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MSQLSGKVALVTGASAGLGAATAKLFAERGATVFGVARDGSRMAEVFADIPGGSFSSVDITSPAACAQAV SECVARFGRLDVLANIAGFHKMRHTVSMTDADWEADLSVNLNGPFYLCRAALPHLLESGGNIVNVASIAG VEGEVYSAGYCAAKHGLIGLTRALAVEFTKERLRVNAICPGGMPTAQTTEFEAPENADWDLIMRIASPRG FMATDDVAKTIAFLASDDAAAIHGAVYRVDNGKGAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3777 | - | - | 100% (246) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_2896 | - | 1e-32 | 35.27% (275) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0489 | - | 5e-32 | 33.20% (247) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 1e-29 | 35.48% (248) | 20-beta-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2757 | - | 1e-127 | 89.02% (246) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 1e-29 | 35.48% (248) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 5e-26 | 35.12% (242) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0072c | - | 2e-29 | 32.60% (273) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_0302 | - | 2e-31 | 36.93% (241) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_0087 | - | 1e-100 | 72.36% (246) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_4358 | - | 1e-110 | 78.05% (246) | D-beta-hydroxybutyrate dehydrogenase |
| M. thermoresistible (build 8) | TH_3018 | - | 8e-30 | 32.25% (276) | PUTATIVE carveol dehydrogenase |
| M. ulcerans Agy99 | MUL_4820 | - | 5e-31 | 36.67% (240) | short-chain type dehydrogenase/reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3777|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2757|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4358|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0087|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3018|M.thermoresistible__bu --------------------------------------------------
Mvan_3777|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2757|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4358|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0087|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3018|M.thermoresistible__bu --------------------------------------------------
Mvan_3777|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2757|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4358|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0087|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3018|M.thermoresistible__bu --------------------------------------------------
Mvan_3777|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2757|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4358|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0087|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3018|M.thermoresistible__bu --------------------------------------------------
Mvan_3777|M.vanbaalenii_PYR-1 -------MSQLSGKVALVTGASAGLGAATAKLFAERGATVFGVARDGSRM
Mflv_2757|M.gilvum_PYR-GCK -------MGQLSGKVAMVTGASAGLGAETAKLFAERGATVFGIARDADRM
MSMEG_4358|M.smegmatis_MC2_155 -------MTDFHGKTALVTGASAGLGAAVAKLLAARGASVFGIARDADRM
MAV_0087|M.avium_104 -------MAALQDKVALVTGASSGLGAETAKLFSSRGATVFGIGRDTARL
MMAR_0302|M.marinum_M ------------MQVAIITGATGGIGFGCAAKLAEMGMAVLGTGRDERRL
MUL_4820|M.ulcerans_Agy99 ------------MQVAIITAATGGIGFGCAAKFAEMSMAVVGTARDERRL
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVES--A
Mb2025|M.bovis_AF2122/97 ------MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEE-
Rv2002|M.tuberculosis_H37Rv ------MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEE-
MAB_0072c|M.abscessus_ATCC_199 ------MTGRLTGKVALVTGAARGIGRAQAVRFAQEGADIIALDICAPVH
TH_3018|M.thermoresistible__bu ------MN-RLQGKVAFITGAARGQGRTHAVRLAQDGADIVAIDLCRQQP
:.*:::..: * * . . . :.
