For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
PRDRMSPRERKLEDRSKFWIGMIAVGVVAAIIASMLLYRQIGFGYTRYQAEFAQAAQLKKGDYVSVAGVD VGEVKSVVLDGTKVLVDLRVRDEVKLGAETQAAIKTTTLLGSRYIELRPRGAGTIPNKRIALSHTEVPYD LQALLADTAATYEQVDATKLAQSIDILAKQLEGLPEALPEAMRNLKDLSGIVSTRRTQIGELLKSASTVT ATLHRQQANLGHLVFQGRDLLGEFVSRKASFQRLMASITKVVDLLSKVVVKDRPAFEKLLQQLRDVTAMA SDHDDYMRNLLQILPVPLRNFTNATGSGYSMGINLTNGLIVDNWMCAISSRAQQWGLIEYFKDCA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4597c | - | - | 100% (346) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1008c | - | e-104 | 53.12% (337) | putative MCE family protein |
| M. abscessus ATCC 19977 | MAB_4566c | - | e-103 | 53.87% (336) | putative Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0606 | mce2C | 2e-28 | 26.99% (326) | MCE-family protein MCE2C |
| M. gilvum PYR-GCK | Mflv_0008 | - | 3e-95 | 49.85% (337) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 1e-35 | 29.14% (326) | MCE-family protein MCE3C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 3e-24 | 23.79% (311) | putative secreted protein |
| M. marinum M | MMAR_0179 | mce6C | 6e-95 | 49.56% (341) | MCE-family protein Mce6C |
| M. avium 104 | MAV_2386 | - | 1e-96 | 50.29% (344) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1145 | - | 1e-93 | 46.96% (345) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2869 | - | 6e-95 | 49.85% (333) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4917 | mce6C | 5e-95 | 49.85% (341) | MCE-family protein Mce6C |
| M. vanbaalenii PYR-1 | Mvan_0961 | - | 4e-97 | 50.72% (345) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1145|M.smegmatis_MC2_155 MAEARKARRRKP--LESYNRLWLGVVAVAVVSVLIGAMLLVRVADIGYT-
TH_2869|M.thermoresistible__bu --------------LETYSRTTLGVIAVAVVAVLVGALLVVKAAGIGYK-
Mflv_0008|M.gilvum_PYR-GCK MAEQTK-RRRRR--LESYHKAWLGTVAVVVVAVLVGALLLIKAADVGYR-
Mvan_0961|M.vanbaalenii_PYR-1 MAERRK-WPRRP--LESYHSAWLGFAAVAVVAVLIGAMLLIKGADVGYR-
MAV_2386|M.avium_104 MRQRLSALTKRP--LESYNKTWLGFVAVAVVAAVIAVMLVVHALGAGYR-
MMAR_0179|M.marinum_M MAERIKHLRPRLRPLASYNKTWLGFVGLSLAVVLIGALLLVKQAGIGYR-
MUL_4917|M.ulcerans_Agy99 MAERIKHLRPRLRPLASYNKTWLGFVGLSLAVVMIGALLLVKQGGIGYR-
MAB_4597c|M.abscessus_ATCC_199 MPRDRMSPRERK--LEDRSKFWIGMIAVGVVAAIIASMLLYRQIGFGYT-
Mb0606|M.bovis_AF2122/97 -----------MRTLTEFNRGRVGMMGAVVTVLVVGVAQSFTSVPMLFAT
MLBr_02591|M.leprae_Br4923 -----------MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFAR
Rv1968|M.tuberculosis_H37Rv -----------MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQG
: * . :. :
MSMEG_1145|M.smegmatis_MC2_155 -QYTARFLQAAALKAGNPVTVAGIPVGEVKSMRLAGDHVEAKIKVRNDVG
TH_2869|M.thermoresistible__bu -EYTARFLQAAALQPGNPITVAGIPVGEVLSMKLNGDHVEARLKVRGDIR
Mflv_0008|M.gilvum_PYR-GCK -TFTAQFLQAAALQPGNPVSVAGIPVGEVTDMKLAGDHVEARFTVRNDVD
Mvan_0961|M.vanbaalenii_PYR-1 -KYTAQFLQAAALQPGNPVTVAGIPVGEVTGMELAGDHVVADFTVRNDVA
MAV_2386|M.avium_104 -HYTAEFAQAASLRAGNPIVVAGIPVGTVTSMKLVGDHVEAGLKVRDNIS
MMAR_0179|M.marinum_M -RYTAEFLQAASLQPDNVVSVAGVPVGNVISVRLAGDHVEARLRVKDNIA
MUL_4917|M.ulcerans_Agy99 -RYTAEFLQAASLQPDNVVSVAGVPVGNVISVRLAGNHVEARLRVKDNIA
MAB_4597c|M.abscessus_ATCC_199 -RYQAEFAQAAQLKKGDYVSVAGVDVGEVKSVVLDGTKVLVDLRVRDEVK
Mb0606|M.bovis_AF2122/97 PTYYAQFADMGGINTGDKVEIAGVNVGLVRSLAIRGNRVLIGFSLPGKT-
MLBr_02591|M.leprae_Br4923 PSYYGQFTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIGTNR-
Rv1968|M.tuberculosis_H37Rv TRVSAYFADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVR
. * : . :. .: : ::* ** * : : * * : : .
