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GQLSGKVAMVTGASAGLGAETAKLFAERGATVFGIARDADRMAEVFADVPGGSFRSVDVTSADECRRAVA ECVAEFGRLDVLANIAGFHKMRHTASMTDDDWATDLSVNLNGPFFLCRAALPHLLETGGNIVNVASIAGV EGEVYSAGYCAAKHGLVGLTRALAIEFTKEKLRVNAICPGGMPTAQTTEFEAPENADWDLIMRIASPRGF MATEDVAKTIAFLASDDAAAVHGAVYRVDNGKGAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2757 | - | - | 100% (246) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4505 | - | 5e-34 | 38.06% (247) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_0661 | - | 8e-32 | 34.00% (250) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2771 | - | 6e-29 | 34.19% (272) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2750 | - | 7e-29 | 34.19% (272) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 8e-26 | 35.12% (242) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0072c | - | 3e-32 | 34.31% (274) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_0387 | fabG3 | 2e-30 | 35.77% (246) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. avium 104 | MAV_0087 | - | 2e-99 | 70.73% (246) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_4358 | - | 1e-110 | 78.46% (246) | D-beta-hydroxybutyrate dehydrogenase |
| M. thermoresistible (build 8) | TH_3962 | - | 9e-31 | 33.58% (274) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1037 | fabG3 | 3e-30 | 35.37% (246) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. vanbaalenii PYR-1 | Mvan_3777 | - | 1e-127 | 89.02% (246) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2757|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3777|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4358|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0087|M.avium_104 --------------------------------------------------
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3962|M.thermoresistible__bu --------------------------------------------------
MMAR_0387|M.marinum_M --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mflv_2757|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3777|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4358|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0087|M.avium_104 --------------------------------------------------
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3962|M.thermoresistible__bu --------------------------------------------------
MMAR_0387|M.marinum_M --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mflv_2757|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3777|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4358|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0087|M.avium_104 --------------------------------------------------
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3962|M.thermoresistible__bu --------------------------------------------------
MMAR_0387|M.marinum_M --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mflv_2757|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3777|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4358|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0087|M.avium_104 --------------------------------------------------
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3962|M.thermoresistible__bu --------------------------------------------------
MMAR_0387|M.marinum_M --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mflv_2757|M.gilvum_PYR-GCK -------MGQLSGKVAMVTGASAGLGAETAKLFAERGATVFGIARDA---
Mvan_3777|M.vanbaalenii_PYR-1 -------MSQLSGKVALVTGASAGLGAATAKLFAERGATVFGVARDG---
MSMEG_4358|M.smegmatis_MC2_155 -------MTDFHGKTALVTGASAGLGAAVAKLLAARGASVFGIARDA---
MAV_0087|M.avium_104 -------MAALQDKVALVTGASSGLGAETAKLFSSRGATVFGIGRDT---
Mb2771|M.bovis_AF2122/97 -----MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIA
Rv2750|M.tuberculosis_H37Rv -----MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIA
MAB_0072c|M.abscessus_ATCC_199 -----MTGR-LTGKVALVTGAARGIGRAQAVRFAQEGADIIALDICAPVH
TH_3962|M.thermoresistible__bu ----LSIMGAFTGKVAFVTGAARGQGRSHALRLAREGAAIVALDIAADID
MMAR_0387|M.marinum_M -------MGRVDGKVALISGGARGMGASHARLLVQEGAKVVIGDILD---
MUL_1037|M.ulcerans_Agy99 -------MGRVDGKVALISGGARGMGASHARLLVQEGAKVVIGDILD---
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVES---
. .*.*:::*.: * * * . ** :.
