUL_4041 | - | 6e-33 | 35.61% (264) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_3777 | - | 1e-100 | 72.36% (246) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3018|M.thermoresistible__bu --------------------------------------------------
Mflv_2757|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3777|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4358|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0087|M.avium_104 --------------------------------------------------
MMAR_4967|M.marinum_M --------------------------------------------------
MUL_4041|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3018|M.thermoresistible__bu --------------------------------------------------
Mflv_2757|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3777|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4358|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0087|M.avium_104 --------------------------------------------------
MMAR_4967|M.marinum_M --------------------------------------------------
MUL_4041|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3018|M.thermoresistible__bu --------------------------------------------------
Mflv_2757|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3777|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4358|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0087|M.avium_104 --------------------------------------------------
MMAR_4967|M.marinum_M --------------------------------------------------
MUL_4041|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3018|M.thermoresistible__bu --------------------------------------------------
Mflv_2757|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3777|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4358|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0087|M.avium_104 --------------------------------------------------
MMAR_4967|M.marinum_M --------------------------------------------------
MUL_4041|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mb2025|M.bovis_AF2122/97 ------MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEE-
Rv2002|M.tuberculosis_H37Rv ------MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEE-
MAB_0072c|M.abscessus_ATCC_199 ------MTGRLTGKVALVTGAARGIGRAQAVRFAQEGADIIALDICAPVH
TH_3018|M.thermoresistible__bu ------MN-RLQGKVAFITGAARGQGRTHAVRLAQDGADIVAIDLCRQQP
Mflv_2757|M.gilvum_PYR-GCK -------MGQLSGKVAMVTGASAGLGAETAKLFAERGATVFGIARDADRM
Mvan_3777|M.vanbaalenii_PYR-1 -------MSQLSGKVALVTGASAGLGAATAKLFAERGATVFGVARDGSRM
MSMEG_4358|M.smegmatis_MC2_155 -------MTDFHGKTALVTGASAGLGAAVAKLLAARGASVFGIARDADRM
MAV_0087|M.avium_104 -------MAALQDKVALVTGASSGLGAETAKLFSSRGATVFGIGRDTARL
MMAR_4967|M.marinum_M -------MTRLVGQRILVTGAGSGIGQATVLRLLDEGATVVGADIDAAGL
MUL_4041|M.ulcerans_Agy99 -------MTRLVGQRILVTGAGSGIGQATVLRLLDEGATVVGADIDADGL
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
: .: :::*.. * * . . ** :.
Mb2025|M.bovis_AF2122/97 ----GKAVAAELADAARYVH----------LDVTQPAQWTAAVDTAVTAF
Rv2002|M.tuberculosis_H37Rv ----GKAVAAELADAARYVH----------LDVTQPAQWTAAVDTAVTAF
MAB_0072c|M.abscessus_ATCC_199 TTITPPATRADLDKTSELVESAGRRVIPGVVDVRNLRDVQTFTQDAVTEF
TH_3018|M.thermoresistible__bu NLDYAQGSPEELKETVRLVEEQGRRIIARQADVRDLASLQAVVDEALAEF
Mflv_2757|M.gilvum_PYR-GCK AEVFADVPGGSFRS----------------VDVTSADECRRAVAECVAEF
Mvan_3777|M.vanbaalenii_PYR-1 AEVFADIPGGSFSS----------------VDITSPAACAQAVSECVARF
MSMEG_4358|M.smegmatis_MC2_155 AEVFTEVPGGRYAS----------------VDISSSQGCDQAVEQCVEQF
MAV_0087|M.avium_104 AEVFAGIERGGFAS----------------VDIASPQACTEAVAQCVRDF
MMAR_4967|M.marinum_M SRTQARTAEAGTGARLTTCQ----------IDVADEKSVVDGVGAAVQAL
MUL_4041|M.ulcerans_Agy99 SRTQARTAEAGTGARLTTCQ----------IDVADEKSVVDGVGAAVQAL
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLS---------------LDVTADDAVDKITEHLHDYQ
*: .
Mb2025|M.bovis_AF2122/97 G-GLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMK
Rv2002|M.tuberculosis_H37Rv G-GLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMK
MAB_0072c|M.abscessus_ATCC_199 G-GLDIVCATAGITSRRMLLDMPESDWQTMLDVNLTGVWHTTRAATPHLI
TH_3018|M.thermoresistible__bu G-HIDILVSNVGISNQGEVVSLTDQQWSDILQTNLIGAWHACRAVLPSMI
Mflv_2757|M.gilvum_PYR-GCK G-RLDVLANIAGFHKMRHTASMTDDDWATDLSVNLNGPFFLCRAALPHLL
Mvan_3777|M.vanbaalenii_PYR-1 G-RLDVLANIAGFHKMRHTVSMTDADWEADLSVNLNGPFYLCRAALPHLL
MSMEG_4358|M.smegmatis_MC2_155 G-QLDTLINVAGFHQMRHTVSVTDEDWAKDLAVNLNGPFFLSRAALPHLL
MAV_0087|M.avium_104 G-GLDVLVNVAGIHRMRRTESMTDEDWEHDLAVNLNGPFFLCRAALPQLL
MMAR_4967|M.marinum_M G-GLDALVNAAGMLRAAHTHQTSIQQWNQIIAVNLTGTFLVVREALPALL
MUL_4041|M.ulcerans_Agy99 G-GLDALVNAAGMLRAAHTHQTSIQQWNQIIAVNLTGTFLVVREALPALL
MLBr_02565|M.leprae_Br4923 GGHADILVNNAGITRDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGS
* . : .*: . * : .** . .