MSMEG_1145|M.smegmatis_MC2_155 LGKDSRAKIMVTTILGSRYLSLEPAGDGT-LPDRTFDLSHTDVPYDLQEA
TH_2869|M.thermoresistible__bu LGEHSRAVIKITTILGSRYLALYPDGPGT-LPDNTFDLKHTEVPYDLQEA
Mflv_0008|M.gilvum_PYR-GCK LGEDSRAVIKVTTILGSRYLSLEPEGTGA-LPDRHFDLSHTEVPYDLQEA
Mvan_0961|M.vanbaalenii_PYR-1 LGEDSRAVIKVTTILGSRYLSLEPEGPGS-LPDRRFDLAHTEVPYDLQEA
MAV_2386|M.avium_104 FGKDSRAQIRVTTILGSRYLALEPNGPAR-LPGNTFDLAHTEVPYDLQAA
MMAR_0179|M.marinum_M LGRDTRAAIKITTIFGSRYIDLHPTGAGV-PPGQTIDLAHTEVPYDLQAA
MUL_4917|M.ulcerans_Agy99 LGRDTRAAIKITTIFGSRYIDLHPTGAGV-PPGQTIDLAHTEVPYDLQAA
MAB_4597c|M.abscessus_ATCC_199 LGAETQAAIKTTTLLGSRYIELRPRGAGT-IPNKRIALSHTEVPYDLQAL
Mb0606|M.bovis_AF2122/97 IGMQSRAAIRTDTILGRKNLEIEPRGSEPLKPNGFLPLAQTTTPYQIYDA
MLBr_02591|M.leprae_Br4923 IGTASRLGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDA
Rv1968|M.tuberculosis_H37Rv LGNRTEVAIKTKGLLGSKFLDVTPRGDG--RLDSPIPIERTTSPYQLPDA
:* :. * ::* : : : . * . : : :: **:
MSMEG_1145|M.smegmatis_MC2_155 LTDVTTTFEKVDSDKFAETLQILGSQLETLPPVIPQALENTHTLSTIIAQ
TH_2869|M.thermoresistible__bu LADVATTYEQVDSDQFAESLAILGRQLETLPPVVPQALENTHTLSSIIAQ
Mflv_0008|M.gilvum_PYR-GCK LTDVTTTFEQVDSDKFAETLSILGRQLQGMPEILPQALENTHTLSTIIAD
Mvan_0961|M.vanbaalenii_PYR-1 LTDVATTFEQVDSDKFAESLAILGRQLQGLPEVVPQALQNTHTLSTILAQ
MAV_2386|M.avium_104 LQDATTTFEQVDSDRFAQSLAVLGKQLEGLPAVVPQAITNIDTLSSIIAT
MMAR_0179|M.marinum_M LADSTRTFEQVDGDRIASSLTVLGQALNGLPDVFPQALENVRALSSVISQ
MUL_4917|M.ulcerans_Agy99 LADSTRTFEQVDGDRIASSLTVLGQALNGLPDVFPQALENVRALSSVISQ
MAB_4597c|M.abscessus_ATCC_199 LADTAATYEQVDATKLAQSIDILAKQLEGLPEALPEAMRNLKDLSGIVST
Mb0606|M.bovis_AF2122/97 FVDVTKAATGWDIDAVKRSLNVLSETFDQTAPHLSAALEGVKAFSDTVGR
MLBr_02591|M.leprae_Br4923 FFDATKVASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGA
Rv1968|M.tuberculosis_H37Rv LGDLAATISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDE
: * : . . . :: :. : . *: . :: :