Mflv_2757|M.gilvum_PYR-GCK ------------DRMAEVFADVPGGSFRS-VDVTSADECRRAVAECVAEF
Mvan_3777|M.vanbaalenii_PYR-1 ------------SRMAEVFADIPGGSFSS-VDITSPAACAQAVSECVARF
MSMEG_4358|M.smegmatis_MC2_155 ------------DRMAEVFTEVPGGRYAS-VDISSSQGCDQAVEQCVEQF
MAV_0087|M.avium_104 ------------ARLAEVFAGIERGGFAS-VDIASPQACTEAVAQCVRDF
Mb2771|M.bovis_AF2122/97 SVPYPLSTADDLAATVELVEDAGGGIVARQGDVRDRASLSVALQAGLDEF
Rv2750|M.tuberculosis_H37Rv SVPYPLSTADDLAATVELVEDAGGGIVARQGDVRDRASLSVALQAGLDEF
MAB_0072c|M.abscessus_ATCC_199 TTITPPATRADLDKTSELVESAGRRVIPGVVDVRNLRDVQTFTQDAVTEF
TH_3962|M.thermoresistible__bu ECFFPLATPEDLQETVRLVEEDGGRILARRGDVRNYDDVKSAVDDGIAQF
MMAR_0387|M.marinum_M ------------EEGKALAEEIGDAARYVHLDVTQPDQWEAAVATAVDEF
MUL_1037|M.ulcerans_Agy99 ------------EEGKALAEEIGDAARYVHLDVTQPDQWEAAVATAVDEF
MLBr_02565|M.leprae_Br4923 ------------AAEALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQ
*:
Mflv_2757|M.gilvum_PYR-GCK G-RLDVLANIAGFHKMR-HTASMTDDDWATDLSVNLNGPFFLCRAALPHL
Mvan_3777|M.vanbaalenii_PYR-1 G-RLDVLANIAGFHKMR-HTVSMTDADWEADLSVNLNGPFYLCRAALPHL
MSMEG_4358|M.smegmatis_MC2_155 G-QLDTLINVAGFHQMR-HTVSVTDEDWAKDLAVNLNGPFFLSRAALPHL
MAV_0087|M.avium_104 G-GLDVLVNVAGIHRMR-RTESMTDEDWEHDLAVNLNGPFFLCRAALPQL
Mb2771|M.bovis_AF2122/97 G-RLDIVVANAGIA-----MMQAGDDGWRDVIDVNLTGVFHTVQVAIPTL
Rv2750|M.tuberculosis_H37Rv G-RLDIVVANAGIA-----MMQAGDDGWRDVIDVNLTGVFHTVQVAIPTL
MAB_0072c|M.abscessus_ATCC_199 G-GLDIVCATAGITSR-RMLLDMPESDWQTMLDVNLTGVWHTTRAATPHL
TH_3962|M.thermoresistible__bu G-PIGIVVANAGIGTAYKKTWEIPEADWRAALDVNLTGVFHTVKAAVPSM
MMAR_0387|M.marinum_M G-KLDVLVNNAGIVALG-QLKKFDLGKWQKVIDVNLTGTFLGMRAAVEPM
MUL_1037|M.ulcerans_Agy99 G-KLDVLVNNVGIVALG-QLKKFDLGKWQKVIDVNLTGTFLGMRAAVEPM
MLBr_02565|M.leprae_Br4923 GGHADILVNNAGITRDK-LLANMDDCRWDAVLEVNLLAPQRLTEGLVGNG
* . : .*: . * : *** . .