Mvan_3777|M.vanbaalenii_PYR-1 AEVFADIPG----------------GSFSSVDITSPAACAQAVSECVARF
Mflv_2757|M.gilvum_PYR-GCK AEVFADVPG----------------GSFRSVDVTSADECRRAVAECVAEF
MSMEG_4358|M.smegmatis_MC2_155 AEVFTEVPG----------------GRYASVDISSSQGCDQAVEQCVEQF
MAV_0087|M.avium_104 AEVFAGIER----------------GGFASVDIASPQACTEAVAQCVRDF
MMAR_0302|M.marinum_M AELTQLPGGP-------------DRIATHPVDLTDDDAPGQLTRAALERW
MUL_4820|M.ulcerans_Agy99 AELTQLPGGP-------------DRIATHPVDPTDDDAPGQLTRAALDRW
MLBr_02565|M.leprae_Br4923 AEALDETANR-------------VGGTTLSLDVTADDAVDKITEHLHDYQ
Mb2025|M.bovis_AF2122/97 ----GKAVAAELADAARYVH----------LDVTQPAQWTAAVDTAVTAF
Rv2002|M.tuberculosis_H37Rv ----GKAVAAELADAARYVH----------LDVTQPAQWTAAVDTAVTAF
MAB_0072c|M.abscessus_ATCC_199 TTITPPATRADLDKTSELVESAGRRVIPGVVDVRNLRDVQTFTQDAVTEF
TH_3018|M.thermoresistible__bu NLDYAQGSPEELKETVRLVEEQGRRIIARQADVRDLASLQAVVDEALAEF
* .
Mvan_3777|M.vanbaalenii_PYR-1 G-RLDVLANIAGFHKMRHTVSMTDADWEADLSVNLNGPFYLCRAALP-HL
Mflv_2757|M.gilvum_PYR-GCK G-RLDVLANIAGFHKMRHTASMTDDDWATDLSVNLNGPFFLCRAALP-HL
MSMEG_4358|M.smegmatis_MC2_155 G-QLDTLINVAGFHQMRHTVSVTDEDWAKDLAVNLNGPFFLSRAALP-HL
MAV_0087|M.avium_104 G-GLDVLVNVAGIHRMRRTESMTDEDWEHDLAVNLNGPFFLCRAALP-QL
MMAR_0302|M.marinum_M G-RIDFLINAAGVGSPKPVHETDDESLDYVLSLMLRAPFRLTREVLP--H
MUL_4820|M.ulcerans_Agy99 G-RIDFLINAAGEGSPKSVHETDDESLDYVLSLMLRAPFRLTREVLP--H
MLBr_02565|M.leprae_Br4923 GGHADILVNNAGITRDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGS
Mb2025|M.bovis_AF2122/97 G-GLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVK-PM
Rv2002|M.tuberculosis_H37Rv G-GLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVK-PM
MAB_0072c|M.abscessus_ATCC_199 G-GLDIVCATAGITSRRMLLDMPESDWQTMLDVNLTGVWHTTRAATP-HL
TH_3018|M.thermoresistible__bu G-HIDILVSNVGISNQGEVVSLTDQQWSDILQTNLIGAWHACRAVLP-SM
* . : .* . * * . .
Mvan_3777|M.vanbaalenii_PYR-1 LESG--GNIVNVASIAGVEGEVYSAGYCAAKHGLIGLTRALAVEFTKERL
Mflv_2757|M.gilvum_PYR-GCK LETG--GNIVNVASIAGVEGEVYSAGYCAAKHGLVGLTRALAIEFTKEKL
MSMEG_4358|M.smegmatis_MC2_155 LQAG--GNIVNVASIAGVEGEVYSAGYCAAKHGLVGLTRALAVEFTKERL
MAV_0087|M.avium_104 LERG--GNIVNVSSIAGVEGQAYSAGYCAAKHGLIGLTRALAVEYTADRL
MMAR_0302|M.marinum_M LRPG--SAIINITSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGAQGI
MUL_4820|M.ulcerans_Agy99 LRPG--SAIINITSTFAVVGGLRGGAYSAAKGGLAALTTHIACQYGAQGI
MLBr_02565|M.leprae_Br4923 ISKG--GRVIVLSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGI
Mb2025|M.bovis_AF2122/97 KEAG-RGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGI
Rv2002|M.tuberculosis_H37Rv KEAG-RGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGI
MAB_0072c|M.abscessus_ATCC_199 IARG-GGAMVLVSSIAGLRGLVGVSHYVAAKHGVVGLMRSLAIELAPHKI
TH_3018|M.thermoresistible__bu IERGQGGSVIFVSSTVGLRGAPGQSHYAASKHGVQGLMLSLANEVGRHNI
* . :: ::* .: * * ::* .: .* * :
Mvan_3777|M.vanbaalenii_PYR-1 RVNAICPGGMPTAQTTEFEAPENADWDLIMRIAS------------PRGF
Mflv_2757|M.gilvum_PYR-GCK RVNAICPGGMPTAQTTEFEAPENADWDLIMRIAS------------PRGF
MSMEG_4358|M.smegmatis_MC2_155 RVNAVCPGGMLTAQTTEFSAPDNADWDLIMRIAA------------PRGF
MAV_0087|M.avium_104 RVNAVCPGGMLTPQIERFSAPDDPNYDLILRTAA------------PRGM
MMAR_0302|M.marinum_M RCNAVAPG-VIQTAMTQHRLADERFRRINVEMTP------------HQRL
MUL_4820|M.ulcerans_Agy99 RCNAVAPG-VIQTAMTQHRLADERFRRLNVEITP------------HQRL
MLBr_02565|M.leprae_Br4923 TINAVAPG-FIETQMTAAIPLAT--REVGRRLNS------------LLQG
Mb2025|M.bovis_AF2122/97 RVNSIHPGLVKTPMT-DWVPEDIFQTALGRAA------------------
Rv2002|M.tuberculosis_H37Rv RVNSIHPGLVKTPMT-DWVPEDIFQTALGRAA------------------
MAB_0072c|M.abscessus_ATCC_199 RVNTVHPTNVDTPMIQNEFVRTLFRPDLEQPTREDFAAAAKTMNLLDLPW
TH_3018|M.thermoresistible__bu RVNSVNPGAVNTEMALNEKLLKMFLPHLENPTREDAAELFSQLTLLPIPW
*:: * . :
Mvan_3777|M.vanbaalenii_PYR-1 MATDDVAKTIAFLASDDAAAIHGAVYRVDNGKGAG---------------
Mflv_2757|M.gilvum_PYR-GCK MATEDVAKTIAFLASDDAAAVHGAVYRVDNGKGAG---------------
MSMEG_4358|M.smegmatis_MC2_155 MDVADVAKTIAFLASDDAAAVHGAVYIVDAGKTAG---------------
MAV_0087|M.avium_104 MRPLDVANVIAFLASDAAAAVHGAVYRVDNGKGAG---------------
MMAR_0302|M.marinum_M GTVDDVANTVAFLCSEGGAFINGQTIVVDGGWSSTKYLSDFALTAQWSPA
MUL_4820|M.ulcerans_Agy99 GTVDDVANTVAFLCSEGGAFINGQTIVVDGG-------------------
MLBr_02565|M.leprae_Br4923 GLPVDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA--------------
Mb2025|M.bovis_AF2122/97 -EPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQP
Rv2002|M.tuberculosis_H37Rv -EPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQP
MAB_0072c|M.abscessus_ATCC_199 VEPLDIANASLFLASDEARYITSVSLPVDAGSTQR---------------
TH_3018|M.thermoresistible__bu VEPEDVSNAVAWLASDEARYIHGAAIPVDGGQLARA--------------
:::: ::. . . *
Mvan_3777|M.vanbaalenii_PYR-1 -----
Mflv_2757|M.gilvum_PYR-GCK -----
MSMEG_4358|M.smegmatis_MC2_155 -----
MAV_0087|M.avium_104 -----
MMAR_0302|M.marinum_M QDDSK
MUL_4820|M.ulcerans_Agy99 -----
MLBr_02565|M.leprae_Br4923 -----
Mb2025|M.bovis_AF2122/97 EWVT-
Rv2002|M.tuberculosis_H37Rv EWVT-
MAB_0072c|M.abscessus_ATCC_199 -----
TH_3018|M.thermoresistible__bu -----