MSMEG_1145|M.smegmatis_MC2_155 RRDQLGELLKTTELISNTLYRQKSTIGSLMNQSNSLLAEFVARRATFHAM
TH_2869|M.thermoresistible__bu RRDQLGELLKTTEMVSTTLRRQQANIGNLVHQGNSLLGEFVARRATFHAM
Mflv_0008|M.gilvum_PYR-GCK RRDQLGSLLETTEVVSNTLRRQQANIGSLVRQGNDLVGEFVLRRASFQAM
Mvan_0961|M.vanbaalenii_PYR-1 RRDQLGALLETTDVVSTTLKRQQSNIASMVRQGNDLVGEFVVRRASFHAM
MAV_2386|M.avium_104 RRDQLGQLLRSTEQVTNTLRRQQAGIGALVDQGQDLLGQFVARRAVFHAM
MMAR_0179|M.marinum_M RRDQLGTLLKSTQNVTDILRRQQSDLGSMIRQGQDLIGEFVAHSAAFHAM
MUL_4917|M.ulcerans_Agy99 RRDQLGTLLKSTQNVTDILRRQQSDLGSMIRQGQDLIGEFVAHSAAFHAM
MAB_4597c|M.abscessus_ATCC_199 RRTQIGELLKSASTVTATLHRQQANLGHLVFQGRDLLGEFVSRKASFQRL
Mb0606|M.bovis_AF2122/97 RGEQIEQLLANANRIARVLGDRSEQVNGLLVNAKTLLAAFKQRSQALRIL
MLBr_02591|M.leprae_Br4923 RDKEIKHLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDAL
Rv1968|M.tuberculosis_H37Rv RDNQLRSLLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRI
* :: *: : : * : : :: : . ::. : : . :
MSMEG_1145|M.smegmatis_MC2_155 MDALTNLVQTLSGIVIDDRPELEKLVEDLRQLSSLLSKNDGMLRSILQTA
TH_2869|M.thermoresistible__bu MDALTVLVQRLSDIVIDDRPELEELLSNLRELSGLLADNDGMLRSILQTT
Mflv_0008|M.gilvum_PYR-GCK MNAITNLVQTLGDIVIEDRPELEALLVNVRELSDMLGQHDDLLRSILQSG
Mvan_0961|M.vanbaalenii_PYR-1 LAAITDLVQTLSDIVIGDRPELEALLVNVRELSDMLGQHDDLVRNILQSG
MAV_2386|M.avium_104 MRSLSSLVDTLSRVVVNDRSGVDALLKDIRDFTGLVSAHDDLLHSLLQVS
MMAR_0179|M.marinum_M MQALTQVVGSLRTIVVDDRAALEDVVQTMEQLSAKLAEQDALFRNLLEIA
MUL_4917|M.ulcerans_Agy99 MQALTQVVGSLRTIVVDDRAALEDVVQTMEQLSAKLAEQDALFRNLLEIA
MAB_4597c|M.abscessus_ATCC_199 MASITKVVDLLSKVVVKDRPAFEKLLQQLRDVTAMASDHDDYMRNLLQIL
Mb0606|M.bovis_AF2122/97 LTNVSEASAQVSGLITDN-PNLNHVLAQLRTVSEELVKRKNELADVAVLL
MLBr_02591|M.leprae_Br4923 LGNVAAFAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQV
Rv1968|M.tuberculosis_H37Rv WANISAVAEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLI
:: : .: : . : :. . .. . .