Mflv_2757|M.gilvum_PYR-GCK LETG--GNIVNVASIAGVEGE----VYSAGYCAAKHGLVGLTRALAIEFT
Mvan_3777|M.vanbaalenii_PYR-1 LESG--GNIVNVASIAGVEGE----VYSAGYCAAKHGLIGLTRALAVEFT
MSMEG_4358|M.smegmatis_MC2_155 LQAG--GNIVNVASIAGVEGE----VYSAGYCAAKHGLVGLTRALAVEFT
MAV_0087|M.avium_104 LERG--GNIVNVSSIAGVEGQ----AYSAGYCAAKHGLIGLTRALAVEYT
Mb2771|M.bovis_AF2122/97 IEQGTGGSIVLISSAAGLVGIGSSDPGSLGYAAAKHGVVGLMRAYANHLA
Rv2750|M.tuberculosis_H37Rv IEQGTGGSIVLISSAAGLVGIGSSDPGSLGYAAAKHGVVGLMRAYANHLA
MAB_0072c|M.abscessus_ATCC_199 IARG-GGAMVLVSSIAGLRGL----VGVSHYVAAKHGVVGLMRSLAIELA
TH_3962|M.thermoresistible__bu IEAGRGGSITLISSSAGLKGY----QHLAPYVSSKHAVIGLMRTLANELA
MMAR_0387|M.marinum_M TAAG-SGSIINVSSIEGLRGA----PAVHPYVASKWAVRGLTKSAALELA
MUL_1037|M.ulcerans_Agy99 TAAG-SGSIINVSSIEGLRGA----PAVHPYVASKWAVRGLTKSAALELA
MLBr_02565|M.leprae_Br4923 SISK-GGRVIVLSSMAGIAGN----RGQTNYATAKAGVIGLTQALAPGLA
* : ::* *: * * ::* .: ** :: * :
Mflv_2757|M.gilvum_PYR-GCK KEKLRVNAICPGGMPTAQTTEFEAP------------ENADWDLIMRIAS
Mvan_3777|M.vanbaalenii_PYR-1 KERLRVNAICPGGMPTAQTTEFEAP------------ENADWDLIMRIAS
MSMEG_4358|M.smegmatis_MC2_155 KERLRVNAVCPGGMLTAQTTEFSAP------------DNADWDLIMRIAA
MAV_0087|M.avium_104 ADRLRVNAVCPGGMLTPQIERFSAP------------DDPNYDLILRTAA
Mb2771|M.bovis_AF2122/97 PQNIRVNSVHPCGVDTPMINNEFFQQWL-------TTADMDAPHNLGNAL
Rv2750|M.tuberculosis_H37Rv PQNIRVNSVHPCGVDTPMINNEFFQQWL-------TTADMDAPHNLGNAL
MAB_0072c|M.abscessus_ATCC_199 PHKIRVNTVHPTNVDTPMIQNEFVRTLFRPDLEQPTREDFAAAAKTMNLL
TH_3962|M.thermoresistible__bu EHNIRVNALCPGSVRTPMIINEPTFKVFRPDLDEPTEADAMEVFRQMPAL
MMAR_0387|M.marinum_M PLNIRVNSIHPGFIRTPMTAN---------------LPDDMVTIPLG---
MUL_1037|M.ulcerans_Agy99 PLNIRVNSIHPGFIRTPMTAN---------------LPDDMVTIPLG---
MLBr_02565|M.leprae_Br4923 EKGITINAVAPGFIETQMTAAIP---------------LATREVGRRLNS
: :*:: * : *
Mflv_2757|M.gilvum_PYR-GCK PRGFMATEDVAKTIAFLASDDAAAVHGAVYRVDNGKGAG------
Mvan_3777|M.vanbaalenii_PYR-1 PRGFMATDDVAKTIAFLASDDAAAIHGAVYRVDNGKGAG------
MSMEG_4358|M.smegmatis_MC2_155 PRGFMDVADVAKTIAFLASDDAAAVHGAVYIVDAGKTAG------
MAV_0087|M.avium_104 PRGMMRPLDVANVIAFLASDAAAAVHGAVYRVDNGKGAG------
Mb2771|M.bovis_AF2122/97 PVELVQPTDIANAVAWLASEEARYVTGVTLPVDAGFVNKR-----
Rv2750|M.tuberculosis_H37Rv PVELVQPTDIANAVAWLASEEARYVTGVTLPVDAGFVNKR-----
MAB_0072c|M.abscessus_ATCC_199 DLPWVEPLDIANASLFLASDEARYITSVSLPVDAGSTQR------
TH_3962|M.thermoresistible__bu PVDVLEPEDISEMVAFLASDAARYVTGLAIPVDAGQLVK------
MMAR_0387|M.marinum_M --RPAESREVSTFVVFLASDDASYATGSEFVMDGGLVTDVPHKQF
MUL_1037|M.ulcerans_Agy99 --RPAESREVSTFVVFLASDDASYATGSEFVMDGGLVTDVPHKQF
MLBr_02565|M.leprae_Br4923 LLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA-----
::: ::* : . :