Mb2025|M.bovis_AF2122/97 EAG-RGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIR
Rv2002|M.tuberculosis_H37Rv EAG-RGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIR
MAB_0072c|M.abscessus_ATCC_199 ARG-GGAMVLVSSIAGLRGLVGVSHYVAAKHGVVGLMRSLAIELAPHKIR
TH_3018|M.thermoresistible__bu ERGQGGSVIFVSSTVGLRGAPGQSHYAASKHGVQGLMLSLANEVGRHNIR
Mflv_2757|M.gilvum_PYR-GCK E-T-GGNIVNVASIAGVEGEVYSAGYCAAKHGLVGLTRALAIEFTKEKLR
Mvan_3777|M.vanbaalenii_PYR-1 E-S-GGNIVNVASIAGVEGEVYSAGYCAAKHGLIGLTRALAVEFTKERLR
MSMEG_4358|M.smegmatis_MC2_155 Q-A-GGNIVNVASIAGVEGEVYSAGYCAAKHGLVGLTRALAVEFTKERLR
MAV_0087|M.avium_104 E-R-GGNIVNVSSIAGVEGQAYSAGYCAAKHGLIGLTRALAVEYTADRLR
MMAR_4967|M.marinum_M DNQ-RSTVVNFSSTSAAFAHPYMAAYAASKGGVQAFTHSLALEYARDGLR
MUL_4041|M.ulcerans_Agy99 DNQ-RSTVVNFSSTSAAFAHPYMAAYAASKGGVQAFTHSLALEYARDGLR
MLBr_02565|M.leprae_Br4923 ISK-GGRVIVLSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGIT
. :: .:* . . * ::* .: .: : * :
Mb2025|M.bovis_AF2122/97 VNSIHPGLVKTPMT-DWVPEDIFQTALGRAA-------------------
Rv2002|M.tuberculosis_H37Rv VNSIHPGLVKTPMT-DWVPEDIFQTALGRAA-------------------
MAB_0072c|M.abscessus_ATCC_199 VNTVHPTNVDTPMIQNEFVRTLFRPDLEQPTREDFAAAAKTMNLLDLPWV
TH_3018|M.thermoresistible__bu VNSVNPGAVNTEMALNEKLLKMFLPHLENPTREDAAELFSQLTLLPIPWV
Mflv_2757|M.gilvum_PYR-GCK VNAICPGGMPTAQTTEFE--APENADWDLIMR----------IASPRGFM
Mvan_3777|M.vanbaalenii_PYR-1 VNAICPGGMPTAQTTEFE--APENADWDLIMR----------IASPRGFM
MSMEG_4358|M.smegmatis_MC2_155 VNAVCPGGMLTAQTTEFS--APDNADWDLIMR----------IAAPRGFM
MAV_0087|M.avium_104 VNAVCPGGMLTPQIERFS--APDDPNYDLILR----------TAAPRGMM
MMAR_4967|M.marinum_M AVCVAPGSIKSGITDATGGYIPADANWSLFTRL-MPILPTTETSSGAGMA
MUL_4041|M.ulcerans_Agy99 AVCVAPGSIKSGITDATGGYIPADANWSLFTRL-MPILPTTETSSGAGMA
MLBr_02565|M.leprae_Br4923 INAVAPGFIETQMTAAIPLATREVGRRLNSLLQG---------------G
: * : :
Mb2025|M.bovis_AF2122/97 EPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPE
Rv2002|M.tuberculosis_H37Rv EPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPE
MAB_0072c|M.abscessus_ATCC_199 EPLDIANASLFLASDEARYITSVSLPVDAGSTQR----------------
TH_3018|M.thermoresistible__bu EPEDVSNAVAWLASDEARYIHGAAIPVDGGQLARA---------------
Mflv_2757|M.gilvum_PYR-GCK ATEDVAKTIAFLASDDAAAVHGAVYRVDNGKGAG----------------
Mvan_3777|M.vanbaalenii_PYR-1 ATDDVAKTIAFLASDDAAAIHGAVYRVDNGKGAG----------------
MSMEG_4358|M.smegmatis_MC2_155 DVADVAKTIAFLASDDAAAVHGAVYIVDAGKTAG----------------
MAV_0087|M.avium_104 RPLDVANVIAFLASDAAAAVHGAVYRVDNGKGAG----------------
MMAR_4967|M.marinum_M DPSVVAGVIAMLVSEDGAFITGTEIRIDGGTHA-----------------
MUL_4041|M.ulcerans_Agy99 DPSVVAGVIAMLVSEDGAFITGTEIRIDGGTHA-----------------
MLBr_02565|M.leprae_Br4923 LPVDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA---------------
:: :. . . :
Mb2025|M.bovis_AF2122/97 WVT
Rv2002|M.tuberculosis_H37Rv WVT
MAB_0072c|M.abscessus_ATCC_199 ---
TH_3018|M.thermoresistible__bu ---
Mflv_2757|M.gilvum_PYR-GCK ---
Mvan_3777|M.vanbaalenii_PYR-1 ---
MSMEG_4358|M.smegmatis_MC2_155 ---
MAV_0087|M.avium_104 ---
MMAR_4967|M.marinum_M ---
MUL_4041|M.ulcerans_Agy99 ---
MLBr_02565|M.leprae_Br4923 ---