MSMEG_1145|M.smegmatis_MC2_155 PIALRNIANMTGTG---NAIDFNSSSGLLVDSWMCAISG-----------
TH_2869|M.thermoresistible__bu PIAVRNLANITGTG---NAIDFNAPGGLLVDSWMCAISG-----------
Mflv_0008|M.gilvum_PYR-GCK PPALRGLANATGMG---NAVEFNAANGLLVDSWMCAISG-----------
Mvan_0961|M.vanbaalenii_PYR-1 PLALRGLANATGSG---NAVDFNAANGLLVDSWMCAISG-----------
MAV_2386|M.avium_104 PIFFREAANLTGDG---NAINFNAPNVPLIDSWMCAISG-----------
MMAR_0179|M.marinum_M PVPVRELANASGYG---NALELNAAAGPLVDSWMCAISG-----------
MUL_4917|M.ulcerans_Agy99 PVPVRELANASGYG---NALEINAAAGPLVDSWMCAISG-----------
MAB_4597c|M.abscessus_ATCC_199 PVPLRNFTNATGSG---YSMGINLTNGLIVDNWMCAISS-----------
Mb0606|M.bovis_AF2122/97 GRYTAALTEAVGSGPFFKAMVVNLLPYQILQPWVDAAFKKRGIDPENFWR
MLBr_02591|M.leprae_Br4923 AAFLPSLNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWR
Rv1968|M.tuberculosis_H37Rv NTYVMSLGESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDP-----
: . * * ::: :: *
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
TH_2869|M.thermoresistible__bu --------------------------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2386|M.avium_104 --------------------------------------------------
MMAR_0179|M.marinum_M --------------------------------------------------
MUL_4917|M.ulcerans_Agy99 --------------------------------------------------
MAB_4597c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0606|M.bovis_AF2122/97 SAGLPEFRWPDPNGTRFPNGAPPAAPPVREGTPKHPGPAVPPGTPCSYTP
MLBr_02591|M.leprae_Br4923 SAGLPEFRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTP
Rv1968|M.tuberculosis_H37Rv -ATLLPSQLTDP-------------------------PTGQPGTP-----
MSMEG_1145|M.smegmatis_MC2_155 ---------------------------RAKQFGMIQYFQDCK--------
TH_2869|M.thermoresistible__bu ---------------------------RAKQFGMIEYFQDCK--------
Mflv_0008|M.gilvum_PYR-GCK ---------------------------RAKQFGMIQYFQDCK--------
Mvan_0961|M.vanbaalenii_PYR-1 ---------------------------RAKQFGMIEYLKDCK--------
MAV_2386|M.avium_104 ---------------------------RAKQFGMIQYFKDCK--------
MMAR_0179|M.marinum_M ---------------------------RAKQFGLIQYFKDCA--------
MUL_4917|M.ulcerans_Agy99 ---------------------------RAKQFGLIQYFKDCA--------
MAB_4597c|M.abscessus_ATCC_199 ---------------------------RAQQWGLIEYFKDCA--------
Mb0606|M.bovis_AF2122/97 AAG----------ALPRPDNPLPCAGATVGPFGGPDFPAPLDVQPSPPNP
MLBr_02591|M.leprae_Br4923 AHPGGNNTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNP
Rv1968|M.tuberculosis_H37Rv --------------------PLPMPYPRTGQGGEPRLTLPDAITGNPGDP
. *
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
TH_2869|M.thermoresistible__bu --------------------------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2386|M.avium_104 --------------------------------------------------
MMAR_0179|M.marinum_M --------------------------------------------------
MUL_4917|M.ulcerans_Agy99 --------------------------------------------------
MAB_4597c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0606|M.bovis_AF2122/97 DGPPPTPGILSAGRPGEPAPAVPGIPMPLPPNAPPGARTQPLEP------
MLBr_02591|M.leprae_Br4923 DGLPLLPGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQD
Rv1968|M.tuberculosis_H37Rv R-YPYRP---------EPPAPPPGGPPPGPPAQQPGDQP-----------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------
TH_2869|M.thermoresistible__bu --------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------
MAV_2386|M.avium_104 --------------------------------
MMAR_0179|M.marinum_M --------------------------------
MUL_4917|M.ulcerans_Agy99 --------------------------------
MAB_4597c|M.abscessus_ATCC_199 --------------------------------
Mb0606|M.bovis_AF2122/97 ----------------FPDGTGGSNQ------
MLBr_02591|M.leprae_Br4923 SSAPHEPREQLSAPLINPGGTGGSGGAGGSRN
Rv1968|M.tuberculosis_H37Rv --------------------------------